Latest ArticlesThis article systematically reviewed the development of acupuncture education in the United States over the past fifty years，analyzing the reasons for its fluctuations and the challenges it faces.Through case studies of the establishment，development，mergers and closures of various acupuncture schools，the article revealed the development model of the acupuncture education industry and its susceptibility to changes in policies，economic environment and market demand.In particular，after the implementation of the“gainful employment”rule，some schools faced a decrease in enrollment and financial pressures，leading to their closure.The deficiencies in teaching systems and research innovation in acupuncture education，the rise of dry needling techniques，and the changes in industry standards have also had a profound impact on the survival of these schools.This article aimed to provide insights and considerations for the sustainable development of acupuncture education in the future through an analysis of these factors.
To solve the problems of complicated rules of measurement of Chinese medicines in ancient books，inconvenience in finding formulaeand lack of modern intelligent applications for ancient books.
It summarized the measurement conversion standards and special meter measurement conversion standards in the past dynasties，proposed a similarity calculation method for medical cases based on the fusion of the features of＂mainevidence+formulaname+composition of traditional Chinese medicine＂，and adopted Enhanced Representation from Knowledge IntEgration（ERNIE）model based on deep learning for model training.Itdesigned and developed an intelligent ancient formula recommendation and measurement conversion system based on deep learning recommender engine，using MySQL database and Django framework.Using MySQL database and Django framework，it designed and developed an intelligent ancient prescription recommendation and measurement conversion system based on deep learning recommendation engine.
The overall recommendation accuracy rate obtained by this method reached 89.55%，the precision rate was 94.51%，and the recall rate was 83.97%，which achieved better results，and the system was able to achieve the intelligent retrieval of formulae and the conversion of Chinese medicine measurement units，recommend a series of ancient formulae with a high degree of matching of the main treatment efficacy according to the symptoms inputted by the user，and display the composition of formulas and the Chinese medicine dosage in accordance with the conversion rules of different dynasties.It also displayed the composition of the formula and the dosage ofChinese medicine according to the conversion rules of different dynasties，which conformed to the modern standard measurement.
The method of intelligent recommendation of prescriptions and conversion of Chinese medicine measurements achieves satisfactory results，provides a new way of thinking for the intelligent recommendation of ancient prescriptions，and has certain reference significance for the standardisation of Chinese medicine dosage and the reference significance for the clinical use of medicines.
Gastric cancer is one of the most common malignant tumors in the digestive tract and poses a serious threat to human health.Early warning and diagnosis can increase the 5-year survival rate by more than 60%.In recent years，machine learning methods have achieved rich results in predicting the precancerous state of gastric cancer.This article first discussed the significant features of the precancerous state of gastric cancer from the aspects of endoscopic images，biochemical markers，gene expression，and traditional Chinese medicine syndromes，and analyzed the advantages and disadvantages of traditional machine learning methods，deep learning methods and various fusion methods by combining the research results of the precancerous state of gastric cancer predicted by machine learning methods.It proposed three suggestions for carrying out multi-center，large-sample cohort studies and building shared data platforms，realizing multi-modal data fusion and enhancing the interpretability of the model，providing methodological references for the“early diagnosis and treatment”of gastric cancer.
To achieve the inter and intraspecific identification of Caohonghua（Carthamus tinctorius L.）from Asteraceae，Xihonghua（Crocus sativus L.）from Iridaceae（originating from Iran）and Zanghonghua（Crocus sativus L.）（originating from Xizang）by using spectroscopic technologies coupled with machine learning methods.
Raman spectroscopy（RS）and terahertz（THz）spectral data was used to identify and characterize Xihonghua（Crocus sativus L.）（origin Iran），Caohonghua（Carthamus tinctorius L.）（origin Gansu）and Zanghonghua（Crocus sativus L.）（origin Xizang）by using machine learning methods including Principal Component Analysis（PCA），Support-Vector Machine（SVM），Random Forest（RF）and deep learning methods including Multilayer Perceptron（MLP），Convolutional Neural Network（CNN），Long Short Term Memory（LSTM）and Genetic Algorithm-Back Propagation（GA-BP）to analyze the THz and RSspectra of three types of samples.The rapid classification and recognition of Chinese herbal medicine with small sample size was realized.
（1）The classification accuracies of the SVM method on the RS data of the three samples before and after dimensionality reduction by PCA were 83.33% and 94.44%，respectively.The MLP classified the THz data before and after dimensionality reduction by PCA with accuracies of 94.00% and 96.79%，respectively.The results indicated that the classification accuracy was further improved by PCA，and THz spectra for deep learning had a higher accuracy than RSspectra.（2）The classification accuracy of neural networks such as MLP，CNN，RBF，GA-BP and LSTM on THz spectral data was higher than that on RSspectra，among which the classification accuracy of LSTM and RF on THz raw data was as high as 100%.Also，these models had high classification accuracy，high speed and good stability.
The combination of spectroscopic and machine learning methods enables inter and intraspecific identification of Xihonghua（Crocus sativus L.），Caohonghua（Carthamus tinctorius L.）and Zanghonghua（Crocus sativus L.），with high accuracy of THz spectroscopic identification.
To explore the regulatory effect of Buyang Huanwu Decoction（补阳还五汤）on phenotypic polarization of microglia in cervical spinal cord injury.
Ninety-six female Sprague-Dawley（SD）rats were randomly divided into sham operation，model，low-dose Buyang Huanwu Decoction and high-dose Buyang Huanwu Decoction groups to establish an acute cervical spinal cord injury model.Motor function recovery of rats was assessed using the Forelimb Locomotor Scale（FLS）score and forelimb grip strength experiment Basso-Beattie-Bresnahan（BBB）score before surgery and at 1，3，7，14，21 and 28 d postoperatively.Animals were sacrificed at 7，28 d postoperatively.Hematoxylin and Eosin（HE）staining was used to evaluate the gross morphology of the injury site.Nissl staining was used to assess neuronal survival，and immunofluorescence staining was used to observe the expression of ionized calcium binding adapter molecule 1（Iba1），inducible nitric oxide synthase（iNOS），arginase 1（Arg1）at 7 days post-injury，and microtubule-associated protein 2（MAP2）at 28 days post-injury.Western blot was used to evaluate the expressions of Iba1，CD86，Arg1 and CD206 at 7 days post-injury，and Enzyme-Linked Immunosorbent Assay（ELISA）was used to measure the levels of tumor necrosis factor-alpha（TNF-α），interleukin-6（IL-6）and interleukin-1β（IL-1β）.
From day 3 to day 28 postoperatively，the motor function in the Buyang Huanwu Decoction groups began to recover significantly compared to the model group（P<0.05）.HE staining showed that compared with that in the model group，the spinal cord tissue structure in the Buyang Huanwu Decoction group was denser，with reduced edema，fewer vacuoles and reduced interstitial spaces，and decreased infiltration of immune/inflammatory cells.Nissl staining showed that the number of neurons in the gray matter was increased in the Buyang Huanwu Decoction groups compared with that in the model group，with some surviving neurons visible.The immunofluorescence staining showed that the fluorescence intensity of MAP2 was significantly increased，the fluorescence intensity of M1-type iNOSwas decreased，and the fluorescence intensity of M2-type Arg1 was increased in the Buyang Huanwu Decoction groups compared with those in the model group（P<0.05）.Western blot showed that the expression levels of iNOSand CD86 were significantly decreased，while the expression levels of Arg1 and CD206 were significantly increased in the Buyang Huanwu Decoction groups compared with those in the model group（P<0.05）.ELISA showed that the levels of TNF-α，IL-6 and IL-1βwere significantly lower in the Buyang Huanwu Decoction groups than those in the model group（P<0.05）.
Buyang Huanwu Decoction can effectively promote the phenotypic transition of microglia from M1 to M2 in rats with cervical spinal cord injury，alleviate neuroinflammatory responses，inhibit secondary injury，and thereby improve motor dysfunction after cervical spinal cord injury.
Atherosclerosis（AS）is a chronic vascular disease，which is the pathological basis of many cardiovascular and cerebrovascular diseases.The rupture of atherosclerotic plaque is prone to serious cardiovascular and cerebrovascular events.The formation mechanism of AS is complex，mainly involving endothelial damage and dysfunction，lipid metabolism disorder deposition，inflammatory response，platelet aggregation and oxidative stress.Xiebai（Allii Macrostemonis Bulbus）is an essential medicine used in the Treatise on Cold Damage and Miscellaneous Diseases to treat chest obstruction and heart pain.It has the functions of dredging Yang and dispersing mass，and promoting Qi circulation to relieve stagnation.Modern research has shown that Xiebai（Allii Macrostemonis Bulbus）contains multiple effective natural active ingredients that work synergistically on multiple signaling pathways.This article reviewed the mechanism of Xiebai（Allii Macrostemonis Bulbus）and its classic compatibility in anti-AS from multiple aspects such as regulating vasodilation function，anti-inflammation，antioxidant stress，anti-platelet aggregation and lowering lipids，by reviewing the relevant literature.This provided a reference for expanding its application scope，fully exerting its therapeutic effect，and developing clinical drugs and future basic research directions.
Wuzhuyu（Euodiae Fructus）is one of the“three seeds and one shell”of Jiangxi's authentic medicinal materials，with a long history and wide application.The author reviewed the historical evolution of the efficacy of Wuzhuyu（Euodiae Fructus）by consulting the works of materia medica.On this basis，taking the modern research of Wuzhuyu（Euodiae Fructus）as the starting point，the literature analysis has been carried out from the aspects of modern pharmacological effects，preparation design and clinical external research.According to the current status of its research，the existing problems were analyzed.For example，the research on the modern pharmacological effects of Wuzhuyu（Euodiae Fructus）focuses on anti-tumor，anti-inflammatory，hepatoprotective，anti-Alzheimer's disease，etc.，but now the research focuses on the corresponding cell model as the research object，and there is a lack of real-world research based on clinical needs.As an important medicine for acupuncture point application，Wuzhuyu（Euodiae Fructus）is often used externally to treat stubborn diseases，and can realize the“internal and external treatment”of a variety of nervous system diseases，cardiovascular system diseases and digestive system diseases.However，at present，there are many scattered clinical external use research reports，mostly focusing on some case reports，lacking in-depth mechanism exploration，and has not yet formed a standardized treatment system，and lacks a standardized collection and sorting of the experience of external use of Wuzhuyu（Euodiae Fructus）.In view of the problems of poor solubility，slow dissolution and low bioavailability of the main pharmacodynamic components such as evodiamine，rutaecarpine and limonin，it is expected to be devel-oped into a candidate drug for the effective treatment of tumors and inflammatory diseases through rational formulation design，such as nano-preparations，phospholipid complexes and inclusion complexes，but the research is limited to the bioavailability changes between the new preparation and the original drug and the quality evaluation of the preparation，and the lack of evaluation of the treatment effect of related diseases restricts the process of new drug creation.In this paper，the modern pharmacological effects，related dosage form design and clinical external use of Wuzhuyu（Euodiae Fructus）were systematically reviewed in recent years，in order to lay a foundation for the in-depth systematic research and development of topical preparations of Wuzhuyu（Euodiae Fructus）.
To analyze the effects of Jiangzi Decoction（降阻汤）combined with antihypertensive therapy on plasma asymmetric dimethylarginine in mild to moderate pregnancy hypertension（ADMA），soluble vascular endothelial growth factor receptor-1（sFlt-1）/placental growth factor（PIGF）and maternal and infant outcomes.
A total of 108 patients with mild to moderate gestational hypertension treated in the hospital from September 2020 to October 2023 were included as research objects.They were divided into two groups by random number table method.Fifty-four patients in the control group received routine antihypertensive treatment，and the other 54 patients in the observation group received Jiangzi Decoction combined with antihypertensive treatment.The efficacy，blood pressure，symptom scores，plasma levels of ADMA and sFlt/PIGF，ultrasound hemodynamic index of placenta and pregnancy outcome were compared between the two groups.
The total effective rate of the observation group was 96.30%，much higher than that of the control group（79.63%）（P<0.05）.After treatment，dizziness，waist and knee weakness，five upset and heat symptom scores and blood pressure levels in the observation group were lower than those in the control group（P<0.05）.After treatment，the values of pulsatility index（PI），resistance index（RI）and S/D in the observation group were lower than those in the control group.The levels of ADMA，sFlt-1 and sFlt-1/PIGF in the observation group were lower than those in the control group，and PIGF levels were higher than those in the control group（P<0.05）.The incidence of adverse pregnancy outcome was3.70% in the observation group，which was much lower than that（14.81%）in the con-trol group（P<0.05）.
Jiangzu Decoction can nourish Yin and suppress Yang，invigorate Qi and tonify kidney，tranquilize the mind and stabilize the fetus.And when combined with antihypertensive therapy for mild to moderate pregnancy hypertension，it can effectively control blood pressure，alleviate symptoms，regulate microcirculation，improve placental hemodynamic indexes，and reduce the levels of ADMA and sFlt/PIGF，improve pregnancy outcomes and ensure the safety of mothers and infants.
Danggui（Angelicae Sinensis Radix）-Huangqi（Astragali Radix）is one of the commonly used Chinese medicine prescriptions，which has a clear compatibility significance for the use of traditional Chinese medicine，and is one of the most representative drug combinations.It can not only be a formula by itself，but also be used as a combination of clinical basic drugs，so it has always been paid attention to by various doctors.Modern pharmacological studies have also shown that Danggui（Angelicae Sinensis Radix）-Huangqi（Astragali Radix）has a good effect on promoting hematopoietic production，inhibiting tumor growth and proliferation，protecting cardiovascular and cerebrovascular vessels，and regulating the immune system，and is often used in clinical treatment of vascular diseases and immunosuppression in tumor patients.Inflammatory factors mediated by nuclear transcription factor-κB（NF-κB）related signaling pathways play an important role in the formation and progression of disease.Studies have shown that TCM monomer and single drug can mediate the reduction of inflammatory response through NF-κB signaling pathway，including regulating the expressions of interleukin（IL）family，cycloceuxy-2（COX-2），vascular endothelial growth factor（VEGF），matrix protease（MMPs）family and other factors，and play an anti-inflammatory role in inhibiting cell adhesion and proliferation.In view of this，the pharmacology and efficacy of Danggui（Angelicae Sinensis Radix）-Huangqi（Astragali Radix）and the regulation of NF-κB signaling pathway were reviewed in this paper，so as to provide relevant reference for future clinical application.
To investigate the effect of Yangwei Granule（养胃颗粒）assisting enteral nutrition support on the nutritional status and Th1/Th2 cells of patients after gastric cancer surgery.
A total of 117 postoperative gastric cancer patients in the hospital from February 2018 to February 2023 were selected and divided into a control group（58 cases）and an experimental group（59 cases）by a random number table.Both groups were treated with routine treatment.The control group was given enteral nutrition support after operation，and the experimental group was given Yangwei Granule based on the control group for continuous treatment for 10 days.The recovery rate of gastrointestinal function，adverse events（including complications and adverse reactions）and TCM syndrome scores（constipation，abdominal distension，lack of food），nutritional status［hemoglobin（Hb），total protein（TP）］，nutritional risk screening 2002（NRS-2002）score，Th1/Th2 cells and their factors［interferonγ（IFN-γ），interleukin-10（IL-10），interleukin-12（IL-12）］were observed and compared before and after treatment between the two groups.
The gastrointestinal function recovery rate of the experimental group was 83.05% higher than that of the control group（65.52%）（P<0.05）.After treatment，the scores of stool，abdominal distension and lack of food in the experimental group were lower than those of the control group（P<0.05）.After treatment，the levels of TP and Hb in the experimental group were higher than those of the control group（P<0.05）.After treatment，the levels of Th1 and Th1/Th2 in the experimental group were higher than those in the control group，and the levels of Th2 cells were lower than those in the control group（P<0.05）.After treatment，the serum levels of IFN-γand IL-12 in the experimental group were higher than those in the control group，and IL-10 levels were lower than those in the control group（P<0.05）.There was no significant difference in the incidence of alkaline reflux gastritis，gastrointestinal discomfort and aspiration pneumonia between the two groups（P>0.05）.
Yangwei Granule assisting by enteral nutrition support applied to patients after gastric cancer surgery can regulate the expressions of Th1/Th2 cells and their factors，promote the recovery of gastrointestinal function，improve TCM syndromes and nutritional status，and has high safety.
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