To investigate the current situation of behavioral problems of senior primary school students in Guizhou Province, and to explore the influence of family-related factors on primary school students’ behavioral problems.

By using the method of multi-stage stratified cluster random sampling, a total of 2 698 subjects were selected from one primary school in each of three urban areas with different levels of economic development in Guizhou Province. The parents of primary school students were investigated with self-made questionnaire and Achenbach Child Behavior Checklist (CBCL). The χ² test was used to compare the differences, and the logistic regression analysis was used to analyze the relationship between family-related factors and pupils’ behavior problems.

The detection rate of behavior problems in senior primary school students was 11.60%, which was 11.79% in boys and 11.40% in girls, respectively, with no significant gender difference (P>0.05). The detection rate of behavior problems in students of grades 4 to 6 was 13.36%, 12.49%, and 9.30%, respectively, and the difference between grades was statistically significant (P<0.05). The top behavioral problem was obsessive-compulsive behavior (4.92%) and hyperactive behavior (3.44%) in 6-11-year-old boys and girls, respectively. The top behavioral problem was hyperactive behavior(2.66%) and aggressive behavior (15.30%) in 12-16-year-old boys and girls, respectively. The results of Logistic regression analysis showed that parents’ introverted personality, mother’s poor health status, and mother’s neglected rearing style were positively correlated with primary school students’ behavior problems (OR=1.52, 1.54, 1.74, and 2.22), while father’s college education, no bad life habits of parents, and father’s democratic rearing style were inversely correlated with primary school students’ behavior problems (OR=0.43, 0.66, 0.64, and 0.59).

The detection rate of behavioral problems among primary school students in Guizhou Province is still at a high level, which is related to various family factors. Parents should improve their own self-quality and improve the family environment to reduce the occurrence of behavioral problems in primary school students.

To explore the effect of a new type of low-protein enteral nutrition on the nutritional status of patients with chronic kidney disease in stage 3-4 under the guidance of individualized diet.

Sixty follow-up outpatients in West China Hospital of Sichuan University were randomly divided into the experimental group and the control group. The two groups were followed up on intervention day 0, day 45, and day 90. According to the principle of intentional analysis, the generalized estimation equation was used to analyze the between-group differences, time change trend, and interaction effect, and the principle of data analysis in accordance with the scheme was used to further verify the stability of results.

There was no significant difference in nutritional adequacy, clinical effectiveness, and anthropometric indexes between the test group and the control group (P > 0.05). During the intervention period, when the energy intake was stable, the intake of protein (χ²=17.680, P<0.001) and sodium salt (χ²=21.427, P<0.001) decreased significantly, while the total protein (χ²=18.075, P<0.001), calcium (χ²=9.438, P=0.009), phosphorus (χ²=13.866, P=0.001), and uric acid (χ²=9.005, P=0.011) fluctuated within the normal range. The results of data analysis in accordance with the scheme were basically consistent with those of intentionality analysis. Only the time change trend of upper arm muscle circumference (χ²=6.435, P=0.040) and the comparison of energy ratio between groups(χ²=4.478, P=0.034) were significantly different.

The new low-protein enteral nutrition preparation is not inferior to the total nutritional formula food for special medical use in improving the nutritional status of patients and delaying the progression of the disease. The use of enteral nutrition under dietary guidance is beneficial to the clinical nutrition management of

To establish a risk assessment model of cardiometabolic multimorbidity (CMM) and validate the model.

The influencing factors of CMM were determined by meta-analysis, and the population exposure rate was obtained by consulting a large cohort study.The CMM risk assessment model was constructed based on Harvard cancer risk index method. The model was verified by the data of China Health and Retirement Longitudinal Study (CHARLS). The SPSS 25.0 software was used to calculate the area under the receiver operator characteristic ROC curve (AUC), sensitivity, specificity, and Hosmer-Lemshow goodness-of-fit test to verify the effect of the model.

A total of 20 articles were included in the meta- analysis. Age, sex, place of residence, education, economic level, BMI, waistline, night sleep, depression, irregular diet, and insufficient intake of vegetables and fruits were the risk factors of CMM. Concerning the model validation results, the area under the ROC curve was 0.712 (95%CI: 0.696-0.728), the Jordan index was 1.42, the sensitivity was 65%, the specificity was 66.1%, and the result of Hosmer-Lemshow goodness-of-fit test was χ²=10.652 (P=0.222).

The CMM risk assessment model based on meta-analysis has good predictive performance and can be used as a tool for CMM risk assessment to guide clinical identification of CMM high-risk groups and implement intervention measures.

To explore the training mode and mechanism of compound talents of preventive medicine and software engineering.

In order to adapt to the development trend of multidisciplinary and new technology integration under the background of new medical science construction and the strategic needs of building a healthy China, the West China School of Public Health and the School of Computer Science (School of Software) of Sichuan University have established a dual bachelor’s degree talent training program in Preventive Medicine and Software Engineering, a teaching professor expert team with cross disciplinary integration, integrated courses and internship bases, through extensive research and expert verification, in accordance with the requirements of the National Standards for Undergraduate Professional Teaching Quality and the Management Measures for Bachelor’s Degree Authorization and Granting. The program aims to recruit dual bachelor’s degree students, strengthen student guidance and teaching feedback, and continuously summarize and improve the talent training mode.

Three sessions of dual bachelor’s degree students in Preventive Medicine + Software Engineering have been recruited, a teaching team integrating medical and engineering has been established, seven integrated courses have been formed, professional training objectives and curriculum systems have been established and continuously improved, and two medical research and practical teaching innovation bases suitable for dual bachelor’s degree students have been established. The adaptability and satisfaction of students have been continuously improved.

The double bachelor degree training model of preventive medicine + software engineering with the characteristics of public health and software has been initially established, which provides an important theoretical and practical reference for the reform of the training mode of medical-industrial integration.

To investigate the relationship between the metabolism score for visceral fat (METS-VF) and new stroke cases in the middle-aged and elderly.

Three Logistic regression models were established based on the data of China Health and Retirement Longitudinal Study (CHARLS) in 2011 and 2018 to study the association between METS-VF and new stroke cases, and the restricted cubic spline model was used to investigate the possible nonlinear relationship.

In total 7 007 participants were included, of which 407 had new stroke. The results of regression model showed that compared with the group with the lowest METS-VF index (Q1), the group with the highest METS-VF index (Q4) had the highest risk of new stroke, with the increased risk by 153% (OR=2.53, 95%CI: 1.87-3.47). Restricted cubic spline regression analysis found that there was a dose-response relationship between METS-VF index and the prevalence of new stroke (P <0.001), showing a J-shape relationship (P _Nonlinear < 0.001).

METS-VF index is closely related to the prevalence of new stroke, and there is a dose-response relationship between them.

To analyze the frequency and influencing factors of blood glucose self-monitoring of blood glucose (SMBG) in Chinese patients with type 2 diabetes mellitus by meta-analysis.

By searching literature in the databases of CNKI, VIP, CBM, Wan Fang Data, PubMed, Embase, Web of science, CINAHL, and the Cochrane Library from the establishment of the database to May 26, 2023, cross-sectional studies on the SMBG frequency standard rate and its influencing factors in Chinese patients with type 2 diabetes were searched. Two researchers independently screened the literature and extracted the data, and meta-analysis was carried out by using Stata 17.0 software.

A total of 17 studies were included, including 14 343 patients with type 2 diabetes, of which 3 403 met the SMBG standard. The results of meta-analysis showed that the reaching standard rate of SMBG frequency in Chinese patients with type 2 diabetes was 26.4%(95%CI: 21.0%-31.8%). Based on the subgroup analysis of evaluation tools, regions, and sample sources, the results showed that the reaching standard rate of evaluation using the applicable guidelines for type 2 diabetes was 33.4% (95%CI: 24.8%-42%), and that using the guidelines for the prevention and treatment of type 2 diabetes was 19.1% (95%CI:11.9%-26.3%). The reaching standard rate of the eastern region was 26.9% (95%CI: 17.8%-36%), and that of the central region was 25.6% (95%CI: 17.5%-33.8%). The reaching standard rate was 27.3%(95%CI: 22.6%-32.1%) when the sample source was hospital and 12.1% (95%CI: 2.6%-21.7%) when the sample source was community. The influencing factors of SMBG reaching standard rate were higher education level (OR=1.591, 95%CI: 1.269-1.994), high income family (OR=1.751, 95%CI: 1.048-2.925), self-efficacy score (OR=2.592, 95%CI: 1.148-5.855), insulin (OR=2.193, 95%CI: 1.561-3.080), long course of disease (OR=1.035, 95%CI: 1.035-1.073), and having received SMBG-related health education (OR=2.195, 95%CI: 1.376-3.499).

The evidence results show that the SMBG frequency of Chinese patients with type 2 diabetes mellitus is low. The patients with higher education level, high income family, high self-efficacy, insulin as hypoglycemic regimen, long course of disease, and receiving SMBG-related health education have higher rate of reaching the standard frequency.

To analyze the changes of schistosomiasis epidemic trend before and after the implementation of schistosomiasis integrated control strategy in China from 1999 to 2015, and to evaluate its effects in the process of schistosomiasis transmission control.

The epidemic data of schistosomiasis in China from 1999 to 2015 were collected, and the interrupted time series (ITS) method was used to analyze the changes of positive rate of blood test, positive rate of fecal test, number of acute schistosomiasis cases, number of cattle, and infection rate of cattle before and after the implementation of the comprehensive control strategy of schistosomiasis.

After the implementation of the integrated schistosomiasis control strategy, the number of acute cases (β₂=-937.433, P < 0.001) and the infection rate of cattle (β₂=-1.606, P=0.012) decreased immediately in 2005. After the implementation of the strategy, the positive rate of blood test (β₃=-1.164, P < 0.001), the positive rate of stool test (β₃=-1.157, P < 0.001), the number of acute cases (β₃=-143.939, P < 0.001), and the infection rate of cattle (β₃=-0.513,P < 0.001) showed a downward trend year by year, which had a long-term effect on the prevention and control of schistosomiasis.

From 2006 to 2015, the positive rate of blood test, the positive rate of stool test, the number of acute cases, and the infection rate of cattle in China showed a decreasing trend, indicating that in the advancing stage of schistosomiasis transmission control in China, the integrated schistosomiasis control strategy based on source of infection control has a significant effect on schistosomiasis control.

To explore the causal relationship between hypothyroidism and the risk of coronary heart disease (CHD) by two-sample Mendelian randomization study.

Based on the association analysis data at the whole genome level, the exposure was hypothyroidism and the outcome was coronary heart disease. Random effect IVW method, MR-Egger method, and weighted median method were used for two sample Mendelian randomized analysis, and heterogeneity test, horizontal multiplicity analysis, and sensitivity analysis were carried out.

The results of random effect IVW method, weighted median method, and MR-Egger regression were 1.137 (95%CI: 1.070-1.209), 1.117 (95%CI: 1.028-1.214), and 1.194 (95%CI: 1.020-1.398), respectively, indicating that hypothyroidism was a risk factor for coronary heart disease with a positive causal correlation between them.

There is a causal relationship between hypothyroidism and the risk of coronary heart disease.

To analyze the prevalence of non-alcoholic fatty liver disease (NAFLD) and its influencing factors, and to explore the role of residual lipoprotein (RC) in risk assessment of NAFLD in the elderly.

The elderly over 60 years old in Xinzheng city, Henan Province in 2021 were selected as the research subjects, and the basic information, physical examination data, and laboratory indexes were collected. The role of RC in risk assessment of NAFLD in the elderly population was investigated by t test, χ² test, and multivariate Logistic regression analysis with the use of SPSS 26.0 software and R4.2.2.

A total of 62 730 elderly people were included in this study, and the prevalence rate of NAFLD was 26.02%. In univariate analysis, with the increase of RC level, the prevalence rate of the elderly population increased steadily, with the lowest in the first quartile and the highest in the second quartile (23.77% and 30.43%, respectively). Multivariate Logistic regression showed that the risk of NAFLD in women was 1.728 times higher than that in men (95%CI: 1.607-1.858), and the increase of age, BMI,waist circumference, fasting blood-glucose (FBG), triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol(LDL-C), and RC increased the risk of NAFLD. For every unit increase in RC, the risk of disease increased by 56.30% (95%CI:1.433-1.704), and after adjusting for confounding factors, RC was still a risk factor for NAFLD.

The prevalence of NAFLD is high in the elderly, and there is an independent correlation between RC and NAFLD.

To investigate the changes and influencing factors of health literacy level of rural residents in Chongqing from 2018 to 2021, and to predict the health literacy level of this population from 2022 to 2024, so as to provide a basis for formulating health promotion strategies in rural areas of Chongqing in the future.

Using the national unified health literacy questionnaire, the health literacy monitoring data of rural residents in Chongqing from 2018 to 2021 were analyzed, and the health literacy status of 73 478 residents from 39 districts and counties in the city were investigated. Multi-variable logistic regression method was used to analyze the influencing factors of residents’ health literacy. The grey prediction model GM (1,1) was used to predict the health literacy level of rural residents in Chongqing from 2022 to 2024.

From 2018 to 2021, the health literacy level of rural residents in Chongqing showed a steady upward trend (χ²_trend =280.989, P<0.001). The four-year health literacy levels were 17.14%, 21.68%, 22.50%, and 24.15%, respectively. Multivariate regression analysis showed that the older age was associated with lower level of health literacy: 45-59 years old: OR=0.761 (95%CI: 0.725-0.800); 60-69 years old: OR=0.455 (95%CI: 0.426-0.485). Higher education level was associated with higher level of health literacy: junior high school: OR=2.551 (95%CI: 2.432-2.675); senior high school/vocational high school/ technical secondary school: OR=4.435(95%CI: 4.145-4.746); college/undergraduate and above: OR=6.890 (95%CI: 6.261-7.582). The forecast result of GM (1,1) showed that the total health literacy of rural residents in Chongqing would rise to 28.54% by 2024. The three aspects of health literacy showed an upward trend. Among the six aspects of health literacy, four aspects of health literacy continued to rise: the literacy of infectious disease prevention and treatment (up to 37.54%), health information literacy (32.39%), chronic disease prevention literacy (29.88%), basic medical literacy (28.59%). Two aspects of health literacy continued to decline with scientific health literacy decreasing to 33.42% and safety and first aid literacy decreasing to 38.57%.

The health literacy of rural residents in Chongqing continued to improve from 2018 to 2021. There is an urgent need to take targeted intervention measures to improve health literacy of the elderly, low-educated, and low-income rural residents. The forecast results show that the literacy level of scientific health concept, safety and first aid literacy will decline in the next three years, so we should pay more attention to it.