Objective: To observe the clinical efficacy of oral Jianpi Shuyi Decoction in treating patients with chronic pancreatitis (CP) of liver depression and spleen deficiency syndrome.Methods: Using a randomized number table method, from September 2019 to July 2023 80 CP patients with liver depression and spleen deficiency syndrome who visited Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine were divided into a control group and an experimental group, with 40 cases in each group. The control group received Western medicine treatment, while the experimental group received the same plus Jianpi Shuyi Decoction. The treatment course was 4 weeks, and both groups were treated for 2 courses. The clinical efficacy, traditional Chinese medicine (TCM) symptom scores, abdominal pain visual analog scale (VAS) scores, laboratory indicators [serum amylase (AMS), lipase (LPS), fasting blood glucose (FBG)] levels, and the diameters of the main pancreatic duct and common bile duct were compared between the two groups.Results: After treatment, the total clinical effective rate in the experimental group was significantly higher than that in the control group (89.74% vs. 68.42%), with a statistically significant difference(P < 0.05). After treatment, abdominal pain, poor appetite, and pain - diarrhea symptoms in the control group were significantly reduced compared with those before treatment (P < 0.05). In the experimental group, abdominal pain, abdominal distension, poor appetite, depression and irritability, loose and sticky stools, and pain - diarrhea symptoms were significantly reduced compared with those before treatment (P < 0.05). Moreover, the scores for abdominal pain, abdominal distension, loose and sticky stools, and pain - diarrhea symptoms in the experimental group were significantly lower than those in the control group (P < 0.05). After treatment, the VAS scores of both groups were significantly reduced (P < 0.05), and the VAS score of the experimental group was significantly lower than that of the control group(P < 0.05). The AMS levels of both groups were significantly reduced (P < 0.05), and the experimental group was significantly lower than the control group (P < 0.05). No significant reduction in LPS level was observed in the control group (P > 0.05), while the LPS level in the experimental group was significantly reduced (P < 0.05) and significantly lower than that in the control group (P < 0.05). No significant reduction in FBG levels was observed in either group(P > 0.05), and there was no statistically significant difference between the two groups (P > 0.05). After treatment, the diameters of the main pancreatic duct and common bile duct in both groups showed no significant changes compared with those before treatment (P > 0.05).Conclusion: Jianpi Shuyi Decoction can effectively alleviate clinical symptoms such as abdominal pain, improve digestive function, reduce serum amylase and lipase levels, alleviate inflammatory responses, and demonstrate good safety in treating CP patients with liver depression and spleen deficiency syndrome.

Objective: To explore the clinical effect of Chaihu Longgu Muli Decoction on breast hyperplasia of liver qi stagnation syndrome and its influence on immune function.Methods: A total of 110 patients with mammary hyperplasia with liver - qi stagnation syndrome admitted to the First Affiliated Hospital of Anhui University of Chinese Medicine from July 2023 to July 2024 were selected and divided into 2 groups according to treatment methods, with 55 cases each. The control group was treated with conventional Western medicine, and the observation group was treated with conventional Western medicine combined with bupleurum keel and oyster soup. The efficacy, TCM syndrome score, improvement of breast mass, serum neurotransmitter indexes [5 - hydroxytryptamine (5 - HT), dopamine (DA)], estrogen indexes[estradiol (E₂), prolactin (PRL), progesterone (P)], immune function indexes and drug safety were compared between the two groups.Results: Compared with the control group, the observation group had higher efficacy and less adverse reactions (P < 0.05). After treatment, the scores of main syndrome, secondary syndrome, mass maximum diameter and visual analogue scale (VAS) were decreased in both groups, and the decrease was more obvious in the observation group (P <0.05). After treatment, the levels of E₂, PRL, 5 - HT and DA were decreased in both groups, the decrease was more obvious in the observation group, the levels of P, CD3⁺ and CD4⁺/CD8⁺ were increased in both groups, and the increase was more obvious in the observation group (P < 0.05).Conclusion: Chaihu Longgu Muli Decoction is used for clinical treatment of mammary hyperplasia of liver qi stagnation syndrome. It can improve clinical symptoms, breast mass and sex hormone levels, regulate serum neurotransmitter and immune function, improve clinical efficacy and drug safety.

Objective: To investigate the differences in clinical blood indicators among infants with cytomegalovirus(CMV) hepatitis of different Traditional Chinese Medicine (TCM) syndromes, providing reference for clinical syndrome differentiation.Methods: A total of 120 infants meeting the diagnostic criteria for cytomegalovirus hepatitis were consecutively enrolled from Beijing Children's Hospital, Capital Medical University, from Febuary 2022 to Febuary 2024, including 40 cases each of dampness - heat internal accumulation syndrome, spleen deficiency with dampness retention syndrome, and qi stagnation with blood stasis syndrome. Differences in red blood cell parameters, platelet parameters, coagulation function, and liver function indicators were compared among the syndromes.Results: No significant differences were found in gender or age among the groups (P >0.05). The disease duration was longer in the spleen deficiency with dampness retention group and qi stagnation with blood stasis group compared to the dampness- heat internal accumulation group (P < 0.01). Regarding liver function, the qi stagnation with blood stasis group had higher GGT levels than the dampness - heat internal accumulation group (P <0.01), while the spleen deficiency with dampness retention group showed higher ALT levels (P <0.01). Both spleen deficiency with dampness retention and qi stagnation with blood stasis groups exhibited higher AST, TBIL, DBIL, and TBA levels than the dampness - heat internal accumulation group (P <0.05, P < 0.01). The qi stagnation with blood stasis group had higher TBIL, DBIL, and TBA levels than the spleen deficiency with dampness retention group (P <0.01). In red blood cell parameters, the spleen deficiency with dampness retention and qi stagnation with blood stasis groups showed lower RBC, HGB, and HCT but higher RDW compared to the dampness - heat internal accumulation group (P <0.05, P < 0.01). Platelet analysis revealed higher PLT in the qi stagnation with blood stasis group than in the spleen deficiency with dampness retention group (P <0.01). Coagulation tests demonstrated longer PT and higher INR in the qi stagnation with blood stasis group(P < 0.01) but lower FIB (P <0.05) versus the dampness - heat internal accumulation group. The spleen deficiency with dampness retention group had prolonged APTT (P < 0.05).Conclusion: Significant differences exist in blood indicators among different TCM syndromes of infantile cytomegalovirus hepatitis, providing a theoretical basis for clinical syndrome differentiation.

Objective: To analyze the application value of the self - designed Xuanfei Tongqiao Decoction combined with acupoint application in the clinical efficacy, inflammatory factors, immune function and prognosis of children with allergic rhinitis. Method: The research subjects were 186 children with allergic rhinitis who were diagnosed and treated in our hospital from September 2022 to August 2024. They were divided into the control group (n = 93) and the observation group (n =93) by the random number table method. The control group was treated with loratadine syrup, while the observation group was treated with self - designed Xuanfei Tongqiao Decoction combined with acupoint application. Both groups were treated for 2 months. Compare the clinical efficacy of the two groups; The levels of inflammatory factors, immune function indicators, TCM syndrome scores and quality of life scores of the two groups of children before and after treatment were compared; Compare the incidence of adverse reactions after treatment between the two groups of children.Results: Compared with the control group, the total effective rate of clinical treatment of the children was significantly increased in the observation group (P < 0.01). After treatment, the levels of C - reactive protein (CRP), tumor necrosis factor α (TNF - α) and interleukin - 6 (IL - 6) were significantly decreased in the observation group compared with the control group (P <0.01). Compared with the control group, the immunoglobulin E(IgE) and eosinophils (EOS) counts were significantly decreased in the observation group after treatment, and the CD4⁺/CD8⁺ levels were significantly increased in the observation group (P < 0.01). Compared with control group, TCM syndrome score and allergic rhinitis Quality of Life questionnaire (RQLQ) score were significantly decreased in observation group after treatment (P <0.01). Compared with the control group, the total incidence of adverse reactions after treatment was significantly reduced in the observation group (P <0.05).Conclusion: The self - proposed Xuanfei Tongqiao Decoction combined with acupoint application has a high clinical efficacy for children with allergic rhinitis. It can effectively improve the inflammatory response, immune function, TCM syndrome score and quality of life of the children, and has high safety.

As crucial components of human life activities, body, Qi, and spirit interact with each other, driving various vital processes. The onset and progression of cervical vertigo are accompanied by changes in body, Qi, and spirit. The "body" aspect is reflected in the pathological state of cervical spine muscle and bone imbalance; the "Qi" aspect manifests as dysfunction of Qi circulation and malnutrition of the brain; the "spirit" aspect is reflected in liver stagnation, muscle tension, and blocked brain connections. The pathological change in the body serves as the pathological foundation for the onset of cervical vertigo, the dysregulation of Qi is the root cause of the disease, and the disturbance of the spirit acts as a pathogenic factor. Therefore, in the treatment of cervical vertigo, it is necessary to emphasize the "unity of body, Qi, and spirit", prioritizing the manipulation of complex shape and the balance of muscles and bones, regulating Qi as the root cause, dredging yang Qi as the method, unblocking the governor vessel and soothing the liver, regulating the mind and stopping vertigo as the key, and utilizing traditional Chinese medicine, acupuncture, massage, psychological counseling, and other comprehensive means of treatment, in order to provide new insights for the clinical diagnosis and treatment of cervical vertigo.

This article explores the pathogenesis of infertility due to diminished ovarian reserve (DOR) based on the "Liver - Kidney Theory" and summarizes Professor Han Yanhua's treatment experience. Based on the differentiation of the liver and kidney organs, the analysis is conducted from three aspects: kidney deficiency and essence depletion, liver failure in dispersion and discharge, and Qi deficiency and blood stasis. Kidney essence deficiency leads to hindered follicular development; liver stagnation and failure in discharge cause imbalance in the storage and discharge of the uterine chamber; Qi deficiency and blood stasis result in blockage of the thoroughfare and conception vessels, making it difficult for sperm and egg to combine, all of which can lead to infertility. Professor Han Yanhua advocates that treatment should focus on regulating the liver and kidney, combining dispersion and tonification, following the storage and discharge of the uterine chamber, and conducting cyclical regulation. Commonly used empirical formulas such as Bailing Tiaogan Decoction and Bushen Huoxue Formula are employed to harmonize Yin and Yang and nourish Qi and blood. This article briefly analyzes Professor Han Yanhua's clinical experience and academic ideas to share with peers, accompanied by one proven case.

Objective: To explore Zhang Zhongjing's understanding of the efficacy and indications of Semen Persicae(Taoren) and his medication characteristics.Methods: Based on the 13 clauses where Zhang Zhongjing applied Semen Persicae and the nine formulas containing Semen Persicae in Treatise on Cold Damage and Miscellaneous Diseases and Synopsis of the Golden Chamber—Dahuang Mudan Tang (Rhubarb and Moutan Decoction), Taobe Chengqi Tang(Peach Kernel Purgative Decoction), Didang Tang (Resistance Decoction), Didang Wan (Resistance Pill), Xiayuxue Tang (Stasis - Expelling Decoction), Biejiajian Wan (Turtle Shell Decoction Pill), Guizhi Fuling Wan (Cinnamon and Poria Pill), Dahuang Zhechong Wan (Rhubarb and Ground Beetle Pill), treatment of horse falls, and all formulus for treating tendon and bone injuries—the efficacy and indications of Semen Persicae were summarized. Results and Conclusion: Semen Persicae can purify the lung and unblock the fu organs, enter the blood and remove stasis, gradually attack and break stasis, and unblock the vessels and activate collaterals to treat acute critical conditions such as intestinal abscess, blood stasis, and tendon and bone injuries. It can regulate qi and blood, nourish blood and supplement deficiency to treat difficult and complicated diseases such as abdominal masses and consumptive blood dryness. It can also expel stasis and regulate menstruation, eliminate masses and stop bleeding to treat gynecological disorders such as postpartum abdominal pain, persistent lochia, unfavorable menstruation, amenorrhea, and female abdominal masses. For acute critical conditions, large doses and aggressive attacking methods are used; for difficult and complicated diseases and chronic conditions, small doses and gradual unblocking methods are applied. Both decoctions and pills are used for long - term treatment. For activating blood and removing stasis, the dosage should be large, mostly decocted and taken with wine; for moistening dryness and moving stagnation, the dosage is slightly smaller, mostly prepared into honeyed pills.

Objective: To explore the effect of acupotomy combined with warm acupuncture and moxibustion on the improvement of vertebral artery blood flow and cervical joint range of motion in the treatment of cervical spondylotic radiculopathy (CSR).Methods: 92 patients with CSR diagnosed and treated in the Pain Department of the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine from June 2023 to June 2024 were selected as the research objects. They were divided into two groups by random number table. 46 patients in the control group were treated by warming acupuncture and moxibustion regularly, and 46 patients in the observation group were assisted with acupotomy at the same time. After three courses of treatment (three weeks), the vertebral artery blood flow, cervical joint range of motion, TCM syndrome score, effective rate and adverse reactions of the two groups were compared.Results: After 3 weeks of treatment, both groups showed significant improvement in bilateral vertebral artery blood flow velocity and bilateral vertebral artery blood flow compared to before treatment. The observation group had higher bilateral vertebral artery blood flow velocity and bilateral vertebral artery blood flow (P <0.05). After 3 weeks of treatment, the cervical joint range of motion scores in both groups decreased significantly compared to before treatment, with the observation group scoring lower than the control group (P < 0.05). After 3 weeks of treatment, the TCM syndrome scores of both groups decreased significantly compared to before treatment (P <0.05), and the TCM syndrome scores of the observation group were significantly lower than those of the control group (P < 0.05). After 3 weeks of treatment, the effective rate of the observation group was higher than that of the control group (P < 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups of patients (P > 0.05).Conclusion: The combined scheme of acupotomy and warm acupuncture and moxibustion has significantly improved the vertebral artery blood flow and the cervical joint range of motion in the treatment of CSR population, which is conducive to improving the therapeutic effect and ensuring the safety.

Objective: To analyze on the effect of Tongyuan acupuncture combined with modified Yiqi Tongluo Decoction in the treatment of patients with limb movement disorders (Qi deficiency and blood stasis syndrome) after stroke.Methods: 172 patients with post stroke limb movement disorders (Qi deficiency and blood stasis syndrome) admitted to Zhengzhou Central Hospital from January 2021 to March 2023 were randomly divided into 4 groups. All four groups received routine treatment, and the acupuncture group was additionally treated with Tongyuan acupuncture, and the Decoction group was additionally treated with modified Yiqi Tongluo Decoction, while the combination group was additionally treated with Tongyuan acupuncture combined with modified Yiqi Tongluo Decoction. All four groups were treated for 3 months. Scores of traditional Chinese medicine symptoms, degrees of neurological deficit, limb motor functions and daily living abilities, clinical efficacy, hemorheological changes and safety were observed.Results: After treatment, the main symptoms, secondary symptoms, tongue pulse and total scores, NIHSS scores, blood viscosity, whole blood high shear viscosity, whole blood low shear viscosity, and red blood cell aggregation indexes of the four groups all decreased (P <0.05), which were lowest in the combination group, higher in the acupuncture group and B, highest in control group (P <0.05). After treatment, the Fugl - Meyer and BI scores in all four groups increased (P <0.05), and those of the combination group were higher than the other three groups (P < 0.05), of which the acupuncture group and the Decoction group were both higher than the control group (P <0.05). The total effective rate of the combination group was highest (97.50%), followed by the acupuncture group and B (80.00%, 82.50%), lowest in control group (63.42%). The incidences of adverse reactions were consistent among the four groups (P >0.05).Conclusion: For patients with limb movement dysfunction (Qi deficiency and blood stasis syndrome) after stroke, Tongyuan acupuncture and modified Yiqi Tongluo Decoction can alleviate symptoms, enhance efficacy, and improve blood rheology. Moreover, the combination of the two has a better effect, with safety.

Objective: To investigate the properties and morphology of Coptis chinensis - Evodia rutaecarpa self- assemblies and their effects on the contents of seven components: epiberberine hydrochloride, coptisine hydrochloride, palmatine hydrochloride, berberine hydrochloride, evodiamine, rutaecarpine, and evodin.Methods: The morphology, fluidity, and water absorption rate of the self - assemblies were characterized. High - performance liquid chromatography(HPLC) was used to compare the differences in the seven components among single decoctions of Coptis chinensis and Evodia rutaecarpa, co - decoction supernatant, and the self - assemblies.Results: The self - assemblies exhibited good fluidity and water - absorbing swelling properties. Scanning electron microscopy revealed that they were spherical particle aggregates. The formation of self - assemblies led to a decrease in the contents of the seven components in the supernatant, with significant reductions in evodiamine, berberine hydrochloride, and evodin, while epiberberine hydrochloride slightly increased. Among the seven components in the self - assemblies, berberine hydrochloride was relatively abundant and likely a key component in the formation of the self - assemblies.Conclusion: A quantitative method for the seven components in Coptis chinensis - Evodia rutaecarpa self - assemblies was established, which can be used by enterprises to monitor changes in the main components in the self - assemblies and supernatant. The Coptis chinensis - Evodia rutaecarpa self - assemblies are fundamentally different from chemical precipitation and can serve as a green strategy for supramolecular design and construction. This provides insights into the reuse of carrier - free self- assembled drugs and offers a new perspective for understanding self - assembly phenomena in traditional Chinese medicine decoctions.