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To study the association between serum albumin level and the risk of respiratory failure after pulmonary infection in patients with pneumoconiosis.
This study utilized data of hospitalized pneumoconiosis patients from 2012 to 2021 and employed the Cox model to analyze the association between baseline serum albumin levels and the risk of respiratory failure following pulmonary infection in male pneumoconiosis patients.
The average age of 1 301 male inpatients with pneumoconiosis was 50.94 ±11.12 years, with a median age of 48 years old. Respiratory failure occurred in 194 patients after infection, and the incidence density was 44.14 per 1 000 person-years. Grouped by whether respiratory failure occurred, there were significant differences between the two groups in terms of age, smoking status, drinking status, length of dust exposure, ALB, BMI and stage of pneumoconiosis (P<0.05). Multivariate Cox regression analysis indicated that compared with pneumoconiosis patients with serum ALB≤35.1 g/L, those with ALB≥40.9 g/L had a reduced risk of developing respiratory failure after infection (HR=0.48, 95%CI: 0.02-0.94, P=0.002). Subgroup analysis revealed that compared with the lowest quartile group (Q1) of serum ALB, in the low BMI group (BMI<18.5 kg/m2), patients in the Q4 group of serum ALB had a significantly lower risk of developing respiratory failure after infection (HR=0.36, 95% CI: 0.20-0.64, P=0.001); in normal BMI group (18.5 kg/m2≤BMI<24 kg/m2), the Q4 group of serum ALB significantly reduced the risk of developing respiratory failure after infection (HR=0.22, 95% CI: 0.09-0.53, P=0.001); and in pneumoconiosis stage 3 group, the Q4 group of serum ALB significantly reduced the risk of developing respiratory failure after infection (HR=0.42, 95% CI: 0.25-0.71, P=0.001). The restricted cubic spline plot showed that when ALB>38.1 g/L, the risk of developing respiratory failure after pulmonary infection in male pneumoconiosis patients decreased progressively with increasing baseline serum albumin levels.
High serum albumin is a protective factor for respiratory failure in male pneumoconiosis patients after pulmonary infection. Serum ALB concentration higher than 38.1 g/L can reduce the risk of respiratory failure after infection.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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