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To evaluate the relationship between alcohol consumption and hyperuricemia in natural population in southwest China, and to further explore the mediating effect of blood lipid level on the relationship between alcohol consumption and hyperuricemia.
Based on the baseline data (2018 to 2019) and the first-round follow-up data (2020 to 2021) of the natural population cohort study in southwest China, a multivariate Logistic regression model was used to analyze the association between alcohol consumption and hyperuricemia. The potential mediating effect of serum lipids was evaluated by causal mediation analysis.
A total of 1 615 people were enrolled in this study, including 162 new cases of hyperuricemia. Each 10g/d increase in pure alcohol intake was positively correlated with the risk of hyperuricemia (OR=1.22, 95%CI: 1.08-1.37). High density lipoprotein (HDL-C) and triglyceride (TG) partially mediated the relationship between alcohol consumption and hyperuricemia, with mediating effects of 16.58% (95%CI: 5.64%-54.01%) and 6.98% (95% CI:1.12%-24.84%), respectively.
The increase of alcohol consumption can increase the risk of hyperuricemia. HDL-C and TG are important mediating factors between alcohol consumption and hyperuricemia. Our study shows that the occurrence and development of hyperuricemia can be prevented by reducing alcohol consumption and controlling blood lipids.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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