To establish amethod for identifying Shicangpu（Acori Tatarinowii Rhizoma）（ATR）from common counterfeits by ultra performance liquid chromatography（UPLC）technology，and to provide reference for quality evaluation and control of ATR.

Waters CORTECST3 column（2.1 mm×150 mm，1.6μm）was used.Methanol：acetonitrile 1：1（A）-water（B）solution was used as mobile phase and gradientelution was performed.The flow ratewas0.2mL/min.The column temperature was40℃.The detection wavelength was275 nm and the sample volume was3μL.The UPLC characteristic map was established to identify ATR from common counterfeits.

The UPLC characteristic map identified 4 common peaks of ATR and identified 1 of them.The similarity among samples was 0.892～0.996.

The established method of characteristic map is simple，reliable，accurate and repeatable，which can identify the authenticity of ATR directly，provide a specific method for the quality control and authenticity identification of ATR，and effectively improve the drug safety of related products.

Taking the odor as the research object，this paper revealed the scientific connotation of the qualitative standard that“the drugwith strong odor has good quality”of Tianma（Gastrodiae Rhizoma）.

The contents of9monomer components and polyphenols in 53 batches of Tianma（Gastrodiae Rhizoma）were determined by high performance liquid chromatography and Folin-Ciocalteu colorimetricmethod.The odor of the samples was quantified by electronic nose technology，and the correlation between the two was analyzed by bivariate correlation method.Taking the quantitative characteristic value of odor as the index，the qualitative identificationmodel of gas-based quality evaluation of differentgrades of Tianma（Gastrodiae Rhizoma）was established by using chemometrics method.

Gastrodin，protocatechuic acid，4-hydroxybenzaldehyde，vanillin，parishin B and polyphenols were all positively correlated with the odor.Differentgrades of Tianma（Gastrodiae Rhizoma）can be distinguished by PCA and DFA models.

The stronger the odor of Tianma（Gastrodiae Rhizoma）is，the higher the contents of the above-mentioned pharmacodynamic components are，which reveals the traditional mechanism that“the drug with strong odor has good quality”of Tianma（Gastrodiae Rhizoma）.The establishment of a qualitative identification model based on objective quantification of odor can be used for the identification of differentgrades of Tianma（Gastrodiae Rhizoma），which lays a foundation for the quality evaluation of Tianma（Gastrodiae Rhizoma）.

To study the effectof Sanqi（Notoginseng Radix et Rhizoma）onmitochondrial energy metabolism of rats with adriamycin induced kidney fibrosis with blood stasis.

Thirty rats were divided into 6 groups random ly，including normal group，model group，Sanqi（Notoginseng Radix et Rhizoma）low-dose group，Sanqi（Notoginseng Radix et Rhizoma）medium-dose group，Sanqi（Notoginseng Radix et Rhizoma）high-dose group and positive control group，with 5 rats in each group.Themitochondrial structure of rat renal tissue was observed by electron microscopy.The contents of adenosine triphosphate（ATP），adenosine diphosphate（ADP），adenosine monophosphate（AMP），the activities of Na⁺ -K⁺ -ATPase，Ca²⁺ -Mg²⁺-ATPase and the activities ofmitochondrial respiratory chain complex enzymeⅠ-Ⅳwere detected by chemical method.The metabolites of urine were analyzed by liquid chromatograph and mass spectrometer.The differential metabolites were enriched by Kyoto Encyclopedia of Genes and Genomes（KEGG）metabolic pathway.

Under electron microscope，the mitochondrial structure of renal tissue in the model group was incomplete，and Sanqi（Notoginseng Radix et Rhizoma）could maintain the homeostasis of renalmitochondrial structure.Sanqi（Notoginseng Radix et Rhizoma）could increase the mitochondrial ATP contentof the renal tissue，the activities of Na⁺-K⁺-ATPase，Ca²⁺-Mg²⁺-ATPase andmitochondrial respiratory chain complex enzymeⅠ-Ⅳ.Sanqi（Notoginseng Radix et Rhizoma）could reduce the contents of mitochondrial ADP and AMP of renal tissue.After analysis and comparison among the groups，11 different urine metabolites were screened，including ferulic acid，forin，arabitol，acetamide，biotin，allantoic acid，6-methylmercaptopurine，4-hydroxy-2-quinolone，aminopentanedioate，6-methyladenine and moupinamide.Further enrichment of urinemetabolites by KEGG in different experimental groups showed that the aldosterone-regulated sodium reabsorption signal pathway was significantly different.

Sanqi（Notoginseng Radix et Rhizoma）regulates the differential urine metabolites and raldosterone-regulated sodium reabsorption signal pathway.Sanqi（Notoginseng Radix et Rhizoma）can improve mitochondrial energy metabolism and renal fibrosis in chronic kidney diseases（CKD）rats with blood stasis bymulti-target and multi-pathway.

To investigate the effectiveness of acupuncture at scalp acupoint penetration acupuncture combined with warming needle moxibustion in improving cognitive function and quality of life in patients with vascular dementia（VD）.

A total of124 patients with Qistagnation and blood stasis type of VD admitted to the hospital between August2017 and July 2019 were selected and divided into the needle therapy group（scalp acupoint penetration acupuncture combined with warming needle moxibustion）and the drug group（butylphthalide soft capsule），62 each in each.Both groups were treated for a total of6 weeks.The clinicalefficacy，traditional Chinese medicine syndrome scores，mini-mental state examination（MMSE），Hasegawa dementia status scale（HDS-R），functional activity questionnaire for social functioning（FAQ），activities of daily living（ADL）and adverse effects occurrence results were observed and recorded for comparison.

The total efficiency of the needle therapy group（82.26%）was significantly higher than thatof the drug group（61.29%）（P<0.05）.Before treatment，the differences in traditional Chinese medicine syndrome scores，the scores of MMSE，HDS-R，FAQ and ADL between the needle therapy group and the drug group were notstatistically significant（P>0.05）.After treatment，the traditional Chinese medicine syndrome scores and FAQ scores were significantly lower（P<0.05），and the scores of MMSE，HDS-R and ADL were significantly higher（P<0.05），and the traditional Chinese medicine syndrome scores and FAQ scores in the needle therapy group were significantly lower than those in the drug group（P<0.05），and the scores of MMSE，HDS-R and ADL in the needle therapy group were significantly greater than those in the drug group（P<0.05）.The differences in the incidence of the total adverse reactions between the needle therapy group and the drug group were not statistically significant（P>0.05）.

The efficacy of scalp acupoint penetration acupuncture combined with warming needle moxibustion in treating VD can effectively improve the patients'cognitive function and quality of life，with good safety，which is worthy of clinical promotion and application.

To observe the clinical effect and safety of Chaipo Decoction（柴朴汤）combined with Sulidi in the treatment of bronchial asthma.

A total of 92 patients with bronchial asthma admitted from March 2022 to March 2024 were included in this study.The patients were divided into two groups by random number table method，namely，the Sulidiere group receiving Sulidiere treatment and the Chaipo Decoction group receiving Sulidiere treatment combined with Chaipo Decoction，with 46 cases in each group.The patient data of each group was observed，including the clinical efficacy，adverse reactions and TCM symptom score before and after treatment（sleeping at night and waking up in the morning with severe cough，dry cough with little or no phlegm，rib distension，restlessness and chest tightness，and discomfort in the throat，etc.）and sputum inflammatory factor index changes，pulmonary function index and index of immune function changes，asthma control test（ACT）and Mini Asthma Quality of Life Questionnaire（Mini AQLQ）.

The total effective rate of the Chaipo Decoction group was higher than that of the Sulidiere group（P<0.05）.The adverse reaction rate of patients in Chaipo Decoction group was similar to that in Sulidiere group（P>0.05）.Before treatment，the patients in both groups received traditional Chinese medicine syndrome scores（sleeping at night and waking up in themorning with severe cough，dry cough with little or no phlegm，rib distension，restlessness and chest tightness，and discomfort in the throat，etc.），interleuin 6（IL-6），interleuin 17（IL-17），tumour necrosis factor-α（TNF-α）and other indicators of sputum factors，forced vital capacity（FVC）and forced expiratory volume in one second（FEV1），percentage of forced expiratory volume at the first second to forced vital capacity（FEV1%）and other pulmonary function indicators，CD3⁺，CD4⁺，CD8⁺，CD4⁺/CD8⁺and other immune function indicators，ACT and Mini AQLQ scores were not significant（P>0.05）.After treatment，TCM syndrome scores（coughing up atnight and in the morning，dry cough with little or no sputum，hypochthmic fullness，upset chest tightness，pharyngeal distress，etc.），sputum inflammatory factor indexes（IL-6，IL-17，TNF-α），lung function indexes（FVC，FEV1，FEV1%），and immune function indexes（CD3⁺，CD4⁺，CD8⁺，CD4⁺/CD8⁺）of all patients in each group，ACT and Mini AQLQ scores were improved.After treatment，patients in the Chaipo Decoction group had TCM syndrome scores（sleeping at night and waking up in the morning with severe cough，dry cough with little or no phlegm，rib distension，restlessness and chest tightness，and discomfort in the throat，etc.），sputum inflammatory factor indexes（IL-6，IL-17，TNF-α），lung function indexes（FVC，FEV1，FEV1%）and immune function indexes（CD3⁺，CD4⁺，CD8⁺，CD4⁺/CD8⁺），ACT and Mini AQLQ scores were better than those in the Seridial group（P<0.05）.

The clinical effect of Chaipo Decoction combined with Sulidi in the treatment of bronchial asthma is good.The inflammation of the patients is significantly improved.The symptoms and lung function are improved.The disease is controlled.The quality of life is improved.The adverse reactions are less.The treatment is relatively safe and reliable.

To study the function of expelling water retention with drastic purgation of Jingdaji（Euphorbiae Pekinensis Radix，EPR）before and after being processed with vinegar on cancerous ascitesmodel rats.

Seventy-two SD male rats were random ly divided into 9 groups：the normal group，model group，positive group（furosemide），EPR and vinegar product groups at low，medium and high dose.Except the normal group，all other groups had intraperitoneal injection with Walker-256 ratascites cancer cells to replicate cancerous ascitesmodel rats.Positive group and each administration groups were orally administered with the corresponding powder，respectively.Normal group and model group were given the same amount of sodium carboxymethyl cellulose（0.5%）for 7 d.1 hour after the lastadministration，the amount of urine and ascites，and the contents of the renin-angiotensin-aldosterone system（RAAS）and antidiuretic hormones（ADH）in the serum were measured.Liver and kidney function indicators，oxidative damage indicators and pathological morphological changes in liver，stomach，intestine and kidney tissues were observed.

Compared with the normal group，the model group showed a significant decrease in urine output and a significant increase in ascites volume（P<0.01），which indicated themodelwas successfully set up.The levels of plasma renin activity（PRA），angiotensinⅡ（AngⅡ），aldosterone（ALD），ADH，creatinine（CRE），blood urea nitrogen（BUN）and the activities of aspartate aminotransferase（AST），alanine aminotransferase（ALT）and malondialdehyde（MDA）in the serum and tissues all significantly increased（P<0.01），while the contents of superoxide dismutase（SOD）and glutathione（GSH）were significantly decreased（P<0.01），also there were obvious tissue damage in liver，stomach，intestine and kidney.Compared with those in themodel group，the urine volume in each administration groups increased，ascites volume，the levels of PRA，AngⅡ，ALD，ADH，CRE and BUN，the activities of AST and ALT and the content of MDA in the serum and tissues decreased，and the contents of SOD and GSH increased.The injury of each administration groups reduced，and there was no significant difference between EPR raw and vinegar-processed product powders.

EPR before and after processing with vinegar have the effects of expelling water retention with drastic purgation，by stimulating the RAAS to eliminate ascites and alleviate oxidative damage of cancerous as cites model rats.