Latest ArticlesTo observe the effect of Duhuo Jisheng Decoction（独活寄生汤）on Toll-like receptor 4（TLR4）/nuclear transcription factorκB（NF-κB）signaling pathway in elderly patients with knee osteoarthritis.
A total of 118 elderly patients with knee osteoarthritis were divided into observation group and control group（59 cases in each）according to random number table method. The control group was treated with Glucosamine Hydrochloride Tablets and the observation group was treated with Duhuo Jisheng Decoction on the basis of the control group，4 weeks for 1 course of treatment，a total of 2 courses of treatment. The clinical efficacy of the two groups was compared，and the TCM syndrome scores，Western Ontario and McMaster University Osteoarthritis Index（WOMAC）scale score and visual analogue scale（VAS）score before and after treatment were compared between the two groups. Serum levels of interleukin-6（IL-6），matrix metalloproteinase-1（MMP-1），osteocalcin（BGP），carboxy-terminal peptideβdegradation product of type I procollagen（β-CTX）and carboxy-terminal peptide（PICP）of type I procollagen，and the protein expressions of TLR4 and NF-κB were observed before and after treatment in the two groups.
After treatment，the total effective rate of the observation group was 96.61%，higher than that（83.05%）of control group，and the difference was statistically significant（P<0.05）. After treatment，the scores of TCM syndrome in both groups were lower than those before treatment，and the score of the observation group was lower than that of the control group（P<0.05）. After treatment，the WOMACscores and VASscores of both groups were lower than those before treatment，and the scores of the observation group were lower than those of the control group（P<0.05）. After treatment，the levels of IL-6，MMP-1，TLR4 and NF-κB protein in two groups were lower than those before treatment，and the levels of the observation group were lower than those of the control group（P<0.05）. After treatment，the levels of serum BGP and PICP of the two groups were higher than those before treatment，and the levels of the observation group were higher than those of the control group，and the serumβ-CTX level of the two groups was lower than that before treatment，and the level of the observation group was lower than that of the control group（P<0.05）.
The application of Duhuo Jisheng Decoction in the elderly patients with knee osteoarthritis is beneficial to improve the clinical efficacy，reduce the pain，fatigue and other symptoms，and enhance the joint function. The mechanism of action may be related to improving bone metabolism indexes，inhibiting inflammatory factors through TLR4/NF-κB signaling pathway and alleviating cartilage damage.
In order to explore the effect of Modified Jiegeng Yuanshen Decoction（桔梗元参汤加减）in the treatment of allergic rhinitis（AR）mediated by advanced glycation end product（AGE）-receptor for advanced glycation end product（RAGE）signaling pathway.
A total of 260 patients with AR treated in the hospital from January 2022 to June 2023 were selected and divided into a control group（130 cases）and an observation group（130 cases）by random number table method. The control group was given loratadine，and the observation group was treated with Modified Jiegeng Yuanshen Decoction of the hospital. The total effective rate，clinical symptoms，expression levels of AGE and RAGE proteins，inflammatory indicators［nuclear factor kappa-B（NF-κB），interleukin-6（IL-6），reactive oxygen species（ROS）］and adverse reactions were compared between the two groups.
Compared with that of the control group，the total effective rate of the observation group was significantly higher（P<0.05），and the clinical symptom scores were significantly decreased（P<0.05），the expression levels of AGEand RAGEproteins and the levels of NF-κB，IL-6 and ROSwere significantly decreased（P<0.05）. Mild adverse reactions such as dizziness，fatigue and gastrointestinal discomfort occurred in both groups. The incidence of adverse reactions in the observation group was slightly lower than that in the control group，but there was no significant difference（P>0.05）.
Modified Jiegeng Yuanshen Decoction can reduce the degree of inflammatory response in patients with AR by inhibiting AGE-RAGE/NF-κB/IL-6 and AGE-RAGE/ROSsignaling pathways，thereby improving the treatment efficiency and relieving clinical symptoms.
The aim was to investigate the effects of Jianpi Fuzheng Runzao Decoction（健脾扶正润燥汤）on the survival and toxic side effects of chemotherapy patients with advanced breast cancer.
A hundred and twenty cases of breast cancer patients in the hospital were included and randomly divided into observation group and control group according to the random number table method，with 60 cases in each group. The control group was given conventional treatment with western medicines，and the observation group was given Jianpi Fuzheng Runzao Decoction on the basis of the control group. The clinical benefit rate，immune function，median survival，median progression-free survival and the occurrence of toxic side effects were observed before and after treatment in both groups.
After treatment，the clinical benefit rate of the observation group was 73.33%（44/60），which was significantly higher than that（53.33%，32/60）of the control group（P<0.05）. After 2 cycles of treatment，the blood routine indexes of the two groups were lower than those before treatment（P<0.05）. After 4 cycles of treatment，the blood routine indexes of the two groups increased，and the improvement of the observation group was significantly better than that of the control group（P<0.05）. After treatment，the levels of immunoglobulin（Ig）G，IgA and IgM of both groups were significantly higher than those before treatment（P<0.05），and the improvement of the indicators of the observation group was significantly better than that of the control group（P<0.05）. The toxic side effects of both groups were classⅠ～Ⅱ，and the incidence rate of toxic side effects was 23.33%（14/60）in the observation group，which was significantly lower than that（45.00%，27/60）in the control group（P<0.05）. After treatment，the median survival（OS）time of the observation group and the control group was 14.2 months and 11.6 months，respectively，and the time of the observation group was better than that of the control group（P<0.05）. The median progression-free survival（PFS）time of the observation group and the control group was7 months and 5.3 months，respectively，and the time of the observation group was better than that of the control group（P<0.05）.
Jianpi Fuzheng Runzao Decoction has significant efficacy in patients with advanced breast cancer chemotherapy，which can effectively improve the survival and immune function，and reduce the incidence of toxic side effects in patients.
To explore the therapeutic effect of Xuefu Zhuyu Decoction（血府逐瘀汤）combined with warm acupuncture and moxibustion on the pain of lumbar disc herniation and its influence on pain mediators and inflammatory factors.
Eighty-six patients with lumbar disc herniation pain admitted to the Second Affiliated Hospital of Heilongjiang University o Chinese Medicine from February 2022 to August 2023 were selected and divided into a study group and a control group using a random number table method，with 43 cases in each group. The control group was treated with warm acupuncture and moxibustion，while the study group was treated with Xuefu Zhuyu Decoction on the basis of the control group. After 14 days of treatment，the traditional Chinese medicine symptoms，efficacy，degree of pain，serum pain mediators and inflammatory factors，and daily activity ability of the two groups of patients were compared，and adverse reactions during the treatment period were recorded.
After treatment，the main symptom scores and secondary symptom scores decreased in both groups（P<0.05）. The main symptom scores and secondary symptom scores in the study group were lower than those in the control group after treatment（P<0.05）. The total effective rate in the study group was higher than that in the control group（P<0.05）. Both groups showed a decrease in scores of back pain，radiating pain，referred pain and neuropathic pain after treatment（P<0.05）. The study group had lower scores of back pain，radiating pain，referred pain and neuropathic pain than the control group after treatment（P<0.05）. The levels of serotonin（5-HT），prostaglandin E2（PGE2）and tumor necrosis factor-alpha（TNF-α）decreased in both groups after treatment（P<0.05）. The study group had lower levels of 5-HT，PGE2 and TNF-αthan the control group after treatment（P<0.05）. The activities of daily living（ADL）scores increased（P<0.05），and the Oswestry Disability Index（ODI）scores decreased in both groups after treatment（P<0.05）. The study group had higher ADL scores than the control group（P<0.05），and ODI scores were lower than those of the control group（P<0.05）. There was no statistically significant difference in the incidence of adverse reactions between the two groups（P>0.05）.
Xuefu Zhuyu Decoction combined with warm acupuncture and moxibustion is helpful to relieve the pain of patients with lumbar disc herniation，inhibit the expressions of pain and inflammatory factors，and improve the ability of daily activities of patients.
To observe the clinical effect of five-element acupuncture and moxibustion reusing the source acupoints combined with Ningshen Wendan Decoction（宁神温胆汤）on schizophrenic auditory hallucinations.
A total of 82 patients with phlegm-fire disturbance type of schizophrenia who were treated in the hospital from June 2021 to January 2023 were selected and divided into conventional group（41 cases）and traditional Chinese medicine（TCM）group（41 cases）by random number table method. The conventional group was given risperidone oral treatment，and the TCM group was given five-element acupuncture reusing the source acupoints combined with Ningshen Wendan Decoction on this basis. TCM syndrome scores，Positive and Negative Symptom Scale（PANSS）and Auditory Hallucinations Rating Scale（AHRS）scores，brain neurotransmitter levels，clinical efficacy and adverse reactions were observed in two groups.
After treatment，TCM syndrome scores，PANSS and AHRSscores and dopamine（DA）level in TCM group were lower than those in the conventional group（P<0.05），and 5-hydroxytryptamine（5-HT）level was higher than that in the conventional group（P<0.05）. The total effective rate of the TCM group was higher than that of the conventional group（P<0.05）. There was no significant difference in the total incidence of adverse reactions between the two groups（P>0.05）.
The five-element acupuncture reusing the source acupoints method combined with Ningshen Wendan Decoction can effectively improve the clinical symptoms such as auditory hallucinations，the levels of brain neurotransmitters，the treatment efficiency and safety.
To investigate the effect of Guling Cream（骨灵膏）on bone regeneration and chondrocyte apoptosis in rabbit knee cartilage defect model.
Thirty male rabbits（New Zealand）were randomly divided into model group，blank control group and Guling Cream low，medium and high dose groups，with 6 rabbits in each group. The model of knee cartilage defect was established by modified joint scoring method. The blank control group did not drill，and the Guling Cream low，medium and high dose groups were given Guling Cream with dose of 1.16 mL/kg（3.70 g/kg），3.47 mL/kg（11.10 g/kg），10.41 mL/kg（33.31 g/kg）by gavage，respectively. The the model group blank and control group were given 3.47 mL/kg normal saline，once every 3 days for 12 weeks. The Wakitani score was used for histological score. Masson staining was used for pathological evaluation，and terminal transferase-mediated dUTP nick end labeling（TUNEL）method was used to detect synovial and chondrocyte apoptosis. The levels of superoxide dismutase（SOD），nitric oxide（NO），lipid peroxide（LPO）in synovial fluid and pyridine phenol（PYD）in urine were detected by enzyme-linked immunosorbent assay.
At the 12th week after administration，the wound area in the model group was uneven，and the cartilage defect area in each dose group was filled in. The surface of the low dose group was rough，while the medium dose group showed less smoothness. The surface of the high dose group was relatively smooth，and the joint cartilage structure was good. Compared with those in the model group，the arrangement of chondrocytes in each dose group was more regular，and chondrocytes secreted more collagen fibers. The histological scores and apoptosis rates of synovial and chondrocytes in the low，medium and high dose groups of were higher than those in the control group and lower than those in the model group. As the dose increased，the histological scores and apoptosis rates of synovial and chondrocytes showed a decreasing trend（P<0.05）. The levels of joint fluid NO and LPO and urine PYD in the low，medium and high dose groups were higher than those in the control group，but lower than those in the model group. As the dose increased，the expression levels showed a descending trend，and the difference was statistically obvious（P<0.05）. The SOD levels in the joint fluid of the low，medium and high dose groups were lower than those of the control group and higher than those of the model group. As the dose increased，the expression level showed an growing trend，and the difference was statistically obvious（P<0.05）.
Guling Cream can improve the cartilage injury and accelerate the repair of cartilage tissue in rabbits with knee cartilage defect possibly by regulating the expressions of oxidative stress factors to inhibit chondrocyte apoptosis and promote cartilage tissue regeneration.
Ischemic stroke is a common clinical cardiovascular and cerebrovascular disease. At present，the incidence of ischemic stroke in China is at a rapid rising stage，exceeding the global average growth level. The molecular mechanism is complex，and the prognosis is poor. After standardized treatment，the patients may still leave a variety of sequelae，mainly including cognitive function and physical motor dysfunction，which can seriously threaten human health. The application effect of modern rehabilitation therapy in patients with ischemic stroke is limited，and the rehabilitation process is long and the effect is slow，which increases the difficulty of cooperation and the benefit of patients is limited. The disorder of Qi and blood and the imbalance of Yin and Yang are the general pathogenesis of sequelae of stroke. Acupuncture therapy is an important part of traditional Chinese medicine，which makes up for the shortcomings of modern medical treatment. It can be treated through the conduction effect of meridians and acupoints as well as specific manipulations. This article reviewed the promotion effect of acupuncture on cognitive function and rehabilitation of physical motor dysfunction after ischemic stroke，further clarified the relevant mechanism of acupuncture in patients with ischemic stroke，revealed the multi-target，multi-layer and multi-pathway characteristics of acupuncture，and pointed out the existing problems and shortcomings of current research so as to provide theoretical basis and method reference for the rehabilitation treatment of patients in the future.
Yimucao（Leonuri Herba）has a long history of drug use as a medicine for promoting blood circulation and regulating menstrual cycle. It mainly contains alkaloids，flavonoids，diterpenes and other chemical components，and has pharmacological effects such as anti-oxidation，anti-apoptosis，anti-inflammatory and analgesic. This paper summarized the chemical composition，pharmacological action，clinical application and safety evaluation of Yimucao（Leonuri Herba）. The quality marker（Qmarker）of Yimucao（Leonuri Herba）was predicted and analyzed from the aspects of plant affinity，traditional medicinal properties and efficacy，component measurability，different origin，harvesting period and different medicinal parts，processing and chemical composition related characteristics，pharmacokinetics，modern clinical use，etc. It is preliminatively speculated that leonurine hydrochloride，stachydrine hydrochloride，stachydrine，leonurine，rutin，quercetin，syringic acid，hyperoside and isoquercitrin are used as Q-markers to provide reference for the study of Q-markers and the establishment of systematic quality control system of Yimucao（Leonuri Herba）.
Panax notoginseng saponins（PNS）are the key active components extracted from Sanqi［Panax notoginseng（Burk.）F. H. Chen.］. They mainly include constant components such as ginsenoside Rb1，Rd，Rg1，Re and notoginsenoside R1，as well as rare components such as ginsenoside CK，F1 and F2. These components can be converted from constant components to rare components by biological enzyme catalysis such asβ-glucosidase andα-L-rhamnosidase or chemical methods. The main action sites were the C-3 and C-20 glycosidic bonds of protopanaxadiol-type ginsenoside and the C-6 and C-20 glycosidic bonds of protopanaxatriol-type ginsenosides. Studies have shown that PNScan exert anti-tumor effects by inhibiting tumor cell proliferation，inducing tumor cell apoptosis，inhibiting cell metastasis and invasion，regulating cell cycle and energy metabolism，promoting tumor microvascular normalization，reversing multi-drug resistance，and sensitizing chemotherapeutic drugs. In this paper，the structures of 32 monomer saponins in PNSwere summarized. The mechanism，action sites and groups of enzymatic and chemical conversions of PNSstructure were comprehensively analyzed. At the same time，the anti-tumor activity and mechanism of PNSand its derivatives were discussed. In addition，this paper believes that future research should explore the structure-activity relationship and pharmacokinetics of PNSin order to efficiently and multi-directionally develop anti-tumor drugs based on PNSto optimize their efficacy and provide reference for their further clinical development.
The traditional Chinese medicine（TCM）appropriate technique，with extensive clinical experience and notable therapeutic effects，are widely used as an adjunct to assisted reproductive technology（ART），which may improve the rate of pregnancy and bring new hope and therapeutic method to infertile patients. However，due to the limited availability of highquality clinical research evidence，there is currently no systematic guideline for the TCM appropriate technique in this field. This consensus，which integrates qualitative and quantitative literature research and nationwide expert opinions，recommends corresponding treatments tailored to different stages of ART. It aims to standardize the clinical practice of TCM appropriate technique during the ART treatment cycle.
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