To analyze the epidemiological trends of lung cancer in China and the world from 1990 to 2021, and to predict future standardized morbidity and mortality. By assessing the key factors affecting the burden of lung cancer, such as age, time period and birth cohort, the aim is to reveal the risk patterns of morbidity and mortality in different groups, provide a scientific basis for lung cancer prevention and control strategies, and support disease prevention, early intervention and resource allocation optimization.

The data of this study were from the Global Burden of Disease 2021 (GBD 2021) database. Statistical analysis was performed using R 4.4.1 software. The annual percent change (APC) and average annual percent change (AAPC) were calculated by Joinpoint regression model to evaluate the trend of lung cancer incidence and mortality. At the same time, the age-period-cohort model combined with the endogenous factor algorithm (IE) was used to decompose and analyze the age, period and cohort effects, and to evaluate the independent effects of each factor on the risk of morbidity and mortality.

From 1990 to 2021, the average annual standardized incidence of lung cancer in China increased by 0.95%(95%CI: 0.76%-1.13%, P<0.001 ), and the average annual standardized mortality increased by 0.38%(95%CI: 0.13% -0.63%, P=0.003). The global standardized incidence of lung cancer decreased by 0.25%(95%CI: -0.36% -0.13%, P<0.001), and the global standardized mortality decreased by 0.54 %(95%CI: -0.7% -0.37%, P<0.001). It is estimated that the overall standardized incidence of lung cancer in China will decrease to 57.78/100 000 by 2044.It is estimated that the overall standardized incidence of lung cancer in China will decrease to 57.78/100 000 by 2044. The standardized incidence rate of male decreased to 73.59/100 000, and the standardized incidence rate of female increased to 44.80/100 000. The global standardized incidence of lung cancer decreased to 29.82/100 000. During the same period, the overall standardized mortality rate of lung cancer in China decreased to 48.23/100 000. The standardized mortality rate of males decreased to 62.88/100 000, while that of females increased to 36.18/100 000. From 1990 to 2021, the RR value of the period change of lung cancer incidence in China increased year by year, and the RR value of the period change of mortality increased first and then decreased. The cohort effect of lung cancer incidence and mortality also showed a trend of increasing first and then decreasing.

From 1990 to 2021, the incidence and mortality of lung cancer in China continued to rise, while the world showed a downward trend. The incidence and mortality of lung cancer increased with age, and men were significantly higher than women. The period effect increased year by year, and the cohort effect increased first and then decreased. The prediction shows that the incidence and mortality of lung cancer in China and the world will decline as a whole from 2022 to 2044, and the global data is positively correlated with SDI.

To investigate the impact of community environment on the trajectory of cognitive function among older adults in China, providing a reference for promoting the construction of age-friendly communities and actively addressing aging.

Based on the data from the China Longitudinal Aging Social Survey from 2014 to 2020, 4 269 elderly individuals were selected. A group-based trajectory model was applied to construct trajectories of cognitive function changes, and a multinomial unordered logistic regression model was used to analyze the relationship between community environment and trajectories of cognitive function.

Three groups of cognitive function trajectories were identified: “Low Decline Group” (21.06%), “Moderate Stable Group” (66.19%), and “High Stable Group” (12.75%). Taking the “low decline group” as the reference group, after controlling for individual basic characteristics and health characteristics, it was found that the higher the community environment score of the elderly, the more their trajectory tended to be in the “High Stable Group” (OR=1.10, 95%CI: 0.93-1.30; OR=1.41, 95%CI: 1.21-1.66), indicating that the community environment has a protective effect on the cognitive decline of the elderly. Stratified analysis showed that compared to females and the elderly living alone, the improvement of the community environment is more beneficial for males and the non-living alone elderly to slow down their cognitive decline.

There is heterogeneity in the cognitive function trajectories of the elderly, and the community environment affects the attribution of cognitive function trajectories. Optimizing the community environment for males and non-lonely elderly can significantly protect their cognitive function.

To investigate the effects of blackcurrant on lipid metabolism and intestinal flora in High-Fat Diet mice.

A total of 150 C57BL/6J mice aged 7-8 weeks were selected, with half male and half female. Twelve mice were randomly selected and fed a normal diet as a blank control group. The other mice were fed a high-fat diet for 8 weeks, and the mice with successful obesity modeling were selected and randomly grouped according to gender. The 60 mice were divided into four groups, including high-fat（normal saline）, low-dose（1 250 mg/（kg·d））, medium-dose（2 500 mg/（kg·d））, and high-dose（5 000 mg/（kg·d））, with six mice in each group. The subjects were given continuous gavage for 10 weeks. To evaluate the effect of the intervention and explore the possible mechanism of the intervention. The results were described by (). Differences between groups were tested by ANOVA (α=0.05).

There were significant differences in liver weight, liver coefficient and kidney weight between ND female group and HFD female group and each subject group (P<0.05). The subcutaneous fat mass, perirenal fat mass, perirenal fat mass, and mesenteric fat mass in the ND male group were significantly different from those in the HFD male group and the LOW male group (P<0.05). The subcutaneous fat mass, perirenal fat mass and uterine fat mass of ND female mice were significantly different from those of HFD female group and LOW female group (P<0.05). There were significant differences in TC, TG, HDL-C and LDL-C between the ND male group and the HFD male group and the HIGH male group (P<0.05), and there were significant differences in TG and LDL-C between the ND female group and the HFD female group, the LOW female group and the HIGH female group (P<0.05). There was a significant difference in ALT among the groups (P<0.05). The cells of the liver tissue and adipose tissue in the ND group were intact, and the cells in the HFD group had large fat vacuoles, and the cells in each test group tended to return to normal levels. There was a significant difference in β-diversity among the four groups (P<0.01). The changes in the abundance of Firmicutes, Bacteroidota, and Verrucomicrobiota were also observed (P<0.05).

Blackcurrant can reduce body fat and visceral fat, regulating blood lipid metabolism, protect liver function and regulate intestinal flora.

To investigate the association between lipoproteins determined by nuclear magnetic resonance (NMR) and osteoarthritis (OA) using Mendelian randomization (MR).

Using the genome-wide association study (GWAS) of 116 NMR-based lipoproteins and total OA, knee OA, and hip OA, univariate MR analyses were conducted to assess the association between lipoproteins and osteoarthritis.

Univariate MR results showed that 73 lipoproteins were significantly associated with total OA, LDL diameter (OR=1.07, 95% CI: 1.03-1.11) and small HDL phospholipids (OR=1.05, 95% CI: 1.01-1.08) presented risk effects on total OA,while the remaining lipoproteins were protective and were distributed in apolipoprotein B, cholesterols, intermediate density lipoprotein, and very-low-density lipoprotein subclasses. 57 lipoproteins were significantly associated with knee OA, all of which were found in total OA, with LDL diameter (OR=1.11, 95% CI: 1.05-1.18) presenting a risk effect on knee OA, while the remaining lipoproteins were protective. 90 lipoproteins were significantly associated with hip OA, with 7 of which presenting risk effects, distributed among HDL cholesterol (OR=1.07, 95% CI: 1.01-1.18)and most of its medium- and large-sized subclasses, while the remaining lipoproteins were protective.

NMR-based lipoproteins were causally associated with OA, as their different sizes and lipid compositions play different roles for OA at different sites.

To determine the optimal cut-off point of the General Self-Efficacy Scale (GSES) among middle school students and to establish a precise criterion for evaluating their self-efficacy.

A convenience sampling method was conducted a total of 2 494 junior high school students from grades 7-9 in two junior high schools in Guangzhou were selected for a questionnaire survey. The questionnaire includes demographic characteristics such as students’ gender, grade, and age, general self-efficacy, sleep, family functioning, and smartphone dependence. The latent profile analysis (LPA) was used to classify students’ self-efficacy, and the optimal cut-off point was determined based on the Receiver Operator Characteristic curve (ROC) and the Volume Under the ROC Surface (VUS).

A total of 2 494 middle school students were surveyed in this study. There were 1 285(51.52%) boys and 1 209(48.48%) girls. The self-efficacy of boys was 27(22-31) and that of girls was 24 (20-29), which is statistically significant different (Z=-7.86, P<0.01). LPA identified three categories of self-efficacy: low (862, 34.56%), medium (1 166, 46.75%), and high (466, 18.69%) self-efficacy types. The VUS method determined the optimal cut-off points for the GSES scale to be 22 and 32 points, respectively.The results of the ordinal logistic regression analysis showed that females (OR=1.58, 95%CI: 1.34-1.86), mild family dysfunction (OR=2.86, 95%CI: 2.38-3.44), severe family dysfunction (OR=4.46, 95%CI: 3.51-5.68), mobile phone addiction (OR=1.58, 95%CI :1.1-1.64), and lack of regular exercise (OR=1.75, 95%CI: 1.43-2.15) were positively associated with low self-efficacy, while sleeping time ≥9 hours (OR=0.78, 95%CI: 0.66-0.93) and outdoor activity time ≥1 hour (OR=0.8, 95%CI: 0.65-0.97) were negatively correlated with low self-efficacy among middle school students.

This study provides a clear and scientific assessment criterion for evaluating the self-efficacy level of middle school students through the combination of LPA and VUS methods, offering a powerful tool for more accurate assessment of middle school students’ self-efficacy.

To analyze the alarm information of monitoring platform for vaccine cold chain in Shandong Province and to provide scientific basis for improving the cold chain guarantee level of vaccines.

We have collected data on overtemperature and blackout alarms from January 1 to December 31, 2024 in Shandong Province through the cold chain monitoring platform, and descriptive analysis was conducted by season, region, and unit type.

The cold chain monitoring platform in Shandong Province is equipped with 5 463 data recording devices and 25 159 data collection devices, which monitor in real-time the temperature of vaccine storage and transportation in 16 cities’ Centers for Disease Control and Prevention and vaccination units throughout the province. The summer month of July has the highest number of alarm information, with an average of 4.2 for overtemperature and 2.0 for blackout alarm. The winter month of December has the lowest number of alarm information, with an average of 1.1 for both overtemperature and blackout alarms. The average number of overtemperature alarms in Tai’an City, Rizhao City, and Heze City exceeds 40, while the average number of overtemperature alarms in Jining City is at least 17.6. The average number of blackout alarms in Binzhou City, Liaocheng City, Heze City, and Dezhou City exceeds 20, while Jinan City has the lowest number of blackout alarms, with an average of 10.1. The CDC has the highest number of overtemperature alarms, with an average of 59.7 alarms. The routine vaccination clinic has the highest number of blackout alarms, with an average of 19.8 alarms. The average number of overtemperature alarms and blackout alarms in the rabies exposure prevention and treatment outpatient department are relatively high, with 48.2 and 18.8 alarms, respectively.

There are seasonal, regional, and unit type differences in vaccine cold chain alarms, and targeted measures should be taken to strengthen vaccine cold chain management and ensure vaccine safety.

To explore the relationship between sleep quality and health-related quality of life (HRQoL) among middle-aged and elderly adults with multiple chronic conditions and their family caregivers based on the actor-partner interdependence model, and to further explore the mediating role of depressive symptoms.

A general information questionnaire, the Pittsburgh Sleep Quality Index (PSQI), the Geriatric Depression Scale (GDS-15), and the Short Form Health Scale (SF-36) were used to survey middle-aged and elderly adults with multimorbidity and their family caregivers, and data were analyzed using actor-partner interdependence model.

Participants’ sleep quality negatively predicted their HRQoL, and depressive symptoms partially mediated the relationship between sleep quality and HRQoL (the actor effect). In addition, sleep quality in middle-aged and elderly adults with multimorbidity positively predicted caregivers’ depressive symptoms, which in turn negatively predicted their HRQoL (β=-0.25, P<0.05)(the partner effect).

Sleep quality in middle-aged and elderly adults with multimorbidity and caregivers can affect their own HRQoL through depressive symptoms. The patient’s sleep can influence the caregivers’ depressive symptoms and the caregivers’ depressive symptoms can influence the patient’s HRQoL.

To analyze the association between Body Roundness Index (BRI) and to cardiometabolic comorbidities among individuals aged 35-75 years in Zhejiang Province.

Residents aged 35-75 years recruited in the 2022 China National Nutrition and Health Survey (Zhejiang region) were selected as the study population. Statistical analyses were performed using R 4.3.3 and SPSS 30.0. The χ² test and logistic regression were used to evaluate the impact of BRI on cardiometabolic diseases.

The overall prevalence rates of hypertension, diabetes, dyslipidemia, coronary heart disease, stroke, and cardiometabolic comorbidities in Zhejiang residents aged 35-75 years were 41.43%, 15.46%, 40.07%, 1.20%, 0.78%, and 27.99%, respectively. Logistic regression analysis showed that after adjusting for confounders, individuals in the fourth quartile (Q4) of BRI had a higher risk of hypertension (OR=4.10, 95%CI: 3.11-5.38）, diabetes (OR=3.18, 95%CI: 2.20-4.61), dyslipidemia (OR=3.84, 95%CI: 2.95-5.00), coronary heart disease (OR=3.40, 95%CI: 0.74-15.71), stroke (OR=1.10，95%CI: 0.34-3.56) and cardiometabolic comorbidities (OR=5.20, 95%CI: 3.76-7.13) compared with the first quartile (Q1). Female participants (OR=1.43, 95%CI: 1.28-1.60) had a lower risk compared to males (OR=1.70，95%CI: 1.48-1.96). Significant interaction effects of age and smoking on the risk of cardiometabolic comorbidities were observed, with the risk significantly higher in middle-aged adults (35-54 years). In a population with normal BMI, ROC curve analysis indicated that BRI was superior to BMI in predicting the risk of CMM, however, both AUC values were below 0.7, suggesting that the predictive ability remains weak.

Higher BRI levels were positively associated with cardiometabolic comorbidities. To identify high-risk populations for cardiometabolic comorbidities early, targeted management and intervention strategies should be implemented to reduce the burden of cardiometabolic diseases. However, caution is warranted when promoting the use of BRI in public health and clinical practice, as further research is needed to validate its effectiveness.

To investigate the association between newly developed non-alcoholic fatty liver disease (NAFLD) in the third trimester of pregnancy and adverse pregnancy outcomes, and to evaluate the necessity of prevention, monitoring, and health education for NAFLD during pregnancy.

This retrospective study included 3 505 singleton primiparous pregnant women without NAFLD in early pregnancy, registered at Beijing Friendship Hospital, Capital Medical University, from March 2020 to December 2022. Logistic regression analysis was used to investigate the association between newly developed NAFLD in the third trimester and adverse pregnancy outcomes, including cesarean section, preterm birth, small-for-gestational-age infants, large-for-gestational-age infants, and postpartum hemorrhage.

After adjusting for factors such as maternal age, gravidity, pre-pregnancy body mass index (BMI) level, gestational weight gain level, relevant medical histories, and educational level, the risk of postpartum hemorrhage was found to be increased in women with newly developed NAFLD in the third trimester (OR=2.136, 95%CI: 1.009-4.080, P=0.031). No statistically significant associations were found with cesarean section, preterm birth, small-for-gestational-age infants, or large-for-gestational-age infants.

A positive association between newly developed NAFLD in the third trimester of pregnancy and postpartum hemorrhage was revealed, highlighting the importance of strengthening surveillance and prevention for NAFLD during pregnancy to reduce the risk of postpartum hemorrhage.