To explore the causal relationship of postoperative fall fear, anxiety, and depression in elderly patients with hip fracture, and to provide reference basis for preventing fall fear and formulating individualized and phased intervention measures in elderly patients with hip fracture.

A total of 367 elderly patients with hip fracture hospitalized in the Department of Orthopedics of a tertiary hospital in Zhengzhou from January to July 2023 were selected by cluster sampling. The patients were investigated with the use of Falls Efficacy Scale-International (FES-I), the Generalized Anxiety Disorder 7 (GAD-7), and the Patient Health Questionnaire 9 (PHQ- 9) at the first time of getting out of bed after operation (T0), 3 months after operation (T1), and 6 months after operation (T2). Mplus 8.3 was used for cross-lagged analysis to explore the causal relationship and action direction among fall fear, anxiety, and depression.

(1) Postoperative fall fear, anxiety, and depression in elderly patients with hip fracture decreased. Fall fear was positively correlated with anxiety and depression, and anxiety and depression were also positively correlated. (2) T0 fall fear positively predicted T1 anxiety, and T1 fall fear significantly predicted T2 anxiety (β₁=0.113, P<0.01; β₂=0.278, P<0.01). (3) T0 fall fear significantly positively predicted T1 depression, and T1 fall fear significantly predicted T2 depression (β₃=-0.133, P<0.05; β₄=-0.124, P<0.05). (4) T0 anxiety significantly positively predicted T1 depression, and T1 anxiety significantly positively predicted T2 depression (β₅=-0.119, P<0.05; β₆=-0.136, P<0.05).

There is a causal relationship between postoperative fall fear, anxiety, and depression in elderly patients with hip fracture. Prevention of depression can start with their fall fear by actively helping elderly patients with hip fracture reduce fall fear, which is beneficial to their physical and mental health after operation.

To investigate the evaluation of integrated care management in patients with pulmonary nodule lung cancer and to provide basis for improving the service quality of integrated care management of chronic disease.

From January 2021 to December 2022, electronic questionnaires were distributed to patients with lung nodule lung cancer who met the inclusion criteria, and an anonymous survey was conducted. The chi-square test was used to compare the evaluation differences among different groups.

A total of 130 valid questionnaires were collected. The overall satisfaction evaluation, recommendation intention, and improvement evaluation of the integrated care management were 95.72, 94.66, and 79.89, respectively. There were significant differences (P<0.05) in satisfaction evaluation among different ethnic groups (χ²=16.788, P=0.010), education level (χ²=24.339, P=0.042), and management time (χ²=19.277, P=0.013). There were significant differences (P<0.05) in recommendation intention among patients of different ethnic groups (χ²=15.943, P=0.0144), occupation (χ²=37.265, P=0.011), and management time (χ²=9.536, P=0.049). There was a significant positive correlation among patient satisfaction evaluation, recommendation intention, and improvement evaluation, and the correlation coefficients were 0.581, 0.723, and 0.538,respectively.

The integrated care management model of pulmonary nodule lung cancer is widely recognized by patients, with high level of satisfactory evaluation, and patients have strong willingness to recommend. This model can significantly improve the medical service experience and treatment effect.

To explore the causal relationship among depressive symptoms in young men who have sex with men young (YMSM) in central China.

A total of 349 eligible YMSM who were recruited in Wuhan, Changsha, and Nanchang in 2017 and completed three rounds of follow-up in 2018 and 2019 were selected as research subjects. The depressive symptoms of the subjects were measured by the center for epidemiological survey-depression scale (CES-D), and the longitudinal network structure of depression was analyzed by cross-lag network.

During the period from baseline to the first round of follow-up, the statistical value of output centrality of loneliness was 3.541, which had the highest impact on other symptoms, followed by dislike for themselves (1.196). The central statistical value of unhappy input was 2.175, followed by boredom (1.124) and bitterness (1.093), indicating that these symptoms were most easily predicted by other symptoms. During the first round of follow-up to the second round of follow-up, unfriendliness (2.440) was the symptom with the highest impact on output expectations, followed by inability to perform daily work (1.708) and dislike for themselves (1.119). Fear (2.437), arduous work (1.374), and hopelessness (1.278) were the most easily predicted by other symptoms. In the YMSM depressive symptom network, loneliness (3.541), unfriendliness (2.440), and dislike for themselves (1.196) constituted a small symptom group, which occupied the core position of the network.

Interpersonal relationship plays an important role in the network structure of depressive symptoms in YMSM population. Future interventions should fully consider this and reduce YMSM depression by promoting social interaction and social integration of YMSM groups.

To analyze the frequency and influencing factors of blood glucose self-monitoring of blood glucose (SMBG) in Chinese patients with type 2 diabetes mellitus by meta-analysis.

By searching literature in the databases of CNKI, VIP, CBM, Wan Fang Data, PubMed, Embase, Web of science, CINAHL, and the Cochrane Library from the establishment of the database to May 26, 2023, cross-sectional studies on the SMBG frequency standard rate and its influencing factors in Chinese patients with type 2 diabetes were searched. Two researchers independently screened the literature and extracted the data, and meta-analysis was carried out by using Stata 17.0 software.

A total of 17 studies were included, including 14 343 patients with type 2 diabetes, of which 3 403 met the SMBG standard. The results of meta-analysis showed that the reaching standard rate of SMBG frequency in Chinese patients with type 2 diabetes was 26.4%(95%CI: 21.0%-31.8%). Based on the subgroup analysis of evaluation tools, regions, and sample sources, the results showed that the reaching standard rate of evaluation using the applicable guidelines for type 2 diabetes was 33.4% (95%CI: 24.8%-42%), and that using the guidelines for the prevention and treatment of type 2 diabetes was 19.1% (95%CI:11.9%-26.3%). The reaching standard rate of the eastern region was 26.9% (95%CI: 17.8%-36%), and that of the central region was 25.6% (95%CI: 17.5%-33.8%). The reaching standard rate was 27.3%(95%CI: 22.6%-32.1%) when the sample source was hospital and 12.1% (95%CI: 2.6%-21.7%) when the sample source was community. The influencing factors of SMBG reaching standard rate were higher education level (OR=1.591, 95%CI: 1.269-1.994), high income family (OR=1.751, 95%CI: 1.048-2.925), self-efficacy score (OR=2.592, 95%CI: 1.148-5.855), insulin (OR=2.193, 95%CI: 1.561-3.080), long course of disease (OR=1.035, 95%CI: 1.035-1.073), and having received SMBG-related health education (OR=2.195, 95%CI: 1.376-3.499).

The evidence results show that the SMBG frequency of Chinese patients with type 2 diabetes mellitus is low. The patients with higher education level, high income family, high self-efficacy, insulin as hypoglycemic regimen, long course of disease, and receiving SMBG-related health education have higher rate of reaching the standard frequency.

To evaluate the relationship between alcohol consumption and hyperuricemia in natural population in southwest China, and to further explore the mediating effect of blood lipid level on the relationship between alcohol consumption and hyperuricemia.

Based on the baseline data (2018 to 2019) and the first-round follow-up data (2020 to 2021) of the natural population cohort study in southwest China, a multivariate Logistic regression model was used to analyze the association between alcohol consumption and hyperuricemia. The potential mediating effect of serum lipids was evaluated by causal mediation analysis.

A total of 1 615 people were enrolled in this study, including 162 new cases of hyperuricemia. Each 10g/d increase in pure alcohol intake was positively correlated with the risk of hyperuricemia (OR=1.22, 95%CI: 1.08-1.37). High density lipoprotein (HDL-C) and triglyceride (TG) partially mediated the relationship between alcohol consumption and hyperuricemia, with mediating effects of 16.58% (95%CI: 5.64%-54.01%) and 6.98% (95% CI:1.12%-24.84%), respectively.

The increase of alcohol consumption can increase the risk of hyperuricemia. HDL-C and TG are important mediating factors between alcohol consumption and hyperuricemia. Our study shows that the occurrence and development of hyperuricemia can be prevented by reducing alcohol consumption and controlling blood lipids.

To investigate the relationship between the intake of flavonoids in diet and total bone mineral content in human body.

Adults aged 20 to 59 years in the National Health and Nutrition Examination Surveys (NHANES) from 2017 to 2018 were selected as research subjects. A multivariate linear regression model was constructed to explore the relationship between dietary flavonoid intake and total bone mineral content adjusting gender, age, race, education level, marital status, economic status, BMI, alcohol consumption, hypertension, diabetes, and cardiovascular disease.

A total of 2 110 participants were included in the study, with the ratio of male to female 1:1. The average total mineral content was 2 341.4 g, and the median intake of total flavonoids in diet was 74.45 mg. After adjusting for sex, age, race, education, marital status, economic status, BMI, alcohol consumption, hypertension, diabetes and cardiovascular disease, the linear regression model showed that the total bone mineral content of the whole body was positively correlated with dietary isoflavone intake (β=0.68, 95%CI:0.26-1.09), and there was a dose-response relationship (P_trend=0.001). In addition, the results of subgroup analysis showed that the positive correlation was stronger in men (β_male=1.39, 95%CI: 0.67-2.11 vs. β_Female=0.18, 95%CI: -0.31 to 0.67, P_inter=0.038).

the intake of isoflavones in diet may increase the content of total bone minerals in human body, but whether there is a gender difference needs to be further explored.

To establish a rapid method for the determination of 33 organophosphorus pesticide residues in four different fruit and vegetable substrates (common type, high pigment type, high fat type, and high sugar type) by QuEChERs pretreatment combined with gas chromatography-tandem mass spectrometry (GC-MS), so as to provide technical support for simultaneous detection and food safety risk assessment of organophosphorus pesticides in different fruits and vegetables.

The samples were extracted with acetonitrile and sodium citrate-disodium hydrogen citrate buffer at the same time, purified with ethylenediamine-N-propyl silane (PSA), octadecylsilane bonded silica gel (C₁₈), and graphitized carbon black (GCB). After nitrogen blowing concentration, the samples were re-dissolved with acetone and detected by gas chromatography-tandem mass spectrometry under multi-reaction ion monitoring (MRM) mode. Quantifications were based on internal standard curves.

The method had good linear relationship in the range of 50 μg/L to 500 μg/L, with the correlation coefficients greater than 0.9950. The detection limits were within 1.50 to 5.04 μg/kg, and the limits of quantification were within 5.01 to 16.78 μg/kg. In the range of 0.040 to 0.200 mg/kg, the average recoveries ranged from 71.4% to 119.1%, with the relative standard deviations less than 12%.

The method is simple and rapid, with high accuracy and precision, which is suitable for the rapid detection and quantitative analysis of 33 organophosphorus pesticide residues in different fruit and vegetable substrates.

To study the causal effects of generalized anxiety disorder, major depressive disorder, schizophrenia, sleep disorder, and psoriasis by two-sample Mendelian randomization analysis.

The single nucleotide polymorphisms (SNPs) associated with four psychiatric traits and psoriasis were screened from the genome-wide association study (GWAS) data base. The relationships between exposures and outcome were analyzed by inverse variance weighting (IVW) method, weighted median (WM) method, and MR-Egger method. The results were mainly evaluated by P value of IVW, odds ratio (OR), and 95% confidence interval (CI). IVW, MR Egger, and MR-PRESSO were used for sensitivity analysis.

The IVW results showed that there was a causal effect between schizophrenia and the risk of psoriasis (OR=1.002,95%CI: 1.000-1.003, P=0.023). In the heterogeneity test, the Cochran’s Q test of the IVW method reported P value of 0.104 and I² of 19.06%, the MR-PRESSO test in the pleiotropy test reported P value of 0.106, and the regression intercept of MR Egger reported P value of 0.272. The sensitivity analysis results were robust, and the results did not show heterogeneity and pleiotropy. No causal relationship was found for generalized anxiety disorder (OR=1.000, 95%CI: 0.999-1.001, P=0.791), major depressive disorder (OR=1.002, 95%CI: 0.998-1.005, P=0.246), sleep disorder (OR=0.999, 95%CI: 0.996-1.001, P=0.614) with psoriasis.

There is a causal relationship between schizophrenia and the risk of psoriasis. Patients with schizophrenia should strengthen the screening and prevention of psoriasis in order to reduce the risk of psoriasis.

To analyze the epidemic characteristics of pertussis in Yangzhou City in 2022 and the vaccine effectiveness(VE) of acellular pertussis vaccine (aPV) against pertussis, and to explore the influencing factors of the case surge under the high vaccine coverage, as well as the responding strategies.

The clinical data of pertussis patients were analyzed using a matched case-control study with the ratio of 1:2 to investigate the vaccine effectiveness of aPV in preventing pertussis.

The incidence-age curve showed the “U-shape”. The incidence of infants at the age of 3 months was higher, which was 127.8/100 000. The second peak occurred in children aged 5 to 7 years, with the incidence exceeding 60/100 000. Among the cases, the breakthrough cases accounted for 86.0%, and the clinical symptoms such as complications of the breakthrough cases were better than those of the unimmunized cases. The total VE of aPV in preventing pertussis was 86.10% (95%CI: 34.70%-97.04%), the VE of 1 dose of aPV in preventing pertussis was 85.35% (95%CI: 31.10%-96.89%), the VE of 4 doses of aPV was 98.20% (95%CI: 74.28%-99.88%), and the VE of onset-vaccination interval less than 1 year was 85.72% (95%CI: 32.8%-99.00%), indicating that the increased duration of time after vaccination was a risk factor for pertussis.

Currently, the immunization strategy of pertussis does not match the epidemic characteristics, and the risk of pertussis is high in infants at the age of 3 months and school-age children. The protective effect of aPV is not timely, so it is necessary to further modify and improve the pertussis immunization strategy, especially to consider the application of pertussis immunization in school-age children.

To investigate the relationship between the metabolism score for visceral fat (METS-VF) and new stroke cases in the middle-aged and elderly.

Three Logistic regression models were established based on the data of China Health and Retirement Longitudinal Study (CHARLS) in 2011 and 2018 to study the association between METS-VF and new stroke cases, and the restricted cubic spline model was used to investigate the possible nonlinear relationship.

In total 7 007 participants were included, of which 407 had new stroke. The results of regression model showed that compared with the group with the lowest METS-VF index (Q1), the group with the highest METS-VF index (Q4) had the highest risk of new stroke, with the increased risk by 153% (OR=2.53, 95%CI: 1.87-3.47). Restricted cubic spline regression analysis found that there was a dose-response relationship between METS-VF index and the prevalence of new stroke (P <0.001), showing a J-shape relationship (P _Nonlinear < 0.001).

METS-VF index is closely related to the prevalence of new stroke, and there is a dose-response relationship between them.