The aim was to investigate the effects of Jianpi Fuzheng Runzao Decoction（健脾扶正润燥汤）on the survival and toxic side effects of chemotherapy patients with advanced breast cancer.

A hundred and twenty cases of breast cancer patients in the hospital were included and randomly divided into observation group and control group according to the random number table method，with 60 cases in each group. The control group was given conventional treatment with western medicines，and the observation group was given Jianpi Fuzheng Runzao Decoction on the basis of the control group. The clinical benefit rate，immune function，median survival，median progression-free survival and the occurrence of toxic side effects were observed before and after treatment in both groups.

After treatment，the clinical benefit rate of the observation group was 73.33%（44/60），which was significantly higher than that（53.33%，32/60）of the control group（P<0.05）. After 2 cycles of treatment，the blood routine indexes of the two groups were lower than those before treatment（P<0.05）. After 4 cycles of treatment，the blood routine indexes of the two groups increased，and the improvement of the observation group was significantly better than that of the control group（P<0.05）. After treatment，the levels of immunoglobulin（Ig）G，IgA and IgM of both groups were significantly higher than those before treatment（P<0.05），and the improvement of the indicators of the observation group was significantly better than that of the control group（P<0.05）. The toxic side effects of both groups were classⅠ～Ⅱ，and the incidence rate of toxic side effects was 23.33%（14/60）in the observation group，which was significantly lower than that（45.00%，27/60）in the control group（P<0.05）. After treatment，the median survival（OS）time of the observation group and the control group was 14.2 months and 11.6 months，respectively，and the time of the observation group was better than that of the control group（P<0.05）. The median progression-free survival（PFS）time of the observation group and the control group was7 months and 5.3 months，respectively，and the time of the observation group was better than that of the control group（P<0.05）.

Jianpi Fuzheng Runzao Decoction has significant efficacy in patients with advanced breast cancer chemotherapy，which can effectively improve the survival and immune function，and reduce the incidence of toxic side effects in patients.