To explore the clinical therapeutic effect of Mongolian medicine Anshen Buxin Liuwei Pills（安神补心六味丸）and Shugan Jieyu Capsules（舒肝解郁胶囊）on post-stroke depression.

A total of 120 patients with post-ischemic stroke depression due to liver stasis and phlegm coagulation syndrome were selected and randomly divided into a control group and an observation group，with 60 cases in each group. On the basis of conventional treatment，the control group was treated with fluoxetine hydrochloride dispersible tablets while the observation group was treated with Anshen Buxin Liuwei Pills and Shugan Jieyu Capsules. The course of treatment for both groups was 8 weeks. The clinical treatment effects，traditional Chinese medicine（TCM）syndrome scores，Hamilton Depression Scale（HAMD）scores，Modified Edinburgh Scandinavian Survival Score（MESSS），serum levels of 5-hydroxytryptamine（5-HT），norepinephrine（NE），brain-derived neurotrophic factor（BDNF）and Brarthel index（BI）between the two groups before treatment and at the 4th and 8th week of treatment were compared.

The total effective rate of the observation group reached 93.33%（56/60）after treatment，which was significantly better than that（80.00%，48/60）of the control group（P<0.05）. The TCM syndrome scores of the patients in both groups showed a trend of significant reduction at the 4th and 8th week of treatment（P<0.05），and at the same time，it could be seen that the scores of the observation group were significantly lower than those of the control group（P<0.05）. The scores of HAMD and MESSSwere significantly lower than those before treatment（P<0.05），while the scores of the observation group were significantly lower than those of the control group（P<0.05）. In both groups，the serum levels of 5-HT，NE and BDNF were significantly higher than those before treatment at the 4th and 8th week of treatment（P<0.05），while the serum levels of 5-HT，NE and BDNF in the observation group were also higher than those in the control group（P<0.05）. BI indexes were higher than those before treatment at the 4th and 8th week of treatment in both groups（P<0.05），while BIindex in the observation group was significantly higher than that in the control group（P<0.05）.

Mongolian medicine Anshen Buxin Liuwei Pills combined with Shugan Jieyu Capsules can significantly improve the clinical efficacy of patients with post-ischemic stroke depression due to liver stasis and phlegm coagulation syndrome，reduce the degree of depression，promote the recovery of neurological function and increase the serum levels of 5-HT，NE and BDNF，thereby improving the quality of life and improving prognosis.

To observe the clinical efficacy of Daxianxiong Decoction（大陷胸汤）in the treatment of severe acute pancreatitis and acute lung injury.

Eighty patients with severe acute pancreatitis and acute lung injury who met the inclusion criteria for this study were randomly divided into two groups using a random number table method. The control group received symptomatic treatment with conventional western medicine，while the observation group combined with oral administration of Daxianxiong Decoction in addition. After 7 days of continuous treatment，the Murray lung injury scores and modified Marshall scores，the blood gas indexes［blood oxygen partial pressure（PaO₂），blood oxygen saturation（SaO₂），partial pressure of carbon dioxide（PCO₂），oxygenation index］，the respiratory mechanics indexes［airway resistance（Raw），work of breath（WOB），dynamic lung compliance（Cdyn）］and the serum inflammatory indexes［C-reactive protein（CRP），tumor necrosis factor-α（TNF-α），interleukin-6（IL-6），procalcitonin（PCT）］between two groups were compared，and the total effective rate and drug safety between the two groups were compared.

After treatment，the scores of Murray lung injury and modified Marshall，the values of PaCO₂，Raw and WOB，the serum levels of CRP，PCT，IL-6 and TNF-αwere all lower than those before treatment（P<0.05），and the scores，values and levels of the observation group were lower than those the control group（P<0.05）. The values of PaO₂，SaO₂ and oxygenation index and Cdyn were higher in both groups（P<0.05），the values of the observation group were higher than those of the control group（P<0.05）. The total effective rate of the observation group（92.5%）was higher than the control group（75.0%）（P<0.05）. There were no adverse reactions related to medication during the treatment in both groups.

The application of Daxianxiong Decoction can reduce serum inflammatory cytokine levels，improve respiratory mechanical parameters and increase oxygen partial pressure and blood oxygen levels in patients with severe acute pancreatitis and acute lung injury，which help to alleviate organ damage in patients with definite therapeutic effects.

To observe the effect of Fuling Sini Decoction（茯苓四逆汤）combined with Danggui Shaoyao Powder（当归芍药散）on serum cardiac troponin levels in patients with chronic heart failure of Yang deficiency and blood stasis syndrome.

Ninety-eight patients with chronic heart failure of Yang deficiency and blood stasis syndrome treated in the hospital from September 2022 to June 2023 were selected as the research objects. All patients were randomly divided into two groups according to the order of admission. There were49 patients in the control group and the observation group. The patients in the control group were treated with conventional anti-heart failure treatment，and the observation group was treated with Fuling Sini Decoction and Danggui Shaoyao Powder on the basis of the control group. After 2 weeks of treatment，the cardiac function classification，TCM syndrome scores，cardiac ultrasound indexes［left ventricular end-systolic diameter（LVESD），left ventricular end-diastolic diameter（LVEDD），left ventricular ejection fraction（LVEF）］，serum detection indexes［high-sensitivity cardiac troponin I（hs cTnI），plasma N-terminal pro-brain natriuretic peptide（NTproBNP）］and adverse reactions were compared between the two groups.

There was no significant difference in cardiac function classification between the two groups before treatment（P>0.05）. After treatment，the cardiac function classification of the observation group was better than that of the control group（P<0.05）. After treatment，the scores of TCM syndromes in the two groups were significantly decreased，and the score of the observation group was significantly lower than that of the control group（P<0.05）. There was no significant difference in cardiac ultrasound indexes between the two groups before treatment（P>0.05）. After treatment，the values of LVESD and LVEDD decreased and LVEF increased in both groups. The above indexes in the observation group were significantly better than those in the control group（P<0.05）. After treatment，the levels of serum hs cTnI and NT proBNP in the two groups decreased significantly，and those in the observation group were significantly lower than those in the control group（P<0.05）.

The treatment of chronic heart failure with Yang deficiency and blood stasis syndrome by Fuling Sini Decoction and Danggui Shaoyao Powder can better improve the cardiac function and TCM syndromes，promote the recovery of cardiac ultrasound indexes and the levels of serum hs cTnI and NT proBNP，and the application effect is satisfactory.

To evaluate the clinical application of Xiaozhong Zhitong Decoction（消肿止痛汤）combined with crude fire needle cauterization in the treatment of perineal abscess in diabetes.

Eighty patients with perineal abscess of diabetes who were definitely diagnosed and systematically treated in the hospital were selected，all of whom met the criteria for inclusion. The data of the patients was collected，with an equal proportion grouping structure，to randomly touch the white and black balls to determine the grouping，a total of two groups. The control group（40 cases）received systemic antibiotics and local sitz baths. The observation group（40 cases）was treated with Xiaozhong Zhitong Decoction fumigation and sitz bath combined with coarse fire needle cauterization. All patients received continuous intervention for 2 weeks as a course of treatment. After all treatment courses were completed to evaluate the clinical efficacy. The inflammatory factor indicators before and after treatment，including C-reactive protein（CRP），interleukin-6（IL-6）and tumor necrosis factorα（TNF-α），visual analog scale（VAS）and quality of life were compared.

The total effective population in the control group accounted for 85.00%（34/40）and that in the observation group accounted for 97.50%（39/40），and the difference was statistically significant（P<0.05）. Serum inflammatory factor indicators（CRP，IL-6，TNF-α）in the observation group after 2 weeks of treatment were lower than those in the control group，and the difference was statistically significant（P<0.05）. The VASscore of the observation group was lower than that of the control group after 3 days of treatment，1 and 2 weeks of treatment，with a statistically significant difference（P<0.05）. After 2 weeks of treatment，the observation group showed better health perception，lifestyle，emotional control，daily living ability，interpersonal relationships and social activities than the control group，with statistically significant differences（P<0.05）.

Xiaozhong Zhitong Decoction combined with coarse fire needle cauterization can improve the efficacy of perineal abscess in diabetes，continuously relieve pain，inhibit inflammation and improve quality of life.

To observe the effects of Qufeng Tongluo Jianshen Prescription（祛风通络健肾方）on the expression levels of p38 mitogen-activated protein kinase（p38MAPK），intercellular adhesion molecule-1（ICAM-1）and monocyte chemotactic protein-1（MCP-1）in patients with chronic glomerulonephritis（CGN）.

A total of 108 CGNpatients treated in the hospital from August 2020 to February 2023 were divided into two groups by simple random method. The conventional group was given conventional symptomatic treatment with Western medicine，while the observation group was given Qufeng Tongluo Jianshen Prescription on the basis of symptomatic treatment，all of which were treated continuously for 8 weeks. The levels of renal function related indexes，renal fibrosis related factors，p38MAPK，ICAM-1，urine red blood cell count（RBC），MCP-1 and high sensitivity C-reactive protein（hs-CRP）were compared between the two groups before and after treatment，and the efficacy，adverse reactions and TCM syndrome scores were recorded between the two groups.

There was no statistical significance in renal function or renal fibrosis before treatment between the two groups（P>0.05）. The levels of serum creatinine（SCr），transforming growth factor-β1（TGF-β1），urea nitrogen（BUN），fibronectin（FN），24 h urinary protein quantity（24 h Upro），cystatin C（CysC），tissue inhibitor of metalloproteinase-（TIMP-1）were lower in two groups after treatment than those before treatment（P<0.05）. The renal function indexes and factors related to renal fibrosis in the observation group were lower than those in the conventional group（P<0.05）. There was no statistical significance in the relative expression levels of p38MAPK，ICAM-1，MCP-1，urinary RBC and hs-CRPbetween the two groups before treatment（P>0.05）. The relative expression levels of p38MAPK，ICAM-1，MCP-1，urinary RBC and hs-CRP in the two groups after treatment were lower than those before treatment，while the levels of the observation group were lower than those of the conventional group after treatment（P<0.05）. There was no statistical significance in the scores of 4 major and 5 secondary symptoms before treatment between the two groups（P>0.05）. After treatment，the scores of four major symptoms（edema of limbs，sore waist and knees，fatigue，abdominal distension），and 5 secondary symptoms（cold appearance and cold limbs，thirst and unwilling to drink，pale complexion，loose stools，frequent urination or nocturia）in the two groups were lower than those before treatment，while the scores of the observation group were lower than those of the conventional group after treatment（P<0.05）. The total effective rate of the observation group was 94.44%（51/54），which was higher than that（81.48%，44/54）of the conventional group，with statistical significance（P<0.05）. The cumulative adverse reaction rate of diarrhea，nausea and abnormal liver function in the observation group was not statistically significant compared with that in the conventional group（P>0.05）.

Qufeng Tongluo Jianshen Prescription can improve the renal function，inhibit renal fibrosis，regulate ICAM-1，MCP-1 and other factors in the treatment of CGN，and improve the curative effect.

To explore the effects of Yishen Paidu Formula（益肾排毒方）combined with Sanqi（Notoginseng Radix et Rhizoma）on serum leptin，blood lipids，oxidative stress and endothelial function in renal failure based on the theory of“intestine-kidney axis”.

A total of 60 cases of renal failure admitted to the traditional Chinese medicine and nephrology department of the hospital from June 2020 to June 2022 were selected as the research subjects. The patients in the control group received levocarnitine injection combined with compoundα-ketonic acid tablets，and those in the experimental group combined Yishen Paidu Formula combined with Sanqi（Notoginseng Radix et Rhizoma）on this basis. The clinical efficacy，blood glucose，blood lipids，leptin，vascular endothelial function，oxidative stress indicators，inflammation indicators and safety were compared between the two groups.

Compared with the control group，the experimental group had a higher overall effective rate（P<0.05）. After treatment，the levels of serum fasting plasma glucose（FPG），total cholesterol（TC），triglyceride（TG），leptin，soluble intercellular adhesion molecule-1（sICAM-1），endothelin-1（ET-1），malondialdehyde（MDA），C-reactive protein（CRP），tumor crossing factor alpha（TNF-α）and interleukin-6（IL-6）were measured in the experimental and control groups decreased compared to those before treatment，while the levels of superoxide dismutase（SOD）increased compared to those before treatment（P<0.05）. The experimental group had the levels of serum FPG，TC，TG，leptin，sICAM-1，ET-1，MDA，CRP，TNF-αand IL-6 were lower than those of the control group（P<0.05），and the level of SOD was higher than that of the control group（P<0.05）. There was no statistically significant difference in the incidence of adverse reactions between the two groups of drugs（P>0.05）.

Yishen Paidu Formula combined with Sanqi（Notoginseng Radix et Rhizoma）exert good therapeutic effects on renal failure，and the improvement of its therapeutic effect may be closely related to the improvement of endothelial and oxidative stress functions.

To explore the clinical efficacy and safety of Qi acupuncture treating osteoporosis of kidney deficiency type.

A total of 100 patients with osteoporosis of kidney deficiency type（admitted from June 2021 to June 2023）were included in the study. The patients were randomly divided into acupuncture and moxibustion group and control group，with 50 cases in each group. The patients in the control group were treated with alendronate tablets and calcium carbonate D3 tablets. Those in the acupuncture and moxibustion group were treated with Qi acupuncture on the basis of the treatment in the control group. During the treatment，4 patients in the acupuncture and moxibustion group fell off and 2 in the control group fell off. The clinical efficacy of each group and the integral changes of traditional Chinese medicine symptoms（lower back pain，foot weakness，tinnitus，deafness，skeletal weakness，forgetfulness and confusion）of patients before and after treatment were compared. The visual analog scale（VAS）was used to evaluate the degree of back pain in each group before and after treatment，and the oswestry disability index（ODI）to evaluate the back pain dysfunction. The changes in serum calcium（Ca）and phosphorus（P），N-terminal mid segment osteocalcin（N-MID），alkaline phosphatase（ALP），human Beta-Crossstraps（β-CTX）and changes in bone density of lumbar spine and femoral neck were observed. The adverse reactions were observed.

The effective rate of patients in the acupuncture and moxibustion group was higher than that in the control group（P<0.05）. Before treatment，the scores of traditional Chinese medicine symptoms（lower back pain，foot weakness，tinnitus，deafness，skeletal weakness，forgetfulness and confusion），VASand ODIscores，serum levels of Ca，P，N-MID，ALPandβ-CTX，lumbar spine and femoral neck bone density between two group had no significant（P>0.05）. After treatment，there were no significant changes in serum Ca or P in each group. The scores of traditional Chinese medicine symptoms（lower back pain，foot weakness，tinnitus，deafness，skeletal weakness，forgetfulness and confusion），VASand ODI scores，the levels of N-MID，ALP andβ-CTX，bone density of lumbar vertebrae and femoral neck were all improved，while in the acupuncture and moxibustion group，the scores of TCM symptoms（lower back pain，foot weakness，tinnitus，deafness，skeletal weakness，forgetfulness and confusion），VAS and ODI scores，the levels of N-MID，ALP andβ-CTX，lumbar spine and femoral neck bone density were superior to those in the control group（P<0.05）. There were fewer adverse reactions in each group（P>0.05）.

The clinical effect of Qi acupuncture on osteoporosis of kidney deficiency type is very good. The pain of patients is relieved，the symptoms are improved and the bone density is increased. There are fewer adverse reactions and it is safe and reliable.

Based on network pharmacology and molecular docking techniques to predict the material basis and toxicity mechanism of Chuanlianzi（Toosendan Fructus）hepatotoxicity and to validate the reducing effects after processing in combination with in vivo and in vitro experiments.

The toxic components and targets of Chuanlianzi（Toosendan Fructus）were collected using the systematic pharmacology analysis platform of traditional Chinese medicine（TCMSP）and the Swiss Target Prediction database，respectively. Liver injury related targets were obtained through GeneCards and OMIM databases. After the common targets were screened by Venny diagram，PPI analysis was carried out by STRING database，and enrichment analysis on GO function and KEGG pathway were conducted to predict their possible toxicity mechanisms. Molecular docking validation and visualization of key components of Chuanlianzi（Toosendan Fructus）hepatotoxicity with key protein binding sites and binding effects were performed using AutoDockTools and PyMOL software. In vivo experiments were conducted to compare the magnitude of acute hepatotoxicity of different processed products of Chuanlianzi（Toosendan Fructus）in mice by detecting the viability of alanine aminotransferase（ALT）and aspartate aminotransferase（AST）in serum and observing the pathologic morphology of liver tissues with HE staining method and to determine the levels of superoxide dismutase（SOD），malondialdehyde（MDA），glutathione（GSH），and glutathione peroxidase（GSH-P_X）and analyzed the reasons for the differences in the hepatotoxicity of different processed products of Chuanlianzi（Toosendan Fructus）in mice from the perspective of oxidative damage.

Network pharmacology showed that Chuanlianzi（Toosendan Fructus）hepatotoxicity components were melianone，Toosendanin and Nimbolin A，and its core targets for liver injury were TP53，IL-6 and CASP3. GO enrichment was analyzed to the biological processes，such as positive regulation of transcription and gene expression，negative regulation of the apoptotic process，and inflammatory response，cellular components，such as extracellular region，outer mitochondrial membrane，mitochondria，protein binding，protein homodimerization activity，enzyme binding and other molecular functions. KEGG pathway analysis screened TNF，PI3K-Akt，IL-17，HIF-1，apoptosis and other key signaling pathways of Chuanlianzi（Toosendan Fructus）-induced hepatotoxicity. The molecular docking results showed that the main toxic components of Chuanlianzi（Toosendan Fructus）could bind well to the core targets. In vivo experimental results showed that compared with the raw Chuanlianzi（Toosendan Fructus），the vinegar-processing，stir-frying to brown and salt-processing products all significantly reduced the activities of ALT and AST in the serum of mice（P<0.05），and the wine-processing product showed a significant increase in both ALT and AST. HE staining showed that the vinegar-processing product，stir-frying to brown and salt-processing products reduced the infiltration of inflammatory cells in the liver tissues and apoptosis of hepatocytes of mice，which suggested that Chuanlianzi（Toosendan Fructus）had the effect of alleviating liver injury after processing. This suggested that Chuanlianzi（Toosendan Fructus）had the effect of reducing liver injury，but the hepatotoxicity of the wine-processing product was greater than that of the raw product. This result suggested that the mechanism of liver toxicity induced by raw Chuanlianzi（Toosendan Fructus）in mice was related to the disruption of their antioxidant defense system，reduced ability to scavenge free radicals and subsequent excessive accumulation of free radicals in the body，which induced cell membrane lipid peroxidation.

The vinegar-processing，stir-frying to brown and salt-processing products may reduce hepatotoxicity by altering the effects of Chuanlianzi（Toosendan Fructus）on hepatotoxic targets such as TP53，IL-6 and CASP3，reducing inflammatory responses and inhibition of cell membrane lipid peroxidation，but the wine-processing product is more toxic and should be avoided in clinical practice.

To establish the fingerprint of Tenghuangtan（Dalbergia hancei Benth）by high performance liquid chromatography（HPLC）and to study the spectral-effect relationship of its antioxidant activity.

HPLC fingerprints of 10 batches of Tenghuangtan（Dalbergia hancei Benth）from different origins were established，and the antioxidant activity of Tenghuangtan（Dalbergia hancei Benth）was investigated by the 1，1-diphenyl-2-trinitrophenylhydrazine（DPPH）method and 2，2-biazobis（3-ethylbenzothiazole-6-sulfonic acid）diammonium salt（ABTS）method，and its antioxidant activity was studied by the grey relational analysis（GRA）method and partial least squares regression analysis（PLSR）method was used for its spectral-effect relationship，and then its antioxidant substance base was screened out.

The HPLC fingerprint patterns of 10 batches of Tenghuangtan（Dalbergia hancei Benth）from different origins were established，and 15 peaks were identified to characterize Tenghuangtan（Dalbergia hancei Benth）. Ten batches of Tenghuangtan（Dalbergia hancei Benth）from different origins were found to possess antioxidant activities in different degrees in a dose-dependent manner.

The HPLC fingerprints of 10 batches of Tenghuangtan（Dalbergia hancei Benth）from different places were successfully established，which provided the basis for in-depth investigation of the antioxidant efficacy of Tenghuangtan（Dalbergia hancei Benth）and its quality standard.