Diabetic nephropathy falls under the category of″Xiaoke Kidney disease″in traditional Chinese medicine and is considered a challenging condition resulting from prolonged and unresolved Xiaoke disease.Professor Nan Zheng believes that the key pathogenesis of Xiaoke Kidney disease lies in ″Toxin-induced damage to the Kidney collateral″.In clinical practice，the development of Xiaoke Kidney disease is analyzed from perspective of″Wind Toxin″as a pathogenic factor and its pathogenesis is explored.The treatment principle of″dispelling Wind and detoxifying as well as unblocking collateral network and protecting Kidney″is proposed.This approach emphasizes diagnosing the cause，considering treatment according to the cause，addressing the root of the disease as well as balancing both symptom relief and root treatment.

Deficiency of brain Qi and failure of Qi Hua are the fundamental causes of this disease.when Qi Hua is impaired，Dampness and Turbidity Toxins are generated internally，and when these Toxins rise upwards the brain marrow is damaged.with the reduction of marrow，the brain declines，and coupled with the disturbance of Shen caused by toxins，the functional failure of Shen activity appears.In clinical practice，treatment is often staged according to the different stages of neurogenic bladder.In the early stage，the pathological changes are mainly characterized by brain Qi deficiency，Kidney Qi deficiency and impaired Qi Hua.The disease is relatively mild and often only presents mild symptoms such as frequent urination，difficulty urinating，and increased nocturia.Treatment mainly focuses on tonifying brain Qi and assisting Yang to transform Qi.In the middle stage，the patient's condition is more complex than before，with both brain Qi deficiency and internally generated Dampness-Turbidity Toxins，damage to brain marrow，and a mix of deficiency and excess，where the root is deficient while the symptom is excess.The pathological mechanism is relatively complex，so treatment often addresses both the root and the symptom，tonifying deficiency while draining excess.Interventions are tailored according to specific symptoms，which may also include remedies for resolving Turbidity，promoting diuresis，and facilitating urination，which works effectively on both cause and manifestation.In the late stage，internal Dampness-Turbidity accumulation gives rise to Toxins，which ascend and impair the brain marrow，and disturb the brain Shen.At this stage，patients have brain Qi deficiency，marrow depletion，and dysfunction of the brain Shen，with deficiency being the main issue.Thus focusing on supporting the Zheng Qi is crucial.Treatment primarily involves nourishing the Kidney and marrow and warming the Kidney to strengthen the brain.Once the Zheng Qi is restored，with additional methods to expel the pathogenic factors being employed.

In clinical practice，application of medicine pares with character of being opposing and complementary in treatment of constipation Theory are as follows:（1）Ascending and descending:The intestines function properly with smooth downward Qi movement.The Middle Jiao（Spleen and Stomach）serves as the pivot for the ascending and descending transport of waste.Spleen Qi governs ascent while Stomach Qi governs descent.The Liver governs ascent and the Lung govern descent.The ascent and descent must coordinate with each other，regulating the flow of Qi.In pathological conditions，when Qi movement is abnormal-either due to weakened Spleen and Stomach transportation and absorption functions or stagnant Qi-the large intestine cannot function properly，leading to retained waste and constipation.（2）Zang and Fu Organ:The large intestine is a hollow organ，responsible for transporting waste but not storing it；it can be full but not solid.Its main function is to move waste.The Lung is solid organ that store vital essence without excreting it；they can be full but not solid.The Lung prefer moisture and dislike Dryness，governing the downward movement and regulating water passages，providing the motive force for the large intestine to expel waste.Pathologically，if Lung Dryness-Heat descends to the large intestine，or its descending function fails，the large intestine cannot transport properly，which causes constipation.（3）Exterior and interior:The large intestine is hollows and belong to the exterior，while the Lung is solid and belong to the interior.The Lung and large intestine interconnect via meridians，establishing exterior-interior relationship between organs，coordinating physiologically and affecting each other pathologically.（4）Deficiency and excess:Constipation involves both deficiency and excess patterns.Heat，Qi and cold-related constipation are excess patterns，while constipation caused by deficiency of Qi，blood and Yin or Yang belongs to deficiency.Different types of constipation often overlap or transform from one type to another，with excess leading to deficiency or deficiency leading to excess.（5）Dryness and Dampness:The large intestine governs Fluid，absorbing water during waste transport to regulate bodily Fluid metabolism.If there is excess Heat in the intestines，it excessively consumes water，leading to Dryness and hard stools；if cold deficiency affects the large intestine，it fails to absorb water，leading to loose stools and other illnesses.（6）Yin and Yang:The large intestine is active and belongs to Yang；when Yang is diseased，Yin accumulates，leading to stagnation and constipation.Professor Mao Dexi proposed that in treating constipation，one should closely follow the disease mechanism，using opposing and complementary medicine pairs，emphasizing medication balance in ascent and descent；combining Cold and Heat to promoting Yang with warming medicine to relieve constipation；using attack and tonification method at the same time to strengthen Spleen and relieve constipation；combining firmness and gentleness in medicine applying to moisten the intestines and relieve constipation；harmonizing Zang and Fu to treat at top aiming at curing disease of lower part of body，i.e.regulating the bowels.All of the above show significant clinical efficacy.

Objective:This study aims to investigate the mechanism by which Shenghui Decoction alleviates cognitive dysfunction in Alzheimer's disease（AD）by counteracting oxidative stress through the Nrf2/HO-1 signaling pathway.Methods:From a total of 45 mice，9 were randomly selected as the normal control group，while the remaining 36 were injected with Aβ25-35 oligomers via stereotaxic brain injection to establish an AD model.The model mice were divided into a model group，a low-dose Shenghui Decoction group，a high-dose Shenghui Decoction group，and a donepezil group，with 9 mice in each group.（1）Behavioral experiments were conducted to assess learning and memory abilities. Immunofluorescence technology was used to detect hippocampal amyloid β-protein（Aβ）deposition in mice，and the effects of Shenghui Decoction on AD-related oxidative stress were explored in combination with fluorescent probes and enzyme-linked immunosorbent assay（ELISA）.（2）Through network pharmacology methods，the active components and related targets of Shenghui Decoction were screened and intersected with disease targets for AD and oxidative stress，thereby constructing a ″Shenghui Decoction active components-targets-AD-oxidative stress″network and protein-protein interaction（PPI）network.Key active components of Shenghui Decoction were identified.In addition，Metascape database and MCODE algorithm were used to obtain target cluster modules，and molecular docking of key active components with cluster module targets was validated using AutoDockTools software.（3）Western blot（WB）experiments were performed to assess the protein expression levels of molecules with the best docking binding energies.Results:Behavioral experiments indicated that Shenghui Decoction（SHD）can improve learning and memory abilities in AD mice，reduce Aβdeposition（P＜0.05），increase superoxide dismutase levels（P＜0.05），and decrease reactive oxygen species and malondialdehyde content（P＜0.05）.Atotal of 48 active components and 114 overlapping targets related to ″AD-SHD-oxidative stress″were identified.The key active components include kaempferol，β-sitosterol，stigmasterol，scopolamine，and tetrahydropalmatine.Eight core targets were involved in important biological processes such as oxidative stress response，reactive nitrogen species response，and hypoxia response，including caspase -3（CASP3），signal transducer and activator of transcription 1（STAT1），peroxisome proliferator-activated receptor gamma（PPARG），nuclear factor erythroid 2（Nrf2），intercellular adhesion molecule-1（ICAM-1），heme oxygenase-1（HO-1），vascular cell adhesion molecule 1（VCAM1），and caspase-1（CASP1）.Molecular docking results showed that the core target HO-1 had the best binding effect with key active components of SHD.WB experiments verified that SHD exerts antioxidant effects by regulating the expression levels of Nrf2 and HO-1. Conclusion:SHD can improve learning and memory abilities in AD mice，reduce Aβproduction，and inhibit oxidative stress，with its mechanism related to the regulation of protein expression levels in the Nrf2/HO-1 pathway.

Objective:To explore the molecular mechanism of acupotomy intervention in knee osteoarthritis（KOA）based on transcriptome sequencing technology.Methods:Nine New Zealand rabbits were randomly divided into a blank group（3 rabbits）and a KOA modeling group（6 rabbits）.The modeling group was subjected to a modified Videman method fixation for6 weeks to establish the KOA model.After removing the fixation device，the rabbits were further randomly divided into a model group and an acupotomy group（3 rabbits each）according to Lequesne scores and intervened for 4 weeks.After the intervention，behavioral assessments were conducted，and transcriptome sequencing，Gene Ontology（GO），and Kyoto Encyclopedia of Genes and Genomes（KEGG）analyses were performed on the rabbit knee cartilage.Results:（1）After the intervention，compared with the model group，the Lequesne scores in the acupotomy group were significantly reduced（P＜0.01）；（2）Compared with the blank group，a total of 1 055 differentially expressed genes（DEGs）were identified in the model group.GO biological process analysis mainly involved functions such as ″inflammatory response″，″immune response″，and″extracellular matrix organization″.KEGG Level 2 analysis showed that the model group was mainly enriched in pathways related to ″infectious diseases″，″signal transduction″，and″immune system″.In addition，the upregulated DEGs in the model group were enriched in pathways such as″cytokine-cytokine receptor interaction″and″phagosome″，while the downregulated DEGs were enriched in ″cancer pathways″and ″axon guidance″. Compared with the model group，312 differentially expressed genes were identified in the acupotomy group.GO analysis indicated that these genes primarily involved functions such as″inflammatory response″，″tumor necrosis factor response″，and ″semaphorin-plexin signaling pathway″.KEGG Level 2 analysis showed enrichment mainly in pathways related to ″signal transduction″，″infectious diseases″，and ″immune system″.Moreover，downregulated DEGs in the acupotomy group were enriched in ″cytokine-cytokine receptor interaction″，″phagosome″，and ″osteoclast differentiation″，while upregulated DEGs were enriched in ″axon guidance″and ″protein digestion and absorption″.（3）qRT-PCR validation showed that acupotomy intervention significantly reduced the mRNA expression of CCL2，CCL7，and IL34. Conclusion:The molecular mechanism of acupotomy intervention in KOA mainly involves functions related to joint cartilage ″signal transduction″，″immune-inflammatory response″，and pathways such as ″cytokine-cytokine receptor interaction″，″phagosome″，and ″axon guidance″.

Objective:To investigate the therapeutic effects and mechanism of Diyu Qingbi Ointment on imiquimod cream（IMQ）-in duced psoriasis model mice.Methods:Fifty BALB/c mice were randomly divided into five groups:blank group，model group，modified Jiawei Qingbi group（treated with modified Diyu Qingbi Ointment），Diyu group（treated with Diyu Qingbi Ointment），and Calcipotriol ointment group.Each group contained 10 mice.The blank group received daily application of Vaseline ointment，while the remaining groups were subjected to daily 5% IMQ application to induce the model，followed 6 hours later by the corresponding drug intervention，continuously for 7 days.On day 7，psoriasis lesion area and severity index（PASI）scores were recorded；after the intervention，mice were sacrificed，psoriatic lesions were collected for HE staining to observe pathological morphological changes.ELISA was used to detect serum expression levels of interleukin-6（IL-6），interleukin-22（IL-22），and tumor necrosis factor-alpha（TNF-α）.qPCR was used to detect mRNA expression levels of Janus kinase 1（JAK1）and signal transducer and activator of transcription 3（STAT3）in lesion tissues；Western blot analysis was used to detect the expression levels of JAK1，p-STAT3/STAT3，and Survivin proteins in psoriatic lesions.Results:HE staining results showed that mice in the model group exhibited erythema，scaling，infiltrative lesions，as well as abnormal keratinization，hyperkeratosis，and Munro microabscesses，indicating psoriasis-like pathological changes. Compared with the model group，the pathological manifestations of each treatment group were alleviated to varying degrees，and PASI scores were significantly reduced，with the modified formula group showing lower PASI scores than the calcipotriol group（P＜0.05）.ELISA results indicated that compared with the blank group，the model group had significantly elevated levels of IL-6，IL-22，and TNF-α（P＜0.05）；compared with the model group，levels of IL-6，IL-22，and TNF-αin each treatment group were significantly reduced（P＜0.05）；IL-6 levels in the modified formula and Sanguisorba officinalis groups were significantly lower than those in the calcipotriol group（P＜0.05），and IL-22 levels in the modified formula group were significantly lower than those in both the Sanguisorba officinalis and calcipotriol groups（P＜0.05）.qPCR and Western blot results showed that compared with the blank group，the model group had significantly higher protein expression levels of JAK1，p-STAT3/STAT3，and Survivin，as well as elevated mRNA levels of JAK1 and STAT3（P＜0.05）；compared with the model group，expression levels of JAK1，p-STAT3/STAT3，Survivin proteins，and JAK1 and STAT3 mRNA were significantly reduced in the treatment groups（P＜0.05）；p-STAT3/STAT3 in the modified formula group was significantly lower than in the Sanguisorba officinalis group（P＜0.05），and JAK1 mRNA expression in the modified formula group was significantly lower than in the calcipotriol group（P＜0.05）. Conclusion:Modified Diyu Qingbi Ointment can reduce the severity of skin lesions in psoriatic model mice and improve their pathological manifestations，performing overall better than Sanguisorba officinalis Qingbi ointment.Its mechanism may be related to reducing the expression of inflammatory cytokines such as IL-6，IL-22，TNF-α，and inhibiting theJAK1/STAT3 signaling pathway as well as the expression of the apoptosis-inhibiting protein Survivin.

Objective:To explore the neuroprotective mechanism of Zuogui Pills in Parkinson's disease（PD）mice based on the p53/p21 pathway.Methods:Sixty male C57BL/6 mice were randomly divided into a control group，model group，low-dose Zuogui Pills group（1.8 g·kg^-1·d^-1），medium-dose Zuogui Pills group（3.6 g·kg^-1·d^-1），high-dose Zuogui Pills group（7.2 g·kg^-1·d^-1），and Madopar group（50 mg·kg^-1·d^-1）using a random number table method.Except for the control group，all other groups were modeled by intraperitoneal injection with 1-methyl-4-phenyl-1，2，3，6-tetrahydropyridine（MPTP）（30 mg·kg^-1·d^-1）for five consecutive days.From the first day of modeling，the treatment groups were administered orally once daily for 10 days. Behavioral assessment，immunohistochemistry，Western Blot，ELISA，β-galactosidase（SA-β-gal）staining，and immunofluorescence staining were used to observe the effect of Zuogui Pills on cellular senescence in PD mice.Results:The open field test results showed that，compared with the control group，the total distance traveled by mice in the model group was reduced（P＜0.01）；compared with the model group，the total distance traveled by mice in the medium-dose and high-dose Zuogui Pill groups，as well as the Madopar group，was increased（P＜0.01）.The pole-climbing test results showed that，compared with the control group，the time for mice in the model group to climb the pole was prolonged（P＜0.05）；compared with the model group，the pole -climbing time was shortened in the high-dose Zuogui Pill group（P＜0.05）.Immunohistochemistry and Western Blot detection of tyrosine hydroxylase（TH）protein showed that，compared with the control group，TH protein expression in the model group was decreased（P＜0.01）；compared with the model group，TH protein expression was increased in the medium-dose and high-dose Zuogui Pill groups，as well as in the Madopar group（P＜0.05 or P＜0.01）.ELISA results showed that，compared with the control group，the levels of dopamine（DA），dihydroxy-phenyl acetic acid（DOPAC），and homovanillic acid（HVA）in the substantia nigra and striatum tissues of the model group were decreased（P＜0.01）；compared with the model group，the levels of DA，DOPAC，and HVA in the substantia nigra and striatum tissues were increased in the low-dose，medium-dose，and high-dose Zuogui Pill groups，as well as in the Madopar group（P＜0.05 or P＜0.01）.Immunofluorescence double staining results showed that compared with the control group，the number of Lamin B1（nuclear lamina protein B1）positive cells in the model group was reduced（P＜0.01），and the number of GFAP（glial fibrillary acidic protein）positive cells was increased（P＜0.01）. Compared with the model group，the numbers of Lamin B1 positive cells in the low-dose，medium-dose，and high-dose Zuogui pills groups，as well as in the Madopar group，were increased（P＜0.01），while the numbers of GFAP positive cells were decreased（P＜0.05 or P＜0.01）.Western blot results showed that compared with the control group，the protein levels of p53（tumor protein 53，TP53），CDKN1A（Cyclin-dependent kinase inhibitor 1A，p21），and CDKN2A（Cyclin-dependent kinase inhibitor 2A，p16）in the substantia nigra tissue of the model group were all elevated（P＜0.01）. Compared with the model group，the protein levels of p53，p21，and p16 in the substantia nigra tissue were reduced in the low-dose，medium-dose，and high-dose Zuogui pills groups，as well as in the Madopar group（P＜0.01）.SA-β-gal staining results showed that compared with the control group，the area of SA-β-gal positive expression in the substantia nigra tissue of the model group was increased（P＜0.01）；compared with the model group，the area of SA-β-gal positive expression was decreased in the medium-dose and high-dose Zuogui pills groups，as well as in the Madopar group（P＜0.05 or P＜0.01）.ELISA results showed that compared with the control group，the levels of IL-6 and IL-8 in the substantia nigra tissue of the model group were increased（P＜0.01）；compared with the model group，the levels of IL-6 and IL-8 in the substantia nigra tissue were reduced in the low-，medium-，and high-dose Zuogui Pill groups，as well as in the Madopar group（P＜0.05 or P＜0.01）. Conclusion:Zuogui Pill may exert a protective effect on PD model mice by alleviating cellular senescence through inhibition of the p53/p21 pathway.

Objective: To observe the clinical efficacy of Xijiao Dihuang Decoction combined with Tripterygium Glycosides Tablet（GTW）in treating patients with allergic purpura（Henoch-Schonlein purpura，HSP）of the blood-heat-wandering syndrome type. Methods:Eighty-two patients with simple skin-type allergic purpura diagnosed with blood-heat-wandering syndrome in traditional Chinese medicine were randomly divided into the Xijiao Dihuang Decoction group（TCMgroup，40 cases）and the GTW group（42 ca ses）.The TCMgroup received Xijiao Dihuang Decoction in addition to conventional Western medical treatment，while the GTW group received GTW along with conventional Western treatment；both groups were treated continuously for 8 weeks.The clinical cure rate，rash remission time，recurrence frequency of skin purpura，and changes in TCMsyndrome scores，urinary microalbumin（M-Alb），β2-microglobulin（β2-Mb），N -acetyl -β-D -glucosaminidase（NAG）enzyme，blood routine，liver and kidney function，and serum Gd-IgA1 levels before and after treatment were compared.Follow-up was conducted up to 26 weeks to evaluate the clinical efficacy，renal protection，and medication safety of the GTW group，and the correlation between serum Gd-IgA1 expression levels and clinical symptoms was analyzed.Results:After 8 weeks of treatment，compared with the Traditional Chinese Medicine（TCM）group，the GTW group showed significantly better outcomes in effective rate，rash resolution time，frequency of HSP recurrence，TCMsyndrome scores，urine M-Alb，β2-MG，NAG enzyme，and serum Gd-IgA1 levels（P＜0.05）. Compared with pretreatment levels in the same group，the GTWgroup showed significant reductions in the aforementioned blood and urine indicators（P＜0.05），whereas in the TCMgroup，post-treatment urine M-Alb and NAG enzyme levels were significantly higher than before treatment（P＜0.05）. Comparisons of red blood cells，ALT，AST，and creatinine levels between the two groups showed no statistically significant differences（P＞0.05）.White blood cell and platelet levels in the GTWgroup were significantly decreased（P＜0.05），but remained within the normal range. Before treatment，serum Gd-IgA1 levels in 82 patients were positively correlated with TCM syndrome scores（r =0.748）.At 26 -week follow-up，the incidence of nephritis in the GTWgroup was significantly lower than in the TCMgroup（P＜0.05），and the onset was significantly delayed（P＜0.05）. Conclusion:GTW can significantly improve clinical symptoms in HSP patients，reduce the recurrence of purpura and the incidence of purpura nephritis，and effectively prevent kidney damage.Its mechanism may be related to the reduction of serum Gd-IgA1 levels in patients with allergic purpura，thereby exerting a renal protective effect.

Objective:This study aims to explore the independent risk factors for portal vein thrombosis（PVT）formation after splenectomy and selective shunt surgery，to construct a nomogram model predicting postoperative PVT，and to clarify the clinical efficacy of inte grative medicine interventions in preventing postoperative PVT.Methods:A retrospective analysis was conducted on clinical data of inpatients undergoing splenectomy or selective shunt surgery for liver cirrhosis at the affiliated hospital of Shaanxi University of Chinese Medicine from August 2014 to December 2022.The study was divided into two parts:Patients were grouped into PVT and non-PVT groups based on the presence of postoperative PVT.Univariate analysis，LASSO regression，and binary logistic regression were performed on general patient characteristics，preoperative and postoperative indicators.A nomogram prediction model was then constructed，with model evaluation using ROC and calibration curves.For patients who received Western medical intervention，they were further divided into a control group and a treatment group based on whether they took traditional Chinese medicine promoting blood circulation and removing blood stasis.The effects of intervention timing and methods on postoperative PVT formation were analyzed，along with comparisons of blood routine and coagulation indices between the two groups.Additionally，the composition of specific traditional Chinese medicines used in the integrated intervention group was statistically analyzed.Results:Analysis of independent risk factors for postoperative PVT formation and the establishment of a nomogram model:This part of the study ultimately included 227 patients，of which 112 developed PVT postoperatively，and 115 did not. Compared with the non-PVT group，patients in the PVT group had differences in age，portal vein diameter（PVD），white blood cell count（WBC）on postoperative day 1，platelet count（PLT），PLT increase，and PLT and PLT increase on postoperative days 3 and 7，all of which were statistically significant（P＜0.05）.According to LASSO-Logistic regression analysis，PVD and PLT increase on postoperative day 7 were independent risk factors for postoperative PVT formation.When PVD ≥ 15.1 mm and PLT increase on postoperative day 7 ≥278.5 ×10⁹ L^-1，the incidence of PVT significantly increased. Based on the Logistic regression analysis，a nomogram prediction model was constructed with an AUC value of 0.756，95% CI（0.693-0.820），and the calibration curve showed good fit，indicating good predictive performance.Evaluation of postoperative PVT formation with integrated Chinese and Western medicine intervention:This part of the study included 127 patients，of whom 60 developed PVT postoperatively，and 67 did not. Compared with the non-PVT group，patients in the PVT group-initiated intervention later，with statistically significant differences（P＜0.05）. Compared with the Western medicine intervention group，the integrated Chinese and Western medicine intervention group had a lower postoperative PVT incidence，with statistically significant differences（P＜0.05）.After treatment，the integrated group also had lower levels ofWBC，PLT，D-dimer（D-D），and fibrin degradation products（FDP），with statistically significant differences（P＜0.05）. Conclusion:PVD and PLT increase on postoperative day 7 are independent risk factors for postoperative PVT formation.When PVD ≥15.1 mm and PLT increase on postoperative day 7 ≥278.5 ×10⁹ L^-1，the incidence of PVT significantly increases.Integrated Chinese and Western medicine intervention can inhibit postoperative PLT elevation，reduce WBC，D-D，and FDP levels，and decrease the occurrence of PVT.

Objective:To explore the effects of Baizi Weijing Decoction combined with acupoint massage on children with mycoplasma pneumonia in terms of respiratory mechanics，pulmonary function，and T-cell subsets.Methods:80 children with mycoplasma pneumonia were selected as research subjects and randomly divided into two groups，40 cases each. Both groups received conventional treatment，the control group additionally received acupoint massage，and the observation group was treated with Baizi Weijing Decoction based on the control group.The clinical efficacy，traditional Chinese medicine syndrome scores，relevant respiratory mechanics indicators，T lymphocyte subsets，and pulmonary function of the two groups were compared.Results:The observation group had shorter hospital stays（6.59 ±1.15 days），time to body temperature normalization（3.18 ±0.85 hours），time for cough disappearance（3.98 ±0.96 days），time for lung rales disappearance（5.82 ±0.54 days），and time for dyspnea disappearance（3.74 ±0.34 days）compared to the control group，which had hospital stays of（9.26 ±1.25 days），time to body temperature normalization（5.87 ±1.03 hours），time for cough disappearance（5.18 ±0.72 days），time for lung rales disappearance（7.11 ±0.69 days），and time for dyspnea disappearance（5.42 ±0.45 days）.The differences between the two groups were statistically significant（P＜0.05）；after treatment，the traditional Chinese medicine syndrome scores for sore throat，fever，cough，and muscle aches in the observation group were（1.15 ±0.26），（1.39 ±0.17），（0.93 ±0.11），and（1.07 ±0.20），respectively，which were lower than those in the control group（P＜0.05）.After treatment，both groups of children showed improvements in oxygenation index and respiratory rate，with the observation group having a higher oxygenation index and a significantly lower respiratory rate than the control group（P＜0.05）.After treatment，the comparison of pulmonary function-related indicators and T lymphocyte subsets between the two groups showed the observation group was significantly better than the control group（P＜0.05）. Conclusion:Baizi Weijing Decoction with acupoint massage can improve the clinical efficacy，accelerate recovery，and improve respiratory mechanics and lung function in children with mycoplasma pneumonia.