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To investigate the relationship between the intake of flavonoids in diet and total bone mineral content in human body.
Adults aged 20 to 59 years in the National Health and Nutrition Examination Surveys (NHANES) from 2017 to 2018 were selected as research subjects. A multivariate linear regression model was constructed to explore the relationship between dietary flavonoid intake and total bone mineral content adjusting gender, age, race, education level, marital status, economic status, BMI, alcohol consumption, hypertension, diabetes, and cardiovascular disease.
A total of 2 110 participants were included in the study, with the ratio of male to female 1:1. The average total mineral content was 2 341.4 g, and the median intake of total flavonoids in diet was 74.45 mg. After adjusting for sex, age, race, education, marital status, economic status, BMI, alcohol consumption, hypertension, diabetes and cardiovascular disease, the linear regression model showed that the total bone mineral content of the whole body was positively correlated with dietary isoflavone intake (β=0.68, 95%CI:0.26-1.09), and there was a dose-response relationship (Ptrend=0.001). In addition, the results of subgroup analysis showed that the positive correlation was stronger in men (βmale=1.39, 95%CI: 0.67-2.11 vs. βFemale=0.18, 95%CI: -0.31 to 0.67, Pinter=0.038).
the intake of isoflavones in diet may increase the content of total bone minerals in human body, but whether there is a gender difference needs to be further explored.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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