Glioma, as a common malignant tumor of the nervous system and one of the malignant tumors with the highest mortality rates globally, still faces the persistent clinical dilemma of low cure rate, high recurrence rate, and extremely poor prognosis to this day. Based on the theory of collateral diseases and the guiding ideology of "smoothly regulating the brain collaterals", this paper conducts in - depth research on the etiology and pathogenesis of glioma, and summarizes that the essence of its etiology and pathogenesis lies in marrow deficiency and collateral asthenia, while its manifestation is the damage to the brain collaterals by toxins. According to the theory that "the collaterals should be kept unobstructed for their normal function", the basic treatment principles are proposed as follows: tonifying the deficiency of the collaterals and replenishing essence and marrow; dispersing with acrid herbs to smooth the collaterals, resolving phlegm and removing blood stasis; freeing the collaterals to dissipate masses, expelling wind and detoxifying.

Objective: To investigate the mechanism of Yangxue Antai serum in regulating the release of exosomes from JEG - 3 cells to affect endothelial cells and endometrial cells.Methods: The exosome release inhibitor GW4869 was used to inhibit the release of exosomes from JEG - 3 cells, and the Yangxue Antai serum interfered with JEG - 3 cells, A co - culture system was established in which JEG - 3 cells or exosomes secreted by JEG - 3 cells were co - cultured with HEC-1 - A cells or HUVECs. The expression of VEGFA and p - VEGFR2 in HUVECs, the expression of EMT - related proteins E - cadherin, Vimentin, N - cadherin and Fibronectin as well as the expression of deciduation - related proteins BMP2, HOXA10, PRL and IGFBP1 in HEC -1 - A cells were measured by Western blot. The migration rate of HUVECs was measured by cell scratch assay. The invasion and migration ability of HUVECs were measured by Transwell assay, F - actin expression was measured by cytoskeleton assay, and the lumen length in HUVECs was measured by tubule formation assay.Results: Compared with Control group, the expressions of VEGFA and p - VEGFR2 in GW4869 group were significantly decreased. The expression of E - cadherin was significantly increased, while the expression of Vimentin, N - cadherin and Fibronectin were significantly decreased. The expressions of BMP2, HOXA10, PRL and IGFBP1 were significantly decreased. Cell invasion and migration ability were significantly decreased, the lumen length was decreased, and the expression of F - actin was significantly decreased. Compared with GW4869 group, the expressions of VEGFA and p - VEGFR2 in GW4869 + Yangxue Antai and GW4869 + exosome group were significantly increased. The expression of E - cadherin was significantly decreased, while the expression of Vimentin, N - cadherin and Fibronectin was significantly increased. The expressions of BMP2, HOXA10, PRL and IGFBP1 were significantly increased. Cell invasion and migration ability were increased significantly, the lumen length was increased, and the expression of F - actin was increased significantly.Conclusion: Yangxue Antai serum can affect the angiogenesis of endothelial cells, EMT and decidualization of endometrial cells by regulating the release of exosomes from JEG - 3 cells.

Objective: To investigate the effects of Dihuang Yinzi on cognitive function of APP/PS1 double transgenic mice and explore its underlying mechanisms.Methods: Forty - five male APP/PS1 double transgenic mice were randomly divided into 5 groups (9 mice per group) : namely the model group (normal saline), the donepezil hydrochloride group(0.84 mg/kg/d), and the low - dose, medium - dose, and high - dose Dihuang Yinzi groups (1.25, 2.5, and 5 g/kg/d, respectively). Additionally, 9 male C57BL/6J mice were used as the blank group (normal saline). All groups were treated continuously for 4 weeks. After 4 weeks, the Morris water maze test was used to evaluate spatial learning and memory abilities in each group. Nissl staining was performed to observe neuronal cells and Nissl bodies in the CA3 region of the hippocampus. Immunohistochemical (IHC) staining was used to observe NDRG2 and GFAP in the CA3 region of the hippocampus. Golgi staining was used to examine the morphology of dendritic spines in pyramidal neurons in the CA3 region of the hippocampus. Immunofluorescence staining was used to detect the expression of postsynaptic density protein - 95 (PSD95) and synaptophysin (SYN) in the CA3 region of the hippocampus. Western blot was used to measure the expression of NDRG2 and EAAT1 in the hippocampus.Results: Compared with the model group, the escape latency of the Morris water maze in each dose group of Dihuang Yinzi was reduced, and the residence time in the target quadrant and the number of crossings in the target quadrant were increased (P <0.01 or P < 0.05). The number of neurons, the number of dendritic branches, and dendritic spines were increased. PSD95 and SYN were up - regulated (P <0.05), while GFAP, NDGR2, and EAAT1 were decreased (P <0.01 or P <0.05).Conclusion: Dihuang Yinzi can improve the cognitive function of APP/PS1 double transgenic mice. Its mechanism of action may be related to down - regulating the expression of NDRG2, regulating astrocytes, subsequently down - regulating EAAT1, reducing the concentration of glutamate in the synaptic cleft, improving synaptic plasticity, and alleviating hippocampal neuronal damage.

Objective: To investigate the protective effect and mechanism of KR ethanol extract on hypoxia - induced TC - 1 injury in mouse lung epithelial cells.Methods: LC - MS was used to analyze the compounds in the alcohol extract of KR. The cell hypoxia model was established by three - gas incubator (37 ℃, 5% CO₂, 94% N₂, 1% O₂). TC - 1 cells were divided into normal group (Normal), hypoxia group (Hypoxia), hypoxia + KR alcohol extract low dose group (Hypoxia + KRL, 90 μg/mL), hypoxia + KR alcohol extract high dose group (Hypoxia + KRH, 180 μg/mL). Cell viability was measured by CCK - 8 assay. The morphological changes of cells were observed by inverted microscope and the number of cells was counted. The leakage of lactate dehydrogenase (LDH) in the supernatant of cell culture medium and the contents of malondialdehyde (MDA), superoxide dismutase (SOD), tumor necrosis factor - α (TNF - α), interleukin -6 (IL - 6) and ATP in cells were detected. The fluorescence intensity of reactive oxygen species (ROS) in cells was observed by fluorescence microscope. The mRNA expression levels of hypoxia - inducible factor - 1α (HIF - 1α), endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS) were detected by RT - qPCR. The protein expression levels of HIF - 1α, eNOS and iNOS in cells were detected by Western blot.Results: Twenty - two compounds were found in the KR ethanol extract. After 24 h of hypoxia treatment, the cells of TC - 1 cells became swollen and round, and the contents of ROS, LDH, MDA, TNF - α and IL - 6 were significantly increased, while the contents of SOD and ATP were significantly decreased. The mRNA and protein expression levels of HIF - 1α and iNOS were significantly increased, while the expression level of eNOS was decreased. After treatment with KR ethanol extract, the number of cells increased significantly, the cell morphology tended to be Normal group, and the contents of ROS, LDH, MDA, TNF - α and IL - 6 decreased. The mRNA and protein expression levels of HIF - 1α and iNOS were decreased. SOD, ATP and eNOS were significantly increased.Conclusion: KR ethanol extract can down - regulate the expression of HIF - 1α when TC - 1 cells are stimulated by hypoxia, and improve cell energy metabolism disorder, oxidative stress response and inflammatory response to exert anti - hypoxia effect.

Objective: To study the anti - inflammatory effect of Perilla Folium with both surfaces purple (PP), Perilla Folium with upper surface green and the lower surface purple (GP), Perilla Folium with both surfaces green (GG) and to analyze the relationship between the anti - inflammatory effect, leaf color chromatic values (L, a*, b*, E* ab, R - value, G - value, and B - value), and the contents of perilla aldehydes, rosmarinic acid, and anthocyanins.Methods: The CCK - 8 method was used to determine the effects of three types of Perilla Folium on RAW 264.7 monocyte - macrophage survival rates, and partial least squares discriminant analysis (PLS - DA) was used to explore the differences between perilla leaves with different leaf colors. Pearson correlation coefficients were used to systematically analyze the correlation between the seven leaf color values, including Red image component mean value(R - value), Green image component mean value (G - value), Blue image component mean value (B - value), Red green value (a*), Yellow blue value (b*), Brightness value (L*), and Total color value (E* ab), as well as the contents of perilla aldehyde, anthocyanin, and rosmarinic acid, and the anti - inflammatory effect in order to reveal the intrinsic links between anti - inflammatory effects and colorimetric characteristics and chemical composition.Results: PP, GP, and GG all showed certain anti - inflammatory effects. At a concentration of 25 mg/mL, the survival rates of PP, GP, and GG ranged from 56% to 94%, 49% to 123%, and 64% to 110%, respectively. One - way ANOVA showed that there was no significant difference among the three. The results of PLS - DA showed that Perilla Folium with different leaf colors were each grouped into one category, and seven key differential indexes, including perilla aldehyde, anthocyanins, R value, b*, E* ab, rosemarinic acid and L*, were screened out. Correlation analysis showed that cell survival rates were positively correlated with b* - value.Conclusion: The anti - inflammatory effects of Perilla Folium did not significantly differ among the three leaf colors, and higher b* - value was associated with stronger anti - inflammatory effects.

Renal hematuria (RH) originates from the glomerulus and is caused by glomerular injury. It is mainly manifested as gross or microscopic hematuria, and its pathogenesis can be divided into two aspects: deficiency and excess. Based on Liu Wansu's theory of "stagnant heat and binding", this article analyzes the functions of wind medicine in "dispelling wind" and "mimicking nature", summarizes the practices of famous doctors and experts, and attempts to explore the clinical application of wind medicine in RH. It is believed that the excess syndrome of RH is mainly manifested as the accumulation of wind - dampness, damp - heat, turbid stasis, etc. The stagnant heat and binding leads to the dysfunction of the opening and closing of the Xuanfu, resulting in blockage. The deficiency syndrome is mainly manifested as the loosening of the Xuanfu, the obstruction of pathogenic factors, and the imbalance of the function of qi - ye in nourishing the body. Both aspects can cause restlessness of the kidney collaterals, and blood flowing out of the vessels instead of following the normal meridians, thus forming RH. The adminstration of wind medicine can reach both inside and outside. Appropriate compatibility of wind medicine can not only eliminate tangible pathogenic factors such as damp - heat, blood stasis, and turbid toxins but also invigorate qi transformation and guide tonic substances. The clinical compatibility of wind medicine has a good curative effect on both the deficiency and excess aspects of RH, providing new ideas and methods for the treatment of RH.

Melasma is a common destructive skin disease, and insomnia is the main cause of its induction and aggravation. Melasma accompanied by insomnia causes obvious troubles to patients' lives, and there is not any well therapeutic regimenat present. Xiao's school of Dermatology of traditional Chinese medicine in Fujian Medical School argues that the main pathogenesis of melasma accompanied by insomnia is the loss of spirit mechanism and the weakness of Qi activity. Its prescription to regulate the spirit of strengthening Qi, promoting blood and removing melasma as the theme, has accumulated certain experience in clinical. Therefore, the purpose of this article is to elucidate Xiao's method of regulating the spirit and removing melasma, explore its legislative ideas, and study its essence of composition, in order to provide new ideas for the diagnosis and treatment of this disease.

Objective: To investigate the effects of internal heat needle therapy combined with isokinetic centrifugal training on knee joint function and lower limb muscle strength in patients with knee osteoarthritis (KOA). Method: The selected study cases were 80 KOA patients who received outpatient and inpatient treatment in the hospital in the past year and a half (January 2023 to July 2024). They were randomly divided into groups (40 cases in each group)according to the random envelope method. The control group was only treated with isokinetic centrifugation training, while the study group was treated with isokinetic centrifugation training + internal heat injection therapy. The efficacy and related clinical indicators were evaluated after 4 weeks.Results: After treatment intervention, the muscle strength, joint mobility, and gait function of the study group patients were significantly stronger than those of the control group(P < 0.05) ; Knee joint pain, functional impairment, traditional Chinese medicine symptoms, inflammatory indicators, and joint fluid protein levels were significantly lower than those in the control group (P < 0.05) ; According to the statistical efficacy, the total clinical effective rate of 92.50% in the study group was significantly higher than that of 72.50% in the control group (P < 0.05).Conclusion: The combination of internal heat needle therapy and isokinetic centrifugal training can synergistically regulate inflammation,repair knee joint biomechanics, significantly improve knee joint function in KOA patients, promote the recovery of lower limb muscle strength, and have high clinical application value.

Objective: To evaluate the curative effect of pounding needling combined with Shaoshanhuo acupuncture(Mountain - burning fire needling technique) in patients with cervical spondylotic radiculopathy (CSR), and to explore its influences on cervical range of motion and hemodynamics parameters.Methods: According to random grouping method, 200 patients with CSR treated in Luoyang Orthopedic - Traumatological Hospital Of Henan Province were divided into control group (n=100, lifting, thrusting and rotating method) and observation group (n = 100, pounding needling combined with Shaoshanhuo acupuncture) between August 2019 and August 2024. All patients were treated for 2 courses of treatment (2 weeks/course). After treatment, clinical curative effect, scores of TCM syndromes, impairment of cervical spine function [neck disability index (NDI)], cervical spine pain [Numerical Rating Scale(NRS)], cervical range of motion and vertebral artery hemodynamics [peak systolic velocity (VS), mean flow velocity(VM), pulsatility index (PI), resistance index (RI)] in the two groups were compared.Results: After treatment, clinical response rates in observation group and control group were 96.00% (96/100) and 88.00% (88/100), the difference was statistically significant (P < 0.05). Compared with control group after treatment, scores of TCM syndromes, NDI and NRS, PI and RI were higher (P <0.01), while cervical range of motion, VS and VM were lower in observation group (P < 0.01).Conclusion: Compared with single therapy, curative effect of combined with Shaoshanhuo acupuncture is more significant, which can effectively improve disease symptoms, cervical range of motion and hemodynamics indexes in CSR patients.

Objective: To conduct a retrospective analysis on the clinical efficacy of the renowned traditional Chinese medicine formula, Lichong Decoction, in treating adenomyosis.Methods: A total of 158 patients with adenomyosis who first visitedthe gynecology outpatient clinic of the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from January 2023 to August 2024 were selected. After screening, 100 patients with adenomyosis of the Qi deficiency and blood stasis pattern were included. They were treated with the Chinese herbal decoction Lichong Decoction, administered from the date of consultation, one dose daily, taken warm, with 30 days as one treatment cycle, for a total of 3 cycles.Results: After treatment, the uterine size in AM patients showed mild reduction; menstrual volume significantly decreased; the dysmenorrhea relief rate was 53% at 3 months post - treatment and 62% at 6 months post- treatment; levels of FSH, LH, E2, P, and T all decreased, with each showing statistical significance (P < 0.05).Conclusion: The Chinese herbal decoction Lichong Decoction has the effects of boosting Qi, regulating menstruation, activating blood circulation, resolving stasis, dispersing masses, and resolving nodules. It can effectively improve uterine volume, reduce excessive menstrual flow, and relieve dysmenorrhea in patients with adenomyosis, with a low incidence of adverse reactions, demonstrating clinical research value.

Objective: To investigate the mechanism of Yishen Qiangjing Decoction in treating male infertility associated with Yang deficiency, based on the ""kidney - governing reproduction"" theory of traditional Chinese medicine (TCM), and to further validate and refine the application of this theory in addressing male infertility, thereby providing substantial support for the inheritance and development of TCM theory.Methods: A total of 78 male infertility patients who were treated at our hospital between March 2021 and March 2023 were recruited and randomly assigned to either a control group or an experimental group using the random number table method, with 39 participants in each group. The control group received conventional treatment, while the experimental group was administered Yishen Qiangjing Decoction based on the theoretical framework of ""kidney governing reproduction"" in addition to the conventional treatment. Compare the clinical therapeutic efficacy (including TCM syndrome scores), sperm quality, and sex hormone levels between the two groups. Conduct a 24 - month follow - up to document fertility outcomes and analyze overall effectiveness.Results: The total clinical efficacy rate in the experimental group was 92.31%, which was significantly higher than the 74.36% observed in the control group (P <0.05). Following treatment, significant improvements were noted in sperm liquefaction time, normal sperm morphology rate, semen volume, sperm concentration, and progressive motility plus non - progressive motility (PR + NP) compared to pre - treatment values in both groups, with greater improvement in the experimental group compared to the control group (P < 0.05). Post - treatment serum levels of follicle - stimulating hormone (FSH) and luteinizing hormone (LH) were markedly reduced in both groups compared to baseline, with a more pronounced decrease in the experimental group relative to the control group (P < 0.05). Conversely, serum testosterone (T) and free testosterone (FT) levels increased significantly post - treatment in both groups compared to baseline, with higher levels achieved in the experimental group compared to the control group (P <0.05). The cumulative pregnancy rate at 24 months was significantly higher in spouses of the experimental group than in the control group (P < 0.05). The median time - to - pregnancy was significantly shorter among spouses of the experimental group compared to the control group (P < 0.05). No statistically significant differences were observed between groups regarding live birth rates or spontaneous abortion rates among patients' spouses (P >0.05).Conclusion: Yishen Qiangjing Decoction, grounded in the theoretical framework of ""kidney - governing reproduction,"" significantly enhances the semen quality and reproductive endocrine function in male infertility patients with Yang deficiency. Through its integrated effects of ""regulating kidney - yang, promoting spermatogenesis, and assisting pregnancy,"" it also increases the natural pregnancy rate of their partners, demonstrating substantial clinical application value.

Objective: To evaluate the clinical efficacy and safety of oral administration of Chailing Decoction combined with external mirabilite application in patients with nephrotic syndrome edema.Methods: Eighty patients with nephrotic syndrome edema admitted to the Second Affiliated Hospital of Hebei University of Chinese Medicine from January 2023 to December 2024 were enrolled. Patients were divided into a control group and a treatment group based on admission sequence (odd and even numbers), with 40 patients in each group. The control group received conventional basic treatment plus external application of magnesium sulfate. The treatment group added Chailing Decoction to the control group's regimen. The two groups were compared in terms of edema treatment efficacy, physiological indicators, traditional Chinese medicine syndrome scores, liver and kidney function indicators, and safety.Results: The total effective rate for edema treatment was significantly higher in the treatment group than in the control group (P <0.05). Pre - treatment physiological and laboratory parameters showed no statistically significant differences between groups(P > 0.05). Post - treatment, the treatment group exhibited significantly lower fasting body weight and lower calf circumference than the control group (P <0.01), while demonstrating significantly higher 24 - hour urine output (P <0.01). Pre - treatment scores for TCM syndromes showed no statistically significant difference between groups (P >0.05). Post - treatment scores for edema, loose stools, fatigue, and poor appetite were significantly lower in the treatment group than the control group (P < 0.01). Pre - treatment liver and kidney function indicators showed no statistically significant difference between groups (P > 0.05). After treatment, alanine aminotransferase levels in the treatment group showed no statistically significant difference compared to the control group (P >0.05). However, 24- hour urinary protein levels, serum cystatin C, and blood urea nitrogen levels were significantly lower in the treatment group than in the control group (P < 0.01). The incidence of adverse reactions between the two groups showed no statistically significant difference (P > 0.05).Conclusion: The combination therapy of oral administration of Chailing Decoction combined with external mirabilite application significantly improved clinical efficacy in patients with nephrotic syndrome edema, enhanced physiological and laboratory parameters, and reduced traditional Chinese medicine syndrome scores. This regimen did not increase adverse reactions and demonstrated high safety.

Objective: To explore the effect of sequential treatment with modified Sanwubai Powder and Xiaoxianxiong Decoction on schizophrenia with phlegm - fire disturbing heart syndrome.Methods: Using the random number table method, 88 patients with schizophrenia and phlegm - fire disturbing heart syndrome who were admitted to the Xianyue Hospital from December 2022 to October 2023 were allocated to the observation group and the control group, with 44 cases in each group. The control group received conventional Western medicine treatment, while the observation group received sequential treatment with modified Sanwubai Powder and Xiaoxianxiong Decoction on the basis of conventional Western medicine (the patients were treated with modified Sanwubai Powder from the 1st to the 2nd week and treated with Xiaoxianxiong Decoction from the 3rd to the 12th week, 12 weeks in total). Comparisons were made between the two groups on traditional Chinese medicine syndrome scores, clinical symptoms, cognitive function, behavioral ability, neurotransmitter levels, and adverse reactions.Results: After treatment, traditional Chinese medicine syndrome scores and the Positive and Negative Syndrome Scale (PANSS) scores of the observation group were lower than those of the control group (P < 0.05). The Mini - Mental State Examination (MMSE) and Scale of Social Function in Psychosis Inpatients (SSPI) scores, gamma - aminobutyric acid (γ - GABA), 5 - hydroxytryptamine (5 - HT) and brain- derived neurotrophic factor (BDNF) levels were higher than those of the control group (P < 0.05). There was no significant difference in adverse reactions between the two groups (P > 0.05).Conclusion: The sequential treatment with modified Sanwubai Powder and Xiaoxianxiong Decoction is markedly effective for schizophrenia with phlegm - fire disturbing heart syndrome. It can significantly improve patients' clinical symptoms, enhance their cognitive function and behavioral abilities, and increase neurotransmitter levels. However, its impact on adverse reactions needs further study.

Objective: To observe the effect of Xiaoyong Liyan Decoction combined with auricular acupoint therapy on the clinical symptoms and inflammatory reaction of recurrent suppurative tonsillitis in pediatric patients with wind- heat - aggravated lung syndrome.Methods: One hundred and seventy cases of children with recurrent suppurative tonsillitis with wind - heat against the lung syndrome admitted to Puyang Hospital of Traditional Chinese Medicine from January 2022 to June 2024 were selected, and were randomly divided into two groups using the envelope method, with 85 cases in a single group. The control group was given conventional symptomatic treatment with western medicine, and the treatment group was given Xiaoyong Liyan Decoction combined with auricular acupoint therapy on the basis of it, with a continuous intervention of 7 d. Inflammatory factors, the time of improvement of symptoms and signs, the degree of tonsillar enlargement, the Chinese medicine symptom scores as well as the rate of adverse reaction reaction were compared between the two groups.Results: White blood cell count (WBC), C - reactive protein (CRP), tumor necrosis factor - alpha (TNF - α), and interleukin 8 (IL - 8) were lower in both groups after treatment compared with before treatment, and were lower in the treatment group after treatment (P < 0.05). The time for fever reduction, disappearance of sore throat, disappearance of purulent secretions, and swelling of tonsils in the treatment group were shorter than those in the control group (P <0.05). The degree of tonsil enlargement after treatment in both groups was improved compared with that before treatment, and the degree of tonsil enlargement after treatment in the treatment group was lighter (P < 0.05). The primary symptom scores (fever, sore throat, tonsillar enlargement, purulent secretion)and secondary symptom scores (irritating dry cough, obstructive sensation, nausea, thirst) were lower in both groups after treatment compared with those before treatment, and they were lower in the treatment group after treatment (P <0.05). There was no difference in the rate of adverse reaction response between the two groups (4.71% in the control group and 7.06% in the treatment group) (P >0.05).Conclusion: Xiaoyong Liyan Decoction combined with auricular acupoint therapy can reduce inflammatory reaction, improve tonsil enlargement and promote disease recovery in pediatric recurrent suppurative tonsillitis with wind - heat against the lungs.

Objective: To analyze the clinical efficacy of the traditional Chinese medicine formula WD3 (WD3)combined with carrilizumab in the treatment of advanced esophageal cancer.Methods: A total of 86 patients with advanced esophageal cancer admitted to the Jiangyin Hospital of Traditional Chinese Medicine from September 2022 to August 2024 were divided into observation group (43 cases,WD3 combined with carrilizumab were used for treatment)and control group (43 cases, carrilizumab was used for treatment) by random number table method. TCM symptom score, quality of life, clinical efficacy, tumor markers, immune function, adverse reactions and prognosis were compared between the two groups.Results: After treatment, the scores of TCM symptoms in 2 groups were decreased(P < 0.05), and the scores in observation group were lower (P < 0.05). After treatment, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire 30 (QLQ - C30) score was increased in both groups(P < 0.05), and higher in observation group (P < 0.05). The objective remission rate and disease control rate of observation group were higher than control group (P <0.05). After treatment, the levels of keratin19 fragment antigen 21 -1 (CYFRA21 - 1), carbohydrate antigen 199 (CA199) and squamous cell carcinoma associated antigen (SCC- Ag) in serum of 2 groups were decreased (P < 0.05), and the levels were lower in observation group (P < 0.05). After treatment, the levels of CD4 ⁺/CD8 ⁺, CD4 ⁺ and CD3 ⁺ were increased in 2 groups (P < 0.05), and higher in observation group (P < 0.05). There were no significant differences in the total incidence of class I to Ⅳ adverse reactions such as thrombocytopenia, rash, liver function injury and gastrointestinal reactions between the two groups(P > 0.05). After one year of follow - up, there were 1 case lost to follow - up in the observation group and 2 cases lost to follow - up in the control group, resulting in a follow - up rate of 96.51% (83/86), and the survival rate was 83.33% (35/42) in the observation group and 63.41% (26/41) in the control group. The survival curve of observation group was better than control group (P <0.05).Conclusion: In patients with advanced esophageal cancer, the combination of WD3 and carrellizumab has significant therapeutic effect, which can improve the quality of life and immune function of patients, reduce the level of tumor markers, is safe and reliable, and can prolong the survival time of patients.

Objective: To observe the efficacy and safety of Jieyu Anchang Tongxie Formula combined with Pinaverium bromide in the treatment of liver - depression and spleen - deficiency syndrome of irritable bowel syndrome with predominant diarrheal (IBS - D).Methods: A total of 112 IBS - D patients with liver - depression and spleen- deficiency treated in Shanghai Fifth People's Hospital from August 2022 to September 2023 were chosen and randomly separated into the observation group (n = 56, Jieyu Anchang Tongxie formula + Pinaverium bromide, 4 weeks) and control group (n=56, Pinaverium bromide, 4 weeks). 8 - week follow - up was arranged after the end to observe the sustained effect. The clinical efficacy, IBS symptom severity questionnaire (IBS - SSS), rectal sensitivity [anal canal resting pressure (ARP), anal maximum contraction pressure (AMCP) , rectal resting pressure (RRP), abdominal pain threshold, defecation threshold], serum vasoactive intestinal peptide (VIP), neurotransmitter [5 - serotonin (5- HT), Neuropeptide Y (NPY), calcitonin gene - related peptide (CGRP)], the number of intestinal flora, quality of life (IBS - QOL), self - rating anxiety scale (SAS) and self - rating depression scale (SDS) were compared between the two groups. The adverse reactions were recorded.Results: The observation group had higher effective rate (92.86%vs 78.57%) (P <0.05); IBS - SSS scores in the observation group were lower than those in the control group at 4 weeks and 8 weeks after treatment (P < 0.05) ; After treatment, ARP, abdominal pain threshold and defecation threshold in the observation group were higher than those in the control group (P <0.05), while the levels of VIP, 5- HT, and CGRP were lower, the levels of NPY were higher, and Lactobacillus acidophilus and bifidobacterium were also higher (P <0.05) ; The observation group had lower IBS - QOL scores, SAS scores and SDS scores (P < 0.05). Th incidence of adverse reactions was similar in the two groups (7.14% and 3.57%, P > 0.05). Conclusions: Jieyu Anchang Tongxie Formula combined with Pinaverium bromide has good efficacy in the treatment of IBS - D, which can significantly improve symptoms, reduce the release of serum VIP, neurotransmitter and inflammatory factors, maintain intestinal mucosal barrier and rectal sensitivity, regulate intestinal flora and negative emotions, and improve patients' quality of life with good safety.

Objective: To explore the effects of Zhilou Sukang Decoction on wound healing and inflammatory factors after mixed hemorrhoids surgery.Methods: A total of 133 patients with mixed hemorrhoids who underwent surgical treatment at Xinrui Hospital in Xinwu District of Wuxi from January 2023 to June 2024 were selected and randomly divided into the control group (n=67) and the observation group (n =66). The control group was given conventional Western medical treatment. On the basis of the treatment of the control group, the observation group was given hemorrhoid fistula Zhilou Sukang Decoction sitz bath. Both groups were intervened for 2 weeks. The healing efficacy, pain degree, anal distension, quality of life, wound area, granulation tissue growth score, inflammatory factors and incidence of adverse reactions were compared between the two groups. Result: In the control group of wound healing, the total effective rate of the observation group (93.94%) was significantly higher than that of the control group (74.63%) (P <0.05) ; One day after the treatment, the wound pain in the observation group was significantly relieved after each sitz bath. In the first week of treatment, the wound pain was more obvious in the control group, while the pain improvement effect was significant in the observation group after applying the sitz bath formula. From the second week, the wound pain in the observation group showed a continuous decreasing trend. In terms of the quantitative comparison of pain, the VAS score of the observation group decreased extremely significantly, and the VAS scores at each stage after treatment were significantly lower than those of the control group (all P < 0.05). After treatment, all pain indicators in both groups decreased, and the improvement degree of pain attack frequency and duration in the observation group was significantly better than that in the control group (all P < 0.05). After the treatment, the scores of the feeling of heaviness in both groups decreased. The observation group was significantly better than the control group in relieving the feeling of heaviness (all P < 0.05). After the treatment, the WHOQOL - BREF scores of both groups increased, and the increase in the observation group was greater (P < 0.05). After 2 weeks of treatment, the wound area and granulation tissue growth score indicators in both groups were significantly improved compared with those before treatment, and the improvement amplitude in the observation group was significantly better than that in the control group (all P < 0.05). After 2 weeks of treatment, the levels of the above inflammatory factors in both groups were significantly lower than those before treatment, and the reduction amplitude in the observation group was significantly better than that in the control group (all P < 0.05). During the treatment period of the two groups, 2 cases of mild local pruritus occurred in the observation group (3.03%), and 1 case of skin redness after iodophor disinfection occurred in the control group(1.49%). There was no significant difference in the incidence of adverse reactions (P > 0.05).Conclusion: The application of Zhilou Sukang Decoction sitz bath combined with western medicine intervention for patients after mixed hemorrhoids surgery can rapidly relieve wound pain, wound area, granulation tissue growth score, improve the feeling of heaving and inflammatory factor levels, and significantly enhance the wound healing effect, therefore, it is worthy of vigorous clinical promotion.

Objective: To analyze the therapeutic effect and immune mechanism of the Jianpi Yishen Huoxue Tongluo Paste Formula on the stable stage of chronic obstructive pulmonary disease (COPD).Methods: The clinical data of 83 COPD patients admitted to the outpatient service of Suzhou Integrated Chinese and Western Medicine Hospital during January, 2021 to August, 2023 were retrospectively analyzed. According to the different treatment methods, they were divided into control group (n = 40,Western medicine treatment) and observation group (n = 43,Western medicine +Jianpi Yishen Huoxue Tongluo Paste Formula),which were treated for 2 months. The clinical efficacy, adverse reactions, Chinese medicine symptom scores before and after treatment, dyspnea severity [modified British Medical Research Council Respiratory Questionnaire (mMRC)], symptoms [COPD Self - Assessment Test Questionnaire (CAT)], exercise endurance [6 - minute walking distance (6MWD)], and T helper cell 17(Th17)/regulatory T were compared between the two groups Cell (Treg) ratio, and the annual number of attacks 1 year before treatment and 1 year after treatment.Results: The total effective rate of observation group was 95.00%, which was higher than that of control group 76.32% (P <0.05). After treatment, the syndrome score, mMRC score,CAT score, annual number of attacks and Th17/Treg ratio were decreased in both groups, and the 6MWD value was increased, and the change was greater in the observation group compared with the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the control group(13.16%) and the observation group (5.00%) (P >0.05).Conclusion: The Jianpi Yishen Huoxue Tongluo Paste Formula is safer and more effective in the treatment of stable COPD It may exert its effect by affecting the Th17/Treg balance.

Objective: To evaluate the therapeutic effect of ""Xingshui Tongqi Decoction"" (XTD) in patients with hydrosalpinx - related infertility of dampness - heat and blood stasis syndrome.Methods: A total of 124 patients diagnosed with hydrosalpinx - related infertility (dampness - heat and blood stasis syndrome) and treated in the First Affiliated Hospital of Hebei University of Chinese Medicine from January 2023 to January 2024 were enrolled. They were randomly divided into a control group (n = 62, conventional postoperative anti - infection therapy) and an observation group (n =62, XTD combined with conventional therapy). All patients underwent hysteroscopic - laparoscopic surgery, followed by 3 menstrual cycles of treatment. Ovarian function (LH, E₂, FSH, AMH), endometrial receptivity(endometrial thickness, volume, PI, RI), TCM syndrome scores, postoperative complications, pregnancy outcomes, and hydrosalpinx recurrence were assessed during a 1 - year follow - up.Results: Compared with the control group, the observation group showed higher LH, FSH, and AMH levels, lower E₂ and TCM syndrome scores, improved endometrial receptivity, higher intrauterine pregnancy rate (P < 0.05), and lower hydrosalpinx recurrence rate (P < 0.05). No significant difference in safety was observed between groups (P > 0.05).Conclusion: XTD combined with hysteroscopic- laparoscopic surgery significantly improves ovarian function, enhances endometrial receptivity, increases intrauterine pregnancy rates, and reduces hydrosalpinx recurrence in patients with hydrosalpinx - related infertility (dampness - heat and blood stasis syndrome) , with a favorable safety profile.

This paper elaborates on the etiology, pathogenesis, and treatment based on syndrome differentiation. It suggests that androgenetic alopecia is fundamentally characterized by deficiency of the internal organs, with dampness, wind, heat, and blood stasis as its secondary manifestations. The discussion covers internal treatment methods such as tonifying the liver and kidney, clearing heat and promoting diuresis, cooling blood and dispelling wind, and nourishing blood and moisturizing dryness, along with external treatments including acupuncture, topical preparations, and massage. The aim is to highlight the unique advantages of Traditional Chinese Medicine in the clinical diagnosis and treatment of this condition, thereby enhancing clinical efficacy. Therefore, recent literature on TCM treatments for androgenetic alopecia has been reviewed in this paper.

Polycystic ovary syndrome (PCOS) is a common reproductive endocrine and metabolic disorder disease and its incidence is increasing year by year. The pathogenesis of this disease has not been clarified, which is also a major challenge in clinical treatment. Cangfu Daotan Decoction, derived from the secret recipe for diagnosis and treatment of Ye Tianshi Nvke Zhenzhi Mifang, is particularly effective in the treatment of PCOS. Studies have found that Cangfu Daotan Decoction exerts therapeutic effects by regulating phosphatidylinositol 3 - kinase/protein kinase (PI3K/Akt), nuclear transcription factor - κB(NF - κB), adenosine monophosphate - activated protein kinase (AMPK), mitogen- activated protein kinase (MAPK), and transforming growth factor - β1/SMAD family member 3 (TGF - β1/Smad3)signaling pathways. In clinical studies, Cangfu Daotan Decoction alone or modified Cangfu Daotan Decoction or in combination with western medicines or external therapies not only can alleviate the clinical symptoms of PCOS,but also are safe and effective, which are worthy of clinical application. This article systematically summarized the research progress of Cangfu Daotan Decoction by analyzing the mechanisms and clinical studies,in order to provide references for further basic experimental research and evidence to support the promotion of Cangfu Daotan Decoction for the treatment of PCOS in the future.