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To investigate the relationship between serum cystatin C (CysC) levels and the risk of frailty.
This study used data from the 2011 China Health and Retirement Longitudinal Study (CHARLS). Through questionnaires and physical examination, 32 items of information were collected from the respondents, such as illness, ability to perform daily activities to calculate the frailty index (FI) to assess the state of frailty. A multivariate logistic regression model was used to explore the relationship between CysC levels and frailty, while restricted cubic spline was used to analyse the non-linear relationship.
A total of 6 941 adults aged 45 years and older, with a mean age of 59.2±9.8 years, 48.1% of whom were male, were included in the study, with a total of 1 004 (14.5%) experiencing frailty. After adjusting for confounders in the multivariate logistic regression model, the risk of developing frailty in the group with the highest CysC level (T3) was 2.13 times higher than that in the group with a lower CysC (T1) (OR =2.13, 95% CI: 1.75-2.60). When CysC was used as a continuous variable, the risk of frailty increased 1.89-fold for each unit increase in CysC. Restricted cubic spline function analyses showed an approximately "J" shaped relationship between CysC levels and the risk of debility (P non-linear<0.05), the risk of frailty increased significantly with increasing CysC levels when CysC levels were ≥1.05 mg/L.
CysC levels are closely related to frailty, and there is a nonlinear relationship between them.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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