The concept of "Internal Deficiency and Latent Wind" was proposed by the Miao Xiyong, a physician in Ming Dynasty, based on the understanding of sages, as a new insight into the pathogenesis of stroke. He believed that in the hot and humid southern regions, people are prone to stroke due to the consumption of true yin and dual deficiency of yin and yang; internal heat becomes rampant, and phlegm - heat congests the airways, leading to the obstruction of the meridians and the onset of stroke. This article starts from the theoretical understanding of 'Internal Deficiency and latent Wind' and, combined with the characteristics of cold regions, suggests that the pathogenesis of ischemic stroke in cold areas is related to the depletion of the liver and kidneys, deficiency of yin and yang; internal phlegm - dampness and heat - stasis interplay; external cold invasion and the mutual stimulation of wind and cold; as well as the combined invasion of external and internal dryness. Treatment should pay attention to the climate and physical characteristics of cold regions, focus on dispersing external wind and removing phlegm - stasis, and emphasize replenishing the true yin of the liver and kidneys. Additionally, moistening agents should be used with discretion to nourish yin, moisten dryness, and open the Xuanfu, with the aim of providing a reference for the clinical prevention and treatment of ischemic stroke in cold regions.

The incidence rate of reflux esophagitis with depression is increasing, which is one of the common diseases in the department of spleen and stomach. The location of reflux esophagitis with depression is in Shaoyang, and the main pathogenesis is the dysfunction of the Shaoyang axis. In terms of treatment, the main approach is to choose a formula and use a combination of tonifying and tonifying agents. Shaoyang is unfavorable and the middle qi is disharmonious. It is advisable to treat it by reconciling Shaoyang, harmonizing the stomach, and reducing adverse reactions. The prescription is Xiaochaihu decoction; If Shaoyang loses its power and the fire is in disorder, it should be treated to harmonize Shaoyang and spread the fire, and then choose Chaihu Guizhi Longgu Muli decoction; Shaoyang depression and damp heat are prevalent, and it is advisable to treat them by dividing and dissipating diarrhea, and promoting Shaoyang. The prescription is Haoqin Qingdan decoction. This article explores the etiology and pathogenesis and drugs and treatment of reflux esophagitis with depression from the perspective of Shaoyang, aiming to provide new ideas for the diagnosis and treatment of reflux esophagitis with depression.

To investigate the mechanism of Yangxin Granules in regulating GSK3β, COX2 and AQP2 to intervene in water - sodium retention in heart failure rats. Methods: One hundred SPF - grade SD rats were randomly divided into sham operation group (10 rats) and modeling group (90 rats). The modeling group underwent ligation of the left anterior descending coronary artery for 2 weeks to establish a post - myocardial infarction heart failure model. The modeling group was then randomly divided into model group, Yangxin Granules low - dose, medium - dose, and high - dose groups, tolvaptan group, and combined intervention group (tolvaptan + Yangxin Granules). All groups received once - daily drug interventions. Urine output was collected at 6, 12, and 24 h during weeks 2 and 4 of treatment. After the final administration, cardiac ultrasound was performed to record left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS). Urine output and body weight were recorded, and heart and kidney indices were calculated. Serum brain natriuretic peptide (BNP) levels were measured by ELISA. Myocardial tissue pathology was observed via HE and Masson staining. Western blot was used to detect expression levels of GSK3β, COX2, and AQP2 proteins in renal tissues.Results: Compared with the model group, Yangxin Granules increased urine output(P < 0.05), decreased serum BNP levels (P <0.05), improved cardiac function (LVEF and LVFS, P < 0.05, P <0.01), and upregulated COX2 expression (P <0.05). Compared with the model group, the tolvaptan and combination groups showed downregulated GSK3β and AQP2 expression (P <0.01). Yangxin Granules alleviated myocardial tissue damage and inflammatory cell infiltration.Conclusion: Yangxin Granules can regulate renal tubular GSK3β and COX2 expression, thereby inhibiting AQP2, reducing water reabsorption, thus exerting therapeutic effects on water - sodium retention in heart failure.

Objective: To investigate the impact of Dahuang Lingxian Formula (Rheum Officinale and Radix Clematidis Formula, DHLX) on the intestinal microbiota's structure and function in guinea pigs suffering from gallbladder stones.Methods: Fifty guinea pigs were randomly assigned to a blank group, a model group, and a traditional Chinese medicine(TCM) group. The model group consumed a high - fat diet to induce gallbladder stones, while the TCM group received DHLX for 8 weeks alongside the same high - fat diet. Colon fecal samples were collected at the 8th week and subjected to 16S rDNA sequencing for analyzing intestinal flora composition, diversity, and functional predictions.Results: ①The OTU count was 4623 in the normal group, 3970 in the model group, and 4335 in the TCM group; 474 OTUs were common to all three groups. ② Major dominant phyla encompassed Bacteroidetes, Firmicutes, Proteobacteria, Verrucomicrobia, and Spirochaetes. In the model group, Bacteroidetes and Verrucomicrobia increased, while Firmicutes and Spirochaetes decreased. Conversely, in the TCM group, Bacteroidetes, Firmicutes, and Verrucomicrobia decreased, while Proteobacteria and Spirochaetes increased. ③ The intestinal flora diversity index (Ace, Chao1, Shannon, Simpson) showed no significant difference between groups. ④ The intestinal flora distribution of the model group significantly diverged from the normal group, with partial overlap observed between the TCM and model groups.⑤In the blank group, Ruminococcus, Rikenellaceae, and other genera were highly expressed; Paludibacteraceae and Verrucomicrobia were prominent in the model group; Alphaproteobacteria and Desulfovibrio were highly expressed in the TCM group. ⑥The intestinal microbiota of the blank group exhibited anaerobic and biofilm synthesis traits. In the model group, Gram - negative bacteria increased, while mobile genetic elements and biofilm synthesis decreased. However, in the TCM group, the characteristics of Gram - negative bacteria and biofilm synthesis were restored.Conclusion: The intestinal microbiota structure undergoes significant changes during gallbladder stone formation, and DHLX effectively regulates the flora, restoring it to a normal steady state.

Objective: To explore the mechanism of liver injury induced by Dictamni Cortex water extract through interference with lipid metabolism in the liver.Methods: Thirty - two SPF - grade male SD rats were randomly divided into four groups: control group, high - dose Dictamni Cortex group (8.1 g/kg), medium - dose group (2.7 g/kg), and low - dose group (0.9 g/kg), with 8 rats in each group. The rats were administered by gavage for 8 weeks. Liver weight, liver - to - body weight ratio, and liver toxicity - related indicators were measured to observe changes in the rats' liver. Hematoxylin - eosin (HE) staining and Oil Red O staining were used to assess the pathological changes and lipid droplet accumulation in liver tissues. The mRNA levels of AMPK, PPAR - α, IL - 1β, and TNF - α were detected in liver tissues. Lipid levels in the liver were analyzed by LC - MS/MS, and multivariate statistical analysis was used to identify differentially expressed lipid metabolites.Results: Compared with the control group, the liver - to - body weight ratio was increased in all Dictamni Cortex dose groups(P < 0.01, P < 0.001). In the high - dose group, AST、ALT、ALB levels were significantly increased (P < 0.05, P < 0.001). HE and Oil Red O staining showed that the high - dose group significantly induced fatty liver lesions in rats. The mRNA levels of inflammatory factors IL - 1β and TNF- α were significantly increased (P < 0.01), while the mRNA levels of PPAR - α, were significantly reduced (P <0.01). Lipidomics analysis showed that, compared to the control group, 156 lipid species were significantly altered in the high - dose group, including glycerolipids, phosphatidylcholine, sphingolipids, etc. Specific lipids such as PC(16∶0/18∶2), PC(16∶0/18∶1)、PC(14∶0/18∶2)、PC(15∶0/18∶2)、TG(16∶0/16∶0/16∶0), TG(18∶0/16∶0/16∶0)、SM(d42∶1), SM (d42∶2), SM (d42∶3) showed significantly variation levels after treatment. These results suggest that the high - dose Dictamni Cortex water extract disturbed lipid metabolism in the liver of rats.Conclusion: The water extract of Dictamni Cortex induces liver injury in rats by interfering with lipid metabolism, particularly sphingolipids (SM), ceramides (Cer), triglycerides (TG), and phosphatidylcholine (PC).

Objective: To investigate the pharmacokinetic effects of Aurantii Fructus Carbon Quantum Dots (AFIC-CDs) on paeoniflorin (PF), the main active component of Paeonia.Methods: Male Kunming mice were randomly divided into three groups: high - dose AFIC - CDs (120 mg·mL^-1) and PF co - administration group (H), low - dose AFIC - CDs (60 mg·mL^-1) and PF co - administration group (L), and PF alone (2.0 mg·mL^-1) group (S). Mice were orally administered mixed solutions of high or low - dose AFIC - CDs with the same dose of PF, or PF alone. Paeoniflorin levels in the mouse blood were determined by indirect competitive enzyme - linked immunosorbent assay(icELISA) using anti - PF monoclonal antibodies, and pharmacokinetic parameters of PF were compared among the groups.Results: Co - administration of AFIC - CDs with PF significantly increased PF blood concentration and the area under the blood concentration - time curve (AUC - t) (P < 0.05, P < 0.01), with increases observed as the AFIC-CDs concentration increased. Compared to PF administration alone, the Cmax of PF in the high - dose and low - dose AFIC - CDs + PF groups increased from (695.43 ± 229.73) ng·mL^-1 to (1 615.31 ± 245.16) ng·mL^-1 and(973.11 ± 155.90) ng·mL^-1, respectively. The AUC - t increased from (90 181.22 ± 20 926.42) ng·min·mL^-1 to(257 510.74 ± 26 729.64) ng·min·mL^-1 and (116 654.67 ± 11 770.02) ng·min·mL^-1, respectively.Conclusion: AFIC - CDs can enhance the bioavailability of PF, providing scientific evidence for clinical co - medication to improve therapeutic efficacy.

The Jiexi acupoint (ST 41) belongs to the Stomach Meridian of Foot - Yangming and has a special anatomical location. Its clinical application reflects the holistic concept of "treating upper diseases from lower." This principle originates from the Huangdi Neijing, which states, "For diseases in the upper body, treat the lower body." This article explores Jiexi's therapeutic approach of treating upper diseases from below from five perspectives: tracing the origins of Jiexi, analyzing its nature, and clarifying its application, clarifying the use of Jiexi Point, enlightenment on the use of Jiexi Point. The Jiexi acupoint is also noted in the phrase "treat muscular atrophy by selecting points on the Yangming meridian," demonstrating its efficacy in treating ankle atrophy. As a key point on the stomach meridian, it helps to alleviate local edema and clear heat in the Stomach meridian. The stomach meridian of Foot - Yangming extends to the hairline and forehead, so needling the Jiexi acupoint can treat upper body conditions, such as headaches and brain disorders, by regulating them from below. In the five elements, Jiexi belongs to fire and shares an affinity with the eyes, heart, and pericardium. The upper portion of the Foot - Yangming meridian connects to the heart, while the major collateral vessel of the stomach, known as Xuli, is located at the point of the heart's pulsation. This connection lays the foundation for treating eye diseases, heart - related conditions, and mental disorders. As an acupoint on the meridian, Jiexi is also indicated for treating coughs, fevers, and chills. Additionally, the theory of "treating edema by targeting the meridian" suggests that Jiexi can be used to address both external coughs and stomach - related coughs accompanied by edema. Jiexi point has a wide range of clinical applications in combination with other points, and it is rich in special needling techniques. Jiexi and Yang Jiao points, both belonging to the fire element, can be used together to treat palpitations. A classic case is appended to verify their effectiveness.

Professor Xie Lin points out that the core pathogenesis of cervical spondylosis lies in the blockage of muscles, bones, and blood vessels, as well as the malnutrition of the muscles and bones. In clinical practice, the diagnosis and treatment should be based on the four diagnostic methods, to clarify the condition of deficiency or excess, and differentiate the symptoms. The treatment principle should focus on muscles and bones, with the main strategy being the elimination of excess and supplementation of deficiency, and the active use of horn medicine. In cases of wind, cold, phlegm, and blood stasis blocking the channels, it is necessary to expel the pathogenic factors, unblock the channels, and benefit the muscles and bones. When the internal organs are deficient in qi and blood, the treatment should aim to nourish the base, supplement deficiency, and nourish the muscles and bones. Additionally, associated symptoms should be considered, and treatments for muscle relaxation, liver wind elimination, and the relaxation of muscles and tendons should be used. Clinical practice has shown good results, as evidenced by the case examples provided.

Tic disorders often co - occur with sleep disorder, mood disorder, learning disorder and other physical and mental diseases, it's characterized by spirit - body disharmony, can be classified as Jueyin wind wood disease. The theory of Jueyin Conghua is believed that Jueyin wind wood is smooth and follows the Shaoyang phase fire, if the wood qi is smooth, the phase fire will transform into the wind wood. Guided by the "Jueyin Conghua theory", the professor Cui xia argues that the key to the pathogenesis of tic disorders and comorbidities lies in the compromised Jueyin pivotal mechanism and aberrant Conghua. The tendency of disease depends on the rise and fall of Jueyin phase fire. If it is too high, the wood will produce fierce wind from fire, and if it is too low, cold and heat will be mixed to generate wind In cases of acute and severe tics, the treatment must concentrate solely on regulating the body, with minor attention to the spirit, prioritizing the method of subduing yang and extinguishing wind. For chronic and mild tics presenting with comorbidity, a concurrent treatment approach is required. This entails simultaneous harmonization of both body and spirit, through dispersing stagnation and nourishing to pacify wind, thereby regulating the qi and blood of the root organ. At the same time, methods such as breath and mental regulation, daoyin (Therapeutic Exercise) and tuina (Chinese medical massage), and spiritual cultivation should be integrated to achieve a combined internal and external therapeutic strategy, enabling a comprehensive intervention for the condition. A case is attached for clinical reference.

Pediatric sinusitis is prevalent among children, which is mainly manifested by a large amount of turbid nasal discharge. Western medicine treats this disease mostly with oral antibiotics and nasal hormones, which have the disadvantages of uncertain efficacy and drug resistance. Traditional Chinese Medicine (TCM) treats this disease through oral and external use of Chinese herbal drugs, offering a relatively safe and low - side - effect treatment option. In this study, we believe that the onset of pediatric sinusitis is related to the external pathogens to the lungs closing to the surface and inside; the heat of the gallbladder leading to the congestion of the nose and orifices; spleen and stomach disorders causing to the imbalance of qi movement. The primary pathogenesis involves internal heat stagnation and obstruction of the nasal passages. The following methods should be used in treating this disease: to resolve the pathogens both external and internal, to dispel external evils and clear the heat in the lungs at the same time; pungent and bitter medicines should be used together, to relieve the heat in the gallbladder; to elevate the clearness and lower the turbidity, regulating the spleen and the stomach Qi. Tongqiao Shengjiang Powder is derived from "Shengjiang Powder", a classic formula for treating epidemics, and is modified by the addition of Magnolia biondii Pamp., ueraria lobata(Willd.) Ohwi, and Glycyrrhiza uralensis Fisch. This formula has excellent therapeutic effects for treating pediatric sinusitis. It has the efficacy of resolving external pathogens and clearing the heat in the lungs, elevating the clearness and lowering the turbidity, and improving nasal ventilation. Although its medicinal flavor is simple, the formula is comprehensive and covers several treatments. It can effectively treat pediatric nasosinusitis of various TCM syndrome types through addition or subtraction. In this paper, one case is attached for clinical reference.

This article is intended to introduce Professor Zhang Xikui's experience in diagnosing and treating gout. In the acute stage of gout, Baihu and Guizhi decoction is prescribed, supplemented with herbs that clear heat and eliminate dampness, cool blood and detoxify, and promote joint circulation. In the remission stage of gout, the formula for tonifying qi and unblocking collaterals is prescribed, supplemented with herbs that reduce phlegm and remove blood stasis, promote yang and cool the blood, resolve nodules and open collaterals, and invigorate the spleen and kidneys. According to the severity of pain and the course of the disease, the Shaoyao Gancao decoction is flexibly combined. Based on the severity of heat, dampness, phlegm, blood stasis, and deficiency, the treatment methods and medications are adjusted. It is also emphasized that the medication should be consistent and attention should be paid to lifestyle regulation.

Objective: To investigate the therapeutic effect of the Spleen - strengthening, Dampness - eliminating, and Turbidity - resolving Formula on patients with Spleen deficiency and damp - phlegm type polycystic ovary syndrome(PCOS) complicated by insulin resistance (IR).Methods: A total of 104 patients diagnosed with Spleen deficiency and damp - phlegm type PCOS complicated by IR were selected from Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine between April 2021 and April 2024. They were randomly assigned to the control group (n = 52, conventional treatment) and the Traditional Chinese Medicine (TCM) group (n = 52, receiving Spleen - strengthening, Dampness - eliminating and Turbidity - resolving Formula in addition to the control group treatment). Hormonal indicators, glucose and lipid metabolism indicators, TCM syndrome scores, imaging indicators, and the incidence of adverse reactions were compared before and after treatment.Results: After treatment, the FSH level in the TCM group was higher than that in the control group, while the levels of LH, AMH, LH/FSH, FPG, FINS, and HOMA - IR were lower (P < 0.05). The TCM group also showed lower scores for symptoms such as loose stools, diarrhea, loss of appetite, and fatigue compared to the control group (P < 0.05). Additionally, the ovarian volume and number of follicles in the TCM group were lower, while the endometrial thickness was higher than those in the control group (P <0.05). The incidence of adverse events in the TCM group did not differ statistically from that in the control group (P >0.05).Conclusion: The spleen - strengthening, dampness - eliminating, and turbidity - resolving formula can significantly improve metabolic status and enhance insulin sensitivity in patients with spleen - deficiency and phlegm- dampness type PCOS combined with IR. It is safe and holds great potential for broad clinical application and precision medicine.

Objective: To explore the clinical efficacy and mechanism of modified Ermiao Pills in improving refractory proteinuria of diabetic kidney disease(DKD) based on the ""Damp - Heat Damaging Kidney"" theory.Methods: A total of 126 patients with diabetic kidney disease were selected from the TCM department and nephrology department of Gulou Hospital affiliated to Nanjing University Medical School from January 2022 to January 2025. All patients were divided into the treatment group (Group A, n = 63) and the control group (Group B, n = 63) using a stratified randomization method with sealed envelopes. Group A received conventional basic treatment combined with modified Ermiao Pills, while Group B received only conventional basic treatment. Clinical assessments were conducted on enrollment day and at week 8 of treatment to evaluate TCM syndrome scores [including polydipsia, limb edema, sticky mouth, and epigastric distension], detect urinary protein profiles [24 - hour urine protein (24hUpro), urinary albumin (UAlb), urinary kidney injury molecule-1 (UKim - 1), urinary N - acetyl - β - D - glucosidase (UNAG)], analyze metabolomics parameters [palmitic acid, L - carnitine, phosphatidylcholine (PC), diacylglycerol (DG)], assess renal function[blood creatinine (Scr), blood urea nitrogen (BUN)], and evaluate safety indicators [red blood cells (RBC), alanine aminotransferase (ALT), albumin (Alb), glycated hemoglobin (HbA1c)]. The clinical efficacy of both groups was compared.Results: After treatment, compared with group B, the scores of polydipsia, limb edema, sticky mouth, epigastric and abdominal distension in group A, as well as the levels of 24hUpro, UAlb, UM - 1, UNAG, palmitic acid, Scr, BUN, were decreased (P < 0.05), while the levels of L - carnitine, PC and Dg were increased (P <0.05). Compared with group B, the total effective rate of group A increased (P <0.05).Conclusion: For the first time in a single - center randomized controlled trial, the combination of modified Ermiao pills and conventional treatment based on the ""damp - heat injuring kidney"" theory has been demonstrated to significantly improve refractory proteinuria in diabetic nephropathy, regulate metabolomic indicators, and protect renal function with high safety. Palmitic acid, L - carnitine, PC, and Dg may serve as potential therapeutic targets for modified Ermiao pills in treating refractory proteinuria of diabetic nephropathy.

Objective: To analyze on the effect of Tongyuan acupuncture combined with modified Yiqi Tongluo Decoction in the treatment of patients with limb movement disorders (Qi deficiency and blood stasis syndrome) after stroke.Methods: 172 patients with post stroke limb movement disorders (Qi deficiency and blood stasis syndrome) admitted to Zhengzhou Central Hospital from January 2021 to March 2023 were randomly divided into 4 groups. All four groups received routine treatment, and the acupuncture group was additionally treated with Tongyuan acupuncture, and the Decoction group was additionally treated with modified Yiqi Tongluo Decoction, while the combination group was additionally treated with Tongyuan acupuncture combined with modified Yiqi Tongluo Decoction. All four groups were treated for 3 months. Scores of traditional Chinese medicine symptoms, degrees of neurological deficit, limb motor functions and daily living abilities, clinical efficacy, hemorheological changes and safety were observed.Results: After treatment, the main symptoms, secondary symptoms, tongue pulse and total scores, NIHSS scores, blood viscosity, whole blood high shear viscosity, whole blood low shear viscosity, and red blood cell aggregation indexes of the four groups all decreased (P <0.05), which were lowest in the combination group, higher in the acupuncture group and B, highest in control group (P <0.05). After treatment, the Fugl - Meyer and BI scores in all four groups increased (P <0.05), and those of the combination group were higher than the other three groups (P < 0.05), of which the acupuncture group and the Decoction group were both higher than the control group (P <0.05). The total effective rate of the combination group was highest (97.50%), followed by the acupuncture group and B (80.00%, 82.50%), lowest in control group (63.42%). The incidences of adverse reactions were consistent among the four groups (P >0.05).Conclusion: For patients with limb movement dysfunction (Qi deficiency and blood stasis syndrome) after stroke, Tongyuan acupuncture and modified Yiqi Tongluo Decoction can alleviate symptoms, enhance efficacy, and improve blood rheology. Moreover, the combination of the two has a better effect, with safety.

Objective: To analyze the curative effect of Huanglian Heye Formula combined with dulaglutide and its influences on insulin resistance and visceral fat index in patients with obese type 2 diabetes mellitus (T2DM) of damp heat affecting spleen type.Methods: A total of 80 patients with obese T2DM of damp heat affecting spleen type admitted to Foshan Fosun Chancheng Hospital were enrolled between January 2023 and December 2024. According to random number table method, they were divided into control group (dulaglutide) and combination group (Huanglian Heye Formula combined with dulaglutide), 40 cases in each group. All patients were treated for 12 weeks. The curative effect, blood glucose indexes [2 h postprandial blood glucose (2hPG), glycated hemoglobin (HbA₁c), fasting plasma glucose (FPG)], insulin resistance index (HOMA - IR), scores of TCM syndromes, obesity indexes and adverse reactions in the two groups were compared before and after treatment.Results: The curative effect of combination group was better than that of control group (P <0.05). After treatment, blood glucose indexes, HOMA - IR, scores of TCM syndromes and obesity indexes were decreased in both groups (P < 0.05), and FPG, 2 hPG, HbA₁c, HOMA - IR, scores of TCM syndromes, body fat percentage and visceral fat index in combination group were lower than those in control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05).Conclusion: Curative effect of Huanglian Heye Formula combined with dulaglutide is good in patients with obese T2DM of damp heat affecting spleen type, which can lower blood glucose, improve insulin resistance, TCM syndromes and reduce visceral fat index.

Objective: To analyze the clinical efficacy of acupoint application combined with doxycycline in the treatment of mycoplasma pneumoniae pneumonia (MPP) complicated with lung consolidation in children with phlegm - heat obstructing the lung syndrome.Methods: A total of 120 children with MPP complicated with lung consolidation and phlegm - heat obstructing the lung syndrome, admitted to Shandong University Qilu Hospital Dezhou Hospital from August 2022 to August 2024, were selected. They were divided into a control group (doxycycline) and an observation group (control group treatment plus acupoint application) using a random number table method, with 60 cases in each group. The treatment course was 10 days. The therapeutic efficacy, symptom disappearance time, hospitalization duration, traditional Chinese medicine (TCM) syndrome scores, inflammatory factors [D - dimer (D - D), interleukin - 6(IL - 6), erythrocyte sedimentation rate (ESR), immunoglobulin - E (IgE), and C - reactive protein (CRP)], and adverse reactions were observed in both groups.Results: The total effective rate in the observation group was higher than that in the control group (P < 0.05). The time to symptom disappearance and the hospitalization duration in the observation group were shorter than those in the control group (P < 0.05). After treatment, the TCM syndrome scores and serum levels of inflammatory factors in the observation group were lower than those in the control group (P <0.01). There was no statistically significant difference in adverse reactions between the two groups (P > 0.05).Conclusion: Acupoint application combined with doxycycline for treating MPP complicated with lung consolidation in children with phlegm - heat obstructing the lung syndrome can alleviate symptoms and inflammatory injury and shorten the hospitalization duration, representing an effective and safe treatment regimen.

Objective: To investigate the efficacy of Chaihu plus Longgu and Muli Decoction combined with Huanglian Wendan Decoction in the treatment of phlegm - fire disturbing the heart type of intractable insomnia and its effect on sleep structure.Methods: Retrospectively selected 92 cases of recalcitrant insomnia patients treated in our hospital as research subjects, the selected time period is January 2022 - October 2024, according to the different treatment methods are divided into 40 cases in the control group (eszopiclone tablets) and 52 cases in the experimental group (control group + Chaihu plus Longgu and Muli Decoction combined with Huanglian Wendan Decoction). The clinical efficacy, TCM scores, sleep structure and sleep quality of the two groups were compared. Safety was analyzed for both groups.Results: After treatment, the effective rate of the experimental group was 96.15%, which was significantly higher than that of the control group, which was 80.00% (P < 0.05). After treatment, the scores of sleep and wakefulness, difficulty in falling asleep, sleeplessness after waking up, and restlessness and dreaminess in the experimental group were significantly lower than those in the control group (P <0.05). After treatment, the levels of rapid eye movement(REM) and non - rapid eye movement (N3) were significantly higher in the experimental group than in the control group (P < 0.05); the levels of non - rapid eye movement (N1) and non - rapid eye movement (N2) were significantly lower in the experimental group than in the control group (P < 0.05). After treatment, patients in the experimental group had significantly lower pulmonary daytime dysfunction, sleep onset, sleep duration, sleep disorder, sleep quality, sleep effectiveness and total score than those in the control group (P < 0.05). After treatment, the incidence of adverse reactions in the experimental group was 15.38% (8/52), higher than the control group's 10.00%(4/40), but there was no significant difference between the two groups (P > 0.05).Conclusion: The combination of traditional Chinese medicine and western medicine (based on the treatment of estazolam tablet and Chaihu plus Longguand Muli Decoction combined with Huanglian Wendan Decoction) has a significant synergistic effect on refractory insomnia of phlegm fire disturbing heart type, which can not only achieve more satisfactory curative effect, but also effectively improve the symptoms of traditional Chinese medicine, significantly improve the sleep quality, optimize the sleep structure, and have higher safety, reflecting the advantages of integrated traditional Chinese and western medicine in the treatment of this disease.

Objective: To explore the clinical effect of Yiqi Huoxue Tongbi Decoction on hemiplegia after ischemic stroke with qi deficiency and blood stasis.Methods: A total of 80 patients with hemiplegia after ischemic stroke with qi deficiency and blood stasis syndrome in Hepatobiliary Hospital of Jiangyin Traditional Chinese Medicine from January 2022 to December 2024 were prospectively selected and divided into 2 groups with 40 cases each according to random number table method. The control group was treated with conventional western medicine, and the observation group was treated with Yiqi Huoxue Tongbi Decoction combined with western medicine. Symptom improvement, curative effect, hemorheology, motor function, neurological function and safety were compared between the two groups. Results After treatment, TCM syndrome score, HCT, FIB, CRP, CysC and BNP levels were decreased in both groups, and the decrease was significant in the observation group (P < 0.05). After treatment, FMA scores and BBS scores in two groups were increased, and the increases in observation group were significant (P < 0.05). The curative effect of observation group was higher than that of control group (P < 0.05).Conclusion: The treatment of Yiqi Huoxue Tongbi Decoction for hemiplegia patients after ischemic stroke with qi deficiency and blood stasis syndrome can promote blood circulation, improve nerve function, and promote the recovery of motor function, so as to effectively improve the curative effect.

Objective: To observe the therapeutic effect of of Wang's Sanhe (lychee, hawthorn and mandarin orange seed) Formula in the treatment of kidney deficiency and stasis type prostatic hyperplasia and its effect on patients' bladder function.Methods: 120 patients with kidney deficiency and stasis type prostatic hyperplasia admitted to the Affiliated Hospital of Shanxi University of Traditional Chinese Medicine from January 2022 to June 2024 were selected and divided into two groups by lottery method. The conventional group was treated with tamsulosin hydrochloride capsule, and the Wang's Sanhe Formula group was combined with Wang's Sanhe Formula on the basis of the conventional group. Bladder function, prostate volume, 24h urination frequency, Chinese medicine symptom scores and changes in the levels of prostate - specific antigen (PSA), monocyte chemokine 1 (MCP - 1) and interleukin-8 (IL- 8) were compared before and after the treatment in the two groups, and adverse reactions were counted in the two groups.Results: Comparison of bladder function before treatment between the conventional group and Wang's Sanhe Formula group showed no statistically significant difference (P > 0.05). Maximum urinary flow rate (Qmax), average urinary flow rate (Qave) and effective bladder capacity were all higher after treatment in the conventional group and Wang's Sanhe Formula group than before treatment, and the differences in voiding time, urinary flow time and time to peak were not statistically significant when compared with those before treatment (P > 0.05). Qmax, Qave, and effective bladder capacity were higher in Wang's Sanhe Formula group after treatment than in the conventional group, and there was no statistically significant difference in voiding time, urine flow time, and time to peak compared with the conventional group (P > 0.05). Comparison of prostate volume, 24h urination frequency and TCM symptom scores before treatment between the conventional group and Wang's Sanhe Formula group, the difference was not statistically significant (P > 0.05). The prostate volume, 24 h urination frequency, and TCM symptom scores decreased after treatment in the conventional group and Wang's Sanhe Formula group compared with those before treatment, and the Wang's Sanhe Formula group was lower than the conventional group after treatment (P < 0.05). Comparison of serum PSA, MCP - 1 and IL - 8 before treatment between the conventional group and Wang's Sanhe Formula group showed no statistically significant difference (P >0.05). Serum PSA, MCP - 1, and IL - 8 decreased after treatment in both the conventional group and Wang's Sanhe Formula group compared with the pre - treatment period, and were lower in the Wang's Sanhe Formula group than in the conventional group after treatment (P < 0.05). Comparing the incidence of adverse reactions between the two groups (11.67% in the conventional group and 8.33% in the Wang's Sanhe Formula group), the difference was not statistically significant (P > 0.05).Conclusion: Wang's Sanhe Formula applied to kidney deficiency and stasis type prostatic hyperplasia can reduce the size of prostate, improve bladder function, reduce serum PSA, MCP - 1, IL - 8 levels and alleviate symptoms.

Objective: To investigate the clinical efficacy of the addition and subtraction of Duhuo Jisheng Decoction on the residual numbness of nerve root after intervertebral foramenoscopy.Methods: 80 patients with residual numbness of nerve roots after undergoing intervertebral foramen endoscopy treatment at Shangqiu Traditional Chinese Medicine Hospital were selected as the research subjects, and they were divided into 40 cases each in the conventional group(treated with methylcobalamin) and the traditional Chinese medicine group (treated with the modified Duhuo Jisheng Decoction on the basis of the conventional group) according to the method of the randomized numerical table generated by the computer for 4 consecutive weeks of treatment. The clinical effects of the two groups were compared. The numbness degree of lower limbs, lumbar function, nerve conduction velocity, evoked somatosensory potential, inflammatory factors and quality of life of the two groups were observed before and after treatment. Compare the adverse reactions and recurrence rates at 3 and 6 months between two groups.Results: After 4 weeks of treatment, the effective rate of the traditional Chinese medicine group was 92.50% (37/40), which was significantly higher than the 72.50%(29/40) effective rate of the conventional group, and the difference was statistically significant (P < 0.05). After treatment, the acupuncture test, visual analog scale (VAS) for numbness, nylon rope test score, Oswestry dysfunction index (ODI), lumbar spinal potential, cauda equina potential, cortical potential, and serum levels of tumor necrosis factor - α (TNF - α), high - sensitivity C - reactive protein (hs CRP), and interleukin - 1β (IL - 1β) in the traditional Chinese medicine group were significantly reduced compared to the conventional group (P < 0.05, P <0.01). The Japanese Orthopaedic Association's back pain score (JOA) and the motor conduction velocity of the tibial and common peroneal nerves were significantly increased compared to the conventional group (P < 0.01). After treatment, the role function, physical function, social function, and material life scores of the traditional Chinese medicine group were significantly higher than those of the conventional group (P < 0.01). The recurrence rate of the traditional Chinese medicine group was 2.50% (1/40) after a 6 - month follow - up, which was significantly lower than the conventional group's 15.00% (6/40), and the difference was statistically significant (P <0.05).Conclusion: The modified Duhuo Jisheng Decoction has a significant effect in treating residual numbness of nerve roots after intervertebral foramen endoscopy. It may improve nerve conduction velocity, alleviate numbness symptoms, improve lumbar spine function, and enhance quality of life by inhibiting inflammatory reactions, and has high safety.

Objective: To observe and analyze the clinical efficacy of Professor Wu Min's anti - allergy Formula from from Shanghai - style Xu's Pediatrics in treating pediatric allergic rhinitis.Methods: A total of 136 pediatric patients with allergic rhinitis treated at Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine and Youyi Community Health Service Center from December 2020 to December 2023 were collected and randomly divided into a treatment group (68 cases, loratadine tablets + anti - allergy Formula) and a control group (68 cases, loratadine tablets). Serum immune indicators and inflammatory factor levels in nasal secretions were measured and compared between the two groups. Symptom improvement and clinical efficacy were evaluated, and adverse reactions were recorded.Results: After treatment, the total serum immunoglobulin (Ig) E and the ratio of helper T cells (Th) 17/regulatory T cells (Treg) in the treatment group were significantly lower than those in the control group (P < 0.05). The interleukin (IL) - 4 level in nasal secretions of the treatment group was significantly lower than that of the control group (P <0.05), while the IL - 10 level was significantly higher (P < 0.05). After treatment, the scores for nasal congestion, nasal itching, runny nose, and sneezing in the treatment group were significantly lower than those in the control group (P <0.05). The total effective rate in the treatment group was significantly higher than that in the control group (P < 0.01). There was no significant difference in the incidence of adverse reactions such as gastrointestinal symptoms and skin reactions between the treatment group and the control group (P >0.05).Conclusion: Professor Wu Min's anti - allergy Formula is highly effective in treating pediatric allergic rhinitis, regulating immune function, reducing inflammatory responses, alleviating symptoms such as nasal congestion and itching, and demonstrating high safety.

Warming and Resolving method is one of the fundamental methods of clinical treatment of traditional Chinese medicine, and it can be seen in the Suwen - The Union of Heaven and Human Beings that the idea of the equilibrium between Yin and Yang can be clarified. The principle that yin and yang imbalance can lead to diseases in the human body. The treatment method of "Warming and Resolving" refers to using Warm Traditional Chinese Medicinal to correct the pathological state of yang deficiency in the body, and combining it with products that promote qi circulation, blood circulation, and blood stasis to resolve pathological results such as phlegm dampness, blood stasis, and pathological disorders caused by yang deficiency and inability to transport and transform. In clinical practice, early and mid stage liver cancer is commonly diagnosed with excess symptoms, while in the late stage, the syndrome gradually shifts from excess to deficiency, resulting in deficiency of positive qi and liver and kidney. On the basis of syndrome differentiation, modern doctors can achieve effective treatment of liver cancer by orally taking decoctions according to the theory of "Warming and Resolving". This article reviews the mechanism and research progress of some warm and warm drugs in the treatment of liver cancer from the perspective of modern pharmacology, providing reference for clinical medication.

Chronic musculoskeletal pain (CMP) is the most common type of chronic pain and includes cervical spondylosis, frozen shoulder, knee osteoarthritis, myofascial pain syndrome, rheumatoid arthritis, and fibromyalgia. At present, the clinical treatment of CMP is mainly based on drug therapy, but there are many adverse reactions in the treatment of Western medicine and there are differences in drug efficacy between different indications. Acupotomy therapy combines the advantages of traditional Chinese medicine acupuncture and Western medical surgical therapy, and is widely used in the treatment of CMP in clinical practice. Acupotomy therapy can improve the structure and function of the musculoskeletal system, affect the conduction of pain, and reduce inflammation through local release, thereby relieving pain and improving limb function. This article summarizes the application and progress of the underlying mechanisms of Acupotomy therapy in the field of CMP, aiming to provide a reference for the prevention and treatment of CMP and the clinical application of Acupotomy therapy.