Objective: To observe the clinical efficacy of Xijiao Dihuang Decoction combined with Tripterygium Glycosides Tablet（GTW）in treating patients with allergic purpura（Henoch-Schonlein purpura，HSP）of the blood-heat-wandering syndrome type. Methods:Eighty-two patients with simple skin-type allergic purpura diagnosed with blood-heat-wandering syndrome in traditional Chinese medicine were randomly divided into the Xijiao Dihuang Decoction group（TCMgroup，40 cases）and the GTW group（42 ca ses）.The TCMgroup received Xijiao Dihuang Decoction in addition to conventional Western medical treatment，while the GTW group received GTW along with conventional Western treatment；both groups were treated continuously for 8 weeks.The clinical cure rate，rash remission time，recurrence frequency of skin purpura，and changes in TCMsyndrome scores，urinary microalbumin（M-Alb），β2-microglobulin（β2-Mb），N -acetyl -β-D -glucosaminidase（NAG）enzyme，blood routine，liver and kidney function，and serum Gd-IgA1 levels before and after treatment were compared.Follow-up was conducted up to 26 weeks to evaluate the clinical efficacy，renal protection，and medication safety of the GTW group，and the correlation between serum Gd-IgA1 expression levels and clinical symptoms was analyzed.Results:After 8 weeks of treatment，compared with the Traditional Chinese Medicine（TCM）group，the GTW group showed significantly better outcomes in effective rate，rash resolution time，frequency of HSP recurrence，TCMsyndrome scores，urine M-Alb，β2-MG，NAG enzyme，and serum Gd-IgA1 levels（P＜0.05）. Compared with pretreatment levels in the same group，the GTWgroup showed significant reductions in the aforementioned blood and urine indicators（P＜0.05），whereas in the TCMgroup，post-treatment urine M-Alb and NAG enzyme levels were significantly higher than before treatment（P＜0.05）. Comparisons of red blood cells，ALT，AST，and creatinine levels between the two groups showed no statistically significant differences（P＞0.05）.White blood cell and platelet levels in the GTWgroup were significantly decreased（P＜0.05），but remained within the normal range. Before treatment，serum Gd-IgA1 levels in 82 patients were positively correlated with TCM syndrome scores（r =0.748）.At 26 -week follow-up，the incidence of nephritis in the GTWgroup was significantly lower than in the TCMgroup（P＜0.05），and the onset was significantly delayed（P＜0.05）. Conclusion:GTW can significantly improve clinical symptoms in HSP patients，reduce the recurrence of purpura and the incidence of purpura nephritis，and effectively prevent kidney damage.Its mechanism may be related to the reduction of serum Gd-IgA1 levels in patients with allergic purpura，thereby exerting a renal protective effect.