To investigate the dose-response relationship between neck circumference and hypertension using restricted cubic spline modeling.

The data for this study were sourced from the 2023 Zigong Respiratory Health Screening Program. A stratified random sample of Zigong residents aged 35 to 75 years was selected to participate in questionnaire surveys, physical measurements, and health examinations. Logistic regression and restricted cubic spline models were employed to investigate the relationship between neck circumference and hypertension.

A total of 4 142 participants aged 35-75 years were enrolled, with a hypertension prevalenceof 36.5%. After adjusting for confounders, the odds ratios (OR) associated with hypertension prevalencewas 1.20(95%CI: 1.01-1.43) for the low neck circumference group and 1.42(95%CI: 1.17-1.72) for the high neck circumference group. Restricted cubic spline analysis showed a U-shaped nonlinear dose-response relationship between neck circumference and prevalence of hypertension in the overall population and in the noncentrally obese population(P<0.001 for overall trend and P<0.05 for nonlinearity). In contrast, in the centrally obese population, a linear dose-response relationship was demonstrated between prevalence of hypertension and neck circumference(overall trend P<0.001, nonlinear P>0.05).

Neck circumference is strongly associated with hypertension and there is a U-shaped dose-response relationship.

To explore the impact of grip strength asymmetry on cognitive function among elderly people in Chengdu, to investigate the mediating role of activities of daily living (ADL) between grip strength asymmetry and cognitive function, and to provide scientific evidence for reducing the risk of cognitive decline.

This study analyzed survey data from Wenjiang District and Longquanyi District in Chengdu in 2023. Handgrip strength asymmetry was calculated from bilateral grip strength measurements, and cognitive function was assessed using the Minimum Mental State Examination (MMSE). Correlation analysis and regression analysis were used to explore the relationship between handgrip strength asymmetry, ADL and cognitive function in the elderly. Bootstrap tested the mediating role of ADL between handgrip strength asymmetry and cognitive function.

The study included 1 110 participants, including both urban and rural residents of Chengdu, with an average age of 72.38±5.82 years, including 660 (59.5%) women. The handgrip strength asymmetry was negatively correlated with cognitive function and ADL (r=-0.121, P<0.001; r=-0.138, P<0.001), ADL was positively correlated with cognitive function (r=0.125, P<0.001). The results of mediating effect test showed that ADL played a partial mediating role between the handgrip strength asymmetry and cognitive function (P<0.05), and the mediating effect accounted for 12.9%.

Our findings suggest that grip strength asymmetry can lead to impairment in activities of daily living, which in turn causes cognitive decline among the elderly population in Chengdu. Thus, ADL plays a partial mediating role between handgrip strength asymmetry and cognitive function. Physical exercise targeting grip strength and ADL may be an effective approach to preventing and delaying cognitive decline.

To assess the level of health literacy on cancer prevention and control and its influencing factors among residents in Sichuan Province, and to provide a scientific basis for optimizing health education strategies on cancer prevention and control.

In April 2023, a convenience sampling method was used to recruit 28 163 permanent residents aged 15-69 from 21 cities (prefectures) in Sichuan Province for a cross-sectional survey. The χ² test was used to analyze the differences among different groups, and the multivariate Logistic regression model was employed to explore the influencing factors of cancer prevention and control literacy.

After weighted adjustment, the overall literacy level of cancer prevention and control among residents in Sichuan Province was 45.16%. There were differences in the literacy levels of various dimensions. Specifically, the literacy levels for cancer awareness, cancer prevention, early diagnosis and treatment, cancer management, and cancer rehabilitation were 37.45%, 48.74%, 63.40%, 79.04%,and 39.22%, respectively. Multivariate logistic regression analysis revealed that residents aged 25-69, with an educational level of junior high school or above, working in government/public institutions, holding urban household registration, with an annual household income of ≥50 000 RMB, non-smokers, and with self-rated health statuses of poor, fair, or good were more likely to possess cancer prevention and control literacy. Conversely, residents with a household size of 4 or more, and those without a family history of cancer were less likely to possess such literacy. All these findings were statistically significant (P<0.05).

The literacy level among residents in Sichuan Province still needs to be improved, requiring enhanced public education on primary cancer prevention and rehabilitation management knowledge, with targeted awareness campaigns for key populations.

To investigate the veterinary drug residue status of commercially available freshwater fish in Henan Province from 2021 to 2024 and evaluate the dietary exposure risk.

A total of 186 samples of freshwater fish were randomly collected from 2021 to 2024, and six quinolone antibiotics, two anesthetics and two sedative-hypnotics were detected according to the standard procedures in the “National Food Contamination and Hazardous Factors Risk Monitoring Operation Manual”. General descriptive analysis and χ² tests were performed using Excel and SAS software. The probability distribution of drug exposure was calculated using Monte Carlo combined with the consumption of freshwater fish in Henan Province, and the health risk was evaluated using the hazard quotient (HQ).

A total of 152 out of 186 freshwater fish samples were detected with veterinary drug residues, with a detection rate of 81.72%; 39 samples were unqualified, with an unqualified rate of 20.96%. The veterinary drug detection rates in descending order were: enrofloxacin, eugenol > diazepam > ofloxacin, oxazepam (χ²=309.867, P < 0.001), and the unqualified rate of diazepam was the highest (χ²=61.822, P < 0.001). There were significantly statistical differences in the detection rates and unqualified rates in different years (χ²=24.962; χ²=19.731, all P < 0.001). There were no statistically significant differences in the detection rates and unqualified rates of veterinary drugs in freshwater fish between farmers’ markets and stores (χ²=0.806, P=0.369; χ²=2.788, P=0.095). The P₉₅ exposure amount of enrofloxacin in freshwater fish consumed by adults in Henan Province was 0.11 μg/(kg·BW), accounting for 1.77% of the ADI. The P₉₅ exposure of eugenol was 4.02 μg/(kg·BW), accounting for 0.16% of the ADI.

Veterinary drug residues were present in freshwater fish sold in Henan Province, but the overall exposure risk was low, with all HQ less than 1.

This study aimed to investigate the trend of abdominal obesity in Guangzhou from 2008 to 2018 and assess the impact of age, period, and cohort effects on its prevalence during this period.

Based on data from the Guangzhou Community Health Survey conducted every five years, residents were classified into abdominal obesity and normal body type groups according to their waist-to-hip ratio. Time trend analysis and age-period-cohort (APC) models were applied to investigate changes in abdominal obesity and its influencing factors among residents aged 15 to 79 years in Guangzhou.

The annual change rate of central obesity from 2008 to 2013 was 2.41% (1.86%-2.95%), whereas from 2013 to 2018, it decreased to -0.67% (-1.21%~-0.12%), indicating an initial increase followed by a subsequent decline. However, no significant decreasing trend was observed among the elderly population. The APC model identified advanced age as a significant factor for abdominal obesity in both men and women. Between 2008 and 2013, the prevalence of abdominal obesity increased by 15%, with women experiencing a greater rise than men, before declining to slightly below the 2008 level by 2018.Cohort effects revealed that individuals born around the time of China's economic reform had a higher risk of abdominal obesity.

Although the prevalence of abdominal obesity in Guangzhou shows a declining trend, it remains at a high level. There is a need for targeted interventions focusing on the elderly and individuals born around the 1970s, who underwent rapid nutritional transitions during that period.

To develop a quality assessment scale for children's musculoskeletal disorders health short videos and evaluate its reliability and validity.

The initial scale was developed through literature review, semi-structured interviews, and Delphi expert consultation. A total of 240 health short videos on children's musculoskeletal disorders were selected from Douyin as research subjects and evaluated by two raters. The 480 datasets were randomly divided into two groups for item analysis and reliability/validity testing.

The scale consisted of 22 items across five dimensions (presentation literacy, creator authority, information comprehensibility, video production quality, and audience feedback). The item-level content validity index and scale-level content validity index were both 1.00. The scale demonstrated a Cronbach's α of 0.812,inter-rater reliability of 0.872, and test-retest reliability of 0.914. All items had factor loadings above 0.400, and the cumulative variance explanation rate of the five dimensions was 67.464%. Confirmatory factor analysis indicated good model fit.

The quality assessment scale for children's musculoskeletal disorders health short videos exhibits good reliability and validity, effectively evaluating the quality of relevant short videos.

To explore the impact of dynamic changes in depressive states on activity of daily living (ADL) limitations among middle-aged and older adults.

Based on data from the China Health and Retirement Longitudinal Study from 2011 to 2020, 8 617 individuals aged 45 and above were included. The transition characteristics of depressive states were analyzed using a Markov chain model. Latent class analysis was used to identify patterns of depressive changes, and the impact of different depressive trajectories on ADL limitations was assessed using multivariate logistic regression.

The transition probabilities of depressive states showed that the stability of no depression (0.76) and severe depression (0.37) was the highest. However, the transition probabilities from no depression to moderate and severe depression were 0.32 and 0.2,respectively. Latent class analysis identified three types of depressive trajectories: low-stable (1 007 cases with ADL limitations), gradually increasing (1 526 cases), and highly fluctuating (665 cases). Multivariate logistic regression showed that compared with the low-stable group, the risk of ADL limitations was significantly higher in the highly fluctuating group (OR=7.75, 95%CI: 6.54-9.17, P<0.05), followed by the gradually increasing group (OR=2.86; 95%CI: 2.58-3.18, P<0.05).

Dynamic changes in depressive states significantly affect ADL limitations. The group with highly fluctuating depressive trajectories has the highest risk. Clinically, it is necessary to strengthen the monitoring of depressive trajectories and design enhanced interventions for individuals with fluctuating depression to improve functional outcomes.

To examine the utilization and influencing factors of rehabilitation services among certified persons with disabilities in China, providing a basis for meeting the rehabilitation service needs of disabled individuals and enhancing service utilization.

Using data from the 2023 national survey on the subjective perceptions and evaluations of the status of persons with disabilities and the national database on persons with disabilities, a descriptive analysis and binary logistic regression analysis were conducted to assess factors associated with rehabilitation service use among certified persons with disabilities.

Among 8 667 certified persons with disabilities, 2 244 individuals used rehabilitation services in the past year, with a utilization rate of 25.89%. Among those who used rehabilitation services, 89% used one type of service, while only 11% used two or more types. Multivariate regression analysis showed that middle and higher income levels (OR=1.318,95% CI: 1.158-1.502; OR=1.625, 95% CI: 1.423-1.856), receipt of disability subsidies (OR=1.515, 95% CI: 1.329-1.726),and health insurance (OR=1.395, 95% CI: 0.972-2.003) were significant factors promoting the use of rehabilitation services.Individuals with mental disabilities (OR=3.034, 95% CI: 2.357-3.904) and physical disabilities (OR=1.202, 95% CI: 0.975-1.483) were more likely to use rehabilitation services. Regarding community support, the presence of rehabilitation service stations (OR=1.174, 95% CI: 1.026-1.343), day care centers (OR=1.439, 95% CI: 1.242-1.668), suitable cultural and sports facilities for persons with disabilities (OR=1.323, 95% CI: 1.170-1.496), and accessibility features in public service locations (OR=1.174, 95% CI: 1.036-1.329) positively influenced rehabilitation service utilization.

The utilization of rehabilitation services among persons with disabilities is closely associated with socioeconomic status, type of disability, and supportive community environments.

This study aims to explore the causal relationship between gut microbiota and frailty using Mendelian randomization (MR) methods and assess the potential mediating or masking effects of immune cells in this relationship.

Genome-wide association study data for 473 gut microbiota taxa, 731 immune cell characteristics, and frailty were extracted from the GWAS Catalog. A two-sample MR approach was employed to evaluate the causal relationship between gut microbiota and frailty. To identify the mediating or masking effects of immune cells, a two-step MR strategy was applied, and reverse MR analysis was conducted to validate the unidirectional nature of the causal mediation pathway (gut microbiota →immune cells → frailty).

The study found that 4 gut microbiota taxa and 17 immune cell characteristics had causal associations with frailty. Mediation analysis revealed two causal mediation pathways: phylum Firmicutes A → CD28+ CD45RA+ CD8br AC → frailty, and species Lachnospira rogosae → CD62L-CD86 + myeloid DC %DC → frailty. Immune cell characteristics acted as masking effects in both pathways, and reverse MR analysis supported the unidirectional nature of these causal relationships.

The causal associations and mediation effects identified in this study provide a theoretical basis and direction for the development of frailty management strategies based on gut microbiota and immune cells.

To evaluate the quality of response reports for non-occupational carbon monoxide poisoning incidents in Shandong Province from 2019 to 2023.

Data were collected from the national “Public Health Emergency Reporting Management Information System” online reporting platform. An indicator system was constructed based on national policy documents and literature analysis, and the weights of indicators were calculated using the Analytic Hierarchy Process (AHP). The quality of the reports was further evaluated using the technique for order preference by similarity to an ideal solution (TOPSIS) method.

The evaluation system consisted of 3 first-level indicators and 11 second-level indicators. The study evaluated a total of 8 612 cases. Temporally, the 2020 emergency response work reports demonstrated the highest comprehensive quality (C_i=0.777), while 2023 showed the lowest (C_i=0.272). At the prefecture-level city tier, Yantai City (C_i=0.778) and Jining City (Ci=0.679) ranked highest. In regional comparisons, the Jiaodong Urban Cluster achieved the best comprehensive quality (C_i=0.596), outperforming both the Provincial Capital Urban Cluster (C_i=0.553) and the Southern Shandong Urban Cluster (C_i=0.359). Evaluation of first-level indicators revealed that the Provincial Capital Urban Cluster excelled in event monitoring and reporting (C_i=0.646) as well as event investigation and handling (C_i=0.566), whereas the Jiaodong Urban Cluster showed significant advantages in post-event performance evaluation (C_i=0.963). The Southern Shandong Urban Cluster exhibited relatively weaker performance across all dimensions.

There are disparities in the performance of the Shandong Province non-occupational carbon monoxide response work report across different years, cities, and regions.