Latest ArticlesJujuboside B（JuB），one of themain constituents of herbal medicine Suanzaoren（Ziziphi Spinosae Semen），possess various pharmacological activities，including anti-inflammatory，antiplatelet and anti-restenosis potentials on the cardiovascular system.However，anti-arrhythmia and underlying mechanisms of JuB are uncertain.This study explored the effects of JuB on the sodium currents（INa）in rat ventricular myocytes using whole-cell patch-clamp techniques and molecular docking studies.The whole-cell patch-clamp technique showed that the current-voltage（Ⅰ-Ⅴ）curves of INa shifted along the positive axis in a dose-dependent manner with JuB.Besides，the administration of JuB caused the steady-state activation curve to shift positively along the voltage axis，i.e.，a depolarization trend but the steady-state inactivation curve of INa shifted negatively，which represented that JuB suppressed the opening process of the Na+channel and may had a strong affinity for binding to sodium channels during inactivation.Themolecular docking study exhibited that JuB was mainly docked in the trans membrane helices of voltage-sensing domain（VSD）ⅢandⅣ of rNav1.5 and rNav1.5/QQQ.The study preliminarily confirmed that JuB can inhibited voltage-gated sodium channel of cardiacmyocytes for the first time.
Multiplemyeloma（MM）is one of the most common malignant tumors of the hematologic system，with multiple myeloma bone disease（MBD）as a hematological complication.MBD is prominently characterized by pathological fractures，osteoporosis and osteolytic lesions，all of which severely impact patients'quality of life and survival rates.The primary mechanisms of MBD involve bone destruction and impaired osteogenesis，especially the abnormal activation of the receptor activator of nuclear factor kappa B（RANK）/ligand of RANK（RANK-L）/osteoprotegerin（OPG）system，along with an imbalance in the regulation of osteoclast and osteoblast function by pro-inflammatory cytokines in the bone marrow microenvironment.In recent years，substantial progress has been achieved in MBD treatment through integrated traditional Chinese and Western therapeutic strategies.This combined approach harnesses multiple therapeutic advantages to alleviate bone pain，enhance bone strength and reduce the risk of complications.To standardize this integrated diagnosis and treatment protocol，an expert team has developed a consensus based on evidence-based medicine and regional resources in traditional Chinese and Western medicine within the Lingnan area.This consensus aims to provide guidance for clinical practice and improve patients'quality of life and prognosis.
Due to the limitations of ancient anatomy，Huangdi Neijing is relatively brief in describing the internal part of the meridian tendons in the human body cavity，which is in sharp contrast to the detailed description of the lay meridian tendons on the body surface and limbs.This difference resulted in the later generations in the development and application of the theory of meridian tendons，more attention was paid to the internal meridian tendons，while the importance of the external meridian tendons was ignored.However，modern medical practice has revealed the close relationship between the meridian tendon and the Zang-Fu organs，which urgently requires us to construct a comprehensive theoretical system to cover both internal and external aspects of the meridian tendon，so as to better guide the clinical treatment.The purpose of this paper was to probe into the anatomical essence of meridian tendon，clarify its direct relationship with Zang-Fu organs，enrich the connotation of meridian tendon theory，and provide solid theoretical support and innovative perspective for the application of meridian tendon therapy in the treatment of Zang-Fu diseases.
Baizhu Powder（白术散）is a classic prescription for invigorating spleen and nourishing stomach from Xiaoer Yaozheng Zhijue.Modern studies show that ithas the functions of regulating intestinal microecology，reducing inflammation，antiviral effect，regulating blood sugar，improving insulin resistance，protecting liver，etc.It is commonly used clinically to treat diarrhea of children，anorexia，auxiliary treatment of diabetes，hyperlipidemia，etc.On the basis of summarizing the research progress of chemical composition，pharmacological action and clinical application of Baizhu Powder，the prediction analysis was carried out according to the“five principles”of quality marker（Q-Marker）.The results showed that ginsenosides Rg1，Rb1，Re，atractylenolideⅠ，Ⅱ，Ⅲ，puerarin，daidzin，daidzein，patchouli alcohol，dehydrocostus lactone，costunolide，liquiritin（SH），glycyrrhizic acid，dehydrotumulosic acid and polyporenic acid C，can be considered as Q-Markers for Baizhu Powder，and this study can provide reference for the quality control of Baizhu Powder.
To investigate the effectiveness of acupuncture at scalp acupoint penetration acupuncture combined with warming needle moxibustion in improving cognitive function and quality of life in patients with vascular dementia（VD）.
A total of124 patients with Qistagnation and blood stasis type of VD admitted to the hospital between August2017 and July 2019 were selected and divided into the needle therapy group（scalp acupoint penetration acupuncture combined with warming needle moxibustion）and the drug group（butylphthalide soft capsule），62 each in each.Both groups were treated for a total of6 weeks.The clinicalefficacy，traditional Chinese medicine syndrome scores，mini-mental state examination（MMSE），Hasegawa dementia status scale（HDS-R），functional activity questionnaire for social functioning（FAQ），activities of daily living（ADL）and adverse effects occurrence results were observed and recorded for comparison.
The total efficiency of the needle therapy group（82.26%）was significantly higher than thatof the drug group（61.29%）（P<0.05）.Before treatment，the differences in traditional Chinese medicine syndrome scores，the scores of MMSE，HDS-R，FAQ and ADL between the needle therapy group and the drug group were notstatistically significant（P>0.05）.After treatment，the traditional Chinese medicine syndrome scores and FAQ scores were significantly lower（P<0.05），and the scores of MMSE，HDS-R and ADL were significantly higher（P<0.05），and the traditional Chinese medicine syndrome scores and FAQ scores in the needle therapy group were significantly lower than those in the drug group（P<0.05），and the scores of MMSE，HDS-R and ADL in the needle therapy group were significantly greater than those in the drug group（P<0.05）.The differences in the incidence of the total adverse reactions between the needle therapy group and the drug group were not statistically significant（P>0.05）.
The efficacy of scalp acupoint penetration acupuncture combined with warming needle moxibustion in treating VD can effectively improve the patients'cognitive function and quality of life，with good safety，which is worthy of clinical promotion and application.
To explore the effect of Qili Qiangxin Capsule（芪苈强心胶囊）on chronic heart failure and its influence on the levels of troponin（cTNI），homocysteine（Hcy），N-terminal B-type natriuretic peptide（NT-proBNP）and highsensitivity C-reactive protein（hs-CRP）in patients.
Ninety-two patients with chronic heart failure were selected and divided into control group and comprehensive group，46 cases in each group.The conventional comprehensive treatment was given，and the comprehensive group was treated with Qili Qiangxin Capsule for 3 months.The therapeutic effect，TCM syndrome scores，cardiac function and the changes of serum levels of cTNI，Hcy，NT-proBNP and hs-CRPwere observed.
There was no significant difference between the two groups in TCM syndrome scores before treatment（P>0.05），but the score decreased after treatment（P<0.05），and the score of the comprehensive group was lower than that of the control group（P<0.05）.There was no significant difference of stroke volume（SV），left ventricular end diastolic diameter（LVEDD），left ventricular ejection fraction（LVEF）or 6-minute walking test distance（6MWT）between the two groups before treatment（P>0.05），but the values of SV，LVEF and 6MWT increased after treatment（P<0.05），and these indexes of the comprehensive group were higher than those of the control group（P<0.05）.The levels of serum cTNI，Hcy，NT-proBNP and hs-CRP in the two groups were not statistically different before treatment（P>0.05），but decreased after treatment（P<0.05），and the levels of the comprehensive group were lower than those of the control group（P<0.05）.The overall curative effect of the comprehensive group was better than that of the control group（P<0.05）.
The treatment of chronic heart failure with QiliQiangxin Capsule is helpful to reduce the serum levels of cTNI，Hcy，NT-proBNP and hs-CRP，improve the symptoms and cardiac function of patients，and then improve the therapeutic effect.
To study the effectof Sanqi（Notoginseng Radix et Rhizoma）onmitochondrial energy metabolism of rats with adriamycin induced kidney fibrosis with blood stasis.
Thirty rats were divided into 6 groups random ly，including normal group，model group，Sanqi（Notoginseng Radix et Rhizoma）low-dose group，Sanqi（Notoginseng Radix et Rhizoma）medium-dose group，Sanqi（Notoginseng Radix et Rhizoma）high-dose group and positive control group，with 5 rats in each group.Themitochondrial structure of rat renal tissue was observed by electron microscopy.The contents of adenosine triphosphate（ATP），adenosine diphosphate（ADP），adenosine monophosphate（AMP），the activities of Na+ -K+ -ATPase，Ca2+ -Mg2+-ATPase and the activities ofmitochondrial respiratory chain complex enzymeⅠ-Ⅳwere detected by chemical method.The metabolites of urine were analyzed by liquid chromatograph and mass spectrometer.The differential metabolites were enriched by Kyoto Encyclopedia of Genes and Genomes（KEGG）metabolic pathway.
Under electron microscope，the mitochondrial structure of renal tissue in the model group was incomplete，and Sanqi（Notoginseng Radix et Rhizoma）could maintain the homeostasis of renalmitochondrial structure.Sanqi（Notoginseng Radix et Rhizoma）could increase the mitochondrial ATP contentof the renal tissue，the activities of Na+-K+-ATPase，Ca2+-Mg2+-ATPase andmitochondrial respiratory chain complex enzymeⅠ-Ⅳ.Sanqi（Notoginseng Radix et Rhizoma）could reduce the contents of mitochondrial ADP and AMP of renal tissue.After analysis and comparison among the groups，11 different urine metabolites were screened，including ferulic acid，forin，arabitol，acetamide，biotin，allantoic acid，6-methylmercaptopurine，4-hydroxy-2-quinolone，aminopentanedioate，6-methyladenine and moupinamide.Further enrichment of urinemetabolites by KEGG in different experimental groups showed that the aldosterone-regulated sodium reabsorption signal pathway was significantly different.
Sanqi（Notoginseng Radix et Rhizoma）regulates the differential urine metabolites and raldosterone-regulated sodium reabsorption signal pathway.Sanqi（Notoginseng Radix et Rhizoma）can improve mitochondrial energy metabolism and renal fibrosis in chronic kidney diseases（CKD）rats with blood stasis bymulti-target and multi-pathway.
To analyze the study of the utility of five-element identification acupuncture in traditional Chinese medicine combined with ABA training in the treatment of children with autism.
Ninety cases of autistic children admitted to the Department of Pediatrics of Nanyang First People's Hospital Affiliated to Henan University from March 2022 to March 2024 were selected for the study.Forty-five cases of the control group were treated with ABA training，and the other 45 cases of the observation group were treated with traditional Chinese medicine five-element identification acupuncture on the basis of the above mentioned treatment，and the clinical effects，the scores on the scales［（Autism Treatment and Evaluation Scale（ATEC），Children's Autism Rating Scale（CARS），Autism Behavioral Scale（ABC）］，serological indexes［tissue-type plasminogen activator（t-PA）and plasminogen activator inhibitor-1（PAI-1）］of the two groups were compared.
The total effective rate of the observation group（97.78%，44/45）was higher than that（82.22%，37/45）of the control group and the difference was significant（P<0.05）.The ATEC scores of both groups were reduced after one and three months of treatment（P<0.05），and the reduction wasmore significant in the observation group compared with that in the control group（P<0.05）.CARSscore and ABC score were reduced in both groups after one and three months of treatment（P<0.05），and the reduction was more significant in the observation group compared with that in the controlgroup（P<0.05）.After one and three months of treatment，t-PA increased and PAI-1 decreased in both groups（P<0.05），and compared with those in the control group，t-PA increased more significantly and PAI-1 decreased more significantly in the observation group（P<0.05）.
After the children diagnosed with autism were treated with the combination of ABA training and traditional Chinese medicine five-element identification acupuncture，the therapeutic effect was remarkable.The treatment could effectively reduce the children's clinical symptoms，improve their serological indexes and promote the recovery of the children.
Gastric ulcer is a common clinical gastrointestinal disease，which is characterized by its susceptibility，recurrence and high medical cost.Nowadays，due to the extensive use of proton pump inhibitors，H2 receptor antagonists and antimicrobial drugs，the incidence of gastric ulcers has decreased，but the recurrence rate of gastric ulcers and the incidence of complications are still not effectively controlled.The Chinese herb Huanglian（Coptidis Rhizoma）has the effects of clearing heat and drying dampness，purging fire and removing toxin，which plays a significant role in the treatment of sores，carbuncles and ulcers，and it can enter the stomach meridian，which iswidely used in the treatment of gastric ulcers，and it can effectively reduce the index of ulcers and accelerate the healing of ulcers.Through searching CNKI，Pubmed and other databases，the article comprehensively discussed the mechanism of Huanglian（Coptidis Rhizoma）and its active ingredients in the treatment of gastric ulcers，in order to provide a basis for the clinical application of Huanglian（Coptidis Rhizoma）in ulcer diseases as well as further scientific research.
To investigate the effect of Zijinlong Tablets（紫金龙片）combined with intravenous immunoglobulin in the treatment of lower respiratory tract infection in the elderly.
Totally 302 elderly patients with lower respiratory tract infections admitted to the hospital from March 2021 to March 2023 were selected and randomly grouped，each with 151 cases.Based on conventional treatment，the control group was given intravenous immunoglobulin，and the study group received Zijinlong Tablets combined with intravenous immunoglobulin.Then the clinicalefficacy，ratio of forced expiratory volume in the firstsecond to forced vital capacity（FEV1/FVC），peak expiratory flow（PEF），maximum voluntary ventilation（MVV），arterial partial pressure of oxygen（PaO2），arterial partial pressure of carbon dioxide（PaCO2），interleukin-6（IL-6），C-reactive protein（CRP），interleukin-1（IL-1），procalcitonin（PCT），immunoglobulin-（Ig）A，IgG，IgM and T-lymphocyte subsets（CD3+，CD4+，CD8+）were compared.
The study group reported a higher overall efficacy rate than the control group（93.38% vs85.43%，P<0.05）.An increase in PEF，MVV and FEV1/FVC were observed in all patients after treatment，and the increase was more notable in the study group than those in the controlgroup（P<0.05）.An elevation in PaO2 and a decrease PaCO2 were detected in all patients，and both improvements were more remarkable in the study group than those in the control group（P<0.05）.After treatment，the levels of IL-6，CRP，IL-1 and PCT showed a decrease in all patients，and the three parameters were all lower in the study group than those in the control group（P<0.05）.The levels of IgA，IgG and IgM demonstrated an increase in all patients，and were all larger in the study group than those in the control group（P<0.05）.An elevation in CD3+and CD4+and a decrease CD8+were found in all patients，and both improvements were more obvious in the study group than those in the control group（P<0.05）.
The application of Zijinlong Tablets combined with intravenous immunoglobulin in the treatment of lower respiratory tract infection in the elderly can effectively improve the pulmonary function and arterial blood gas indexes，attenuate the cellular inflammatory response，ameliorate the body immune function and promote the recovery of the patients.
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
