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To investigate the association between newly developed non-alcoholic fatty liver disease (NAFLD) in the third trimester of pregnancy and adverse pregnancy outcomes, and to evaluate the necessity of prevention, monitoring, and health education for NAFLD during pregnancy.
This retrospective study included 3 505 singleton primiparous pregnant women without NAFLD in early pregnancy, registered at Beijing Friendship Hospital, Capital Medical University, from March 2020 to December 2022. Logistic regression analysis was used to investigate the association between newly developed NAFLD in the third trimester and adverse pregnancy outcomes, including cesarean section, preterm birth, small-for-gestational-age infants, large-for-gestational-age infants, and postpartum hemorrhage.
After adjusting for factors such as maternal age, gravidity, pre-pregnancy body mass index (BMI) level, gestational weight gain level, relevant medical histories, and educational level, the risk of postpartum hemorrhage was found to be increased in women with newly developed NAFLD in the third trimester (OR=2.136, 95%CI: 1.009-4.080, P=0.031). No statistically significant associations were found with cesarean section, preterm birth, small-for-gestational-age infants, or large-for-gestational-age infants.
A positive association between newly developed NAFLD in the third trimester of pregnancy and postpartum hemorrhage was revealed, highlighting the importance of strengthening surveillance and prevention for NAFLD during pregnancy to reduce the risk of postpartum hemorrhage.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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