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To study the causal effects of generalized anxiety disorder, major depressive disorder, schizophrenia, sleep disorder, and psoriasis by two-sample Mendelian randomization analysis.
The single nucleotide polymorphisms (SNPs) associated with four psychiatric traits and psoriasis were screened from the genome-wide association study (GWAS) data base. The relationships between exposures and outcome were analyzed by inverse variance weighting (IVW) method, weighted median (WM) method, and MR-Egger method. The results were mainly evaluated by P value of IVW, odds ratio (OR), and 95% confidence interval (CI). IVW, MR Egger, and MR-PRESSO were used for sensitivity analysis.
The IVW results showed that there was a causal effect between schizophrenia and the risk of psoriasis (OR=1.002,95%CI: 1.000-1.003, P=0.023). In the heterogeneity test, the Cochran’s Q test of the IVW method reported P value of 0.104 and I2 of 19.06%, the MR-PRESSO test in the pleiotropy test reported P value of 0.106, and the regression intercept of MR Egger reported P value of 0.272. The sensitivity analysis results were robust, and the results did not show heterogeneity and pleiotropy. No causal relationship was found for generalized anxiety disorder (OR=1.000, 95%CI: 0.999-1.001, P=0.791), major depressive disorder (OR=1.002, 95%CI: 0.998-1.005, P=0.246), sleep disorder (OR=0.999, 95%CI: 0.996-1.001, P=0.614) with psoriasis.
There is a causal relationship between schizophrenia and the risk of psoriasis. Patients with schizophrenia should strengthen the screening and prevention of psoriasis in order to reduce the risk of psoriasis.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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