Latest ArticlesTo investigate the clinical efficacy of 3HRZE/6HRE regimen assisted by Bushen Huoxue Formula in the treatment of patients with intermediate and advanced renal tuberculosis, and to analyze the safety of this therapeutic strategy.
The clinical data of 122 patients with advanced renal tuberculosis who were treated in Shaanxi Provincial Tuberculosis Prevention and Treatment Hospital from March 2021 to June 2024 were retrospectively analyzed. According to different treatment regimens, they were divided into control group and observation group. 61 patients in the control group were treated with 3HRZE/6HRE regimen alone. 61 patients in the observation group were treated with Bushen Huoxue Formula combined with 3HRZE/6HRE regimen. The course of treatment was 9 months. The clinical efficacy, inflammatory response [interferon-gamma (IFN-γ), interleukin-6 (IL-6), blood sedimentation rate (ESR)], liver and kidney function [azelaic transaminase (AST), blood urea nitrogen (BUN), quantitative 24 h urinary protein (24 h UTP)], quality of life determination scale (QLICD-PT) scores, and the incidence rate of adverse reactions were observed in the two groups.
The total effective rate of the observation group was higher than that of the control group (P <0.05). After treatment, the levels of IFN-γ, IL-6, ESR, BUN, and 24 h UTP were lower than those before treatment in both groups (P <0.05), and the observation group was lower than the control group (P <0.05); and the levels of AST and the scores of each dimension of QLICD-PT were higher than those before treatment, and the observation group was higher than the control group (P <0.05). There was no statistically significant difference in the incidence of adverse reactions in the observation group compared with the control group (P > 0.05).
Bushen Huoxue Formula assisted 3HRZE/6HRE regimen in treating patients with intermediate and advanced renal tuberculosis can significantly improve the therapeutic efficacy and quality of survival, and improve the liver and kidney function, inhibit the expression of inflammation, and have a good safety.
To investigate the clinical efficacy of fire needle pricking combined with Kinesio taping in the treatment of lateral femoral cutaneous neuritis caused by military training, and to analyze its mechanism from the perspective of traditional Chinese medicine theory.
A total of 70 patients diagnosed with lateral femoral cutaneous neuritis induced by military training in the Department of Traditional Chinese Medicine Rehabilitation, No. 910 Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army from November 2023 to November 2024 were enrolled. They were randomly divided into a control group (fire needle pricking alone) and an experimental group (fire needle pricking combined with Kinesio taping), with 35 cases in each group. Traditional Chinese medicine (TCM) syndrome scores, Visual Analog Scale (VAS) scores, Japanese Orthopaedic Association (JOA) scores, pain mediators (PGE2, 5-HT), and SF-36 scores were evaluated in both groups.
After treatment, the TCM syndrome scores, VAS scores, and levels of PGE2 and 5-HT in the experimental group were significantly lower than those in the control group (P <0.05). The JOA scores, as well as the SF-36 subscale scores for physical function, emotional function, cognitive function, social function, role function, and general health, were significantly higher in the experimental group than in the control group (P < 0.05). The total effective rate in the experimental group was higher than that in the control group (P < 0.05).
Fire needle pricking combined with Kinesio taping demonstrates significant therapeutic effects in treating lateral femoral cutaneous neuritis caused by military training. It can rapidly alleviate pain and improve sensory disturbances. The mechanism may be associated with inhibiting local inflammatory responses and promoting nerve repair. This combined therapy is safe and easy to operate, making it suitable for widespread application in the prevention and treatment of military training-related injuries.
This study systematically analyzed the relevant literature on animal models of pulmonary nodules in recent years and integrated the understanding of their etiology, pathogenesis, diagnosis, and syndrome differentiation treatment from both traditional Chinese medicine (TCM) and Western medicine. On this basis, the application characteristics of existing models were compared, and their clinical consistency was evaluated from both TCM syndrome types and Western medical indicators. The study found that most existing models were established by inducing inflammation, fibrosis, or tumors, and they performed well in simulating the imaging manifestations of pulmonary nodules. In terms of Western medical indicators, the consistency of the models in pathological and imaging indicators was 70%-85%, indicating that they could well simulate the morphology and some pathological processes of nodules, but there were still limitations in dynamic progression and systemic physiological changes. In terms of TCM syndrome differentiation, the pathological manifestations of the models mostly corresponded to the " phlegm" and " blood stasis" categories, with the highest consistency with the syndrome of phlegm and blood stasis combination (about 60%), but the overall simulation of " deficiency syndromes" such as qi deficiency and yin deficiency was significantly insufficient. In summary, although the existing models can reflect some key features of pulmonary nodules, especially in Western medical indicators and phlegm and blood stasis syndrome types, they still lack systematic simulation of TCM overall syndrome differentiation, especially in the dimension of deficiency syndromes. Future research can utilize multi-omics dynamic monitoring technology to construct new animal models that better conform to the TCM syndrome differentiation concept, in order to provide beneficial references for related research on pulmonary nodules. This study systematically reviewed and analyzed recent literature on animal models of pulmonary nodules. By integrating insights from both traditional Chinese medicine (TCM) and Western medicine regarding the etiology, pathogenesis, clinical diagnostic criteria, and syndrome differentiation and treatment of pulmonary nodules, the study compared the applications of existing animal models and evaluated their clinical relevance based on two criteria: consistency with TCM syndrome patterns and alignment with Western medical indicators. The findings indicate that current animal models are primarily established through induction of inflammation, fibrosis, or tumorigenesis, all of which effectively replicate the imaging characteristics of pulmonary nodules. The concordance with Western medical indicators ranges from 70% to 85%. Pathologically, these models most closely reflect the TCM concepts of phlegm and blood stasis, showing the highest correspondence-up to 60%-with the phlegm-stasis intermingling syndrome. While there is a measurable alignment between the pathological features of these models and the TCM theory of phlegm and stasis, they remain limited in representing systemic deficiency patterns. Therefore, future research should aim to integrate multi-omics dynamic monitoring approaches and develop more sophisticated animal models that better embody the holistic principles of TCM syndrome differentiation, thereby providing more meaningful support for pulmonary nodule research.
Ovarian aging is an important factor causing female infertility, and its pathogenesis is complex. Currently, the use of hormone replacement therapy has limitations. Therefore, in-depth exploration of the pathogenesis of ovarian aging and seeking safe and effective treatment methods have great clinical application value. Metabolic reprogramming plays an important role in the growth, development, and maturation of oocytes, and its abnormalities can accelerate ovarian aging by activating related signaling pathways and regulating the expression of apoptosis related proteins. In recent years, research on the regulation of metabolic reprogramming by traditional Chinese medicine to delay ovarian aging has made certain progress. This article summarizes and analyzes the metabolic reprogramming abnormalities in sugar, lipid, amino acid, and immune metabolism during ovarian aging, and summarizes the relevant studies on the regulation of these core metabolic links by traditional Chinese medicine extracts and formulas to delay the process of ovarian aging. The aim is to provide new clinical treatment ideas for delaying ovarian aging and improving female fertility from the perspective of regulating metabolic reprogramming by traditional Chinese medicine.
The theory of blood turbidity holds great significance in the syndrome differentiation and treatment of pulmonary nodules (PNs). The state of blood turbidity is a unique interpretation by traditional Chinese medicine of the microenvironment of PNs. Based on the theory of blood turbidity and combined with the dynamic evolution law of PNs, this article conducts an in-depth analysis of the syndrome differentiation and treatment of PNs. It is proposed that "the injury of collaterals by turbid blood" is the core pathogenesis of the occurrence and development of PNs. It is pointed out that the stagnation in collaterals is the pathological basis for the occurrence of PNs. The damage of collaterals by turbid blood is the pathological key to the progression of PNs. The blockage of collaterals by turbid toxin is the premise for the canceration of PNs. Therefore, in the treatment, it is advocated to start from the perspective of "the injury of collaterals by turbid blood", with the general principle of clearing and resolving blood turbidity and restoring the function of collaterals. Combining syndrome differentiation with stage differentiation, integrating the methods of relieving depression and regulating qi, assisting yang and restraining yin, resolving phlegm, promoting blood circulation, removing blood stasis, detoxifying, dredging collaterals, nourishing collaterals, and opening collaterals, which provides ideas for the treatment of PNs.
To explore the intervention mechanism of icaritin (ICT) on myocardial injury in sepsis.
Mice were divided into control group, model group, AMPK activator (MET) group, icaritin (ICT) group and icaritin+AMPK inhibitor compound C (ICT+CC) group, with 12 mice in each group. Except for the control group, the other mice were intraperitoneally injected with LPS. ICT group was intraperitoneally injected with ICT 30 minutes before modeling, and ICT+CC group was injected with AMPK inhibitor Compound C at the same time. After 24 hours of modeling, cardiac function, myocardial pathological changes, AMPK pathway and pyroptosis-related protein expression, serum inflammatory factors and myocardial injury markers were detected.
The intervention of ICT and AMPK activators significantly improved the survival rate of mice, increased cardiac LVEF and LVFS, and decreased LVIDD and LVIDS. Tissue damage was reduced and inflammatory cell infiltration was reduced. The levels of serum TNF-α, IL-1β, IL-18, CK-MB and LDH were decreased. The ratio of p-AMPK/AMPK was increased, and the expression of NLRP3, ASC, Cleaved Caspase-1, GSDMD-NT and Cleaved IL-1β was decreased (P < 0.05). Compound C could reverse the improvement effect of ICT on myocardial injury, increase inflammation index and pyroptosis protein expression (P <0.05).
ICT can improve myocardial injury and inflammatory response in sepsis mice, and its mechanism may be related to the activation of AMPK to inhibit pyroptosis mediated by NLRP3 signaling pathway.
To investigate the effect of Mulberry twig (Sangzhi) alkaloids (SZ-A), which is a new traditional Chinese medicinal, on myocardial fibrosis in diabetes mellitus (DM) and its underlying molecular mechanism.
The diabetic mouse model was established using high-fat diet combined with streptozotocin injections. Mice were randomly divided into non-diabetic (ND), diabetic (DM), and SZ-A low- (50 mg/kg/d) or high-dose (100 mg/kg/d) groups. Myocardial fibrosis-related proteins (Collagen Ⅰ, TGF-β1, Smad2/3, and their phosphorylated forms) were analyzed by Western blot, while mRNA levels of fibrosis markers (Collagen Ⅰ/Ⅲ, α-SMA, Fn1, Postn) were quantified via qRT-PCR. Molecular docking simulations (AlphaFold2/Autodock) were performed to validate interactions between SZ-A components (DNJ, FGM, DAB) and TGF-β1.
SZ-A treatment significantly reduced myocardial Collagen deposition in diabetic mice, downregulated mRNA expression of Collagen Ⅰ/Ⅲ, α-SMA, Fn1, and Postn (P < 0.05), and suppressed TGF-β1 expression and Smad2/3 phosphorylation. Molecular docking revealed stable binding affinities between DNJ/FGM/DAB and TGF-β1. Exogenous TGF-β1 administration reversed SZ-A's anti-fibrotic effects, restoring Collagen Ⅰ, TGF-β1, and p-Smad2/3 levels (P <0.05).
SZ-A ameliorates diabetic myocardial fibrosis by targeting the TGF-β1/Smad signaling pathway, highlighting its therapeutic potential for diabetic cardiomyopathy.
To investigate the effect of three different strains on the chemical composition of Polygonatum in the fermentation process of Polygonatum.
the crushed Rhizoma Polygonati was prepared into a suspension according to the 30 ∶ 70 ratio of care solution, and the three activated bacterial solutions of Lactobacillus casei, Lactobacillus rhamnosus and Bacillus subtilis were separately added according to the 5% inoculum. The sample morphology and the number of viable bacteria were observed. Ultra performance liquid chromatography quadrupole time-of-flight mass spectrometry (uplc-q-tof-ms) was used to analyze the differential chemical components of Polygonatum sibiricum before and after fermentation.
Rhizoma Polygonati was thickened after fermentation, with fluidity and sour taste. Milky white folds appeared after fermentation by Lactobacillus rhamnosus and Bacillus subtilis. On the 6th day of fermentation, Lactobacillus casei and Bacillus subtilis had the highest viable counts, which were 3.40 × 108 CFU/g and 2.62 × 109 CFU/g, respectively; The number of viable bacteria was the highest when Lactobacillus rhamnosus was fermented for 7 days, which was 2.59 × 108 CFU/g; Three triterpenoid saponins, 2 flavonoids, 1 organic acid.
Lactobacillus rhamnosus and Lactobacillus casei can convert triterpenoid steroidal saponins into aglycones during the fermentation of Polygonatum sibiricum, and the utilization effect of saponins is better. Bacillus subtilis can convert flavonoid glycosides into aglycones, and the utilization effect of flavonoid glycosides is better.
To optimize the extraction process of total flavonoids from Mayaqi and study its antioxidant activity and stability.
Key factors were screened by Plackett-Burman experiment, and the optimal process was obtained by Box-Behnken Design surface design; The antioxidant activity of total flavonoids of Mayaqi was evaluated by measuring the scavenging effects on hydroxyl radicals, DPPH radicals, ABTS radicals and the ability to reduce ferric ions. The correlation between the concentration of total flavonoids extract and different antioxidant activities was by SPSS software, and the effects of temperature, light and pH on the stability of antioxidant activity were investigated.
The optimal extraction technology for total flavonoids from Mayaqi was as follows: extraction 140 W, ethanol concentration 65%, temperature 70 ℃, extraction time 30 min, and the extraction rate of total flavoids was 4.608 5 ±0.031 7 mg/g. The scavenging effects of the total flavonoids extract on Mayaqi DPPH radicals, and ABTS radicals, and the ability to reduce ferric ions were 64.16%、55.67%、95.97% and 50.49%, of the same concentration of Vc, respectively. Correlation showed that the concentration of the total flavonoids extract from Mayaqi was significantly correlated with the scavenging rate of xyl radicals. The antioxidant stability test showed that the total flavonoids extract from Mayaqi should be stored at low (below 25 ℃), away from light, and in neutral conditions.
This technology is stable and feasible, and the total flavonoids extract Mayaqi has high antioxidant activity.
Based on the Philosophy of "harmony" in Chinese medicine, Professor Piao Bingkui believes that "disharmony" is an important factor in the development of triple-negative breast cancer, and thus puts forward the characteristic concept of treating tumors by "harmonizing its disharmony" of the body, the "state of harmony" of the body is restored, and the coexistence of human tumors can even be achieved; in the clinical application, he advocates the combination of traditional Chinese and Western medicines, combining the evidence and diseases, intervening in the whole process, and treating the tumor at different stages. This article summarizes Professor Piao Bingkui's clinical experience in the treatment of triple-negative breast cancer based on the Philosophy of "Harmonizing Disharmony" and illustrates it with a medical case.
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