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To explore the impact of grip strength asymmetry on cognitive function among elderly people in Chengdu, to investigate the mediating role of activities of daily living (ADL) between grip strength asymmetry and cognitive function, and to provide scientific evidence for reducing the risk of cognitive decline.
This study analyzed survey data from Wenjiang District and Longquanyi District in Chengdu in 2023. Handgrip strength asymmetry was calculated from bilateral grip strength measurements, and cognitive function was assessed using the Minimum Mental State Examination (MMSE). Correlation analysis and regression analysis were used to explore the relationship between handgrip strength asymmetry, ADL and cognitive function in the elderly. Bootstrap tested the mediating role of ADL between handgrip strength asymmetry and cognitive function.
The study included 1 110 participants, including both urban and rural residents of Chengdu, with an average age of 72.38±5.82 years, including 660 (59.5%) women. The handgrip strength asymmetry was negatively correlated with cognitive function and ADL (r=-0.121, P<0.001; r=-0.138, P<0.001), ADL was positively correlated with cognitive function (r=0.125, P<0.001). The results of mediating effect test showed that ADL played a partial mediating role between the handgrip strength asymmetry and cognitive function (P<0.05), and the mediating effect accounted for 12.9%.
Our findings suggest that grip strength asymmetry can lead to impairment in activities of daily living, which in turn causes cognitive decline among the elderly population in Chengdu. Thus, ADL plays a partial mediating role between handgrip strength asymmetry and cognitive function. Physical exercise targeting grip strength and ADL may be an effective approach to preventing and delaying cognitive decline.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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