To identify potential drug targets related to preeclampsia and explore their public health value in precision prevention based on gene expression–associated genetic variants and Mendelian randomization.

By integrating genome-wide association studies (GWAS) and expression quantitative trait loci (eQTL) data, potential druggable genes for preeclampsia were identified using Summary data-based Mendelian Randomization (SMR), Transcriptome-Wide Association Study (TWAS), and colocalization analysis. Drug annotation and potential side effect assessments were conducted using public drug databases, and Phenome-wide Mendelian Randomisation (MR-PheWAS) was applied to evaluate potential causal associations between the identified genes and 783 disease traits.

Seven potential drug targets were identified: ALDH2, BCAR1, IL27, MUTYH, PABPC1, SULT1A1 and SULT1A2. Among them, IL27 and SULT1A1 showed consistent and significant associations across multiple analyses. ALDH2 and MUTYH were identified as strong candidates with known involvement in oxidative stress and DNA repair pathways. Several genes were linked to existing drugs, suggesting potential for drug repurposing in preeclampsia.

Drug-target Mendelian randomization provides novel insights into the molecular mechanisms of preeclampsia and facilitates the identification of therapeutic targets. The findings offer a promising foundation for early screening, genetic risk stratification, and individualized prevention, contributing to the development of precision public health strategies for pregnancy-related disorders.

To investigate the current distribution status and multimorbidity patterns of chronic diseases among the elderly population in China, and provide reference for formulating chronic disease management measures.

Based on the CHARLS database in 2020, a total of 10,635 elderly individuals aged 60 and above were included to investigate the prevalence trends of 15 common chronic diseases. The actual expected ratio (O/E) and agglomerative hierarchical clustering analysis were employed to explore the patterns of comorbidity.

The prevalence of chronic diseases among elderly people in China was 86.39%, with hypertension (48.49%), arthritis (43.12%), and stomach diseases (excluding tumors or cancer) (32.06%) being the main causes. The multimorbidity rate was 66.30%, and the top three coexisting diseases were "hypertension+arthritis" (22.28%, O/E=1.07), "hypertension+dyslipidemia" (20.25%, O/E=1.44), and "stomach disease+arthritis" (18.65%, O/E=1.35). The top three coexisting diseases were "hypertension+arthritis+dyslipidemia" (10.31%, O/E=1.70), "hypertension + dyslipidemia + heart disease" (9.70%, O/E=2.65), and "arthritis + stomach disease + hypertension" (9.49%, O/E=1.42). Agglomeration hierarchical cluster analysis was divided into clusters according to malignant tumors, emotional and mental diseases, " stroke + memory related diseases + Parkinson’s disease", "dyslipidemia + diabetes + hypertension + heart disease", "chronic lung disease + asthma + stomach disease + arthritis + liver disease +kidney disease", forming a multimorbidity model.

The overall prevalence of chronic diseases among elderly people in China is increasing year by year, and there is a clustering trend.

To investigate the daily dietary nutrient intake and energy expenditure of university students in Sichuan, in order to understand the levels of dietary nutrient intake and physical activity among college students. To evaluate the adequacy of the students’ nutritional requirements by analyzing the intake and energy contribution of the three major macronutrients, as well as the daily energy expenditure and its composition from physical activities.

A convenient sample of 200 college students in a university of Sichuan were included in the study. Body mass index (BMI) and body fat ratio (BFR) were measured using a body composition analyzer. A three-day 24-hour dietary recall method was used to investigate dietary intake, while the Bouchard Physical Activity Diary and triaxial accelerometer AntiGraph wGT3X-BT were used to investigate subjects’ physical activity and energy expenditure.

The median daily energy intake was 2 237 kcal/d for male students and 1 620 kcal/d for female students. The median daily macronutrient intakes for males were: protein 81 g/d, fat 72 g/d, and carbohydrate 295 g/d,and for females: protein 65 g/d, fat 58 g/d, and carbohydrate 210 g/d. The macronutrient energy ratios were 53∶15∶32 for both genders. The median daily energy expenditure was 473 kcal/d for males and 309 kcal/d for females.

Male college students’ daily energy intake and expenditure are significantly higher than females. College students generally show issues of relatively insufficient energy intake, high fat intake, relatively low carbohydrate intake, and insufficient moderate to high-intensity exercise. College students generally lack moderate-to-vigorous physical activity. Students should be encouraged to actively participate in physical activities to promote balanced diets and a healthy lifestyle.

To describe the changes in the burden of depression among Chinese residents from 1990 to 2021 and to forecast future trends, providing reference for the prevention and control of depression.

Based on the 2021 Global Burden of Disease data, indicators such as the number of cases, incidence rate, prevalence rate, and disability-adjusted life years (DALYs) along with DALYs rates were selected to calculate the rate of change. The Join point regression model was employed to calculate the annual percentage change (APC) and average annual percentage change (AAPC) to analyze the trend of disease burden. Future trends were predicted using R software combined with the GM (1,1) model.

In 2021, the total number of depression cases in China was approximately 42.36 million, with an incidence rate of 2 977.354 per 100 000 and a standardized incidence rate of 2 345.079 per 100 000. The total DALYs attributed to depression were 7.8659 million years, with a total DALYs rate of 552.87 per 100 000 and a standardized DALYs rate of 430.61 per 100 000. Compared to 1990, the standardized prevalence rates for the total population, males, and females decreased by 6.39%, 2.4%, and 9.17%, respectively; the standardized incidence rates decreased by 10.79%, 3.96%, and 14.93%; and the standardized DALYs rates decreased by 9.02%, 3.85%, and 12.43%. Join point regression analysis indicated that from 1990 to 1995 and from 2010 to 2015, the standardized incidence rate of depression among the total population in China showed an increasing trend (APC of 1.56% and 1.37%, respectively), while from 1995 to 2000 and 2005 to 2010, it exhibited a decreasing trend (APC of -2.74% and -1.45%,respectively). The standardized prevalence rates from 1990 to 1992, 1992 to 1995, and 2019 to 2021 all showed an upward trend (APC of 1.67%, 0.48%, and 0.96%, respectively), whereas from 1995 to 2000, 2000 to 2005, 2005 to 2010, and 2010 to 2019, they demonstrated a downward trend (APC of -1.06%, -0.22%, -1.02%, and -0.15%, respectively). The standardized DALYs rate increased from 1990 to 1994 (APC of 1.75%) and showed a decreasing trend from 1994 to 2000 and from 2000 to 2006 (APC of-1.55% and -0.46%, respectively).

The burden of depression among Chinese residents is increasing, with a higher burden observed in females. The risk of depression among the elderly should not be overlooked. Continued efforts are needed to enhance public awareness of depression-related health knowledge and implement preventive interventions.

To explore the differences in the status of co-morbid combinations and health-related quality of life between urban and rural middle-aged and elderly people, and to provide a reference for improving the health of middle-aged and elderly people with co-morbid combinations of chronic diseases.

A total of 6 481 middle-aged and elderly people aged ≥50 years with at least two chronic diseases in China Healthy Aging and Reproductive Lifestyle Survey (CHARLS) 2020 were selected. The basic characteristics of urban and rural chronic disease co-morbid middle-aged and elderly people were described, the health-related quality of life was evaluated using the health utility value of EQ-5D-3L, and the combination of urban and rural chronic disease co-morbid combinations was analyzed using the association network diagram and Apriori association rule.

The health utility value of the elderly in urban chronic disease co-morbidities was 0.8532±0.2400, which was higher than that of the elderly in rural chronic disease co-morbidities (0.8409±0.1952). The top five urban strong link chronic disease co-morbidity combination weights were: hypertension+dyslipidemia; hypertension+heart disease; hypertension+arthritis; gastric disease+arthritis; dyslipidemia+heart disease. In rural areas, there were: gastric disease+arthritis; hypertension+arthritis; hypertension+dyslipidemia; and hypertension+gastric disease. Chronic disease co-morbidities in rural middle-aged and elderly people produced 105 association rules and 86 association rules in urban. Among the top 10 association rules in terms of strength of association rules, there were 9 association rules for hypertension and 1 association rule for chronic lung disease in the rural posterior, while there were 6 association rules for hypertension, 3 association rules for dyslipidemia and 1 association rule for chronic lung disease in the urban posterior.

Health related quality of life of elderly people with chronic disease co-morbidities was higher in urban than in rural areas, with emphasis on pain management and depression and anxiety management in elderly people with chronic disease co-morbidities. There are differences in the combination of chronic disease co-morbidities in urban and rural areas, and the binary, ternary, and quaternary co-morbidity associations between common chronic disease illnesses are high, and hypertension and other chronic diseases and co-morbidities are the highest, and attention should be paid to preventive treatment of hypertension.

To evaluate the impact of DRG medical insurance payment reform on the quality development of a tertiary comprehensive hospital in Guangxi.

This study selected data on all inpatient settlement cases in the hospital from 2020 to 2021, and calculated the DRG grouping of all cases according to the national CHS-DRG version 1.0 grouping plan. The interruption time series analysis method was further used to analyze the level and trend changes of indicators after the DRG policy reform in hospitals in December 2020. These indicators included total weight, case group index, cost consumption index, time consumption index, average length of stay, average hospitalization cost per visit, etc. They were used to evaluate the hospital’s medical service capacity, medical service efficiency, and medical safety, in order to understand the quality of the hospital.

A total of 72 089 cases were included in this study. Indicators such as cost consumption index (β=-0.242, P=0.001), time consumption index (β=-0.119, P=0.002), average length of stay (β=-1.543, P=0.011), proportion of high incidence cases (β=-0.028, P=0.026), and average cost of hospitalization (β=-3 669.366, P=0.026) showed an immediate decrease during the implementation of DRG policy.

After implementing the DRG policy reform, the hospital has significantly improved the efficiency of medical services, but still faces the challenge of adjusting structure and increasing quality.

To explore the mediating effect of self-perceived aging on the relationship between digital health literacy and technophobia of the rural elderly.

By using the method of multi-stage sampling, 503 rural elderly in Hebei Province were investigated by general data questionnaire, technophobia scale, simplified self-perceived aging scale, and digital health literacy assessment scale from July to August, 2023. The mediating effect test program was used for mediating analysis and Bootstrap test was used for verification.

The scores of technophobia, self-perceived aging, and technophobia of the elderly in rural areas of Hebei Province were 36.40±10.22, 51.99±8.24, and 39.76±13.82, respectively. Pearson correlation analysis showed that digital health literacy was negatively correlated with technophobia and self-perceived aging (r=0.433, P < 0.001; r=0.454, P < 0.001), while self-perceived aging was positively correlated with technophobia (r=0.401, P < 0.001). The mediating effect test results showed that self-perceived aging had mediating effect between digital health literacy and technophobia of the rural elderly, and the mediating effect accounted for 40.0%.

Digital health literacy and self-perceived aging of the elderly directly affect technophobia. At the same time, digital health literacy can also indirectly affect technophobia through self-perceived aging.

To analyze the trends and characteristics of the number of patients, prevalence, incidence, disability-adjusted life years (DALY), and years lived with disability (YLD) of depressive disorders among the Chinese population from 1990 to 2021, with the hope of providing a theoretical basis for early prevention, intervention, and clinical decision-making regarding depressive disorders.

Depressive disorders data from the GBD 2021 database (Global Burden of Disease Study 2021 Data Resources) were extracted to analyze the number of patients, incidence, prevalence, DALY and YLD in the Chinese population. The software STATA 14.0 and Joinpoint Regression Program 4.8.0.1 were utilized to analyze the incidence, prevalence, DALY, and YLD of depressive disorders across different genders and age groups. Furthermore, the average annual percent change (AAPC) in depressive disorders was calculated.

In 2021, there were 42.3602 million new cases of depressive disorders in China, an increase of 38.9% from 30.4910 million in 1990. The number of patients was 53.1147 million, an increase of 54.0% from 34.4794 million in 1990. Both the standardized incidence and prevalence showed a slow downward trend (the AAPC was -0.57% and -0.44%, respectively, P<0.001). The incidence of depressive disorders in people aged 10 to 24 showed a sudden increase in different years, and the incidence of depressive disorders in people over 65 also showed an accelerating upward trend. The DALY in 1990 and 2021 were 5.4267 million and 7.8659 million person-years, respectively, with a cumulative increase of 44.9%. The DALY rate increased from 461.27 /100 000 to 552.87 /100 000, with an increase of 19.8%. The standardized DALY and YLD rates decreased slowly with each year (the AAPC was -0.53% and -0.53%, respectively, P<0.001).

Depressive disorder is still one of the main causes of global disease burden and a major public health issue facing our country. There is an urgent need to actively explore and implement effective prevention and treatment strategies to reduce the disease burden of depressive disorders.

To analyze the epidemiological characteristics of hand, foot, and mouth disease (HFMD) in Hebei Province from 2014 to August 2024, and to provide a scientific basis for the formulation of effective prevention and control measures.

The case report data of HFMD in Hebei Province from 2014 to August 2024 were extracted from the Chinese Disease Prevention and Control Information System. Descriptive epidemiological methods were used for analysis, and the incidence trend of HFMD was predicted by the ARIMA model.

A total of 371 393 cases of HFMD were reported with 26 deaths from 2014 to August 2024. The average annual incidence and mortality rates were 45.279 1 per 100 000 and 0.003 2 per 100 000, respectively. The incidence rate of HFMD decreased year by year, as did the number of severe cases and deaths. The disease showed a clear seasonal pattern, with a high incidence period from May to July every year. The incidence rates in Langfang, Baoding, and Chengde were high. Children aged 1-4 were the most susceptible group, with more male cases than female. Enterovirus 71, Coxsackievirus A16, and other enteroviruses accounted for 20.62%, 26.87%, and 52.51%, respectively. Using the SARIMAX model to predict the number of HFMD cases from September 2024 to August 2025, which would decrease first and then increase. And the seasonal peak of incidence in 2025 would be higher than that in 2024.

The incidence rate of HFMD in Hebei Province has shown a downward trend, but the peak in 2025 is predicted to be higher than that in 2024. It is necessary to strengthen the monitoring of the epidemic and etiology, scientifically formulate prevention and control plans, and prepare for the response.

To study the single-disease settlement cost and its influencing factors for age-related cataract surgery patients under the centralized volume-based procurement policy of intraocular lens, and to provide theoretical suggestions and data support for optimizing the cost structure, controlling the growth of medical costs, and improving the quota payment policy of intraocular lens materials.

The medical records and single-disease payment information of 215 age-related cataract patients admitted to the Department of Ophthalmology of a provincial tertiary public general hospital in Guangzhou from June 1, 2021 to April 30, 2022 were collected. Descriptive analysis, new grey correlation analysis and multiple linear regression model were used to analyze the composition and influencing factors of single-disease settlement expenses and the burden of intraocular lens materials.

The treatment cost, intraocular lens cost and diagnosis cost were the main types of hospitalization expenses for age-related cataract surgery patients (accounting for 52.12%, 19.79% and 13.56% respectively, accounting for 85.47% in total). At the same time, it was also the main type of expense affecting the average hospitalization expense per time (the correlation coefficients were 1.000, 0.751, 0.717). Multiple linear regression analysis showed that the length of hospital stay, anesthesia type (local anesthesia as the reference, general anesthesia β=3 513.340) and intraocular lens type (soft spherical three-piece monofocal non-astigmatism type as the reference, soft aspheric one-piece monofocal astigmatism type β=2 590.090; soft aspheric one-piece continuous visual field non-astigmatism type β=10 496.020, soft aspheric one-piece trifocal non-astigmatism type β=21 889.810) were the influencing factors of hospitalization expenses (P<0.001). Under the medical insurance limit payment of intraocular lens material fee, the proportion of the highest burden of patients is low when the selected intraocular lens unit price is less than the maximum limit standard (1 800 yuan), and the proportion of the highest burden of patients increases with the increase of the price of intraocular lens when the selected intraocular lens unit price is more than the maximum limit standard (1 800 yuan).

The structure of hospitalization expenses for age-related cataract surgery becomes more reasonable under the centralized volume-based procurement policy of intraocular lens, and the labor value of medical staff is realized. However, more attention should be paid to the changes of intraocular lens costs and diagnostic fees in the future. Shortening the length of hospital stay, reasonable selection of anesthesia methods, reasonable selection of different types of intraocular lens and reducing the price of intraocular lens can effectively reduce the hospitalization cost of age-related cataract surgery patients. Appropriately raising the fee limit of intraocular lens materials according to the affordability of local medical insurance fund is helpful to reduce the cost burden of surgical patients.