To systematically evaluate the willingness to receive HPV vaccination and influencing factors among college students in China.

Relevant studies were retrieved from PubMed, Embase, Web of Science, The Cochrane Library, CINAHL, PsycINFO, China Biomedical Literature Database, CNKI, Wanfang Database, and VIP Database from the establishment of the databases to March 12, 2025. Meta-analysis was conducted using Stata 17.0 and RevMan 5.4 to assess the willingness to receive HPV vaccination and influencing factors among college students.

A total of 35 studies involving 62 958 samples were included. The meta-analysis results showed that the willingness rate of college students in China to receive HPV vaccination was 67.0%. Female (OR=3.47, 95% CI: 2.49-4.85), having a history of sexual behavior (OR=1.91, 95% CI: 1.09-3.35), accepting premarital sex (OR=1.36, 95% CI: 1.04-1.78), having a family history of tumors (OR=1.69, 95% CI: 1.28-2.23), monthly consumption level≥2 000 yuan (OR=1.50, 95% CI: 1.22-1.84), knowing about HPV vaccine (OR=1.75, 95% CI: 1.11-2.77), knowing that HPV vaccine is on the market (OR=1.71, 95% CI: 1.44-2.03), knowing that HPV infection is related to cervical cancer (OR=1.44, 95% CI: 1.15-1.81), having someone around who has received HPV vaccine (OR=2.23, 95% CI: 1.66-3.01), and having a high score in the cognition of HPV and its vaccine (OR=1.86, 95% CI: 1.32-2.62) were identified as promoting factors.

The willingness rate of Chinese college students to receive the HPV vaccine is relatively high, relevant epidemic prevention departments and health institutions should strengthen the professional popularization of HPV vaccine-related knowledge among college students, and try to improve the HPV vaccine vaccination service system and cervical cancer prevention and control service system.

To explore the equity of health supervisor allocation in health supervision agencies in Yunnan Province from 2019 to 2023, and to provide a basis for further optimizing the reform of health supervision in Yunnan Province.

Using the National Health Supervision Information Reporting System and Yunnan Statistical Yearbook data, the configuration of health supervisors in agencies in Yunnan Province was described, and the equity was analyzed by using the agglomeration degree and the Theil Index.

The number of health supervisors in Yunnan Province from 2019 to 2023 was 1 795, 1 762, 1 824, 1 796 and 1763, respectively;The numbers of health supervisors per 10 000 population was 0.37, 0.36, 0.39, 0.38, and 0.38, respectively.The health supervisor’s agglomeration degree in the four regions of Yunnan Province from 2019 to 2023 was different, with that in Central and Northeast regions were always greater than 1, and Northwest region was always the lowest and less than 1 (0.61-0.67). The difference between the health supervisor agglomeration degree and population agglomeration degreeranged from -0.68 to 0.74, with the difference fluctuating around 0 for Northwest and Central regions, also the difference for Northeast Yunnan was always less than 0. There was no significant change in the Theil Index of health supervisors in Yunnan Province from 2019 to 2023, and the Theil Index by geographical distribution (0.073-0.078) was always higher than that calculated by population distribution (0.030-0.032), and the contribution rate between regions was greater than that with regions.

The provision of health supervisors in Yunnan Province has improved, but it is still lower than the national standard.The geographic equity of the allocation is not as fair as the demographic equity. The distribution of resources for health supervisors should be conducted with comprehensive consideration of the population density and the radius of the medical services.

To investigate the associations between serum liver enzymes of alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT) and cardiovascular diseases in the Chinese community-dwelling older adults.

Based on the baseline data of the West China Health and Aging Cohort, a total of 7 422 participants aged 60 years and above without liver diseases were selected in this study. Logistic regression and restricted cubic spline models were used to analyze the dose-response relationship between serum liver enzymes and the risk of coronary artery disease (CAD) and stroke.

Logistic regression models showed that compared with the lowest serum ALT level group, the highest group had a higher risk of CAD (OR=1.35, 95% CI: 1.06-1.74). Restricted cubic spline models showed no nonlinear association between serum ALP, ALT, AST, and GGT and the risk of CAD (P_nonlinearity=0.796,0.122, 0.583, and 0.424, respectively). For stroke, the risk in the highest serum ALP level group was higher compared with the lowest group (OR=1.27, 95% CI: 1.02-1.58); additionally, each one-unit increase in log₁₀ALP was associated with a higher risk of stroke (OR=2.13, 95% CI: 1.01-4.47). Restricted cubic spline models showed no nonlinear association between serum ALP,ALT, AST, and GGT and stroke (P_nonlinearity=0.595, 0.669, 0.809, and 0.907, respectively).

Higher serum liver enzymes may be associated with an increased risk of cardiovascular diseases in the Chinese older adults.

In order to further optimize the allocation of primary health resources, this study analyzed the status quo and equity of primary health resources allocation in Inner Mongolia from 2019 to 2023.

Using Lorenz curve, Gini coefficient and Theil index, the equity of primary health resource allocation in Inner Mongolia was measured and analyzed.

In the medical and health resources of all the cities in Inner Mongolia Autonomous Region, Hohhot ranked first. According to the fairness of population allocation, the Gini coefficient ranged from 0.025 9 to 0.155 3，the total Theil index ranged from 0.004 0 to 0.077 3，and the intra-regional variance rates ranged from 61.65% to 93.50%. According to the fairness of geographical area allocation, the Gini coefficient ranged from 0.453 8 to 0.516 5, the total Theil index ranged from 0.256 7 to 0.352 8, and the inter-regional difference rate ranged from 13.12% to 24.93%. According to the fairness of GDP allocation, the Gini coefficient ranged from 0.100 7 to 0.379 2, the total Theil index ranged from 0.096 9 to 0.240 2, and the inter-regional difference rate ranged from 24.56% to 38.06%.

The total amount of primary health resources in Inner Mongolia has achieved continuous growth, but there is a structural imbalance in the allocation of medical human capital. The fairness of allocation according to population and GDP is significantly better than that according to geographical area. The distribution of primary health resources in different cities is uneven, forming a gradient pattern of "central uplift-edge collapse", with noticeable underutilization of primary health resources.

To analyze the relationship between circadian syndrome (CircS), changes in CircS and the progression of frailty, providing a theoretical basis for the early prevention of frailty and the development of interventions.

Based on data from the 2011—2018 China Health and Retirement Longitudinal Study (CHARLS), the frailty index (FI) was constructed using 39 health deficits to examine frailty, and CircS was diagnosed by metabolic syndrome (MetS) components, sleep and depression. Changes in CircS were obtained by comparing the status of CircS in 2011 and 2015. The relationships between CircS, changes in CircS, and the risk of frailty, as well as FI trajectories, were analyzed by Cox proportional hazards regression and linear mixed-effects models.

In the fully adjusted Cox regression model, CircS was significantly associated with the risk of frailty (HR=1.604, P<0.001). Individuals with abnormal component scores of 6 (HR=2.110, P<0.001) or 7 (HR=3.136, P<0.001) showed a substantial increase in the risk of frailty compared with no CircS. Compared with persistent CircS-free individuals, those newly developing CircS (HR=2.534, P<0.001), and those with persistent CircS (HR=3.681, P<0.001) were at higher risk of frailty. In fully adjusted linear mixed-effects models, FI increased significantly faster in participants with CircS compared with individuals without CircS (β=3.932, P<0.001) and tended to increase significantly as the number of abnormal components increased (P_trend<0.001). Participants with CircS had the greatest increase in FI compared with individuals who were persistently CircS-free (β=5.588, P<0.001). Age (P=0.013) and alcohol consumption (P=0.023) interacted with CircS, but the direction of the effect of CircS on frailty remained consistent across subgroups.

CircS and its changes were positively associated with the progression of frailty among Chinese middle-aged and older adults, underscoring the importance of early identification of CircS and monitoring the changes in CircS to reduce the risk of frailty and mitigate the progression of frailty.

To fit and predict the incidence trend of pulmonary tuberculosis in Guiyang City, assess whether the End TB Strategy target for 2035 (incidence <10 per 100 000 population) can be achieved, and provide a reference for relevant departments to optimize prevention and control measures.

Based on the anonymized tuberculosis case data from Guiyang City between 2010 and 2024, after excluding records with missing onset times and duplicate entries, a transmission dynamics model was constructed by integrating demographic and epidemiological data. Taking into account the latent period of tuberculosis, infection progression, and case detection, the Bayesian method was employed to estimate transmission parameters and predict incidence trends from 2025 to 2050. The effectiveness of various control measures was evaluated through parameter optimization strategies.

The model achieved a mean absolute percentage error (MAPE) of 5.02%, and an R² of 0.86 in fitting the 2010—2019 data. Projections indicated that under current strategies, Guiyang City would fail to meet the 2035 TB control target. However, with optimized interventions, the target could be achieved two years ahead of schedule.

Enhancing active case detection and preventive treatment for latent TB infections could enable Guiyang City to reach the End TB Strategy’s 2035 goal.

To analyze the spatial-temporal clustering of mumps during periods with different immunization strategies in Tai’an.

The immunization strategy for MuCV from 2009 to 2024 was divided into 1-dose period (2009-2013), 2-dose early period (2014-May 2020), and 2-dose later period (June 2020-2024). Mumps incidence data from 2009 to 2024 were obtained from the China Disease Control and Prevention Information System for descriptive epidemiological, trend analysis and spatial-temporal clustering analysis during different immunization strategy periods.

The annual average incidence rate of mumps in Tai’an from 2009 to 2024 showed a general downward trend during the three immunization periods (χ²_trend=4 273.971, P<0.001), and there were statistically significant differences (χ²=4 977.100, P<0.001). The trend surface analysis showed that it increased first and then decreased from west to east during three immunization periods. From north to south, the rate decreased and then increased during the 1-dose period, whereas a generally downward trend was observed during the 2-dose period. The global spatial autocorrelation analysis showed that mumps exhibited significant spatial clustering (P<0.001) during three immunization periods. The local autocorrelation analysis showed that the "High-High" clusters were predominantly concentrated in the townships/subdistricts covered by Taishan District, Daiyue District, Mount Tai Scenic Area, and Ningyang County, while the "Low-Low" clusters were mainly distributed in those under Feicheng City and Xintai City during the three immunization periods. The spatiotemporal scanning analysis showed that the main clusters were predominantly located in townships/subdistricts covered by Ningyang County, Taishan District, Daiyue District, and the Mount Tai Scenic Area during the three immunization periods, and this was basically consistent with the "high-high" clusters identified by the local spatial autocorrelation analysis.

The incidence of mumps during different immunization strategy periods exhibited spatial-temporal clustering in Tai’an City. It is necessary to strengthen the surveillance and early warning for mumps in high-priority regions.

To analyze the risk factors for renal failure in patients with chronic kidney disease (CKD) complicated by hypertension.

A total of 230 CKD patients with hypertension admitted to Chaohu Hospital Affiliated to Anhui Medical University from April 2023 to April 2024 were enrolled. According to the occurrence of renal failure, the patients were divided into the renal failure group (n=47) and the non-renal failure group (n=183). Baseline characteristics were compared between the two groups. Lasso regression and multivariate logistic regression were used to screen for risk factors of renal failure.

Among the 230 patients, 47 (20.43%) developed renal failure. Logistic regression analysis revealed that hyperuricemia (OR=3.104, 95% CI: 1.661-5.800), anemia (OR=3.413, 95% CI: 1.706-6.828), hyponatremia (OR=2.852, 95% CI: 1.383-5.882),proteinuria (OR=2.858, 95% CI: 1.318-6.198), advanced age (OR=2.579, 95% CI: 1.396-4.765), and uncontrolled blood pressure (OR=2.211, 95% CI: 1.193-4.096) were independent risk factors for renal failure in CKD patients with hypertension.

CKD patients with hypertension have a high risk of renal failure. Advanced age, uncontrolled blood pressure, hyperuricemia, anemia, hyponatremia, and proteinuria are significant risk factors for renal failure in this population.

To clarify the spatial and temporal distribution pattern of the incidence of non-occupational carbon monoxide poisoning in Shandong Province, to reveal the meteorological driving factors behind it, and to provide reference for its scientific prevention and control.

Non-occupational carbon monoxide poisoning incident reports were collected through the China Disease Control and Prevention Information System Public Health Emergency Reporting Management Information System. Descriptive analysis was used to study the prevalence characteristics of non-occupational carbon monoxide poisoning. Spatial autocorrelation analysis and spatio-temporal scanning analysis were performed to explore spatio-temporal aggregation using ArcGIS 10.7 and SaTScan 10.1.2 software, respectively. The influence of meteorological factors on the incidence of non-occupational carbon monoxide poisoning was assessed using an optimal parameter geographical detector.

A total of 12 088 cases of non-occupational carbon monoxide poisoning were reported in Shandong Province from 2019 to 2023, with peak incidence from November to March of the next year each year, and middle-aged and older populations people as the main high-risk groups. Global spatial autocorrelation analysis showed spatial clustering of non-occupational carbon monoxide poisoning incidence rates in both 2020—2022(P<0.05). The southern part of Shandong Province was gradually developing into a new hot spot. Spatio-temporal scanning analysis detected five aggregation zones, of which the primary aggregation zone was mainly concentrated in the northern part of Shandong Province (Nov 2019—Mar 2021, LLR=2 003.71, P<0.001). The results of the optimal parameter geographical detector showed that relative humidity and barometric pressure were important meteorological factors affecting morbidity, with the largest interaction between relative humidity and wind speed.

Non-occupational carbon monoxide poisoning in Shandong Province showed seasonal spatiotemporal clustering. It is recommended to strengthen the winter and spring health education work for middle-aged and older populations and other high-risk groups. At the same time, disease prevention and control organizations at all levels should establish good information communication with meteorological and propaganda departments. Early warning of non-occupational carbon monoxide poisoning accidents in key endemic areas such as northern Shandong Province and southern Shandong Province should be strengthened through these initiatives.

To explore the association between serum uric acid (SUA), the uric acid to high-density lipoprotein cholesterol ratio (UHR), and liver function among Zhuang minority male residents aged 35-74 years in Guangxi, and to provide scientific evidence for developing strategies to regulate SUA levels and preserve hepatic health.

A cross-sectional study was conducted based on the Guangxi Ethnic Minorities Cohort, using structured questionnaires, physical examinations, and blood and urine sample collection. Logistic regression analysis was used to identify factors associated with liver dysfunction, while restricted cubic spline was performed to evaluate dose-response relationships of SUA and UHR with liver dysfunction.

This study included 4 977 Zhuang minority male adults, with a mean age of 54.8 years. Among them,38.4% of participants had middle school education, 53.9% were farmers, and 47.1% with household income over 30 000 Yuan in the past year, 30.9% with SUA levels >420 μmol/L, and 10.4% had liver dysfunction. After adjusting for confounders, compared to the normal SUA group, the adjusted OR(95% CI) for liver dysfunction in the 421-479 μmol/L and ≥480 μmol/L groups were 1.30 (1.01-1.67) and 1.69 (1.32-2.15), respectively. Compared with the lowest UHR quartile (≤22.25%), the adjusted OR (95% CI) for the 22.26-28.96%, 28.97-38.26%, and ≥38.27% quartiles were 1.23 (0.89-1.71), 1.76(1.24-2.50), and 2.08 (1.39-3.11), respectively. The risk of liver dysfunction increased non-linearly with the increase of SUA and UHR levels (P_nonlinearity <0.001).

SUA and UHR demonstrated significant associations with the risk of liver dysfunction among Zhuang minority male residents aged 35-74 years in Guangxi. Targeted health education efforts should be strengthened to control SUA levels and reduce UHR, thereby helping to preserve liver function in middle-aged and older individuals of the Zhuang minority.