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To investigate the effect of depressive symptoms on the risk of developing type 2 diabetes mellitus in middle-aged and elderly people in China.
Based on the data from the China Health and Retirement Longitudinal Study (CHARLS) 2011 and 2018, 9 697 middle-aged and elderly people aged 45 years or older were included as study subjects. Chained equations were used to perform g-formula analysis after multiple interpolation of missing values of covariates, and stratified analyses were performed to explore the association between depressive symptoms and the risk of developing type 2 diabetes mellitus with respect to age and gender.
The results of the analysis after multiple interpolation of covariates and adjustment for confounding showedthat the mean risk of developing type 2 diabetes mellitus in study participants with depressive symptoms which was 1.3 times higher than that of those without depressive symptoms ［RR(95% CI):1.37(1.15-1.62)］, with a mean hazard difference of 0.02. Those with mild depressive symptoms had a mean risk of type 2 diabetes mellitus of 1.27 times higher than that of those without depressive symptoms ［RR(95% CI):1.27(1.07-1.52)］, with a mean difference of 0.01; those with severe depressive symptoms had a mean risk of developing type 2 diabetes mellitus that was 2.22 times higher than that of those who were not depressed ［RR(95% CI):2.22(1.64-3.00)］; the mean difference was 0.06.
Depressive symptoms and the risk of type 2 diabetes mellitus were significantly associated with the risk of developing type 2 diabetes mellitus among middle-aged and elderly people in China. Associated with the risk of developing type 2 diabetes, the risk of developing the disease increased with the severity of depressive symptoms.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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