Phenotypic age acceleration is an important risk phenotype for multiple chronic diseases. Nutrient supplements are widely used among middle-aged and older adults, often in combination, as a potential strategy to address age-related health concerns. However, the associations between supplement combinations and phenotypic age acceleration remain insufficiently evaluated. This study aims to examine the associations of supplement use and common combinations with phenotypic age acceleration.

A cross-sectional analysis was conducted using baseline data from the UK Biobank, including 415 636 participants aged 40-69 years. Multivariable linear regression and restricted cubic spline models were applied to assess the associations between supplement use and phenotypic age acceleration.

Regular supplement users accounted for 50.6% of participants, and had lower phenotypic age acceleration than non-users (β=-0.18 years, 95% CI: -0.21~-0.15). Phenotypic age acceleration decreased non-linearly with increasing number of supplements. Use of glucosamine, fish oil, or multivitamins alone was associated with lower phenotypic age acceleration, with the strongest association observed for glucosamine (β=-0.39 years, 95% CI: -0.47~-0.30). The association was stronger for the combination of glucosamine and fish oil (β=-0.60 years, 95% CI: -0.69~-0.52). Adding vitamin C or calcium to this combination also showed negative associations, whereas combinations containing zinc showed no clear association.

Regular nutrient supplement use was associated with lower phenotypic age acceleration, with a non-linear decrease as the number of supplements increased. Associations varied across combinations, and those containing glucosamine and fish oil showed more consistent associations.

To examine the association between dietary patterns and emotional distress among medical students through a cross-sectional analysis, providing scientific evidence for promoting mental health in this population.

A cross-sectional survey was conducted among 1 305 medical students from medical colleges in Tianjin from January 2022 to February 2023 using the Symptom Checklist-90 and a food frequency questionnaire. Principal component analysis was used to identify dietary patterns, and the factor scores of each dietary pattern were categorized into T1, T2, and T3 groups according to tertiles. Multivariable logistic regression was used to analyze the association between different dietary patterns and emotional distress.

The proportion of medical students with emotional distress was 16.7%. Three distinct dietary patterns were derived from the analysis: a diverse diet, a beverages-snacks-pickled foods diet, and a nuts-fruits-beans diet. Among them, high intake of the beverages-snacks-pickled foods pattern (T3) was positively associated with emotional distress (OR=1.812, 95% CI: 1.238-2.651, P<0.05), and this association persisted after adjustment (OR=1.992, 95% CI: 1.336-2.971, P<0.05). In contrast, moderate intake of this pattern (T2) was inversely related to emotional distress (OR=0.618, 95% CI: 0.389-0.982, P<0.05). Other associations were non-significant after adjustment (P>0.05).

There is an association between dietary patterns and emotional distress. Medical students should optimize their daily dietary structure and reasonably control sugar and salt intake to prevent emotional distress.

To investigate the current status of emotional eating behaviors during pregnancy, construct a network model to analyze symptoms and influencing factors, and provide targets for precision intervention.

Pregnant women were recruited from a maternal and child health hospital in Ningxia using convenience sampling. Emotional eating behaviors were measured using the revised Dutch Eating Behavior Questionnaire (DEBQ). The symptom network of emotional eating behaviors and its relationship with influencing factors were analyzed using the “bootnet” package in R 4.4.3.

The mean score of emotional eating behaviors in pregnant women was 19.82±7.68. “Craving food when disappointed” was the core symptom, with the strongest association observed between “craving food when disappointed” and “craving food when fearful” (edge weight=0.48). In the influencing factor network, the restrictive eating behavior cluster showed the strongest association with the emotional eating behavior cluster (mean edge=0.05), while psychological resilience exhibited a negative correlation with “craving food when fearful” (edge=-0.05). Within the restrictive-emotional eating behavior network, “considering the relationship between body weight and food” and “craving food when bored” demonstrated the strongest connections (edge=0.09).

The core symptom of emotional eating in pregnant women is “eating when disappointed”. Eating behaviors triggered by fear and goal frustration, as well as cognition about the relationship between body weight and food, are key influencing factors.

To explore the relationship between postpartum depression and intimate partner psychological violence during pregnancy and childbirth among postpartum women in rural poverty-stricken areas, as well as the role of social support in this process.

A total of 467 women of childbearing age within one year after childbirth in rural poverty-stricken areas were selected and investigated using the general demographic data questionnaire, the Edinburgh Postnatal Depression Scale, the Abuse Assessment Questionnaire, and the Social Support Rating Scale. Spearman correlation analysis was used to test the relationship between variables, and the Process 4.1 plugin in SPSS was used to test the mediating effect.

The detection rate of postpartum depression symptoms among postpartum women was 32.76%. Intimate partner psychological violence during pregnancy and childbirth was positively correlated with postpartum depression (r_s=0.367, P<0.001), while social support and its various dimensions were negatively correlated with postpartum depression (r_s=-0.389, P<0.001). Social support played a partial mediating role between the two, explaining 15.89% of the total effect.

Both intimate partner psychological violence during pregnancy and childbirth and social support are factors associated with postpartum depression among postpartum women, and social support plays a partial mediating role in this process.

To analyze the compliance of urban populations at high risk of breast cancer in Nanchang City from 2021 to 2023 and explore potential influencing factors, in order to provide a scientific basis for improving screening participation rates and optimizing screening strategies.

Permanent registered residents aged 45-74 years in Nanchang City were selected for a breast cancer risk factor survey and risk assessment. Individuals assessed as high-risk for breast cancer were recommended to undergo combined breast ultrasound and X-ray examinations at designated hospitals. SPSS 25.0 was used to perform χ² analysis to compare screening participation rates across groups with different characteristics. Multivariable logistic stepwise regression analysis was also conducted to identify factors associated with screening participation.

A total of 9 138 high-risk individuals for breast cancer were enrolled, of whom 4 228 participated in breast cancer screening, yielding an overall participation rate of 46.27%. Multivariable logistic stepwise regression analysis showed that higher education level (OR=1.235, 95% CI: 1.052-1.450), current smoking (OR=1.519, 95% CI: 1.296-1.779), exposure to secondhand smoke (OR=1.784, 95% CI: 1.621-1.964), history of childbirth (OR=2.631, 95% CI: 2.141-3.233), history of benign breast disease (OR=1.846, 95% CI: 1.683-2.025), and family history of breast cancer in blood relatives (OR=1.560, 95% CI: 1.406-1.731) were facilitating factors for screening participation (P<0.05). In contrast, age 65-74 years (OR=0.572, 95% CI: 0.508-0.645), screening in 2022 (OR=0.644, 95% CI: 0.573-0.724) and 2023 (OR=0.709, 95% CI: 0.637-0.789), engaging in physical exercise ≥3 times per week (OR=0.763, 95% CI: 0.691-0.844), and history of breastfeeding (OR=0.882, 95% CI: 0.803-0.970) were inhibiting factors for screening participation (P<0.05).

The screening rate among urban populations at high risk of breast cancer in Nanchang City was relatively low and influenced by multiple factors, including education level, smoking history, childbirth history, breastfeeding history, physical exercise, and family history of breast cancer. It is recommended to adopt targeted health education, strengthen social support networks, and focus on subgroups with low screening participation in future efforts to improve screening coverage and enhance prevention and control outcomes.

To understand the prenatal screening results and genotype distribution features of thalassemia among pregnant women in Zunyi area, and to provide a scientific basis for the development and optimization of thalassemia prevention and control strategies.

A retrospective analysis was conducted on the clinical data of 1 876 pregnant women who underwent prenatal check-ups at the First People’s Hospital of Zunyi from February 2023 to September 2023. All 1 876 pregnant women were initially screened for thalassemia using red blood cell indices and hemoglobin electrophoresis. Thalassemia gene detection based on third-generation sequencing technology was performed for screening-positive pregnant women and 228 voluntarily tested screening-negative pregnant women. The positive rate of thalassemia screening, the rate of genetic diagnosis and the distribution features of genotypes were analyzed.

Among 1 876 pregnant women, 178 cases (9.49%) were positive for thalassemia screening, and 67 cases (37.64%) were diagnosed with thalassemia through genetic testing, including 41 cases of α-thalassemia and 26 cases of β-thalassemia. A total of 228 pregnant women with negative thalassemia screening voluntarily underwent thalassemia gene testing, and 14 cases of thalassemia carriers were detected (with a carrier rate of 6.14%), all of whom were α-thalassemia carriers. A total of 55 cases (67.90%) of α-thalassemia and 26 cases (32.10%) of β-thalassemia were detected in this study, and the carrier rate of α-thalassemia was higher than that of β-thalassemia. Among them, the main genotypes of α-thalassemia were --^SEA/αα (30.91%) and -α^3.7/αα (27.27%). The main genotypes of β-thalassemia were CD17/N (38.46%) and CD41-42/N (26.92%).

The carrier rate of thalassemia among pregnant women in Zunyi area is relatively high, with α-thalassemia being predominant. The main genotypes are --^SEA/αα (α-thalassemia), -α^3.7/αα (α-thalassemia), CD17/N (β-thalassemia), and CD41-42/N (β-thalassemia), and a certain proportion of missed cases in the initial screening and rare genotypes were observed.

To investigate the current status and influencing factors of job competency among personnel with public health-related responsibilities in community health service centers within the context of the integration of medical care and disease prevention.

Using a mixed research design approach, the quantitative research employed a multistage sampling method. Based on the job competency assessment scale, self-assessment of job competency was conducted through self-evaluation. For the qualitative study, one-on-one interviews were conducted, and three-level coding based on grounded theory was used to explore the influencing factors of job competency among personnel with public health-related responsibilities.

The quantitative research indicated a job competency score of 4.15±0.50. Across the three dimensions, the self-rated scores in descending order were: professional values (4.40±0.56), personal efficacy (4.20±0.58), and professional literacy (3.86±0.67). Educational attainment was identified as the primary factor influencing the total competency score (P<0.05). Although age and years of work experience did not significantly affect the total score, they showed significant differences in the dimensions of professional literacy and professional values, respectively (P<0.05). The qualitative analysis extracted six influencing factors: professional capability, organizational environment, social responsiveness, comprehensive skills, institutional safeguards, and resource systems. Among these, professional capability (27.35%) and organizational environment (24.63%) accounted for the highest proportions.

The overall job competency score of personnel with public health-related responsibilities in community health service centers in Chengdu was 4.15, demonstrating a structural pattern characterized by “high professional values yet relatively insufficient professional literacy”. Competency is influenced by multidimensional factors. Systematic efforts should be directed toward enhancing professional training, optimizing the organizational environment, and improving institutional safeguards to comprehensively strengthen personnel competency.

To explore the current status of delayed medical care behavior and its influencing factors among the elderly in China, in order to provide a reference for further improving the health outcomes of older adults.

Data were derived from the 2021 Chinese General Social Survey (CGSS). Participants aged 60 years and older were enrolled in this study. Grounded in Andersen’s behavioral model of health care utilization, binary logistic regression combined with decision tree analysis was employed to identify key influencing factors.

Binary logistic regression revealed that delayed medical care behavior was significantly less likely among adults aged ≥81 years (OR=0.486), married older adults (OR=0.118), individuals with general high school or vocational education (OR=0.426), college graduates (OR=0.249), participants with high health literacy (OR=0.191), rural residents (OR=0.591), individuals from higher household economic backgrounds (OR=0.420), older adults receiving social support (OR=0.291), regular health check-up attendees (OR=0.228), and participants reporting strong self-efficacy (OR=0.553). Conversely, significantly higher risks were observed among older adults with poor communication skills with medical professionals (OR=3.104), individuals with ≥3 chronic conditions (OR=2.211), participants experiencing anxiety regarding healthcare accessibility (OR=2.122), and older adults reporting anxiety concerning medical affordability (OR=3.363), all P<0.05. The decision tree model identified seven predictive factors (P<0.05), with marital status showing the strongest association with delayed medical care behavior among older adults.

The rate of delayed medical care among older adults in China is high, and differentiated and targeted preferential healthcare policies should be implemented for older adults, the medical security system should be improved, health education activities should be actively carried out, and older adults should be guided to seek medical care appropriately.

To explore the impact of subjective economic status on the mental health of the elderly and provide a basis for improving their mental health.

Based on the data from the China Family Panel Studies in 2022, this study was conducted using descriptive analysis, one-way ANOVA, Spearman correlation analysis, multiple linear regression, and heterogeneity analysis.

The proportions of participants who self-rated their economic status as difficult, average, and good were 24.94%, 42.48%, and 32.58%, respectively. There were significant differences in depression levels and life satisfaction among the elderly with different subjective economic statuses (P<0.001). Subjective economic status was significantly negatively correlated with depression levels (r=-0.126, P<0.001), and significantly positively correlated with life satisfaction (r=0.322, P<0.001). Compared with the elderly who self-rated their economic status as difficult, those with an average economic status had significantly lower depression levels (B=-0.568, P=0.002), and significantly higher life satisfaction (B=0.179, P<0.001). Those with a good economic status had significantly lower depression levels (B=-0.430, P=0.037), and significantly higher life satisfaction (B=0.456, P<0.001). The results of the heterogeneity analysis showed that the negative impact of subjective economic status on depression levels was significant among the older adults aged 60-64 years and ≥75 years. The positive impact on life satisfaction was significant in all age groups, with the most prominent effect among older adults aged 65-69 years and a significant effect among those aged ≥75 years only when economic status was good.

A high subjective economic status can significantly reduce depression levels and improve life satisfaction among the elderly, and this impact shows significant group heterogeneity. It is necessary to strengthen the economic security of the elderly, alleviate their life pressure, and thereby improve their mental health status to promote active aging.