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To investigate the associations between serum liver enzymes of alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT) and cardiovascular diseases in the Chinese community-dwelling older adults.
Based on the baseline data of the West China Health and Aging Cohort, a total of 7 422 participants aged 60 years and above without liver diseases were selected in this study. Logistic regression and restricted cubic spline models were used to analyze the dose-response relationship between serum liver enzymes and the risk of coronary artery disease (CAD) and stroke.
Logistic regression models showed that compared with the lowest serum ALT level group, the highest group had a higher risk of CAD (OR=1.35, 95% CI: 1.06-1.74). Restricted cubic spline models showed no nonlinear association between serum ALP, ALT, AST, and GGT and the risk of CAD (Pnonlinearity=0.796,0.122, 0.583, and 0.424, respectively). For stroke, the risk in the highest serum ALP level group was higher compared with the lowest group (OR=1.27, 95% CI: 1.02-1.58); additionally, each one-unit increase in log10ALP was associated with a higher risk of stroke (OR=2.13, 95% CI: 1.01-4.47). Restricted cubic spline models showed no nonlinear association between serum ALP,ALT, AST, and GGT and stroke (Pnonlinearity=0.595, 0.669, 0.809, and 0.907, respectively).
Higher serum liver enzymes may be associated with an increased risk of cardiovascular diseases in the Chinese older adults.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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