To analyze the multiple mediating effects of social support and sense of meaning of life on the quality of death in elderly terminally ill patients.

By using convenience sampling method, 276 elderly patients and their attending nurses were investigated with general data questionnaire, perceived social support scale, life significance source scale for the elderly, family care index scale, and ICU nurse version QODD-14 scale. Pearson was used to analyze the correlation, and Amos software was used to establish structural equation model (SEM) and mediate effect test.

(1) The scores of quality of death, family function, social support, and sense of life were 62.52±8.67, 7.54±1.14, 52.53±7.64, and 107.54±13.58, respectively. (2) The quality of death of elderly deathbed patients was positively correlated with family function, social support, and sense of life meaning (r = 0.762, 0.886, and 0.795, P < 0.05). Family function was positively correlated with social support and sense of life meaning (r = 0.528, 0.499, P < 0.05). There was a positive correlation between social support and sense of life meaning (r = 0.665, P < 0.05). (3) Specific intermediary effect of social support accounted for 20.22%, specific intermediary effect of sense of life meaning accounted for 17.06%, and multiple intermediary effect of social support-sense of life meaning accounted for 6.54%.

Family function can indirectly affect the quality of death by regulating social support and sense of life meaning.

To explore the effect of serum lipid levels on the risk of developing cognitive decline in middle-aged and older adults.

Data were obtained from the China Retirement and Follow-up Survey Cohort(CHARLS) cohort from 2011-2018, and middle-aged and older adults aged ≥45 years were selected for cognitive assessment of middle-aged and older adults who were followed up in 2018 by using the Chinese version of the Brief Mental Scale(MMSE), and multifactorial logistic regression was utilized to analyze middle-aged and older adult populations for serum total cholesterol(TC), triglycerides(TG), high-density lipoprotein cholesterol(HDL), low-density lipoprotein cholesterol(LDL) and lipid composite index(LCI) in relation to cognitive function.

A total of 6 556 participants with a mean age of 57.03 ± 8.03 years were included. After adjusting for multiple confounders, compared with the lowest quartile group(Q1), highest quartile group(Q4) of TG(OR=1.229, 95% CI:1.036-1.456), LDL(OR=1.221, 95% CI:1.034-1.443), and LCI(OR=1.282, 95% CI:1.081-1.522) were positively associated with the cognitive decline. The risk of developing cognitive decline was positively associated with the risk of cognitive decline, HDL(OR=0.765, 95% CI:0.646-0.906) was negatively associated with the risk of cognitive decline, and TC(OR=1.010, 95% CI:0.855-1.193) was not associated with the risk of cognitive dysfunction, and the difference was not statistically significant.

TG, LDL and LCI are risk factors for the risk of cognitive decline in middle-aged and elderly people, and HDL are protective factors for the risk of cognitive decline in middle-aged and elderly people.

To systematically evaluate the post-market safety of human papilloma virus vaccine in Jiangxi province．

The doses number of HPV administered from 2017 to 2022 wascollected from all the vaccination institutions, and theadverse events followingimmunization（AEFI）cases were collected through the AEFI Surveillance Module of Chinese Disease Control and Prevention Information System. Using descriptive statistics, the incidences and epidemiological characteristics were estimated．

81 AEFI cases of HPV were reported from 2017 to 2022，and the incidence was 3.38 per 100 000 doses. Moreover, the incidence of HPV2, HPV4 and HPV9 were 3.21, 3.38 and 3.84 per 100 000 doses, respectively. A totalof 71.60% cases were 20-39 years old and 75.31%occurred in 2 days after inoculation. 59.26% were common adverse reactions. Most rare vaccine reactions were allergic rashes, and the reported incidence was 0.50 per 100 000 doses.

The human papilloma virus vaccine has acceptable safety profile in Jiangxi. The sensitivity of monitoring system needs to be further improved.

To explore the current situation and trend of growth, development and nutrition of children aged 3-6 in Zhejiang Province, To provide reference for improving growth and development level.

Under the unified organization of the National Physical Fitness Monitoring Center, the research group measured the body shape data of children aged 3 to 6 years in Zhejiang Province, and compared and analyzed the body shape data of children aged 3 to 6 years in Zhejiang Province based on 2014 and 2020.

In terms of growth and development, the children aged 3-6 years in Zhejiang Province were in good condition in 2020, and all indicators of boys were higher than those of girls (P<0.05), with a small urban-rural difference. Compared with 2014, height (F_man=4.08, P<0.05; F_women=210.82, P<0.01), weight (F_man=18.33, P<0.01; F_women=10.26, P<0.01) and BMI (F_man=25.41, P<0.01; F_women=6.19, P<0.05) increased in 2020 (P<0.05). In terms of nutritional status, the prevalence rates of overweight and obesity were 13.0% and 8.4% among children aged 3-6 years in Zhejiang province in 2020, and the prevalence rates of overweight and obesity in boys were higher than those in girls (P<0.05). The rates of overweight and obesity in rural boys were 1.6% and 2.6% higher than those in urban children, and the rates in rural girls were 2.4% and 1.2% higher than those in urban children. From 2014 to 2020, the overall prevalence rates of overweight and obesity in young children showed an upward trend. The overweight and obesity rates in boys increased by 3.1% and 2.0%, respectively (P< 0.05), and girls increased by 0.9% and 0.4%, respectively.

In Zhejiang Province, children’s growth and development level increase steadily, but the risk of overweight and obesity is on the rise, especially in rural areas. Effective measures should be taken to curb the growing trend of overweight and obesity.

To analyze the prevalence of dementia among elderly people in China, to look into the factors that may influence it, and to consider the impact of the interplay between depression and reduced activity of daily living (ADL) function.

This study, which used data from the 2018 Chinese Longitudinal Healthy Longevity Survey (CLHLS), described the statistical status of dementia in 7 588 people over the age of 60 and explored the interaction between depression and different types of activities of daily living abilities on the prevalence of dementia based on logistic regression modelling.

High level of chronic disease co-morbidity (OR=1.634, 95% CI: 1.133-2.355), depression (OR=2.141, 95% CI: 1.505-3.044), impaired basic activity of daily living (BADL)(OR=5.576, 95% CI:4.249-7.317) and reduced instrumental activity of daily living (IADL) (OR=2.663, 95% CI: 1.738-4.082) were risk factors for dementia in older adults. There was an additive interaction between depressive symptoms and impaired BADL capacity. Older adults with depressive symptoms and reduced BADL performance had a 13.917-fold (OR=13.917, 95% CI: 8.694-22.279) increased chance of developing dementia.

Additive interaction between the depressive symptoms and impaired BADL capacity on the development of dementia, adopting effective steps to manage depressive symptoms and enhance BADL ability will help lower that risk.

To provide basis for health-related physical curriculum reform and health education in primary and secondary schools.

In September 2018, a total of 23 191 students from grades 1 to 12 in Chengdu were selected for a physical fitness test using a stratified random cluster sampling method. Additionally, 1 024 middle school students from grades 7, 8, 10, and 11 were randomly selected for a lifestyle questionnaire survey. Rank correlation analysis was employed to compare the differences in physical fitness among students with different BMI levels, and linear correlation analysis was used to examine the associations between physical fitness and lifestyle factors such as diet, exercise, and sleep.

The respondents’ sit-and-reach test scores (r_s=0.042, P=0.009), grip strength (r_s=0.499, P<0.001) increased with BMI level, while the vital capacity body mass index decreased with BMI level (r_s=-0.242, P<0.001). With increasing BMI levels, the physical comprehensive scores of the respondents tended to increase at first and then decrease. Using BMI as the independent variable and physical comprehensive score as the dependent variable, a total of eight regression equations were derived. As follows: Grades 3-4: male students: y=-0.016X²+0.423X-2.532, female students: y=-0.005X²+0.123X-0.588; Grades 5-6: male students: y=-0.027X²+0.841X-6.214, female students: y=-0.012X²+0.314X-1.741; Grades 7-9: male students: y=-0.038X²+1.521X-14.666, female students: y=-0.008X²+0.163X-0.132; Grades 10-12: male students: y=-0.035X²+1.428X-14.233, female students: y=0.007X²-0.390X+5.160. The pass rates of the surveyed subjects in the standing long jump (r=0.567, P<0.001) and visual acuity (r=0.425, P<0.001) were positively correlated with exercise. The vital capacity body mass index pass rate for male students(r=0.504, P=0.028) was positively correlated with exercise. The BMI pass rate for female students was positively correlated with both diet (r=0.688, P=0.017) and exercise (r=0.497, P=0.012).

Middle school students’ vital capacity body mass index, standing long jump, and visual acuity status were related to exercise. Female students’ BMI was related to diet. The physical fitness, BMI, and lifestyle of primary and middle school students are mutual influence, mutual cause and effect.

To study the single-disease settlement cost and its influencing factors for age-related cataract surgery patients under the centralized volume-based procurement policy of intraocular lens, and to provide theoretical suggestions and data support for optimizing the cost structure, controlling the growth of medical costs, and improving the quota payment policy of intraocular lens materials.

The medical records and single-disease payment information of 215 age-related cataract patients admitted to the Department of Ophthalmology of a provincial tertiary public general hospital in Guangzhou from June 1, 2021 to April 30, 2022 were collected. Descriptive analysis, new grey correlation analysis and multiple linear regression model were used to analyze the composition and influencing factors of single-disease settlement expenses and the burden of intraocular lens materials.

The treatment cost, intraocular lens cost and diagnosis cost were the main types of hospitalization expenses for age-related cataract surgery patients (accounting for 52.12%, 19.79% and 13.56% respectively, accounting for 85.47% in total). At the same time, it was also the main type of expense affecting the average hospitalization expense per time (the correlation coefficients were 1.000, 0.751, 0.717). Multiple linear regression analysis showed that the length of hospital stay, anesthesia type (local anesthesia as the reference, general anesthesia β=3 513.340) and intraocular lens type (soft spherical three-piece monofocal non-astigmatism type as the reference, soft aspheric one-piece monofocal astigmatism type β=2 590.090; soft aspheric one-piece continuous visual field non-astigmatism type β=10 496.020, soft aspheric one-piece trifocal non-astigmatism type β=21 889.810) were the influencing factors of hospitalization expenses (P<0.001). Under the medical insurance limit payment of intraocular lens material fee, the proportion of the highest burden of patients is low when the selected intraocular lens unit price is less than the maximum limit standard (1 800 yuan), and the proportion of the highest burden of patients increases with the increase of the price of intraocular lens when the selected intraocular lens unit price is more than the maximum limit standard (1 800 yuan).

The structure of hospitalization expenses for age-related cataract surgery becomes more reasonable under the centralized volume-based procurement policy of intraocular lens, and the labor value of medical staff is realized. However, more attention should be paid to the changes of intraocular lens costs and diagnostic fees in the future. Shortening the length of hospital stay, reasonable selection of anesthesia methods, reasonable selection of different types of intraocular lens and reducing the price of intraocular lens can effectively reduce the hospitalization cost of age-related cataract surgery patients. Appropriately raising the fee limit of intraocular lens materials according to the affordability of local medical insurance fund is helpful to reduce the cost burden of surgical patients.

To establish a high throughput method for the detection of 22 plant toxins in urine and blood by ultra performance liquid chromatography-triple quadrupole mass spectrometry.

The samples were extracted by acetonitrile oscillation, centrifuged, and the supernatant was purified by QuEChERS. Then, the matrix was matched with standard curve and quantified by external standard method. The full scanning mode of UPLC-MS /MS was used to quantitatively analyze and determine 22 kinds of target substances simultaneously. The influence of different extraction solvents, the selection and dosage of purification agent on sample extraction and purification by QuEChERS method was compared, and the sensitivity of the instrument was improved by optimizing the separation conditions of liquid chromatography and mass spectrometry parameters.

The regression equations of the 22 components to be measured in urine and blood had an outstanding linear relationship, with correlation coefficients were ≥0.996.The detection limits were 0.01～1.00 μg/L and 0.01～0.90 μg/L, the lower limits of quantification were 0.1-3.0 μg/L and 0.03-3.0 μg/L.The average recovery rates of spiked were 70.5%-125% and 73.7% -118%, Intraday precision and Daytime precision (RSD) were 1.2% to 15.2% (n=6) and 1.2% to 13.5% (n=6), respectively.

The method is rapid, accurate, sensitive and has high throughput. It can realize the rapid and efficient quantitative analysis of 22 plant toxins in blood and urine, and provide a reference for the determination oftrace plant toxins in biological samples.

To study the quality-of-life level and its differentiation characteristics of elderly people in rural areas of China.

Based on the China Health and Retirement Longitudinal Study in 2018, we constructed an indicator system for evaluating the quality of life of rural elderly people from four levels: individual, family, society, and policy. The entropy method was used to objectively assign weights and calculate the quality-of-life score. The evaluation results were analyzed from three aspects: population characteristics, spatial correlation, and spatial distribution.

Marital status (F=35.27, P<0.001) and educational level (F=10.80, P<0.001) had a significant impact on the quality of life of rural elderly people. The distribution of quality of life was spatially correlated (I=0.432, P<0.001). There are a total of 16 provinces (accounting for 57.142%) with quality levels in the middle, low, and low-level regions, mainly located in the central and western regions.

More than half of the rural elderly in provinces have a quality of life in areas with a moderate or lower level, exhibiting a positive spatial clustering feature, roughly showing a distribution pattern of high in the east and low in the west. Special attention should be paid to the quality of life of unmarried, widowed, low educated, and central and western provinces.