To explore the potential pathways influencing self-management behaviors among community patients with peptic ulcers, providing a basis for interventions aimed at enhancing self-management in this population.

From March to August 2024, a stratified cluster sampling combined with convenience sampling was employed to randomly select 640 community patients with peptic ulcers from five administrative districts in Hengyang city for a questionnaire survey. Data analysis was conducted using SPSS 26.0 for t-tests, ANOVA, and partial correlation analysis, and a chain mediation model was constructed using Process 4.0 plugin model 6.

Health literacy had a significant direct effect on self-management (b=0.322, 95%CI: 0.254-0.390); the mediating effects of social support and self-efficacy between health literacy and self-management were 0.067 (95%CI: 0.043-0.098) and 0.100 (95%CI: 0.069-0.135), respectively. The chain mediating effect of social support and self-efficacy was also significant (b=0.016, 95%CI: 0.008-0.025).

Enhancing the level of health literacy among community patients with peptic ulcers is beneficial for improving social support and increasing self-efficacy, thereby enhancing self-management levels.

To investigate the implementation effects of the DIP payment reform on rehabilitation inpatients, providing empirical support for assessing the applicability of current medical insurance payment reform to rehabilitation inpatients.

An interrupted time series analysis was conducted using data from the discharge summaries of rehabilitation inpatients at a large tertiary public hospital in Chengdu from 2019 to 2023.

A total of 2 143 rehabilitation inpatient cases were included in this study. After the reform, indicators reflecting the operational efficiency of the rehabilitation department showed a positive trend, with the average monthly inpatient visits steadily increasing (β = 0.395, P < 0.001). The average length of stay decreased but not significantly (β < 0, P > 0.05). The treatment costs, reflecting the technical labor value of rehabilitation physicians, significantly decreased (β = -45.251, P < 0.05), while drug costs increased (β = 2.36, P < 0.05). The changes in patient financial burden indicators were minimal, with out-of-pocket expenses showing a slight increase (β = 1.818, P > 0.05).

The results indicate that the DIP payment reform has weak control over the length of stay for rehabilitation patients. After the reform, the out-of-pocket expenses for patients did not decrease, and their medical needs were not adequately met. Future efforts should focus on establishing a patient demand-oriented payment method for rehabilitation medical insurance.

Based on the known interaction between OPC-167832 and the DprE1 protein, this study aims to establish an evaluation method for the antituberculosis drug activity targeting the key metabolic enzyme DprE1 of Mycobacterium tuberculosis.

First, the DprE1 protein was expressed using the pET28a-Rv3790 vector, and the molecular chaperone CPN60.2 of Mycobacterium tuberculosis was expressed using the pGro7-Rv0440 vector. Both vectors were co-transformed into E. coli BL21 for DprE1 protein expression. The target protein was purified via Ni-NTA affinity chromatography and identified using LC-MS mass spectrometry. Secondly, the direct interaction between the DprE1-targeting inhibitor and DprE1 was assessed using isothermal titration calorimetry (ITC). Finally, computational simulation techniques were employed to dock OPC-167832 with the DprE1 protein.

The pET28a-Rv3790 and pGro7-Rv0440 expression vectors were successfully constructed, leading to the expression and purification of soluble DprE1 protein. ITC results indicated a significant heat change upon the binding of DprE1 to OPC-167832. Molecular docking results revealed that the hydrogen bond binding site of OPC-167832 with DprE1 was primarily located at Pro316, while the binding sites for the fluorinated hydrogen bond were His132 and Asn364.

The soluble DprE1 protein was successfully expressed, and its interaction with OPC-167832 resulted in a measurable heat change. This confirms the successful establishment of an evaluation method for the antituberculosis drug activity targeting the key metabolic enzyme DprE1 of Mycobacterium tuberculosis. This study provides an experimental basis and methodological support for the activity evaluation of DprE1-targeting inhibitors against Mycobacterium tuberculosis.

To analyze the composition, mortality, and corresponding trends of hospitalized patients with malignant tumors in Chengdu from 2016 to 2020, providing an effective reference for cancer prevention and control in Chengdu and its districts and counties.

Based on relevant information from the first hospitalization records of malignant tumor patients in 87 municipal and county-level hospitals in Chengdu from 2016 to 2020, this study analyzed the composition of hospitalized malignant tumor patients, the incidence by age group, mortality, and their trends across different regions of Chengdu.

From 2016 to 2020, the total number of first-time hospitalized malignant tumor patients in Chengdu’s 87 hospitals was 287 901 (165 359 males and 122 542 females). The top five malignant tumor cases were lung cancer, rectal cancer, liver cancer, esophageal cancer, and colon cancer. Over the five years, the total number of hospitalized malignant tumor patients in the city showed an increasing trend, rising from 46 377 cases in 2016 to 65 488 cases in 2020, with a fixed-base growth rate of 41.2%.In 2020, compared to 2016, the number of hospitalized malignant tumor patients decreased in Xinjin District, Shuangliu District, Pengzhou city, and Dayi County, with decrease rates of 44.7%, 10.3%, 6.0%, and 1.9%, respectively; while in other districts and counties, the number of hospitalized malignant tumor patients increased, with the fastest growth observed in Pidu District, Wuhou District, Jinjiang District, Wenjiang District, and Jintang County, with fixed-base growth rates of 143.0%,119.6%, 111.0%, 56.3%, and 53.4%, respectively. The number of deaths among hospitalized malignant tumor patients was 21 381 (13 808 males and 7 573 females), with the mortality from various malignant tumors increasing annually, from 3 742 cases in 2016 to 4 504 cases in 2020, resulting in a fixed-base growth rate of 20.4%. The top five malignant tumors by mortality were lung cancer, liver cancer, colon cancer, esophageal cancer, and gastric cancer.

The burden of malignant tumors in Chengdu is increasing, with slight variations in the composition and mortality of malignant tumors across different districts and counties, indicating the need for localized cancer prevention and control policies.

To investigate the factors influencing Guangzhou residents’ willingness to use “Internet + pharmaceutical services”, providing references for optimizing related service platforms.

A questionnaire was designed based on the UTAUT model, and from January to May 2024, residents of Guangzhou were surveyed. Structural equation modeling was utilized to test the path relationships and mediating effects, constructing a model of the influencing factors on residents’ willingness to use“Internet + pharmaceutical services”.

Social influence (β=0.319, P<0.001), effort expectancy (β=0.264, P<0.05), and performance expectancy (β=0.256, P<0.001) positively impacted the willingness of Guangzhou residents to use “Internet +pharmaceutical services”. Social influence had a significant positive effect on performance expectancy (β=0.764, P<0.001), and performance expectancy partially mediated the positive effect of social influence on willingness to use. Facilitating factors (P>0.05) did not have a significant effect on willingness.

Performance expectancy, effort expectancy, and social influence are the main factors affecting Guangzhou residents’willingness to use “Internet + pharmaceutical services”. Related platforms should innovate and improve their design based on residents’ needs, ensuring the practicality and usability of services to enhance user experience. Additionally, promoting and publicizing “Internet + pharmaceutical services” should be strengthened to leverage social influence, thereby increasing public recognition and willingness to use.

To investigate the status and influencing factors of social frailty in elderly patients on Maintenance Hemodialysis (MHD) and to construct a nomogram prediction model.

A survey was conducted among 340 elderly MHD patients using a general information questionnaire, social frailty scale, hemodialysis self-management scale, Toronto Alexithymia Scale, Family Care Index, and Social Support Rating Scale. Independent influencing factors were identified, and a nomogram prediction model was constructed and evaluated.

The prevalence of social frailty among elderly MHD patients was 28.82%. Binary logistic regression analysis revealed that a history of falls in the past year (OR=3.117, 95% CI: 1.249-7.778), self-care ability (OR=4.058, 95% CI: 2.002-8.228), alexithymia (OR=1.073, 95% CI: 1.009-1.141), family care level (OR=0.744, 95%CI: 0.612-0.903), and social support (OR=0.886, 95% CI: 0.801-0.981) were significant influencing factors for social frailty in elderly MHD patients (all P<0.05). The area under the receiver operating characteristic curve for the constructed model was 0.921(95% CI: 0.893-0.950), with the maximum Youden index being 0.688, an optimal cutoff value of 0.330, sensitivity of 83.7%, and specificity of 85.1%, indicating high discrimination of the model. The Hosmer-Leeshawn test yielded χ²=10.465, P=0.234,suggesting good model fit. Internal validation calibration curves indicated satisfactory calibration of the model. Decision curve analysis demonstrated high clinical utility of the model.

The nomogram prediction model developed in this study is a practical and convenient tool that aids in predicting the risk of social frailty in elderly MHD patients.

To analyze the distribution characteristics of mothers with different parities in Hebei Province and their impact on pregnancy outcomes.

Data from 398 111 mothers who delivered in 22 hospitals across 10 cities in Hebei Province were analyzed. Based on previous delivery counts (excluding the current hospitalization), mothers were categorized into three groups:primipara (parity=0), multipara (parity=1), and grand multipara (parity≥2). The distribution characteristics of mothers by parity were analyzed, and the influence of different parities on pregnancy outcomes was assessed using multifactorial logistic regression.

From 2014 to 2022, the average age of mothers in all three groups showed an upward trend, as did the proportion of grand multipara mothers. With the increase in hospital level, the proportion of primipara mothers rose, while the proportions of multipara and grand multipara mothers declined. The proportion of primipara mothers in provincial and municipal hospitals was higher than that in county and township hospitals, where the proportions of multipara and grand multipara mothers were lower. As parity increased, the incidence rates of anemia, placenta previa, placental abruption, preterm birth, cesarean delivery, macrosomia, low Apgar scores, and perinatal mortality also increased. Conversely, the incidence rates of gestational diabetes, gestational hypertension, abnormal fetal position, soft birth canal lacerations, postpartum hemorrhage, and low birth weight exhibited a “U” trend. Using primipara (parity=0) mothers as the reference group, the results of the multifactorial logistic regression analysis indicated that parity≥1 was a risk factor for anemia (OR=1.041, 95%CI: 1.024-1.058), gestational diabetes (OR=1.301, 95% CI: 1.237-1.375), placenta previa (OR=1.565, 95% CI: 1.359-1.802), soft birth canal lacerations (OR=1.394, 95% CI: 1.157-1.681), and macrosomia (OR=1.222, 95%CI: 1.189-1.257). In contrast, it was a protective factor against gestational hypertension (OR=0.677, 95% CI: 0.651-0.703),abnormal fetal position (OR=0.650, 95% CI: 0.617-0.684), cesarean delivery (OR=0.296, 95% CI: 0.290-0.301), and low birth weight (OR=0.872, 95% CI: 0.830-0.917). Parity≥2 was identified as a risk factor for preterm birth (OR=1.470, 95% CI: 1.372-1.575) and postpartum hemorrhage (OR=1.242, 95% CI: 1.086-1.420).

The risk of adverse pregnancy outcomes varies with parity. Targeted prevention of gestational complications and comorbidities should be implemented during prenatal care for mothers of different parities to reduce the risk of adverse maternal and infant outcomes.

To explore the association between overt proteinuria (OP) and moderately reduced estimated glomerular filtration rate (MG) in relation to the incidence of coronary artery disease (CAD).

The study targeted elderly individuals (aged ≥60 years) who completed at least two national basic public health service health examinations at a community health service center in Chengdu from 2017 to 2022. A total of 4 316 subjects were categorized into four groups based on the presence or absence of OP and MG: no OP no MG (NP[MG-]), OP no MG (OP[MG-]), no OP with MG (NP[MG+]),and OP with MG (OP[MG+]). An intrinsic time-dependent Cox analysis was conducted to evaluate the association of estimated glomerular filtration rate and proteinuria, individually or in combination, with the risk of CAD.

The study included 4 316 subjects with a median follow-up time of 6.25 years, during which 419 developed new cases of CAD. The results indicated that compared to the group with both indicators negative, the risk of CAD increased by 15% (HR=1.15, 95% CI: 0.88-1.41) for those with moderately reduced estimated glomerular filtration rate (MG+), by 14% (HR=1.14, 95% CI: 0.76-1.51) for those with overt proteinuria (OP), and by 93% (HR=1.93, 95% CI: 1.50-2.37) for those with both indicators positive (OP[MG+]). The combined use of both indicators demonstrated a superior discriminatory effect on CAD risk compared to the use of either indicator alone.

Routine screening for estimated glomerular filtration rate and albuminuria in the elderly population is recommended, as the combined assessment of both indicators is more effective in identifying individuals at high risk for coronary artery disease.

To analyze the prevalence and influencing factors of different obesity metabolic phenotypes in middle-aged and elderly populations in Hubei Province, aiming to provide scientific reference and decision-making basis for early prevention and intervention of obesity-related diseases.

A population involved in the “National Cardiovascular Disease High-risk Population Early Screening and Comprehensive Intervention Project” from January 2016 to December 2019 in Hubei Province was selected to analyze the prevalence and epidemiological characteristics of different obesity metabolic phenotypes and to explore the influencing factors of obesity metabolic phenotypes in middle-aged and elderly populations in Hubei.

A total of 112 270 participants were included in this study. The prevalence rates of metabolically healthy overweight or obese, metabolically unhealthy normal weight, and metabolically unhealthy overweight or obese were 15.78%, 21.16%, and 42.82%, respectively. The results of the unordered multinomial logistic regression showed that, compared to the metabolically healthy normal weight group, living in rural areas (OR=1.08, 95%CI: 1.03-1.13; OR=1.21, 95%CI: 1.16-1.25), being in the older age group (aged 65 and above, OR=3.39,95%CI: 3.15-3.64; OR=3.31, 95%CI: 3.12-3.52), being male (OR=1.22, 95%CI: 1.16-1.29; OR=1.17, 95%CI: 1.12-1.22), and alcohol consumption (OR=1.15, 95%CI: 1.08-1.23; OR=1.14, 95%CI: 1.07-1.20) were associated with an increased risk of being metabolically healthy overweight or obese, metabolically unhealthy normal weight, and metabolically unhealthy overweight or obese.Higher education level (high school or above, OR=0.87, 95%CI: 0.84-0.92), higher household annual income (≥50 000 yuan, OR=0.81, 95%CI: 0.76-0.86), and smoking (OR=0.67, 95%CI: 0.63-0.70) were associated with a decreased risk of being metabolically unhealthy overweight or obese (all P < 0.01).

The prevalence of metabolically unhealthy overweight or obesity is high in Hubei Province, and it is essential to strengthen prevention and control efforts, particularly targeting older males in rural areas, those with low income, low education levels, and individuals with alcohol consumption habits.

To investigate the contamination status of quinolone veterinary drug residues in animal-derived foods sold in Guizhou Province and assess the dietary exposure risk.

From 2019 to 2023, a total of 818 samples of animal-derived foods were collected from nine cities (prefectures) in Guizhou Province to monitor quinolone veterinary drug residues.The average, maximum, P₅₀, and P_97.5 values were calculated, and dietary exposure risk was assessed using the point estimate method in conjunction with food intake data from the western region of China.

Different levels of enrofloxacin, ciprofloxacin, pefloxacin, and ofloxacin were detected in pork, chicken, eggs, freshwater fish, and freshwater shrimp. The detection rates for enrofloxacin, ciprofloxacin, pefloxacin, and ofloxacin were 5.50% (45/818), 2.44% (20/818), 0.37% (3/818),and 0.61% (5/818), respectively. The dietary exposure levels of quinolone veterinary drugs through animal-derived foods for different age groups were 0.06 to 5 300.22 ng/(kg·d) (3-5 years), 0.09 to 5 981.67 ng/(kg·d) (6-11 years), 0.05 to 4 080.37 ng/(kg·d) (12-17 years), 0.04 to 2,812.93 ng/(kg·d) (18-59 years), and 0.04 to 2 370.91 ng/(kg·d) (≥60 years). The risk ratios corresponding to the average, maximum, P₅₀, and P_97.5 values for enrofloxacin and ofloxacin ranged from 0.0 003 to 0.9 941.

The risk of dietary exposure to quinolone veterinary drugs through animal-derived foods in the Guizhou population is low; however, attention should be paid to the 3-11 age group.