Objective: To investigate the therapeutic effect of the Spleen - strengthening, Dampness - eliminating, and Turbidity - resolving Formula on patients with Spleen deficiency and damp - phlegm type polycystic ovary syndrome(PCOS) complicated by insulin resistance (IR).Methods: A total of 104 patients diagnosed with Spleen deficiency and damp - phlegm type PCOS complicated by IR were selected from Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine between April 2021 and April 2024. They were randomly assigned to the control group (n = 52, conventional treatment) and the Traditional Chinese Medicine (TCM) group (n = 52, receiving Spleen - strengthening, Dampness - eliminating and Turbidity - resolving Formula in addition to the control group treatment). Hormonal indicators, glucose and lipid metabolism indicators, TCM syndrome scores, imaging indicators, and the incidence of adverse reactions were compared before and after treatment.Results: After treatment, the FSH level in the TCM group was higher than that in the control group, while the levels of LH, AMH, LH/FSH, FPG, FINS, and HOMA - IR were lower (P < 0.05). The TCM group also showed lower scores for symptoms such as loose stools, diarrhea, loss of appetite, and fatigue compared to the control group (P < 0.05). Additionally, the ovarian volume and number of follicles in the TCM group were lower, while the endometrial thickness was higher than those in the control group (P <0.05). The incidence of adverse events in the TCM group did not differ statistically from that in the control group (P >0.05).Conclusion: The spleen - strengthening, dampness - eliminating, and turbidity - resolving formula can significantly improve metabolic status and enhance insulin sensitivity in patients with spleen - deficiency and phlegm- dampness type PCOS combined with IR. It is safe and holds great potential for broad clinical application and precision medicine.

Polycystic ovary syndrome  /  Spleen deficiency and damp - phlegm  /  Spleen - strengthening, Dampness- eliminating and Turbidity - resolving Formula  /  Insulin resistance