To analyze the epidemiological characteristics of hepatitis E in Heilongjiang Province from 2010 to 2022, and to provide scientific basis and data support for the prevention and control of hepatitis E in Heilongjiang Province.

The data of reported cases of hepatitis E in Heilongjiang Province from 2010 to 2022 were collected. Descriptive epidemiological methods were used to describe the temporal, spatial and population distribution characteristics of cases of hepatitis E. Joinpoint regression model was used to analyze the trend of hepatitis E. and to calculate the Annual Percentage Change (APC).

From 2010 to 2022, the reported incidence of hepatitis E in Heilongjiang Province showed a decreasing trend, and the annual reported incidence was 1.27/100 000. There were reported cases of hepatitis E in every month, and the peak period of hepatitis E was from October to April of the following year. Hepatitis E cases were reported every year in all cities (places) of Heilongjiang Province, and the top five regions reported annual incidence were Qitaihe City (238/100 000), Hegang City (203/100 000), Shuangyashan City (194/100 000), Jixi City (156/100 000) and Yichun City (154/100 000). The reported incidence rates of both men and women decreased year by year, with APC of -8.41% (95% CI: -11.31%- -5.42%, P<0.001) for men and -5.22% for women (95% CI：-9.12% - -1.09%，P=0.013), the incidence of male was higher than that of female. The cumulative number of cases in the 45-55 age group was 1 430(30.45%). The results of occupation distribution showed that 1 380 cases (29.39%) were housework and unemployed, and 1 204 cases (25.64%) were farmers.

The reported incidence of hepatitis E in Heilongjiang Province from 2010 to 2022 shows a decreasing trend, but there arestill significant seasonal, regional and population characteristics. Winter and spring arethe peak of the incidence, and men, 45-65 years old age group, household workers and unemployed people and farmers arethe high incidence groups of hepatitis E. In the future, targeted health publicity activities should be carried out for key groups to promote hepatitis E vaccination, which is expected to further reduce the incidence of hepatitis E in Heilongjiang Province.

To study the coordinated development of healthcare resource allocation and service utilization in Jiangsu Province.

Using various statistical methods, its spatio-temporal evolution characteristics and driving factors were profiled.

The degree of coupling coordination showed an overall upward trend during 2015-2021, which declined in 2020 but quickly rebounded in the following year; the province’s entropy-weighted TOPSIS composite index was basically below 0.5, with Nanjing, Wuxi, and Suzhou’s composite scores significantly higher than those of other cities, and the service utilization index as a whole was significantly higher than that of the resource allocation index; Lianyungang, in terms of the value of the degree of relative development, was much higher than that of the province’s other cities, presenting an extremely significant resource over-advancement type; the influence factors selected in this paper can be better realistic and statistically significant in terms of selection objectives and significance.

The coordinated development of medical resource allocation and service utilization of health institutions in prefecture-level cities in Jiangsu Province has obvious geographical boundaries of spatial and temporal changes,2015-2021. In addition, although the better economically developed areas performs better than the relatively less economically developed areas in terms of healthcare resource allocation and service utilization but shows a regression in the composite scores, healthcare resource allocation may be an entry point for the balanced development of the province. The study also find that factors such as population distribution and level of economic development have a significant impact on the degree of coordination over the seven years.

To explore the relationship between cardiovascular health (CVH) and depression in postmenopausal women.

Utilizing data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018, logistic regression analysis was conducted to examine the association between CVH and depression in postmenopausal women. Restricted cubic spline (RCS) models were employed to reveal potential nonlinear associations between the two.

After adjusting the covariates, the risk of depression was significantly reduced in the moderate and high CVH groups (OR=0.50, 95% CI: 0.34-0.72; OR=0.25, 95% CI: 0.07-0.90). A significant nonlinear association was also observed between CVH and depression (P-overall<0.001, P-nonlinear<0.001). Subgroup analysis results showed a significant negative association between high levels of CVH and depression among 18 to 59 years of age (OR=0.12, 95% CI: 0.02-0.55), non-Hispanic blacks (OR=0, 95% CI: 0.00-0.00), other races (OR=0.14, 95% CI: 0.04-0.55), below high school (OR=0.06, 95% CI: 0.01-0.33), above high school (OR=0.12, 95% CI: 0.02-0.89), married/cohabiting (OR=0.06, 95% CI: 0.01-0.25), overweight/obese (OR=0.06, 95% CI: 0.02-0.21), and non-users of hormone replacement therapy (OR=0.12, 95% CI: 0.04-0.42).

A significant negative correlation exists between CVH levels and the risk of depression in postmenopausal women. This underscores the importance of CVH in the mental health of postmenopausal women. Healthcare providers should prioritize the potential psychological impact of CVH on postmenopausal women and incorporate it into comprehensive strategies for depression prevention and intervention.

To investigate the prevalence and influencing factors of insufficient sleep and excessive sleep among Chinese adults from 2010 to 2020, thereby providing a basis for policies aimed atimproving sleep conditions for adults.

Data from the China Family Panel Studies (CFPS) between 2010 and 2020 were utilized. Self-reported nighttime sleep duration was measured, with less than 7 hours classified as insufficient sleep and 9 hours or more classified as excessive sleep. Chi-square tests and Poisson regression models were employed to analyze the frequency and influencing factors.

A total of 9,505 individuals were included in the study. The results indicated that 45.84% of adults reported never experiencing insufficient sleep, while 48.27% of adults reported never experiencing excessive sleep. Poisson regression analysis indicated that females (RR=1.073, 95% CI: 1.028-1.119), increasing age (RR=1.404, 95% CI: 1.305-1.511; RR=1.887, 95% CI: 1.755-2.030; RR=2.092, 95% CI: 1.934-2.263), urban areas (RR=1.219, 95% CI: 1.178-1.260), eastern region (RR=1.346, 95% CI: 1.287-1.409) and central region (RR=1.430, 95% CI: 1.370-1.492), general health (RR=1.114, 95% CI: 1.075-1.154) and unhealthy status (RR=1.164, 95% CI: 1.109-1.221), and higher depression symptom scores (RR=1.018, 95% CI: 1.014-1.022) are risk factors for increased frequency of insufficient sleep. Married/cohabiting (RR=0.894, 95% CI: 0.816-0.980), high school (RR=0.951, 95% CI: 0.904-1.000) and college or above (RR=0.894, 95% CI: 0.828-0.965), BMI<18.5 kg/m² (RR=0.932, 95% CI: 0.871-0.996) are protective factors against increased frequency of insufficient sleep. Aged 30-44 years (RR=0.757, 95% CI: 0.712-0.806) and aged 45-59 years (RR=0.834, 95% CI: 0.783-0.888), married/cohabiting (RR=0.920, 95% CI: 0.847-0.999), junior high school (RR=0.822, 95% CI: 0.789-0.856), high school (RR=0.667, 95% CI: 0.627-0.709) and college or above (RR=0.416, 95% CI: 0.371-0.467), urban (RR=0.737, 95% CI: 0.709-0.766), eastern region (RR=0.698, 95% CI: 0.667-0.730) and central region (RR=0.768, 95% CI: 0.737-0.799) are protective factors against increased frequency of excessive sleep, while unhealthy (RR=1.100, 95% CI: 1.046-1.158) is a risk factor for increased frequency of excessive sleep.

The frequency of insufficient sleep and excessive sleep among Chinese adults is closely related to various sociodemographic factors, physical and mental health conditions, and smoking habits. The government and all sectors of society should prioritize high importance on the sleep conditions of adults and take effective measures to improve sleep health literacy among adult population, ultimately promoting overall health and well-being.

To describe and analyze the disease burden of dengue fever in China from 1990 to 2021, and to provide evidence for the prevention and control of the disease.

Using the open data of the Global Burden of Disease (GBD) database from 1990 to 2021, this study analyzed the trend of dengue disease burden. The Joinpoint regression model was used to reflect the change trend of dengue burden, and the ARIMA time series model was used to predict the dengue disease burden in China in the next ten years.

The incidence and prevalence of dengue fever in China increased from 0.37/100 000 and 0.02/100 000 in 1990 to 1.88/100 000 and 0.11/100 000 in 2021, and the DALYs rate decreased from 0.30/100 000 in 1990 to 0.04/100 000 in 2021. From 1990 to 2021, the age-standardized incidence and prevalence of dengue fever in China increased from 0.38/100 000 and 0.02/100 000 to 2.01/100 000 and 0.12/100 000, and the age-standardized DALYs rate decreased from 0.32/100 000 to 0.05/100 000. The Joinpoint regression model showed that, the age-standardized incidence rate (AAPC=5.59%, P<0.05) and age-standardized prevalence rate (AAPC=5.57%, P<0.05) of dengue fever in China from 1990 to 2021 showed an increasing trend, while the age-standardized DALYs rate (AAPC=-5.84%, P<0.05) showed a decreasing trend. The ARIMA forecast model showed a small decline in the burden of dengue in China from 2022 to 2031.

In China, the incidence and prevalence of dengue fever and its age-standardized rate showed an increasing trend, while the DALYs rate and age-standardized DALYs rate showed a decreasing trend. The burden of dengue fever in China is still relatively heavy, so preliminary screening and health education of dengue fever should be strengthened, and corresponding preventive measures should be formulated according to the characteristics of dengue disease burden.

To investigate the mediating effects and critical influences of triglyceride glucose (TyG) and triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) indices on the association of unhealthy lifestyle and hypertension in an occupational population, and to provide a scientific basis for hypertension in occupational populations.

A cross-sectional survey design was employed based on data from the Southwest Occupational Population Cohort. Unhealthy lifestyle was assessed based on scoring for smoking, alcohol consumption, unhealthy dietary patterns, low physical activity, and abnormal BMI. A multivariable logistic regression model was used to analyze the association between the unhealthy lifestyle score and hypertension. Causal mediation analysis was employed to estimate the mediating effects of TyG and TG/HDL-C. Additionally, network analysis was conducted to explore the correlation between among unhealthy lifestyle, TyG, TG/HDL-C, and hypertension.

A total of 24 545 study participants were included, with an average age of (37.37±10.60) years. Regression analysis revealed that the risk of hypertension increased with the number of unhealthy lifestyle factors. Compared with those with no unhealthy lifestyle factors, individuals with all five unhealthy lifestyle factors simultaneously had a 3.06-fold risk of developing hypertension (95% CI: 2.54-3.69). Mediation analysis indicated that TyG and TG/HDL-C mediated 34.25% and 6.64% of the effects, respectively, linking unhealthy lifestyle and hypertension. Among them, TyG emerged as the primary mediating factor and exhibited the highest bridge strength centrality in the network constructed for unhealthy lifestyle, TyG, TG/HDL-C, and hypertension.

Unhealthy lifestyle is associated with an increased risk of developing hypertension and shows a cumulative effect, and TyG is an important mediator and a key node in the network, suggesting that interventions should be carried out to target unhealthy lifestyle and TyG, which may contribute to hypertension prevention.

To evaluate the current status and development trends of Inflammatory Bowel Disease (IBD) in China, providing decision support for policy adjustments by government and health departments.

Data extraction from the 2024 Global Burden of Disease (GBD) database was conducted for indicators related to the incidence, prevalence, mortality, and Disability-Adjusted Life Years (DALYs) of IBD in China. Joinpoint regression analysis was used to calculate the Annual Percent Change (APC) and the Average Annual Percent Change (AAPC). Additionally, an Autoregressive Integrated Moving Average Model (ARIMA) was employed to forecast disease characteristics from 2022 to 2031.

From 1990 to 2021, the number of prevalent cases, incident cases, and deaths from IBD in China, as well as the age-standardized prevalence rate (ASPR), and age-standardized incidence rate (ASIR) showed an upward trend. By 2021, these figures stood at 168077 prevalent cases, 24 941 new cases, and 5 640 deaths, with ASPR and ASIR reaching 9.16 per 100 000 people and 1.4 per 100 000 people, respectively, representing a significant increase compared to 1990 levels. Meanwhile, the age-standardized mortality rate (ASMR) and age-standardized DALY rate (ASDR) exhibited a downward trend, standing at 0.33 per 100 000 people and 7.68 per 100 000 person-years in 2021, with notable differences observed across age groups and genders. The ARIMA model predicted that by 2031, the ASPR, ASIR, ASMR, and ASDR would decrease compared to 2021 levels, projecting figures of 5.23 per 100 000 people, 1.20 per 100 000 people, 0.21 per 100 000 people, and 5.41 per 100 000 person-years, respectively.

Currently, the incidence and prevalence of IBD in China are on the rise. Although this trend may change over the next decade, given China’s large population base and demographic structure, it is essential to strengthen primary and secondary prevention efforts among key populations, particularly males and the elderly.

To explore the impact of hypertension diagnosis and measured blood pressure on depressive symptoms in middle-aged and older adults, providing evidences for depression prevention in this population.

Data from four waves (2013-2020) of the China Health and Retirement Longitudinal Study (CHARLS) were analyzed, including a total of 4 106 participants aged 45 and older. A linear mixed-effects model was used to examine the effect of hypertension on depressive symptoms.

In the univariate analysis, compared to respondents who with undiagnosed hypertension (32.64%), those diagnosed with hypertension showed a higher proportion of depressive symptoms (33.51%). After adjusting for covariates in the multivariate analysis, diagnosed hypertension (OR=1.05, P=0.003) remained associated with a higher risk of depression. However, elevated blood pressure without diagnosis did not have a significant effect on depressive symptoms (OR=0.99, P=0.454).

Hypertension diagnosis is associated with an increased risk of depressive symptoms among middle-aged and elderly individuals. Therefore, clinicians are advised to monitor not only blood pressure control in hypertensive patients but also their mental health, providing psychological support to prevent emotional issues that may arise from the diagnosis, thus enhancing patients’ quality of life.

To understand the status of knowledge-attitude-practices (KAP) of meal replacement food among college students in Hainan Province.

From April 2023 to February 2024, a stratified random cluster sampling method was used to select 2,451 college students from three universities in Hainan Province for a questionnaire survey. The knowledge and attitude levels of students with different characteristics were analyzed by T-test or ANOVA, and multiple response analysis was used for multiple choice questions in practice.

Knowledge of meal replacement food scored (5.67±2.26) (51.5%), attitude (10.85±4.28) (60.3%). 77.7% of university students wanted to continue consuming and try meal replacement food. And 73.5% of students accepted meal replacement food at a price of ‘≤15 RMB/meal’. The college students were mainly concerned about the nutritional balance (21.1%) and safety (19.2%) of the products. Their preferred product types were mainly meal-replacement biscuits (19.2%) and meal-replacement shakes (18.7%). The key considerations for purchasing meal replacement food were brand awareness of the product (18.7%) and price (16.5%). The channels for learning about meal replacement food were mainly the Internet or self-media (36.3%), and purchasing them was mainly from online shopping malls or supermarkets (32.0%).

College students in Hainan Province have a low level of knowledge about meal replacement food but have a positive attitude. They have a high willingness to consume meal replacement food. When shopping, the main factors they consider are the nutritional balance and safety of the product, brand awareness and price. They mainly obtain information about meal replacement food and purchase it online.

To evaluate the current status of health-related quality of life (HRQoL) and its influencing factors in patients with Wilson’s disease (WD), and to compare them with the standards of the general population in China.

A cross-sectional study of 123 patients with WD from July 14, 2023, to March 14, 2024, was conducted to assess the HRQoL using the EuroQol five-dimensional three-level questionnaire (EQ-5D-3L) and converted using the Chinese value set. The Tobit regression model was used to identify potential factors associated with HRQoL.

The health utility value of WD patients grouped by age was significantly lower than that of the general population (P<0.001). Patients also reported more health problems in all dimensions of EQ-5D-3L than in the general population (P<0.001). The Tobit regression analysis shows that per capita monthly income, low-copper diet, phenotypes, and mental health status are significantly correlated with health utility values.

Patients with WD have a worse HRQoL than the general population in China. The HRQoL of patients can be improved by advocating a scientific low-copper diet, raising health awareness, and paying more attention to the psychological conditions of patients with WD, especially neuropsychiatric patients.