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To explore the impact of the triglyceride-glucose index (TyG) and obesity indicators on the risk of non-alcoholic fatty liver disease (NAFLD) among participants aged ≥60 years, so as to provide evidence for the early prevention of NAFLD.
A stratified random cluster sampling method was used to select 95 932 elderly individuals in 2022 in Nanjing. These individuals underwent questionnaires, physical examinations, and laboratory tests. A logistic regression model was used to analyze the effects of the TyG and multiple obesity indicators on the risk of NAFLD, followed by the interaction analysis between TyG and each obesity indicator. The diagnostic value of the TyG and its combination with obesity indicators was assessed using receiver operating characteristic curves.
In the study, the prevalence of NAFLD was 39.66%. After adjusting for confounding factors, logistic regression analysis showed that as the increase of TyG and obesity indicators, including BMI, Chinese visceral adiposity index, and lipid accumulation product, the risk of NAFLD in the elderly increased, with odds ratios of 1.86 (1.80-1.93), 3.69 (3.57-3.80), 3.66 (3.54-3.79), and 3.28 (3.17-3.39), respectively (P<0.001). Interaction analysis revealed that compared to low levels of both the TyG and obesity indicator, one variable at a high level or both at high levels increased the risk of NAFLD, indicating a synergistic effect. The diagnostic ability of the TyG combined with obesity indicators for NAFLD risk was higher than that of the TyG alone.
The risk of NAFLD in individuals aged ≥60 years increases with higher levels of the TyG and obesity indicators, and they have a combined effect on NAFLD risk. TyG combined with BMI may be a simple and efficient tool for the early screening of NAFLD in elderly people.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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