To investigate the effects of age combinations and fertility assessment results on the clinical pregnancy outcome of in vitro fertilization-embryo transfer (IVF-ET) / intracytoplasmic sperm injection (ICSI).

A retrospective cohort was established based on the data of 5 104 cycles of IVF-ET/ICSI transplantation from 11 assisted reproductive institutions in the east, central, and west regions. According to the age registered at the first fertility evaluation, the couples were divided into group A (female < 35, male < 40), group B (female < 35, male ≥ 40), group C (female ≥ 35, male < 40), and group D(female ≥ 35, male ≥ 40). The results of clinical pregnancy rate and first fertility among the four groups were compared by Chi-square test and one-way ANOVA.

The clinical pregnancy rates of the four age groups treated with IVF-ET were 58.23%, 54.12%, 40.57%, and 30.70%, respectively (χ²=167.214, P < 0.001), and those of ICSI were 59.29%, 62.5%, 49.07%,and 34.31%, respectively (χ²=23.834, P < 0.001). There was no significant difference in the clinical pregnancy rate between the two treatments of IVF-ET/ICSI between group A and group B (χ²=0.574, P_IVF-ET=0.449, χ²=0.099, PICSI=0.754) but the clinical pregnancy rate of group C was significantly higher than that of group D in the two treatments of IVF-ET/ICSI, which was (χ²=11.581, P_IVF-ET=0.001; χ²=4.695, P_ICSI=0.03).

When the woman is less than 35 years old, the age of the man has no significant effect on the clinical pregnancy rate treated with IVF-ET/ICSI. When the woman is ≥ 35 years old, the clinical pregnancy rate of the man < 40 years old receiving IVF-ET/ICSI is significantly higher than that of the man ≥ 40 years old, which suggests that if the couple with fertility intention is in the age range of ≥ 35 years old for woman and < 40 years old for man, they should actively evaluate the fertility and choose the appropriate medical treatment plan in time.

To evaluate the relationship between alcohol consumption and hyperuricemia in natural population in southwest China, and to further explore the mediating effect of blood lipid level on the relationship between alcohol consumption and hyperuricemia.

Based on the baseline data (2018 to 2019) and the first-round follow-up data (2020 to 2021) of the natural population cohort study in southwest China, a multivariate Logistic regression model was used to analyze the association between alcohol consumption and hyperuricemia. The potential mediating effect of serum lipids was evaluated by causal mediation analysis.

A total of 1 615 people were enrolled in this study, including 162 new cases of hyperuricemia. Each 10g/d increase in pure alcohol intake was positively correlated with the risk of hyperuricemia (OR=1.22, 95%CI: 1.08-1.37). High density lipoprotein (HDL-C) and triglyceride (TG) partially mediated the relationship between alcohol consumption and hyperuricemia, with mediating effects of 16.58% (95%CI: 5.64%-54.01%) and 6.98% (95% CI:1.12%-24.84%), respectively.

The increase of alcohol consumption can increase the risk of hyperuricemia. HDL-C and TG are important mediating factors between alcohol consumption and hyperuricemia. Our study shows that the occurrence and development of hyperuricemia can be prevented by reducing alcohol consumption and controlling blood lipids.

To study the causal effects of generalized anxiety disorder, major depressive disorder, schizophrenia, sleep disorder, and psoriasis by two-sample Mendelian randomization analysis.

The single nucleotide polymorphisms (SNPs) associated with four psychiatric traits and psoriasis were screened from the genome-wide association study (GWAS) data base. The relationships between exposures and outcome were analyzed by inverse variance weighting (IVW) method, weighted median (WM) method, and MR-Egger method. The results were mainly evaluated by P value of IVW, odds ratio (OR), and 95% confidence interval (CI). IVW, MR Egger, and MR-PRESSO were used for sensitivity analysis.

The IVW results showed that there was a causal effect between schizophrenia and the risk of psoriasis (OR=1.002,95%CI: 1.000-1.003, P=0.023). In the heterogeneity test, the Cochran’s Q test of the IVW method reported P value of 0.104 and I² of 19.06%, the MR-PRESSO test in the pleiotropy test reported P value of 0.106, and the regression intercept of MR Egger reported P value of 0.272. The sensitivity analysis results were robust, and the results did not show heterogeneity and pleiotropy. No causal relationship was found for generalized anxiety disorder (OR=1.000, 95%CI: 0.999-1.001, P=0.791), major depressive disorder (OR=1.002, 95%CI: 0.998-1.005, P=0.246), sleep disorder (OR=0.999, 95%CI: 0.996-1.001, P=0.614) with psoriasis.

There is a causal relationship between schizophrenia and the risk of psoriasis. Patients with schizophrenia should strengthen the screening and prevention of psoriasis in order to reduce the risk of psoriasis.

To establish a risk assessment model of cardiometabolic multimorbidity (CMM) and validate the model.

The influencing factors of CMM were determined by meta-analysis, and the population exposure rate was obtained by consulting a large cohort study.The CMM risk assessment model was constructed based on Harvard cancer risk index method. The model was verified by the data of China Health and Retirement Longitudinal Study (CHARLS). The SPSS 25.0 software was used to calculate the area under the receiver operator characteristic ROC curve (AUC), sensitivity, specificity, and Hosmer-Lemshow goodness-of-fit test to verify the effect of the model.

A total of 20 articles were included in the meta- analysis. Age, sex, place of residence, education, economic level, BMI, waistline, night sleep, depression, irregular diet, and insufficient intake of vegetables and fruits were the risk factors of CMM. Concerning the model validation results, the area under the ROC curve was 0.712 (95%CI: 0.696-0.728), the Jordan index was 1.42, the sensitivity was 65%, the specificity was 66.1%, and the result of Hosmer-Lemshow goodness-of-fit test was χ²=10.652 (P=0.222).

The CMM risk assessment model based on meta-analysis has good predictive performance and can be used as a tool for CMM risk assessment to guide clinical identification of CMM high-risk groups and implement intervention measures.

To explore the causal relationship between hypothyroidism and the risk of coronary heart disease (CHD) by two-sample Mendelian randomization study.

Based on the association analysis data at the whole genome level, the exposure was hypothyroidism and the outcome was coronary heart disease. Random effect IVW method, MR-Egger method, and weighted median method were used for two sample Mendelian randomized analysis, and heterogeneity test, horizontal multiplicity analysis, and sensitivity analysis were carried out.

The results of random effect IVW method, weighted median method, and MR-Egger regression were 1.137 (95%CI: 1.070-1.209), 1.117 (95%CI: 1.028-1.214), and 1.194 (95%CI: 1.020-1.398), respectively, indicating that hypothyroidism was a risk factor for coronary heart disease with a positive causal correlation between them.

There is a causal relationship between hypothyroidism and the risk of coronary heart disease.

To investigate the relationship between the metabolism score for visceral fat (METS-VF) and new stroke cases in the middle-aged and elderly.

Three Logistic regression models were established based on the data of China Health and Retirement Longitudinal Study (CHARLS) in 2011 and 2018 to study the association between METS-VF and new stroke cases, and the restricted cubic spline model was used to investigate the possible nonlinear relationship.

In total 7 007 participants were included, of which 407 had new stroke. The results of regression model showed that compared with the group with the lowest METS-VF index (Q1), the group with the highest METS-VF index (Q4) had the highest risk of new stroke, with the increased risk by 153% (OR=2.53, 95%CI: 1.87-3.47). Restricted cubic spline regression analysis found that there was a dose-response relationship between METS-VF index and the prevalence of new stroke (P <0.001), showing a J-shape relationship (P _Nonlinear < 0.001).

METS-VF index is closely related to the prevalence of new stroke, and there is a dose-response relationship between them.

To investigate the epidemic characteristics of pulmonary tuberculosis in Guilin, Guangxi Zhuang Autonomous region from 2012 to 2022, and to provide theoretical basis for the prevention and control of pulmonary tuberculosis in Guilin.

The relevant information of pulmonary tuberculosis cases reported by China Disease Prevention and Control Information system (Tuberculosis Surveillance and Report Management system) from 2012 to 2022 in Guilin, Guangxi Zhuang Autonomous region was collected. The distribution characteristics and incidence trend of pulmonary tuberculosis in Guilin from 2012 to 2022 were analyzed by chi-square and chi-square trend, and the average annual reported incidence and etiological positive rate of pulmonary tuberculosis were visually analyzed.

From 2012 to 2022, a total of 32 319 cases of pulmonary tuberculosis were reported in Guilin, with an average annual incidence of 59.40/100 000. The reported incidence of tuberculosis decreased from 68.59/100 000 in 2012 to 45.99/100 000 in 2022, with an annual decline rate of 4.08%. In total 12 132 cases were etiologically positive, accounting for 37.53%. The incidence of pulmonary tuberculosis decreased in all age groups in Guilin. The incidence increased with age (Z=21.017, P < 0.001). The reported incidence of males and females was basically stable at 3:1, and the reported incidence of males was higher than that of females (χ²=25.87, P < 0.001). Farmers were the main occupations of patients (23 375 cases), accounting for 72.32%. The reported incidence rate of pulmonary tuberculosis in more than half of the counties (districts) in Guilin was higher than the annual average level of the whole city, with Lipu county (88.96/100 000) being the highest. The etiological positive rate of most counties (districts) was higher than the average annual level of the whole city, with Pingle county (31.65/100 000) being the highest.

The reported incidence of pulmonary tuberculosis in Guilin shows an overall downward trend from 2012 to 2022. The high incidence of pulmonary tuberculosis is characterized by age 65 and above, male, occupation as farmer, and the place of residence in the south of Guilin.

To explore the relationship between Mediterranean dietary pattern and bone mineral density (BMD) in the middle-aged and elderly, so as to provide reference for nutritional prevention and control of bone health.

A total of 909 community residents aged 45 and above in Urumqi were enrolled from July 2018 to February 2019. The calcaneal bone mineral density (BMD) was measured by ultrasonic BMD device. The dietary intake information was collected by semi-quantitative food frequency questionnaire and scored by Mediterranean dietary pattern. Univariate and multiple linear regression were used to analyze the influencing factors of Mediterranean dietary score and bone mineral density and the relationship between them.

There were significant differences in the scores of Mediterranean dietary patterns among people of different genders (t=-2.199, P=0.028) and educational levels (F=6.986, P=0.001). There were significant differences in BMD T value among different genders (t=-4.632, P<0.001), age (F=19.753, P<0.001), smoking (t=3.617, P<0.001), physical activity level (F=5.858, P=0.003), and sleep duration (F=6.651, P=0.01). The results of multiple linear regression showed that there was a positive correlation between Mediterranean dietary pattern score and bone mineral density T value in the middle-aged and elderly women (β=0.090, P=0.024),while there was no statistical significance in male population model.

There is a positive correlation between Mediterranean diet and bone mineral density in middle-aged and elderly women. It is suggested that middle-aged and elderly residents adjust their diet to protect bone health.

To investigate the relationship between the intake of flavonoids in diet and total bone mineral content in human body.

Adults aged 20 to 59 years in the National Health and Nutrition Examination Surveys (NHANES) from 2017 to 2018 were selected as research subjects. A multivariate linear regression model was constructed to explore the relationship between dietary flavonoid intake and total bone mineral content adjusting gender, age, race, education level, marital status, economic status, BMI, alcohol consumption, hypertension, diabetes, and cardiovascular disease.

A total of 2 110 participants were included in the study, with the ratio of male to female 1:1. The average total mineral content was 2 341.4 g, and the median intake of total flavonoids in diet was 74.45 mg. After adjusting for sex, age, race, education, marital status, economic status, BMI, alcohol consumption, hypertension, diabetes and cardiovascular disease, the linear regression model showed that the total bone mineral content of the whole body was positively correlated with dietary isoflavone intake (β=0.68, 95%CI:0.26-1.09), and there was a dose-response relationship (P_trend=0.001). In addition, the results of subgroup analysis showed that the positive correlation was stronger in men (β_male=1.39, 95%CI: 0.67-2.11 vs. β_Female=0.18, 95%CI: -0.31 to 0.67, P_inter=0.038).

the intake of isoflavones in diet may increase the content of total bone minerals in human body, but whether there is a gender difference needs to be further explored.

To investigate the level of cadmium in food sold in Nanshan District of Shenzhen, and to evaluate its exposure risk based on the dietary intake of residents in Shenzhen.

Using stratified random sampling method, 810 food samples sold in Nanshan district of Shenzhen city were collected from 2018 to 2022. The content of cadmium in the samples was determined by inductively coupled plasma mass spectrometry (ICP-MS), and the test results were evaluated according to GB2762-2022 “Food Safety National Standard for Contaminants in Food”. Based on the residents’ dietary intake, point assessment, margin of safety (MOS), and chemical carcinogen risk model were used to evaluate the exposure risk of cadmium to residents’ health.

The average content of cadmium in 810 food samples was 0.325 mg/kg, the detection rate was 44.44% (360/810), and the over-standard rate was 6.17% (50/810). The average monthly dietary exposure of cadmium was 17.731 μg/(kg·BW), MOS > 1, R^c was 4.030 × 10^-5 per year, and the monthly high-end dietary exposure of cadmium was 38.536 μg/(kg·BW), MOS < 1, R^c was 8.740 × 10^-5 per year, suggesting that there was carcinogenesis risk through daily dietary intake.

There is cadmium contamination in food sold in Nanshan district of Shenzhen city. The health risk of residents exposed to cadmium through daily diet is low, but there is a health risk among people exposed to high-end diet. The relevant departments should strengthen the supervision of food sold in the market, especially rice and rice products, aquatic products, and vegetables, so as to control the health risk of dietary exposure to cadmium.