To investigate the relationship between serum cystatin C (CysC) levels and the risk of frailty.

This study used data from the 2011 China Health and Retirement Longitudinal Study (CHARLS). Through questionnaires and physical examination, 32 items of information were collected from the respondents, such as illness, ability to perform daily activities to calculate the frailty index (FI) to assess the state of frailty. A multivariate logistic regression model was used to explore the relationship between CysC levels and frailty, while restricted cubic spline was used to analyse the non-linear relationship.

A total of 6 941 adults aged 45 years and older, with a mean age of 59.2±9.8 years, 48.1% of whom were male, were included in the study, with a total of 1 004 (14.5%) experiencing frailty. After adjusting for confounders in the multivariate logistic regression model, the risk of developing frailty in the group with the highest CysC level (T3) was 2.13 times higher than that in the group with a lower CysC (T1) (OR =2.13, 95% CI: 1.75-2.60). When CysC was used as a continuous variable, the risk of frailty increased 1.89-fold for each unit increase in CysC. Restricted cubic spline function analyses showed an approximately "J" shaped relationship between CysC levels and the risk of debility (P _non-linear<0.05), the risk of frailty increased significantly with increasing CysC levels when CysC levels were ≥1.05 mg/L.

CysC levels are closely related to frailty, and there is a nonlinear relationship between them.

To construct an evaluation index system of information literacy for public health personnel, and to provide reference for assessing the level of information literacy of public health personnel.

The indicator pool of the indicator system was constructed through the literature research method and combining with the actual work, 19 experts in related fields were invited to conduct two rounds of expert consultation by the Delphi method, so as to determine the final indicators, and the weights of indicators at all levels were determined by the hierarchical analysis method.

The positive coefficients of the two rounds of expert consultation were greater than 90%, and the expert authority coefficients were 0.895 and 0.922. The expert Kendall coordination coefficients were 0.152 and 0.121, respectively P<0.001, and the differences were all statistically significant. Through two rounds of expert consultation, the evaluation index of information literacy of public health personnel constructed by 4 first-level indicators, 15 second-level indicator systems and 38 third-level indicators of information awareness, information knowledge, information competence and information utilization ethics were finalized.

The index system has certain reliability and scientificity, and can provide a reference basis for measuring the information literacy level of public health personnel.

Toanalyze the prevalence and determinants of chronic obstructive pulmonary disease (COPD) among the Hani ethnic minority older adults in rural areas of Yunnan Province.

The multi-stage stratified random sampling method was employed to select 1 402 rural Hani ethnic minority older adults aged ≥60 years in Mojiang County, Yunnan, each participant received a questionnaire survey and physical examination. Structure Equation Modeling (SEM) was applied to assess the possible influencing factors of COPD status.

Among the Hani ethnic minority older adults investigated, the prevalence of COPD was 8.84%. Men had a significantly higher prevalence of COPD than women (12.04% and 5.90%, χ²=16.348,P<0.001). Prevalence of COPD increased with advancing age (χ²=5.625,P=0.018). Hani older adults with a family history of COPD, individuals with low body mass index, and smokers had a higher prevalence of COPD than their counterparts (χ²=13.791,χ²=36.651,χ²=14.963,P<0.001). The results of SEM analysis indicated that gender, age, low body mass index, smoking had an effect on prevalence of COPD with the total effects of -2.53, 0.66, 1.79, 1.20 and 0.30, respectively.

The prevalence of COPD among Hani older adults was comparatively low in rural Yunnan, and men, advanced age groups, those with a family history of COPD, those with a low body mass index, and smokers were the priority populations for COPD prevention and control.

To intervene in the process of the information epidemic's impact on public anxiety through a mediated model with moderation, and to explore the relationship between information epidemic and anxiety and its mechanism of action, with a view to better solving the difficulties it poses, eliminating the atmosphere of public anxiety shrouded by the information epidemic under the public health emergencies, and further stifling the possibilities of the generation of social risk crises.

Using a combination of convenience sampling and snowball sampling, 1 580 valid questionnaires were surveyed nationwide, and descriptive statistical analyses, regression analyses, and mediated moderated effects analyses were conducted.

Information epidemic had a positive predictive effect on anxiety level (β=0.14, P<0.001), mental toughness partially mediated the relationship between information epidemic and anxiety level 0.30 (95% CI:0.10-0.52), with the indirect effect accounting for 15.4 % of the total effect; and education level played a moderating role in the second half of the pathway of the aforementioned mediation model (β=-0.36, P<0.001).

In the context of public health emergencies, it is recommended to improve the public's mental toughness and education level to mitigate the adverse impacts of information outbreaks, and then reduce the negative emotions of public anxiety.

To explore the relationship between Internet use and cognitive function in the elderly.

Based on the data of China Family Panel Survey (CFPS) in 2020, the IADL scale and the mobile center self-rating depression scale were used to measure the disability status and depression status of the elderly. Two-column correlation analysis was used to analyze the correlation. This paper constructed a multiple mediating effect model to study the mediating path of the impact of Internet use on the cognitive function of the elderly.

After controlling for age, gender, marital status, and intergenerational support, the regression results showed that the use of the network had a significant direct impact on the cognitive function of the elderly (β=0.688, t=7.36, P<0.001), and depression and disability significantly affected the cognitive function of the elderly (β=-0.018, t=-2.696, P<0.05; β= -0.114, t=-4.83, P<0.001). The results of mediating effect analysis showed that the simple mediating effects of depression and disability between Internet use and cognitive function of the elderly were 0.044 (95% CI: 0.011 3-0.083 4) and 0.040 (95% CI:0.015 8-0.064 2), respectively, and the chain mediating effect was 0.006 (95% CI:0.000 4-0.013 2).

Depression and disability status have a mediating effect between whether or not to use the network and the cognitive function of the elderly, and depression and disability have a chain mediating effect in whether or not to use the network to affect the cognitive function of the elderly. With the popularization of the Internet, we should promote the use of the Internet in the elderly, and pay attention to the physical and mental health of the elderly, so as to protect the cognitive function of the elderly and delay or prevent the occurrence of cognitive impairment in the elderly.

To analyze the unqualified situation of blood test of voluntary blood donors in Changsha from 2018 to 2022, and to provide reference for the formulation of recruitment strategy of voluntary blood donors.

From January 2018 to December 2022, 792 508 voluntary blood donors in Changsha area (Changsha Blood Center) were selected as the subjects of this study. Blood samples were tested by enzyme-linked immunosorbent assay (ELISA) twice and nucleic acid detection (NAT) once. The unqualified blood tests in different years and populations were described.

The total unqualified rate of voluntary blood donors in Changsha from 2018 to 2022 was 1.76%, with the highest rate in 2018 (1.90%) and the lowest rate in 2022 (1.56%). The total failure rate of alanine aminotransferase (ALT) and hepatitis B virus surface antigen (HBsAg) ranked first (1.00%) and second (0.62%), respectively. There were significant differences in the unqualified rate of blood test for HBsAg, anti-HCV, anti-HIV, anti-TP, ALT and the single reactivity rate of nucleic acid test (NAT) among different years (P<0.05), and there were significant differences in the unqualified rate of blood test for volunteer blood donors with different gender, age, education level and occupation (P<0.05).

The total unqualified rate of blood testing of voluntary blood donors in Changsha from 2018 to 2022 has significantly decreased compared with that before 2018 in the same region, and ALT and HBsAg are the main reasons for unqualified blood testing. In order to promote the sustainable and healthy development of voluntary blood donation in Changsha, it is necessary to further improve the blood testing technology, optimize the blood collection and supply process, and then improve the accuracy of the test results.

To explore the association between the dietary diversity score (DDS) and the prevalence of possible sarcopenia among the elderly.

We conducted this analysis utilizing the cross-sectional data from the Chinese longitudinal healthy longevity survey and happy family study(CLHLS-HF, wave 2018 ). A standard developed by the Asian Working Group for Sarcopenia 2019(AWGS2019) was used to assess the possibility of sarcopenia. We have constructed four new indicators of DDS as follows: total diet, animal-based diet, plant-based diet, and plant-based diet without the consumption of legume products and nuts. We used the Logistic regression analysis to evaluate the association between the DDS of the total diet, animal-based diet, plant-based diet, and plant-based diet without the intake of legume products and nuts and possible sarcopenia. These associations were statistically adjusted for a variety of potential confounders. Sensitivity analysis and subgroup analyses were performed.

The analysis included 2 555 participants (mean age of 84.4 years). 1 244 (48.7％) were male and 1 311 (51.3％) were female. 1 632 elderly people had possible sarcopenia. DDS in the possible sarcopenia group was significantly lower than that in the non-sarcopenia group (P < 0.001). In our study, we found that participants with a higher DDS of the total diet (OR=0.544, 95% CI：0.405-0.732), animal-based diet (OR=0.613, 95% CI：0.423-0.888), and plant-based diet (OR=0.469, 95% CI：0.321-0.684) and plant-based diet without the consumption of legume products and nuts (OR=0.382, 95% CI：0.206-0.709) were at a lower risk of developing sarcopenia. In sensitivity analyses, the associations remained unchanged. In subgroup analysis, total diets, animal-based diet, and plant-based diet were still associated with a reduced risk of possible sarcopenia in the male population, while plant-based diet and plant-based diet without the intake of legume products and nuts were associated with a reduced risk of possible sarcopenia in the female population.

Taking a diversified diet may reduce the risk of developing sarcopenia. According to the findings of this study, adopting a diversified diet might reduce the risk of sarcopenia for older adults.

To analyze the trend of incidence and mortality of liver cancer due to HBV (hepatitis B virus, HBV) infection in China from 1990 to 2019, and to provide a scientific basis for the prevention and control of liver cancer.

Using the Global Burden of Disease database, the incidence and mortality of liver cancer due to HBV infection in China were analysed from 1990 to 2019, and a Joinpoint regression model was applied to analyse the trends in the incidence and mortality of liver cancer due to HBV infection. An age-period-cohort model was constructed to analyze the effects of three factors: age, period, and cohort on changes in morbidity and mortality.

The overall trend of the standardized incidence rate and the standardized mortality rate of liver cancer due to HBV infection for both men and women in China from 1990 to 2019 showed a decreasing trend. The average annual rates of change in the standardized incidence rate for men and women were -2.94% and -4.24%, respectively. And the average annual rates of change in the standardized mortality rate were -3.35% and -4.45%, respectively. The age-period-cohort model showed that the risk of morbidity and mortality for males and females tended to increase and then decrease with age, and the overall trend decreased with period and birth cohort, but there was a slight increase locally.

The incidence and mortality rates of liver cancer caused by HBV infection show a substantial downward trend from 1990 to 2019. In the future, the problem of HBV-induced liver cancer will remain serious, and it is recommended that hepatitis B (Hepatitis B) vaccination be expanded among high-risk groups, and that public education on health behaviors be strengthened and early screening for liver cancer be actively carried out.

To investigate the sedentary behavior of middle-aged and elderly non-diabetic population in Lanzhou and explore its correlation with insulin resistance (IR).

A cluster random sampling method was used to select residents aged 40-75 years from the survey data of the "REACTION Study" conducted between 2014 and 2016 in Lanzhou. A total of 3 609 individuals who met the inclusion criteria were included in this study. The sedentary time was divided into <3 h/d, 3-5 h/d and ≥5 h/d groups. Insulin resistance was diagnosed using the homeostasis model assessment of insulin resistance (HOMA-IR). Multivariate logistic regression analysis was performed to examine the association between sedentary behavior and IR, while subgroup analysis explored this relationship among different population subgroups.

The average daily sedentary time for study population was found to be approximately 4.00±1.92 h/d, with an overall prevalence rate of IR at 25.0%. The prevalence rates of IR for those with a sedentary time <3 h/d, 3-5 h/d and ≥5 h/d were observed as follows: 21.7%, 24.9% and 31%, respectively, with statistically significant differences (χ²=24.447, P<0.05). After adjusting for various confounding factors through logistic regression analysis, it was revealed that compared with sedentary <3 h/d, sedentary ≥5 h/d was a risk factor for the prevalence of IR (OR=1.468, 95% CI:1.168-1.845, P<0.05). Subgroup analysis indicated that only within subgroups consisting of individuals aged≥65 years old (OR=1.060,95% CI:1.005-1.118), insufficient physical activity (OR=1.071, 95% CI:1.017-1.128), hyperlipidemia (OR=1.071,95% CI:1.001-1.145), no hyperuricemia (OR=1.062, 95% CI:1.010-1.117), fatty liver (OR=1.133, 95% CI:1.038-1.237), and WC≥85 cm (OR=1.079, 95% CI:1.017-1.144), increased sedentary time was associated with increased risk of IR (all P<0.05).

Sedentary behavior is positively associated with the occurrence of IR in middle-aged and elderly non-diabetic population.However, the findings may vary across populations with distinct characteristics.

To explore the longitudinal trajectory of systolic blood pressure (SBP) and its influencing factors in community hypertensive patients.

We used data from national basic public health services for nine counties in Shandong Province to conduct a prospective cohort study. Group-Based Trajectory Modeling (GBTM) was used to explore the trajectory of systolic blood pressure. Repeated measurement analysis of variance was used to describe the changes in trajectories, and multinomial logistic regression was used to explore the influencing factors of the trajectories.

A total of 104 402 hypertension patients were included. The systolic blood pressure trajectories could be divided into four groups: Stage-1 high blood pressure gradually decreased group (21.8%), Stage-1 high blood pressure stable group (55.5%), Stage-2 high blood pressure gradually decreased group (7.2%) and Stage-2 high blood pressure increased group (15.6%). The results of repeated measures analysis of variance showed that there was a significant difference in systolic blood pressure values at different time points or different groups (P<0.001, P<0.001). The results of multinomial logistic regression showed that compared with the group with Stage-1 high blood pressure gradually decreased, the people with less education(OR=82.68, 95% CI:75.60-90.42), physical inactivity(OR=2.77, 95% CI:2.19-3.50), high frequency of drinking(OR=1.39, 95% CI:1.17-1.64), general compliance behavior(OR=1.44, 95% CI:1.18-1.75), intermittent medication(OR=2.15, 95% CI:1.98-2.34) were more likely to be classified into the group with Stage-2 high blood pressure increased. People with increased age (OR=1.03, 95% CI:1.02-1.03), and regular medication (OR=1.94, 95% CI:1.79-2.11) were more likely to be classified into the group with Stage-2 high blood pressure gradually decreased.

The systolic blood pressure trajectories in hypertensive patients can be divided into 4 categories. In the future, we should make more efficient assessments and interventions based on homogeneous populations of systolic blood pressure trajectories and their risk factors.