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To identify potential drug targets related to preeclampsia and explore their public health value in precision prevention based on gene expression–associated genetic variants and Mendelian randomization.
By integrating genome-wide association studies (GWAS) and expression quantitative trait loci (eQTL) data, potential druggable genes for preeclampsia were identified using Summary data-based Mendelian Randomization (SMR), Transcriptome-Wide Association Study (TWAS), and colocalization analysis. Drug annotation and potential side effect assessments were conducted using public drug databases, and Phenome-wide Mendelian Randomisation (MR-PheWAS) was applied to evaluate potential causal associations between the identified genes and 783 disease traits.
Seven potential drug targets were identified: ALDH2, BCAR1, IL27, MUTYH, PABPC1, SULT1A1 and SULT1A2. Among them, IL27 and SULT1A1 showed consistent and significant associations across multiple analyses. ALDH2 and MUTYH were identified as strong candidates with known involvement in oxidative stress and DNA repair pathways. Several genes were linked to existing drugs, suggesting potential for drug repurposing in preeclampsia.
Drug-target Mendelian randomization provides novel insights into the molecular mechanisms of preeclampsia and facilitates the identification of therapeutic targets. The findings offer a promising foundation for early screening, genetic risk stratification, and individualized prevention, contributing to the development of precision public health strategies for pregnancy-related disorders.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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