Latest ArticlesAccording to the relevant theories of traditional Chinese medicine，there are differences in popularity，blood，body fluid and other aspects of different constitutions，which affect their health and disease manifestations.In recent years，although the research based on TCM constitution identification has made breakthrough progress，it still faces many challenges.Therefore，this paper proposed a graph convolutional network（GCN）model of TCM constitution identification based on facial feature extraction，which combined data augmentation and GCN model to solve the problems of insufficient dataset and poor recognition ability of machine learning models.Firstly，data augmentation techniques were employed to expand the acquired image dataset，thereby enhancing the generalization ability and stability of model training.Subsequently，these images were segmented to construct a graph structure suitable for the graph convolutional network model.Finally，the model was sent to a Softmax classifier for classification.Experimental results indicated that the proposed model achieved accuracy and recall，and F1 scores were 77.97%，78.98% and 77.87% respectively in constitution identification，outperforming classical machine learning models for constitution identification.
The traditional single-cycle pulse recognition methods encounter significant limitations in practical applications due to the morphological diversity，cycle variability and individual differences inherent in the wrist pulse signals.In this study，it focused on solving the classification problem of multi-period pulse recognition，and constructed an image-based dataset by integrating the amplitude and temporal information of pulse signal through the Markov Transition Field（MTF）.Building upon this foundation，it set up new deep-learning network model，TCANet（Temporal Convolutional Attention Network），which leveraged the depth-wise separable convolutions and self-attention mechanisms to markedly improve the accuracy and efficiency of pulse image classification.The experimental outcomes revealed that TCANet achieved the impressive performance metrics，including 94.74% accuracy，94.79% precision，94.74% recall and 94.76% F1 score in recognizing the slippery，stringy and normal wrist pulses.This indicated that it had excellent performance and wide application potential in the field of multi cycle pulse recognition.
To evaluate the effect of the clearing heat，resolving phlegm and dredging Fu-organs method on secondary pulmonary infection after early gastric tube nasogastric feeding in patients with hypertensive intracerebral hemorrhage.
A hundred patients with secondary pulmonary infection after early gastric tube nasogastric feeding in hypertensive intracerebral hemorrhage were selected and random ly divide into two groups，with 50 cases in each group.The control group received basic treatment.On the basis of the control group，the observation group was treated with the method of clearing heat，resolving phlegm and dredging Fu-organs.One course of the treatment was two weeks.The therapeutic effects of two groups were compared.The inflammatory markers［interleukin-6（IL-6），tumor necrosis factor-α（TNF-α），hypersensitivity C-reactive protein（hs-CRP）］and arterial blood gas indicators［partial pressure of oxygen（PaO2），partial pressure of carbon dioxide（PaCO2）］before and after treatment were used to evaluate clinical pulmonary infection score（CPIS）.
The clinical efficacy of the observation group was better than that of the control group，and the difference was statistically significant（P<0.05）.The serum levels of IL-6，TNF-αand hs-CRP in the observation group after 2 weeks of treatment were lower than those of the control group and the difference was statistically significant（P<0.05）.After 2 weeks of treatment，the value of PaO2 in the observation group was higher than that in the control group，and the value of PaCO2 was lower than that in the control group，with a statistically significant difference（P<0.05）.The CPIS score of the observation group was lower than that of the control group after 1 and 2 weeks of treatment，and the difference was statistically significant（P<0.05）.
The clearing heat，resolving phlegm and dredging Fu-organs method has a definite control effect on secondary pulmonary infection after early gastric tube nasogastric feeding in hypertensive intracerebral hemorrhage，which helps to inhibit inflammation，improve arterial blood oxygen and reduce the degree of infection.
To analyze the effect of Ningxin Anshen Decoction（宁心安神汤）on attention deficit hyperactivity disorder（ADHD）under the guidance of brain-gut axis theory on intestinal flora.
A total of 102 children with attention deficit hyperactivity disorder were included in the study.They were divided into two groups by random number table method.Fifty-one cases in the control group were treated with Methylphenidate Hydrochloride Tablets，and 51 cases in the observation group were treated with Ningxin Anshen Decoction on this basis.The difference of efficacy，symptom score，Attention Deficit Hyperactivity Disorder Scale（SNAP-Ⅳ），number vanishing test（NCT）error rate，child Behavior Scale（CBCL）and intestinal flora index were compared between the two groups.
The total effective rate of the observation group was 96.08%（49/51），which was much higher than 78.43% （40/51）of the control group（P<0.05）.After treatment，the scores of hyperactivity，restlessness，distraction，polyglot and irritability in the observation group were lower than those in the control group，and the SNAP-Ⅳscore and NCT error rate in the observation group were lower than those in the control group，and the CBCL score was higher than that in the control group（P<0.05）.After treatment，the levels of Bifidobacterium，Lactobacillus and Faecalis in observation group were higher than those in control group，and Enterococcus was lower than those in control group（P<0.05）.
-Ningxin Anshen Decoction under the guidance of brain-gut axis theory have a clear effect in the treatment of attention deficit hyperactivity disorder，which can adjust the balance of intestinal flora，increase the contents of Bifidobacterium and Lactobacillus，effectively improve the symptoms of children，the attention ability and cognitive function，and has high application value.
To explore the clinical efficacy of Tongbian Decoction（通便汤）in treating functional constipation patients with Qi and Yin deficiency type by regulating the brain-gut-microbiota axis signaling pathway and analyze its mechanism of action.
Seventy-four patients with functional constipation who visited the Department of Colorectal and Traditional Chinese Medicine of Dangshan County People´s Hospital from January 2023 to December 2023 were selected.They were randomly divided into a Western medicine group and a Chinese medicine group using a random number table method，with 37 patients in each group.The Western medicine group was treated with Pulucabili Tablets，while the Chinese medicine group was treated with Tongbian Decoction.The clinical efficacy，symptoms，psychological status and adverse reactions of two groups as well as the changes in gut microbiota and brain gut peptide levels before and after treatment were compared.
The effective rate in the Western medicine group was 64.86%（24/37），while that in the Chinese medicine group was 83.79%（31/37）. Compared with the Western medicine group，the effective rate of the Chinese medicine group was significantly higher（P<0.05）.According to the severity，the symptoms scored 0-3 points in order.After 4 weeks of treatment，the symptom scores of fecal morphology/type，defecation interval and difficulty of defecation in the Chinese medicine group were significantly lower than those in the Western medicine group（P<0.01）.After the intervention，the scores of Hamilton Anxiety Scale（HAMA）and Hamilton Depression Scale（HAMD）in Chinese medicine group were significantly lower than those in western medicine group（P<0.01）. Compared with those in western medicine group，the levels of serum 5-hydroxytryptamine（5-HT），vasoactive intestinal peptid（VIP）and neuropeptide Y（NPY）in Chinese medicine group were significantly lower with statistical significance（P<0.01）.There was no significant difference in the levels of Bifidobacterium，Lactobacillus or Faecalibacterium prausnitzii between the two groups before intervention（P>0.05）.After the intervention，the levels of Bifidobacterium，Lactobacillus and Faecalibacterium prausnitzii in the Chinese medicine group were significantly higher than those in the Western medicine group.The main adverse reactions of all patients during the intervention process were nausea，vomiting，loss of appetite，abdominal pain，diarrhea，dizziness and headache.There was no significant difference in the incidence of adverse reactions between the two groups（P>0.05）.
Tongbian Decoction has a good clinical effect in treating functional constipation by regulating the brain-gut-microbiota axis signaling pathway.It can improve the psychological status of patients，regulate the gut microbiota and serum levels of brain gut peptides such as 5-HT，VIP and NPY，and there is no increase in adverse reactions.
To observe the clinical efficacy of Ding´s Benefiting Qi and Nourishing Yin Decoction（益气养阴汤）in the treatment of prolonged menstruation due to deficiency of both Qi and Yin.
This study selected 108 patients with deficiency of both Qi and Yin type of menstrual extension who were treated in the gynecology department of The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine from September 2021 to September 2022 as the subjects.They were randomly divided into two groups using a random number table.Both groups received basic treatment.The control group received the treatment with Callicarpa nudiflora Dispersible Tablets，and the observation group received treatment with Ding´s Benefiting Qi and Nourishing Yin Decoction.Both groups were treated continuously for three courses of treatment.The differences in therapeutic efficacy，menstrual time，recurrence rate and sex hormones，traditional Chinese medicine symptom score，duration of basal body temperature（BBT）and high temperature phase，fibrinogen（FIB）and platelet count（PLT）were compared between two groups.
The total effective rate of the observation group was higher than that of the control group，and the overall menstrual time and average menstrual time were shorter than those of the control group，with statistical differences（P<0.05）.There was no statistically significant difference in the TCM symptom scores between the two groups before treatment（P>0.05）.After treatment，the scores of fatigue，dry throat and mouth，lack of breath and lazy speech，restlessness and heat，self sweating，constipation，dizziness，blurred vision and short red urine in both groups decreased compared to those before treatment（P<0.05）.The TCM symptom score of the observation group after treatment was lower than that of the control group（P<0.05）.There was no statistically significant difference in sex hormones between the two groups before treatment（P>0.05）.After treatment，the levels of estradiol（E2），luteinizing hormone（LH）and progesterone（P）decreased in both groups compared to those before treatment.However，there was no statistically significant difference in follicle stimulating hormone（FSH）levels compared to those before treatment（P>0.05）.After treatment，the levels of E2，P and LH in the observation group were lower than those in the control group，and there was no statistically significant difference in FSH compared to that of the control group（P>0.05）.There was no statistically significant difference in the duration of BBT hyperthermia phase，FIB or PLT between the two groups before treatment（P>0.05）.After treatment，the duration of high temperature phase of BBT decreased in both groups compared to that before treatment，while PLT increased compared to that before treatment.There was no statistically significant difference in FIB compared to that before treatment（P>0.05）.After treatment，the duration of BBT hyperthermia phase in the observation group was lower than that in the control group，while PLTwas higher than that in the control group.There was no statistically significant difference in FIB compared to that of the control group（P>0.05）.The recurrence rate of the observation group was 14.89%（7/54），which was lower than that of the control group（37.04%，20/54），with a statistical difference（P<0.05）.
In the treatment of prolonged menstruation due to deficiency of both Qi and Yin，Ding´s Benefiting Qi and Nourishing Yin Decoction can reduce symptoms，regulate sex hormone levels，improve the therapeutic efficacy，and reduce the recurrence rate.
To explore the effect of Bailing Capsule（百令胶囊）combined with aminophylline in the treatment of chronic obstructive pulmonary（COPD）in stable phase and the effect on the expression of Kelch like epichlorohydrin related protein-1（Keap1）-nuclear transcription factor erythroid 2p45（Nrf2）-antioxidant response element（ARE）signaling pathway，so as to provide effective reference for clinical medication.
A prospective randomized controlled study of 112 patients with stable COPD in the hospital from February 2020 to March 2023 were selected and divided into combination group（56 cases）and control group（56 cases）by random number table.Both groups were given conventional treatment.On this basis，the control group was given aminophylline，and the combination group was given Bailing Capsule combined with aminophylline，both of which were treated for 3 months.The efficacy，the 6-min walking distance，changes in dyspnea index（TDI）and lung function［expiratory volume in the first second（FEV1），forced vital capacity（FVC），FEV1/FVC］，serum inflammatory factor indicators［tumor necrosis factor-α（TNF-α），interleukin-6（IL-6），high-sensitivity C-reactive protein（hs-CRP）］，immune function indexes（CD3+，CD4+，CD4+/CD8+）and the expression of Keap1-Nrf2-ARE signal pathway before and after treatment of the two groups were compared.
（1）Efficacy and symptom improvement：The total effective rate of the combination group was 91.07%（51/56），which was higher than that of the control group（75.00%，42/56）.After treatment，the TDI was higher than that of the control group（P<0.05）.（2）Sports endurance and lung function：After treatment，the 6-min walking distance，the levels of FEV1，FVC and FEV1/FVC in both groups increased compared to those before treatment，and the indexes of the combination group were higher than those of the control group（P<0.05）.（3）Inflammatory response：Compared with those before treatment，after treatment，the serum levels of inflammatory factors such as TNF-α，IL-6 and hs-CRP were significantly reduced，with a higher decrease in the combination group（P<0.05）.（4）Immune function：After treatment，the levels of CD3+，CD4+and CD4+/CD8+in the combination group were higher than those in the control group（P<0.05）.（5）Keap1-Nrf2-ARE signaling pathway：After treatment，the expression levels of Keap1，Nrf2 and ARE proteins increased in both groups，with the combination group showing a more significant increase（P<0.05）.
The combination of Bailing Capsule and aminophylline has a significant clinical effect in the treatment of stable COPD，which can effectively promote the improvement of patients’symptoms，improve lung function and exercise endurance，while reducing the body´s inflammatory response，improving immune function and up-regulating the expression of Keap1-Nrf2-ARE signaling pathway.
To explore the clinical effect of Qisheng Gushen Decoction（芪参固肾汤）combined with irbesartan in the treatment of chronic kidney disease at stage 2～3.
A total of 110 patients with chronic kidney disease at stage 2～3（admitted from August 2021 to October 2023）were divided into decoction group and western medicine group by random number table method，with 55 cases in each group.The western medicine group received irbesartan and other western medicines，and the decoction group was treated with Qisheng Gushen Decoction on the basis of the western medicine group.In the course of treatment，1 case was shed in the western medicine group and 2 cases were shed in the decoction group.The data of each group was observed as follows：curative effect，integral changes of TCM symptoms（main disease and secondary disease）before and after treatment，changes of renal function indicators，changes of inflammatory factors indicators，changes of intestinal flora，changes of T lymphocyte subsets and other immune function indicators，adverse reactions.
The total effective rate of the decoction group was significantly higher than that of the western medicine group（P<0.05）.After treatment，the scores of TCM syndrome（main disease and secondary disease），24-hour urinary protein quantification（24 h-UTP），serum creatinine（SCr），urea nitrogen（BUN），albumin（ALB），estimated glomerular filtration rate（eGFR），interleukin-6（IL-6），interleukin-17（IL-17）and hypersensitive C-reactive protein（hs-CRP），intestinal flora indicators such as Lactobacillus acidophilus，bifidobacterium and Escherichia coli，and immune indicators such as T lymphocyte subsets（CD3+，CD4+，CD8+，CD4+/CD8+）were improved.In the decoction group，these indexes were all better than those in western medicine group（P<0.05）.The total adverse reaction rate of the decoction group was lower than that of the western medicine group（P<0.05）.
Qisheng Gushen Decoction combined with irbesartan in the treatment of chronic kidney disease at stage 2～3 can regulate the immune function，improve the renal function，immune function and inflammatory response of patients，enhance the therapeutic effect，and reduce adverse reactions，and the treatment is safe and reliable.
Based on the “brain-derived neurotrophic factor（BDNF）/phospho-tropomyosin receptor kinase B（TrkB）/p38/c-Jun N-terminal kinase（JNK）”signaling pathway，this study aimed to investigate the mechanism of electroacupuncture stimulation of pain points in the treatment of myofascial pain syndrome（MPS）.
SD rats were divided into normal group，model group，electroacupuncture group and western medicine group.MPSmodel rats were established by a combination of percussion and centrifugal exercise，followed by electroacupuncture stimulation of pain points and oral administration of celecoxib for intervention.After the experiment，the morphology of muscle tissues in rats of each group was observed by hematoxylin-eosin（HE）and Masson staining.Prussian blue staining was used to observe the degranulation of mast cells in the muscle tissues of each group.TUNEL fluorescence staining was used to observe the cell apoptosis in the muscle tissues of each group.Reverse Transcription Polymerase Chain Reaction（RT-PCR）was used to detect the mRNA expression levels of Bcl-2 associated X protein（Bax），B-cell lymphoma-2（Bcl-2），cysteine aspartate-specific protease 3（Caspase-3），BDNF，TrkB，p38 and JNK in the muscle tissues of each group.Wes was used to detect the protein expression levels of Bax，Bcl-2，Caspase-3，BDNF，p-TrkB，p-p38 and p-JNK in the muscle tissues of each group.
HE and Masson staining indicated that both electroacupuncture and celecoxib intervention can improve muscle pathological damage caused by MPS，and can inhibit mast cells degranulation and apoptosis of muscle cell.Electroacupuncture and celecoxib intervention can increase Bcl-2 mRNA expression and decrease the mRNA expressions of Bax，Caspase-3，BDNF，TrkB，p38 and JNK，increase Bcl-2 protein expression and decrease protein expressions of Bax，Caspase-3，BDNF，p-TrkB，p-p38 and p-JNK.Electroacupuncture was more effective than celecoxib.
Electroacupuncture can treat MPS by inhibiting the BDNF/Trkb/p38/JNK signaling pathway，thereby reducing cell apoptosis in MPSaffected muscle tissue.In traditional Chinese medicine theory，electroacupuncture can be used to restore the imbalance of Qi，blood，Yin and Yang in the body，but the corresponding mechanism still needs further exploration.
This study aimed to explore the efficacy of Centella Asiatica Cream in treating hypertrophic scars.
A total of 107 patients with keloid lesions were included.Following a double-blind allocation principle，the patients were divided into an experimental group（49 cases）and a control group（58 cases）.The Vancouver Scar Scale（VSS）and the Patient and Observer Scar Assessment Scale（POSAS）were employed to evaluate changes in color，hardness，height，vascularization，texture and pain before and after treatment in both groups.
At the 12th and 24th week of treatment with Centella Asiatica Cream，the experimental group demonstrated statistically significant differences in keloid scar diameter，pigmentation，thickness，vascular distribution and softness according to the VSS compared with those of the control group（P<0.05）.The POSAS observer scale indicated significant statistical differences between the two groups at the 12th and 24th week（P<0.05），while the POSAS patient scale showed significant differences at the 4th，12th and 24th week（all P<0.05）.
Centella Asiatica Cream formulation showed significant efficacy in the repair of hypertrophic scars.
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
