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To explore the effect of serum lipid levels on the risk of developing cognitive decline in middle-aged and older adults.
Data were obtained from the China Retirement and Follow-up Survey Cohort(CHARLS) cohort from 2011-2018, and middle-aged and older adults aged ≥45 years were selected for cognitive assessment of middle-aged and older adults who were followed up in 2018 by using the Chinese version of the Brief Mental Scale(MMSE), and multifactorial logistic regression was utilized to analyze middle-aged and older adult populations for serum total cholesterol(TC), triglycerides(TG), high-density lipoprotein cholesterol(HDL), low-density lipoprotein cholesterol(LDL) and lipid composite index(LCI) in relation to cognitive function.
A total of 6 556 participants with a mean age of 57.03 ± 8.03 years were included. After adjusting for multiple confounders, compared with the lowest quartile group(Q1), highest quartile group(Q4) of TG(OR=1.229, 95% CI:1.036-1.456), LDL(OR=1.221, 95% CI:1.034-1.443), and LCI(OR=1.282, 95% CI:1.081-1.522) were positively associated with the cognitive decline. The risk of developing cognitive decline was positively associated with the risk of cognitive decline, HDL(OR=0.765, 95% CI:0.646-0.906) was negatively associated with the risk of cognitive decline, and TC(OR=1.010, 95% CI:0.855-1.193) was not associated with the risk of cognitive dysfunction, and the difference was not statistically significant.
TG, LDL and LCI are risk factors for the risk of cognitive decline in middle-aged and elderly people, and HDL are protective factors for the risk of cognitive decline in middle-aged and elderly people.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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