Objective: To explore the effect of sequential treatment with modified Sanwubai Powder and Xiaoxianxiong Decoction on schizophrenia with phlegm - fire disturbing heart syndrome.Methods: Using the random number table method, 88 patients with schizophrenia and phlegm - fire disturbing heart syndrome who were admitted to the Xianyue Hospital from December 2022 to October 2023 were allocated to the observation group and the control group, with 44 cases in each group. The control group received conventional Western medicine treatment, while the observation group received sequential treatment with modified Sanwubai Powder and Xiaoxianxiong Decoction on the basis of conventional Western medicine (the patients were treated with modified Sanwubai Powder from the 1st to the 2nd week and treated with Xiaoxianxiong Decoction from the 3rd to the 12th week, 12 weeks in total). Comparisons were made between the two groups on traditional Chinese medicine syndrome scores, clinical symptoms, cognitive function, behavioral ability, neurotransmitter levels, and adverse reactions.Results: After treatment, traditional Chinese medicine syndrome scores and the Positive and Negative Syndrome Scale (PANSS) scores of the observation group were lower than those of the control group (P < 0.05). The Mini - Mental State Examination (MMSE) and Scale of Social Function in Psychosis Inpatients (SSPI) scores, gamma - aminobutyric acid (γ - GABA), 5 - hydroxytryptamine (5 - HT) and brain- derived neurotrophic factor (BDNF) levels were higher than those of the control group (P < 0.05). There was no significant difference in adverse reactions between the two groups (P > 0.05).Conclusion: The sequential treatment with modified Sanwubai Powder and Xiaoxianxiong Decoction is markedly effective for schizophrenia with phlegm - fire disturbing heart syndrome. It can significantly improve patients' clinical symptoms, enhance their cognitive function and behavioral abilities, and increase neurotransmitter levels. However, its impact on adverse reactions needs further study.

Schizophrenia  /  Phlegm - fire disturbing heart syndrome  /  Modified Sanwubai Powder  /  Xiaoxianxiong Decoction