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Research Progress on Regulating Metabolic Reprogramming with Traditional Chinese Medicine to Improve Ovarian Aging
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Wenlong QI1, Zhicheng JIA2, Yongqian LI1, Peixuan WANG1, Mengyu SHI1, Xinxin YANG1, Xinwei SUN1, Ying GUO1, 3, *
Acta Chinese Medicine and Pharmacology | 2026, 54(8) : 119 - 128
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Acta Chinese Medicine and Pharmacology | 2026, 54(8): 119-128
Research Progress on Regulating Metabolic Reprogramming with Traditional Chinese Medicine to Improve Ovarian Aging
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Wenlong QI1, Zhicheng JIA2, Yongqian LI1, Peixuan WANG1, Mengyu SHI1, Xinxin YANG1, Xinwei SUN1, Ying GUO1, 3, *
Affiliations
  • 1.Shandong University of Traditional Chinese Medicine, Jinan 250014, China
  • 2.Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
  • 3.The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, China
Published: 2026-08-20 doi: 10.19664/j.cnki.1002-2392.260171
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Ovarian aging is an important factor causing female infertility, and its pathogenesis is complex. Currently, the use of hormone replacement therapy has limitations. Therefore, in-depth exploration of the pathogenesis of ovarian aging and seeking safe and effective treatment methods have great clinical application value. Metabolic reprogramming plays an important role in the growth, development, and maturation of oocytes, and its abnormalities can accelerate ovarian aging by activating related signaling pathways and regulating the expression of apoptosis related proteins. In recent years, research on the regulation of metabolic reprogramming by traditional Chinese medicine to delay ovarian aging has made certain progress. This article summarizes and analyzes the metabolic reprogramming abnormalities in sugar, lipid, amino acid, and immune metabolism during ovarian aging, and summarizes the relevant studies on the regulation of these core metabolic links by traditional Chinese medicine extracts and formulas to delay the process of ovarian aging. The aim is to provide new clinical treatment ideas for delaying ovarian aging and improving female fertility from the perspective of regulating metabolic reprogramming by traditional Chinese medicine.

Traditional Chinese Medicine (TCM)  /  Metabolic reprogramming  /  Ovarian aging  /  Infertility  /  Review
Wenlong QI, Zhicheng JIA, Yongqian LI, Peixuan WANG, Mengyu SHI, Xinxin YANG, Xinwei SUN, Ying GUO. Research Progress on Regulating Metabolic Reprogramming with Traditional Chinese Medicine to Improve Ovarian Aging[J]. Acta Chinese Medicine and Pharmacology, 2026 , 54 (8) : 119 -128 . DOI: 10.19664/j.cnki.1002-2392.260171
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Article Info
doi: 10.19664/j.cnki.1002-2392.260171
  • Receive Date：2025-03-15
  • Online Date：2026-09-17
  • Published：2026-08-20
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History
  • Received：2025-03-15
  • Revised：2025-10-21
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Affiliations
    1.Shandong University of Traditional Chinese Medicine, Jinan 250014, China
    2.Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
    3.The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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