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A Mendelian randomization study on the causal relationship between hypothyroidism and coronary heart disease
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Xiao-lin XIA1, 2, Ye LIU2, Xiao-bing XU1, Jun-tong MENG3, Yan WANG4
Modern Preventive Medicine | 2024, 51(3) : 412 - 416
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Modern Preventive Medicine | 2024, 51(3): 412-416
• Epidemiology and Statistical Methods •
A Mendelian randomization study on the causal relationship between hypothyroidism and coronary heart disease
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Xiao-lin XIA1, 2, Ye LIU2, Xiao-bing XU1, Jun-tong MENG3, Yan WANG4
Affiliations
  • School of Nursing, Qingdao University, Qingdao, Shandong 266071, China
Published: 2024-02-10 doi: 10.20043/j.cnki.MPM.202306452
Outline
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Objective

To explore the causal relationship between hypothyroidism and the risk of coronary heart disease (CHD) by two-sample Mendelian randomization study.

Methods

Based on the association analysis data at the whole genome level, the exposure was hypothyroidism and the outcome was coronary heart disease. Random effect IVW method, MR-Egger method, and weighted median method were used for two sample Mendelian randomized analysis, and heterogeneity test, horizontal multiplicity analysis, and sensitivity analysis were carried out.

Results

The results of random effect IVW method, weighted median method, and MR-Egger regression were 1.137 (95%CI: 1.070-1.209), 1.117 (95%CI: 1.028-1.214), and 1.194 (95%CI: 1.020-1.398), respectively, indicating that hypothyroidism was a risk factor for coronary heart disease with a positive causal correlation between them.

Conclusion

There is a causal relationship between hypothyroidism and the risk of coronary heart disease.

Hypothyroidism  /  Coronary heart disease  /  Mendelian randomization
Xiao-lin XIA, Ye LIU, Xiao-bing XU, Jun-tong MENG, Yan WANG. A Mendelian randomization study on the causal relationship between hypothyroidism and coronary heart disease[J]. Modern Preventive Medicine, 2024 , 51 (3) : 412 -416 . DOI: 10.20043/j.cnki.MPM.202306452
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Year 2024 volume 51 Issue 3
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Article Info
doi: 10.20043/j.cnki.MPM.202306452
  • Receive Date：2023-06-22
  • Online Date：2026-03-19
  • Published：2024-02-10
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History
  • Received：2023-06-22
Funding
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    School of Nursing, Qingdao University, Qingdao, Shandong 266071, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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