Guizhi (Cinnamomi Ramulus) is sweet and warm, attributed to the heart, lung and bladder meridians. Guizhi (Cinnamomi Ramulus) and its medicinal pairs have a long history of clinical application. This article focused on the pharmacological effects of Guizhi (Cinnamomi Ramulus) and the network pharmacology based on Guizhi (Cinnamomi Ramulus)-Huangqi (Astragali Radix), Guizhi (Cinnamomi Ramulus)-Gancao (GLycyrrhizae Radix et Rhizoma), Guizhi (Cinnamomi Ramulus)-Mahuang (Ephedrae Herba), Guizhi (Cinnamomi Ramulus)-Sangzhi (Mori Ramulus), Guizhi (Cinnamomi Ramulus)-Danggui (Angelicae Sinensis Radix), Guizhi (Cinnamomi Ramulus)-Xiebai (Allii Macrostemonis Bulbus)-Banxia (Pinelliae Rhizoma), Guizhi (Cinnamomi Ramulus)-Lulutong (Liquidambaris Fructus), Guizhi (Cinnamomi Ramulus)-Chishao (Paeoniae Radix Rubra), Guizhi (Cinnamomi Ramulus)-Baizhu (Atractylodis Macrocephalae Rhizoma)-Fuling (Poria), Guizhi (Cinnamomi Ramulus)-Cangzhu (Atractylodis Rhizoma), Guizhi (Cinnamomi Ramulus)-Fuling (Poria), Guizhi (Cinnamomi Ramulus)-Chaihu (Bupleuri Radix) and Guizhi (Cinnamomi Ramulus)-Fuzi (Aconiti Radix Lateralis Praeparata), as well as the modern experimental research process and common clinical application of Guizhi (Cinnamomi Ramulus)-Mahuang (Ephedrae Herba), Guizhi (Cinnamomi Ramulus)-Gancao (Glycyrrhizae Radix et Rhizoma) and Guizhi (Cinnamomi Ramulus)-Fuling (Poria). The above contents systematically revealed the connotation and interpretation of the application of Guizhi (Cinnamomi Ramulus) and its drug pairs as well as the modern clinical application and research progress of Guizhi (Cinnamomi Ramulus) and its drug pairs to explore the scientificity of the compatibility of Guizhi (Cinnamomi Ramulus), provide a basis for better elaboration of the mechanism of action of Guizhi (Cinnamomi Ramulus) and its drug pairs, a traditional Chinese medicine basis and method for the systematic study of the compatibility theory of Guizhi (Cinnamomi Ramulus) and its drug pairs, and new ideas for the further development and utilization of Guizhi (Cinnamomi Ramulus) and its drug pairs.