To observe the effects of Qufeng Tongluo Jianshen Prescription（祛风通络健肾方）on the expression levels of p38 mitogen-activated protein kinase（p38MAPK），intercellular adhesion molecule-1（ICAM-1）and monocyte chemotactic protein-1（MCP-1）in patients with chronic glomerulonephritis（CGN）.

A total of 108 CGNpatients treated in the hospital from August 2020 to February 2023 were divided into two groups by simple random method. The conventional group was given conventional symptomatic treatment with Western medicine，while the observation group was given Qufeng Tongluo Jianshen Prescription on the basis of symptomatic treatment，all of which were treated continuously for 8 weeks. The levels of renal function related indexes，renal fibrosis related factors，p38MAPK，ICAM-1，urine red blood cell count（RBC），MCP-1 and high sensitivity C-reactive protein（hs-CRP）were compared between the two groups before and after treatment，and the efficacy，adverse reactions and TCM syndrome scores were recorded between the two groups.

There was no statistical significance in renal function or renal fibrosis before treatment between the two groups（P>0.05）. The levels of serum creatinine（SCr），transforming growth factor-β1（TGF-β1），urea nitrogen（BUN），fibronectin（FN），24 h urinary protein quantity（24 h Upro），cystatin C（CysC），tissue inhibitor of metalloproteinase-（TIMP-1）were lower in two groups after treatment than those before treatment（P<0.05）. The renal function indexes and factors related to renal fibrosis in the observation group were lower than those in the conventional group（P<0.05）. There was no statistical significance in the relative expression levels of p38MAPK，ICAM-1，MCP-1，urinary RBC and hs-CRPbetween the two groups before treatment（P>0.05）. The relative expression levels of p38MAPK，ICAM-1，MCP-1，urinary RBC and hs-CRP in the two groups after treatment were lower than those before treatment，while the levels of the observation group were lower than those of the conventional group after treatment（P<0.05）. There was no statistical significance in the scores of 4 major and 5 secondary symptoms before treatment between the two groups（P>0.05）. After treatment，the scores of four major symptoms（edema of limbs，sore waist and knees，fatigue，abdominal distension），and 5 secondary symptoms（cold appearance and cold limbs，thirst and unwilling to drink，pale complexion，loose stools，frequent urination or nocturia）in the two groups were lower than those before treatment，while the scores of the observation group were lower than those of the conventional group after treatment（P<0.05）. The total effective rate of the observation group was 94.44%（51/54），which was higher than that（81.48%，44/54）of the conventional group，with statistical significance（P<0.05）. The cumulative adverse reaction rate of diarrhea，nausea and abnormal liver function in the observation group was not statistically significant compared with that in the conventional group（P>0.05）.

Qufeng Tongluo Jianshen Prescription can improve the renal function，inhibit renal fibrosis，regulate ICAM-1，MCP-1 and other factors in the treatment of CGN，and improve the curative effect.