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To investigate the efficacy and safety of Shiwei Shengxue Decoction in improving the nutritional status of patients with advanced non-small cell lung cancer (NSCLC) cachexia (Qi and Blood Deficiency Syndrome).
A prospective cohort study design was adopted. Patients with advanced NSCLC who met the diagnostic criteria for Qi and Blood Deficiency Syndrome and cancer cachexia, admitted to Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, and Shunyi Hospital, Beijing Hospital of Traditional Chinese Medicine, from March 2023 to March 2024, were enrolled. Based on whether they received Shiwei Shengxue Decoction (treatment for≥4 weeks), patients were naturally assigned to an exposed group and a non-exposed group. Both groups received conventional nutritional treatment.
After propensity score matching (PSM), 45 pairs of patients were included. The total effective rate for improving nutritional status in the exposed group was 77.8% (35/42), which was significantly higher than that in the non-exposed group (48.9%, 22/45), with a statistically significant difference (P < 0. 05). The exposed group showed superior improvements in increasing food intake, maintaining body weight, enhancing grip strength, and raising serum hemoglobin (Hgb) levels compared to the non-exposed group (P <0.05). However, no statistically significant differences were observed in KPS scores or serum albumin (ALB) levels between the two groups (P > 0.05). No adverse events were reported during the study period.
Shiwei Shengxue Decoction can effectively improve the nutritional status of patients with advanced NSCLC cachexia (Qi and Blood Deficiency Syndrome) with a favorable safety profile.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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