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To investigate the association between lipoproteins determined by nuclear magnetic resonance (NMR) and osteoarthritis (OA) using Mendelian randomization (MR).
Using the genome-wide association study (GWAS) of 116 NMR-based lipoproteins and total OA, knee OA, and hip OA, univariate MR analyses were conducted to assess the association between lipoproteins and osteoarthritis.
Univariate MR results showed that 73 lipoproteins were significantly associated with total OA, LDL diameter (OR=1.07, 95% CI: 1.03-1.11) and small HDL phospholipids (OR=1.05, 95% CI: 1.01-1.08) presented risk effects on total OA,while the remaining lipoproteins were protective and were distributed in apolipoprotein B, cholesterols, intermediate density lipoprotein, and very-low-density lipoprotein subclasses. 57 lipoproteins were significantly associated with knee OA, all of which were found in total OA, with LDL diameter (OR=1.11, 95% CI: 1.05-1.18) presenting a risk effect on knee OA, while the remaining lipoproteins were protective. 90 lipoproteins were significantly associated with hip OA, with 7 of which presenting risk effects, distributed among HDL cholesterol (OR=1.07, 95% CI: 1.01-1.18)and most of its medium- and large-sized subclasses, while the remaining lipoproteins were protective.
NMR-based lipoproteins were causally associated with OA, as their different sizes and lipid compositions play different roles for OA at different sites.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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