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Research Progress on Mechanism of Astragaloside Ⅳ in Treatment of Diabetic Retinopathy
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Xiaotong LIU1, Junqiang NIU1, Xiaoquan YAO1, Miao SUN1, Wenli ZHANG1, Tingting CHEN2, Yurui ZHAN1
Chinese Archives of Traditional Chinese Medicine | 2026, 44(9) : 236 - 241
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Chinese Archives of Traditional Chinese Medicine | 2026, 44(9): 236-241
• Platform of Provincial Project •
Research Progress on Mechanism of Astragaloside Ⅳ in Treatment of Diabetic Retinopathy
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Xiaotong LIU1, Junqiang NIU1, Xiaoquan YAO1, Miao SUN1, Wenli ZHANG1, Tingting CHEN2, Yurui ZHAN1
Affiliations
  • 1.Department of Traditional Chinese Medicine, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu, China
  • 2.The First School of Clinical Medicine of Lanzhou University, Lanzhou 730000, Gansu, China
Published: 2026-09-10 doi: 10.13193/j.issn.1673-7717.2026.09.044
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Diabetic retinopathy (DR) is one of the most frequent and serious retinal microvascular complications of diabetic mellitus (DM), which belongs to the category of intraocular disturbance diseases of traditional Chinese medicine. Astragaloside Ⅳ (AS-Ⅳ), the main active component of Huangqi (Astragali Radix), integrates multiple pharmacological targets that align with the complex pathogenesis of DR. For the past few years, numerous studies have focused on the impact of AS-Ⅳ on DR, confirming its effects through various mechanisms such as hypoglycemic effect, anti-oxidative stress damage, inhibition of vascular endothelial growth factor (VEGF), anti-apoptosis of retinal cells, suppression of inflammatory responses, and inhibition of ferroptosis, thereby obstructing the occurrence and progression of DR through multiple pathways and targets. This paper mainly reviewed the research progress of AS-Ⅳ on the treatment of DR in order to provide reference for its further development and utilization and clinical application.

traditional Chinese medicine  /  traditional Chinese medicine monomer  /  astragaloside Ⅳ  /  diabetic retinopathy  /  mechanism of action  /  review
刘小通, 牛军强, 姚晓泉, 孙邈, 张文丽, 陈亭亭, 詹玉蕊. 黄芪甲苷对糖尿病视网膜病变作用机制研究进展. 中华中医药学刊, 2026 , 44 (9) : 236 -241 . DOI: 10.13193/j.issn.1673-7717.2026.09.044
Xiaotong LIU, Junqiang NIU, Xiaoquan YAO, Miao SUN, Wenli ZHANG, Tingting CHEN, Yurui ZHAN. Research Progress on Mechanism of Astragaloside Ⅳ in Treatment of Diabetic Retinopathy[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (9) : 236 -241 . DOI: 10.13193/j.issn.1673-7717.2026.09.044
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Year 2026 volume 44 Issue 9
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doi: 10.13193/j.issn.1673-7717.2026.09.044
  • Online Date：2026-10-20
  • Published：2026-09-10
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    1.Department of Traditional Chinese Medicine, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu, China
    2.The First School of Clinical Medicine of Lanzhou University, Lanzhou 730000, Gansu, China
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