Objective Establish a ultra high performance liquidchromatography (UPLC) method for the simultaneous determination of sevenginsenosides Rg1, Re, Rf, Rb1, Rc, Rb2, and Rd in ginseng medicinalmaterials. Methods Using CAPCELL PAK ${\mathrm{C}}_{18}\mathrm{{MG}}\left({{2.0}\mathrm{\;{mm}}\times {150}\mathrm{\;{mm}},{2.0\mu}\mathrm{m}}\right)$ Chromatographic column with gradientelution of acetonitrile-0.05% phosphoric acid solution as mobile phase,flow rate of ${0.38}\mathrm{\;{mL}}\cdot {\mathrm{{min}}}^{-1}$ ,detection wavelength of ${203}\mathrm{\;{nm}}$ , column temperatureof ${30}^{\circ }\mathrm{C}$ , andinjection volume of ${1\mu}\mathrm{L}$ . Results All 7 ginsenosides can be completelyseparated and have a good linear relationship $\left({{r}^{2}> {0.999}}\right)$ withina certain linear concentration range, with an average recovery rate of ${97.22}\%\sim {104.56}\%$ ; Therelative standard deviation (RSD) is ${0.4}\%\sim {1.8}\%\left({n = 9}\right)$ ,and the precision RSD is ${0.57}\%\sim {1.42}\%$ . Conclusion Thismethod has strong specificity, excellent precision, good accuracy, andmore efficient detection process, and can be used for the determinationof seven ginsenosides in ginseng medicinal materials.

Objective To establish a rapid, accurate and sensitive gaschromatography-mass spectrometry (GC-MS) method for the detection ofdichloroacetic acid (DCA) and trichloroacetic acid (TCA) in drinkingwater samples, and to evaluate the performance and practical applicationof the method. Methods The samples were pretreated by liquid-liquidextraction derivatization technology and then analyzed by GC-MS. ${50\mu }\mathrm{L}$ and ${100\mu }\mathrm{L}$ of DCA and TCAstandards were prepared into mother solutions with concentrations of ${5\mu }\mathrm{g}/\mathrm{{mL}}$ and ${10\mu }\mathrm{g}/\mathrm{{mL}}$ ,respectively, and then diluted with methanol to form a series ofstandard solutions with concentration gradients for the establishment ofstandard curves. 1,2-Dibromopropane was used as the internal standardsubstance to prepare an internal standard extract of ${166.1\mu }\mathrm{g}/\mathrm{L}$ tocorrect the error in the sample analysis process. The spike recoveryexperiment was carried out on ultrapure water to evaluate the accuracyand precision of the method, and the detection limit of the method wasdetermined by the signal-to-noise ratio (S/N) method. Finally, 103drinking water samples were tested to analyze the contents of DCA andTCA. Results The linear ranges of the standard curves were $1 \sim {20}\mathrm{{\mug}}/\mathrm{{mL}}$ for DCA and $1\sim {40}\mathrm{{\mu g}}/\mathrm{{mL}}$ for TCA, withcorrelation coefficients $\left({r}^{2}\right)$ greater than 0.99,recoveries of 99.4%~114.3%, RSDs less than 3.541%, and detection limitsof ${0.1\mu }\mathrm{g}/\mathrm{L}$ and ${0.2\mu }\mathrm{g}/\mathrm{L}$ for DCA and TCA, respectively. The contents of DCA and TCA in 103drinking water samples were lower than the national standard limits,with average concentrations of ${0.25\mu}\mathrm{g}/\mathrm{L}$ and ${0.48\mu}\mathrm{g}/\mathrm{L}$ , respectively, and the data werestatistically significant $\left({P<{0.05}}\right)$ . Conclusion The GC-MS method has good linearity, accuracy, precision and sensitivity, and can meet the needs of drinking water safety monitoring. The method was applied to 103 drinking water samples, and the results showed that the drinking water quality met the national standards and was not seriously contaminated by DCA and TCA.

Objective To compare the diagnostic value and healtheconomic value of rapid detection of mycobacterium tuberculosis andrifampicin resistance (XpertMTB/RIF), mycobacterium nucleic acidPCR-fluorescent probe detection (MTB-NTM-PCR) and RNA isothermalamplification real-time fluorescence detection (SAT-TB) in detectingbronchial alveolar lavage fluid (BALF) in smear-negative pulmonarytuberculosis Be worth. Methods A retrospective analysis was conducted on100 patients with clinically diagnosed pulmonary tuberculosis butnegative sputum smears admitted to Guiyang Public Health TreatmentCenter from January 2019 to July 2022. All patients had negative sputumsmears for three consecutive times and underwent fiberoptic bronchoscopyin the fiberoptic bronchoscopy room of our hospital. BALF specimens weresimultaneously tested by smear acid-fast staining, GeneXpert MTB/RIF,MTB-PCR and SAT-TB detection methods. Taking the final clinicaldiagnosis of pulmonary tuberculosis as the gold standard, the diagnosticefficiency of the three methods and cost-effectiveness analysis werecalculated. Results The positive rates of XpertMTB/RIF, MTB-PCR andSAT-TB in 100 BALF samples were 53.00%, 43.00% and 35.00%, respectively.Taking clinical diagnosis as the gold standard, the positive rates ofXpertMTB/RIF $\left({{\chi }^{2}= {21.459}, P<{0.001}}\right)$ , MTB-PCR $\left({{\chi }^{2}= {17.695}, P<{0.001}}\right)$ , SAT-TB $\left({{\chi }^{2}= {12.631}, P<{0.001}}\right)$ and clinical diagnosis were statisticallysignificant. The sensitivity of XpertMTB/RIF, MTB-PCR, SAT-TB,XpertMTB/RIF+MTB-PCR, XpertMTB/RIF+SAT-TB, MTB-PCR+SAT-TB and the threecombined detections were 64.20%, 53.09%, 43.21% and 67, respectively ${90}\%,{66.67}\%,{58.02}\%,{69.14}\%$ ; Thespecificity was ${94.74}\%,{100.00}\%,{100.00}\%,{94.74}\%,{94.74}\%,{100.00}\%$ ,94.74%, respectively. ROC analysis showed that The AUC of XpertMTB/RIF,MTB-PCR, SAT-TB, XpertMTB/RIF+MTB-PCR, XpertMTB/RIF+SAT-TB,MTB-PCR+SAT-TB and the combined detection were 0.795, 0.765, 0.716 and0.813, respectively 0.807, 0.790, 0.819. Conclusion In the rapiddetection of negative tuberculosis, it is not recommended to select theabove three tests at the beginning of diagnosis and treatment. In termsof cost effectiveness, MTB-PCR can be used as the preferred diagnosticmethod for smear-negative pulmonary tuberculosis.

With the rapid development of China's economic market, the safety evaluation of mechanical and electrical products has become a key link for enterprises to enhance their competitiveness. Through the application of systematic functional risk assessment, the standardization and scientific nature of safety evaluation of mechanical and electrical products can be improved. This paper mainly analyzes the difference between mechanical and electrical product safety evaluation and general evaluation and the specific application of functional hazard assessment in mechanical and electrical product safety evaluation. The results show that functional hazard assessment can comprehensively and scientifically evaluate the safety performance of mechanical and electrical products, and provide strong support for the selection of products with higher cost performance. It also provides useful reference and guidance for practical application, and further promotes the development of safety evaluation of electromechanical products in our country.

Objective Gray mold is an important disease in thestrawberry production process, which seriously affects its yield andquality. This article aims to study the resistance of gray moldpathogens in different strawberry production areas in Zhejiang Provinceto fludioxonil, in order to clarify the current use status and futuremedication strategies of this fungicide. Methods This article uses themycelial growth rate method to conduct indoor toxicity testing on 184strains isolated from strawberry gray mold disease samples in 7 regionsof Zhejiang Province, in order to determine their sensitivity tofludioxonitril and count the frequency of occurrence of resistant andsensitive strains. Results The results showed that the strawberry graymold strain in Quzhou area had the highest sensitivity to fludioxonil,with an average ${\mathrm{{EC}}}_{50}$ value of ${0.014\mu }\mathrm{g}/\mathrm{{mL}}$ ,while the strawberry gray mold strain in Huzhou area had the lowestsensitivity to fludioxonil, with an average ${\mathrm{{EC}}}_{50}$ value of ${0.032\mu }\mathrm{g}/\mathrm{{mL}}$ and asensitivity baseline of ${0.018\mu}\mathrm{g}/\mathrm{{mL}}$ and the sensitive baseline value forthe whole province is ${0.018\mu}\mathrm{g}/\mathrm{{mL}}$ . Conclusion At present, a few lowresistant strains have appeared in the Zhejiang region, indicating thatthe strawberry gray mold fungus has developed certain resistance tofludioxonitril. The sensitivity baseline value has increased compared toprevious research results, but the overall level of drug resistance isstill controllable.

Objective To establish an extraction process and contentdetermination method for quercetin in Gentiana macrophylla, and optimizethe processing technology of Gentiana macrophylla. Methods This studyused ultrasound assisted extraction to extract quercetin from Gentianamacrophylla, and determined the content of quercetin in four processedGentiana macrophylla decoction pieces by HPLC-ELSD. Results The optimalprocess conditions for ultrasonic extraction of quercetin from Gentianamacrophylla are: ethanol volume fraction of 75%, ultrasonic time of 45minutes, solid-liquid ratio of 1 : 10, and ultrasonic temperature of ${30}^{\circ }\mathrm{C}$ . Thehighest yield of quercetin is ${3.40}\mathrm{{mg}}/\mathrm{g}$ . Conclusion The established extraction process and content determinationmethod for quercetin galls have good repeatability, stability, andreliability, which can provide reference for optimizing the processingtechnology of Gentiana macrophylla decoction pieces.

Objective To establish a method for determining thecontents of paeoniflorin, cinnamaldehyde and paeonol in Guizhi JiliuPills. Methods The RP-HPLC wavelength switching method was used, theanalysis was achieved on an ES Epic ${\mathrm{C}}_{18}\left({{4.6}\mathrm{\;{mm}}\times {250}\mathrm{\;{mm}},{5\mu}\mathrm{m}}\right)$ column, the mobile phase was acetonitrile-0.1% aqueous solution of phosphoric acid gradient elution, the flowrate was ${1.0}\mathrm{\;{mL}}/\mathrm{{min}}$ , thecolumn temperature was ${25}^{\circ }\mathrm{C}$ and thedetection wavelength were ${230}\mathrm{\;{nm}}$ $\left({0\sim {25}\mathrm{\;{min}}}\right),{290}\mathrm{\;{nm}}\left({{25}\sim {41}\mathrm{\;{min}}}\right)$ and ${274}\mathrm{\;{nm}}\left({{41}\sim {51}\mathrm{\;{min}}}\right)$ . Results The linear ranges of paeoniflorin, cinnamaldehyde and paeonolwere 3.6169~90.4232 μg/mL ( $r={0.9993}$ ),1.8388~45.9695 μg/mL ( $r={0.9999}$ ),2.0240~50.5994 μg/mL ( $r={0.9999}$ ). The average sample recovery rates were95.4%(RSD=1.2%), 93.0%(RSD=0.7%) and 94.2%(RSD=1.2%) respectively. Conclusion This method is accurate, sensitive, and has strong specificity. It can be used for the quality control of Guizhi Jiliu Pills.

Objective To explore the determination of trace glutathioneby resonance scattering spectral quenching method and improve thesensitivity of the method. Methods In the pH 3.0 phosphoric acid-boricacid-acetic acid buffer solution (BR buffer), $\mathrm{{Fe}}\left(\mathrm{{III}}\right)$ reacts with ${\mathrm{K}}_{4}\left\lbrack {\mathrm{{Fe}}{\left(\mathrm{{CN}}\right)}_{6}}\right\rbrack$ to form Prussian blue ion associates, and the system exhibits a strongresonance scattering effect at ${337}\mathrm{\;{nm}}$ . When glutathione isadded, the sulfhydryl group in glutathione molecules can reduce Fe(III)to Fe(II), causing quenching of the system and weakening the resonancescattering quenching effect. Results The linear regression equation forglutathione within the concentration range of 0.010 to ${2.0\mu }\mathrm{g}/\mathrm{{mL}}$ is ${\Delta l}= {299.77\rho }+{774.52}$ , with an ${r}^{2}$ of 0.9929 and a detection limit of ${0.0024\mu }\mathrm{g}/\mathrm{{mL}}$ . Conclusion This method is simple and highly sensitive, and satisfactoryresults are obtained when used for the determination of glutathione indrugs.

University laboratory as an important base of scientific research and teaching, safety management is very important. Effective laboratory management plays an important role in ensuring the smooth operation of practical teaching and scientific research and the safety of teachers and students. This study focuses on the current situation and challenges of the safety management of specialized biological laboratories related to agriculture, focusing on four core elements of laboratory management system, reagent management, equipment management and waste liquid treatment. Through the construction of scientific management system, explore the safety management system of biological laboratories related to agriculture, aiming to improve the safety management ability of scientific research laboratories in local universities under the background of new agricultural science.

This paper discusses the importance and related requirements of discipline in geological experiment testing, including operation discipline, data discipline, safety discipline, confidentiality discipline and team discipline. It elaborates on how to keep discipline by strengthening discipline awareness, strengthening training and learning, establishing supervision mechanism, setting an example and taking serious accountability measures. It emphasized the key role of strict discipline in ensuring the smooth progress of geological experiment and test work, achieving reliable results and promoting the development of geological undertakings, and called on all personnel engaged in geological experiment and test work to always bear in mind the discipline requirements, work solidly with a high sense of responsibility and mission, and lay a solid foundation for geological scientific research and resource development and utilization.

With the deepening of double first-class"construction in Chinese universities, the introduction of a large number of scientific research talents, the rapid expansion of scientific research laboratories, the laboratories of science and technology departments are facing the dilemma of limited space and unreasonable layout, at the same time, safety check tasks at all levels are continuously detailed, quantified and standardized. In view of the lack of professional safety inspection personnel, heavy safety inspection tasks, hidden danger rectification is not in place and other problems, this paper puts forward solutions at the college level. This paper explores how to optimize the existing safety inspection system at the college level, and systematically and professionally carry out special rectification of the safety hazards in the laboratory under its jurisdiction. In practice, explore how to better mobilize resources such as lab safety officers and students so that lab safety becomes a habit that can be cultivated, which in turn promotes lab safety at the college and university levels.

University laboratories are characterized by their complex functions, high safety risks, and significant management challenges. Establishing a sound safety education and training model is an important means to promote the safety management of laboratories. This study discusses the current issues in safety education and training for university laboratories, including the structural issue that safety education and training are not incorporated into the laboratory management system, the process issue of having a singular form of safety education and training and a lack of targeted content, and the result issue of the absence of an evaluation mechanism for safety education and training. In response to these issues, a university laboratory safety education and training model based on structure-process-result is constructed around pre-experiment, during-experiment, and post-experiment stages, providing references for improving the safety literacy of laboratory personnel and ensuring the safe operation of laboratories.

Laboratory is an important structure in the field of health inspection, and the management level of laboratory directly affects the effect of disease control and prevention. In recent years, with the vigorous development of the laboratory field, the emergence of many new laboratory reagents and laboratory technologies has effectively improved the efficiency of clinical laboratory, but it also poses new challenges to the development of existing laboratory management. The lack of reagent management system, the lack of talent team construction and the inability of information technology advantages are one of the practical difficulties of laboratory management at this stage. It is difficult to avoid the influence of human factors on the quality of inspection, and it is impossible to promote the high-quality development of inspection work. In recent years, with the development of emerging technology industry, emerging technology has potential value in the optimization management of laboratory. This paper reviews four emerging technologies, namely automation pipeline, artificial intelligence technology, cloud management platform and virtual simulation, aiming to solve the problem of lack of reagent management system in traditional laboratory inspection management and difficulty in highlighting the advantages of information technology. So as to promote the inspection laboratory management system update iteration, towards the direction of digital, scientific development.

University laboratory is the main place of experimental teaching and scientific research, which plays an important role in universities. The safety management of the laboratory is the guarantee of the efficient operation of the laboratory and the improvement of the level of teaching and research. Meanwhile, the laboratory is also a place where the potential high-risk accidents happened. Aiming at the problem in the laboratory safety management, we have improved the laboratory safety management measures to prevent and reduce the occurrence of laboratory safety accidents. This article mainly proposed the potential safety hazards and improvement strategies for the laboratory management, offering valuable insights for refence.

In the context of high-quality development in China, some operating methods of the traditional inspection and testing industry can no longer meet the actual testing needs, and the rise and development of digitalization and intelligence will promote the revolutionary transformation of the inspection and testing industry. This paper introduced the iron ore moisture detection and control system, and discussed its application in moisture detection. Firstly, the pain points and risks of the traditional inspection methods of iron ore were analyzed, and the concept and significance of the iron ore moisture detection and control system were introduced. The module composition and operation methods of the iron ore moisture detection and control system were introduced in detail, including the design of hardware equipment, cloud computing and process management and control applications. Finally, examples were demonstrated and analyzed. The advantages and application prospects of iron ore moisture detection and control system in inspection and testing industry were demonstrated. It provides a theoretical basis for the digitization and intellectualization of iron ore moisture detection.

Objective To realize the intelligentization and visualization of laboratory management and effectively improve the efficiency and quality of inspection work by taking the digital scheme of building drug inspection laboratory in Taizhou Pharmaceutical Inspection Institute as an example. Methods Through the mode of “internet+technology service", the whole process of "one-stop" service was realized in scientific experiment, technology research and development, safety evaluation, industry cultivation and other aspects at drug testing institution. Results Since the operation of the digital laboratory of Taizhou Institute of Drug Control for 2 years, more than 6,700 drug testing reports had been completed, 21 sets of high-end instruments and equipments with a value of 25 million yuan had been shared freely through the "drug inspection pass" service platform, providing efficient services for more than 200 enterprises and institutions, completing 2960 batches of entrusted testing business, reducing the laboratory operation cost by 20%, solving 280 technical problems for pharmaceutical enterprises, directly reducing the cost of more than 400000 yuan for pharmaceutical enterprises, shortening the service cycle to 10~15 working days after entrusted by the enterprise through the platform, and improving the efficiency by 30%. Conclusion The foundation of digital laboratory enables the testing institution to achieve comprehensive, efficient and accurate management and coordination, improve the efficiency and quality, improve the scientific and normative nature of testing work, provide high-efficiency and high-quality services for the development of pharmaceutical enterprises, and provide solid technical support for the digital, precise and intelligent governance of drug supervision work.

With the rapid development of technology and the deepening of digital transformation, inspection and testing institutions are confronted with significant challenges in the digitization and intelligent transformation of equipment management. This paper aimed to discuss the application of intelligent equipment management in inspection and testing institutions, analyze the current status of equipment management in inspection and testing institutions, point out existing problems and shortcomings, and propose specific scenarios for the application of artificial intelligence, big data analysis, automation control and Internet of things technology in intelligent equipment management, so as to achieve equipment predictive maintenance and optimize equipment resource allocation, remote control and information sharing to improve the efficiency of equipment management, ensure the quality of testing, to meet the increasingly complex testing needs. This paper also discussed the advantages of digital intelligent management in improving instrument and equipment testing efficiency, ensuring testing quality and reducing operating costs, summarized the important role of digital intelligent management in inspection and testing institutions, looked forward to the future trend, and put forward development suggestions, in order to provide reference and reference for promoting the digitalization and intelligent transformation of equipment management in inspection and testing institutions.

Informatization construction is a necessary means to realize the quality management of ecological environmental monitoring. This paper took the construction practice of the ecological environment monitoring quality management system in Guangxi as an example, combined with the problems existing in inspection and testing institutions, and used information technology to propose a system construction and design based on quality management as the goal. Quality control was carried out from multiple perspectives such as monitoring process, standard methods, data review, system judgment, and process supervision, realizing the full process management and traceability of ecological environment monitoring, accelerating the construction of standardized, standardized, refined, intelligent, and precise quality management, which helped to promote the high-quality development of ecological environment intelligent monitoring.

As a new supervision mode, intelligent supervision is being explored in the field of food safety in China. By integrating modern information technologies such as big data, cloud computing, the Internet of Things and artificial intelligence, intelligent supervision aims to realize the whole-process monitoring, risk early warning and efficient response to food safety. This study aims to explore the application and prospect of smart supervision in the field of food safety. By integrating modern information technology, smart supervision can effectively improve supervision efficiency, reduce food safety risks, and enhance public confidence in food safety. At the same time, for the challenges faced by smart regulation, this paper discusses how to improve the legal and regulatory framework of smart regulation, strengthen technological innovation, enhance public participation, and how to build a multi-participation regulatory mechanism to ensure the healthy development of smart regulation in the field of food safety in China.

This paper discusses the significance of the construction of open sharing platform for large instruments and equipment, and analyzes the main problems existing in the construction of large instrument sharing platform in local undergraduate colleges, such as insufficient investment funds, imperfect sharing mechanism, weak testing level and insufficient utilization of instruments and equipment. The paper puts forward some practical suggestions on the construction of the open sharing platform of large instruments and equipment by increasing the capital investment, improving the open sharing mechanism, assembling and strengthening the experimental technical team, and developing and mining the testing

Quality control of cement concrete raw materials in highway engineering is a key factor in ensuring engineering quality and durability. This paper analyzes the importance, content and existing problems of cement concrete raw material testing and inspection, and proposes a series of quality control measures. These measures include formulating scientific and reasonable testing and inspection processes, strengthening the management of raw material use and inspection, and optimizing the inspection environment. By taking these measures, the quality of cement concrete engineering can be effectively improved, and the smooth construction and long-term use of highway engineering can be guaranteed.

Total nitrogen, as a fundamental indicator for water quality monitoring, is an important indicator for measuring the degree of water pollution, self purification status, and eutrophication. It is of great significance for evaluating water quality and protecting the ecological environment. This article explores the main factors affecting the detection process of total nitrogen in water using ultraviolet digestion spectrophotometry. By optimizing the detection process through methods such as sample self influencing factors, digestion process control, and reagent and drug purification, the problem of high experimental blank has been effectively solved, and the reliability and accuracy of the detection have been improved.

Total sulfur in coal is one of the important indicators for evaluating coal quality. In order to effectively and economically utilize coal resources, it is necessary to comprehensively understand the total sulfur content in coal. Based on the principle of coulometric titration and the consideration of man-machine material loop measurement, this paper deeply explores the main factors affecting the measurement accuracy, aiming to significantly improve the accuracy of total sulfur determination through systematic analysis of the influence of various factors on the detection and standardization of the correct use, inspection and maintenance of the instrument.

Objective To study the automatic iodine analyzer to detectthe content of iodine in urine, so as to provide a scientific andefficient method for the majority of urinary iodine detection workers. Methods The linear range and correlation coefficient, detection limit,precision and accuracy of the method were tested to understand thefeasibility of the method. Results The linear range of this method is $0 \sim {400}\mathrm{{\mug}}/\mathrm{L}$ , the linear equation was $\lg A =- {0.0014C}+ {0.0013}$ , thecorrelation coefficient(r)was 0.9998, and the Limit of Detection (LD)was ${3.9\mu }\mathrm{g}/\mathrm{L}$ ,the relative standard deviation (RSD) was ${2.7}\%\sim {4.3}\%$ ; the detectionresults of low and high concentrations of urinary iodine referencematerials were in the range of uncertainty; 50 urine samples of pregnantwomen were randomly selected for iodine determination. By comparing theautomatic iodine analyzer with the manual method, the relative deviationof the results is $-{9.9}\%\sim {12.8}\%$ , which meets thequality control requirements of the National Reference Laboratory foriodine deficiency disorders for 3 consecutive years, he participated inthe national external quality control examination of IDD laboratoriesand passed all of them. Conclusion The linear range, correlationcoefficient, detection limit, precision and accuracy of the method aresatisfactory, and the method has a high degree of automation, reducingthe detection time and the workload of the staff, at the same time, ithas advantages in toxicity and waste disposal, so the automatic iodineanalyzer method is suitable for the determination of iodine in urine,especially for the detection of large-scale urine iodine, suitable forpopularization.

Objective To establish a high performance liquidchromatography method for the determination of the content uniformity ofpromethazine hydrochloride, and to provide a reliable experimental basisfor the subsequent study of the content uniformity and content qualityof pediatric drugs after manual breaking tablets. Methods Highperformance liquid chromatography was used, octadecyl silane bondedsilica gel was used as the column filling agent, water (adjusted pH to2.3 with glacial acetic acid)-methanol (55 : 45) was used as the mobilephase, and the detection wavelength was ${254}\mathrm{\;{nm}}$ . ResultsPromethazine hydrochloride showed a good linear relationship in therange of 17.392~26.088 μg/mL, and the linear equation was: $\mathrm{Y}= {55272}\mathrm{X}+{348938}\left({{r}^{2}= {0.9986}}\right)$ . The method recoveryrate was between 100.22% and 101.40%, and the RSD was ${0.49}\%$ . The content uniformity ofpromethazine hydrochloride was in accordance with the provisions of thefour general principles of the Chinese Pharmacopoeia 2020 edition.Finally, this method was used to analyze the accuracy of children’sdrugs by different methods of dosing by the content and contentuniformity of promethazine hydrochloride tablets. Conclusion The method has strong specificity in determining the content uniformity and content of promethazine hydrochloride, and the accuracy and precision are good. The dose accuracy of children’s tablets is reduced by many times of dosing, and it also provides very important data theoretical and practical significance for promoting the dose accuracy of children’s tablets.

Objective To analyze the content of heavy metals in water and fish in Huayuan River. Methods Microwave digestion and inductively coupled plasma mass spectrometry (ICP-MS) were used to determine the heavy metal content of common freshwater fish such as Branchfish, Carassius elegans, Siniperca elegans and grass carp in Huayuan River. Results The content of heavy metals (Cu, Zn, As, Pb, Cd, Fe, Mn) in all sections of Huayuan River was lower than the standard limit of Class III water in GB 3838-2002, and the overall water quality was good. The cross section fish Cd and As in the upstream border town are slightly polluted. In the lower reaches of Huayuan River, Pb and As were slightly polluted, while Cd was seriously polluted. The single heavy metal hazard coefficient (THQ) and the composite heavy metal hazard coefficient (TTHQ) of fish in Huayuan River are both less than 1, which indicates that the enrichment of heavy metals in fish in Huayuan River will not cause harm to human consumption. Conclusion The results of this study reflect the influence of water pollution degree on heavy metal enrichment of fish in Huayuan River to some extent, and provide reference and theoretical support for the assessment of ecological security, fish resource diversity and food safety of Huayuan River in this region.

Objective To discuss the dispersion and correlation of granite in Foshan, analyze the causes of the dispersion and the measures to reduce the dispersion. Methods 10 groups of granite samples from a place in Foshan were selected for laboratory tests of physical and mechanical properties, and the data were analyzed statistically. Results The water content, bulk density, particle density and uniaxial compressive strength of granites in this area have a certain correlation, and there are discretization. Conclusion Analysis of the correlation and discreteness of test results is helpful to improve the reference value of test data and provide theoretical support for engineering applications.

Objective This study was aimed at the accurate determination of heavy metals in water quality by inductively coupled plasma mass spectrometry (ICP-MS), so as to improve the analysis accuracy and provide scientific basis for water quality monitoring. Methods The water samples were collected for filtration and acidification. Agilent 7700x was used to detect lead, cadmium, arsenic and mercury according to EPA 6020B standard. The power, argon flow rate and sample introduction rate were optimized. Results The single factor analysis of variance showed that the optimized ICP-MS significantly improved the sensitivity and accuracy of heavy metal detection. RSD was less than 5% in repeated experiments, and the recovery rate was 95%~105%. Conclusion This study successfully improved the accuracy of water quality analysis, and the optimization method provided reliable technical support for environmental monitoring.

Water quality safety is the key to ensuring human health and sustainable social development. With the increase of pollutants and the upgrading of detection technology, multi-parameter analyzers play a core role in water quality detection. This article reveals the important role of multi-parameter analyzers in efficient and accurate assessment of water quality. Special attention was paid to its outstanding performance in the detection of heavy metals, toxic substances and microbial contamination, and its significant advantages such as high efficiency, automation, multi-parameter simultaneous detection and remote monitoring were detailed. The development trend of miniaturization, intelligence and networking of multi-parameter analysis instruments provides important technical support and scientific basis for improving the efficiency and accuracy of water quality detection, ensuring water quality safety, and promoting ecological protection and sustainable development. And provide a more rigorous and scientific reference basis for the design and implementation of similar testing projects.

With the continuous deepening of the national institutional reform process, the social functions of drug regulatory departments have become increasingly prominent, and there is an urgent need to strengthen the implementation of responsibilities, improve the work framework system, and enhance the effectiveness of drug adverse reaction monitoring. Based on this, this article first introduces the importance of strengthening the monitoring of adverse drug reactions and analyzes the composition of the elements of adverse drug reaction monitoring. On the basis of exploring the current situation and difficult issues of adverse drug reaction monitoring by drug regulatory authorities, combined with relevant practical experience, this paper proposes methods and countermeasures for drug adverse reaction monitoring by drug regulatory authorities under institutional reform, including improving the establishment of monitoring institutions and strengthening the management of reporting units.

Objective To investigate the distribution of Escherichia coli (E. coli) contamination in fruits sold in some cities and counties of Hainan Province, and to analyze the isolates for drug resistance, aiming at identifying the risk of foodborne E. coli and evaluating its potential impact on food safety. Methods Isolation and identification of E. coli in samples and detection of drug resistance of E. coli isolates by VITEK 2 method. Results A total of 51 strains of E. coli were isolated from 240 fruit samples, with a detection rate of 21.3%. 19 strains of E. coli were drug-resistant, with a resistance rate of 37.3%, including 7 single-resistant and 12 multi-resistant strains. Comparative analysis of the distribution of E. coli in different regions and fruits showed that fruit species and sampling locations had a significant effect on the distribution of Escherichia coli. Conclusion The distribution of E. coli in commercially available fruits is widespread and drug-resistant, the detection of pathogenic bacteria distribution and drug resistance in fruits should be strengthened, and this study also provides an important reference basis for food safety management and monitoring.

With the development of China’s economy, people’srequirements for water quality are getting higher and higher. In orderto protect water resources, we need to do a good job of water qualitymonitoring, real-time monitoring of water quality indicators, timelyfind the trend of water quality changes, and analysis and prediction.The accurate determination of the permanganate index $\left({\mathrm{{COD}}}_{\mathrm{{Mn}}}\right)$ ,as a key indicator for evaluating the degree of pollution by organicmatter and reductive inorganic matter in water bodies, is of greatsignificance. The purpose of this paper is to discuss the qualitycontrol methods during the determination of permanganate index in waterin order to improve the accuracy and reliability of the results.

With the gradual depletion of natural sand resources, the replacement of natural sand by machine-made sand is an inevitable trend, and the performance of machine-made sand has a certain impact on the workability, mechanics and durability of concrete. In 2023, Zhenjiang Construction Engineering Quality Inspection Association carried out the comparison of machine-made sand laboratories, analyzed the testing ability level of each laboratory and identified the problems existing in the laboratory, and carried out technical analysis on the factors affecting the detection results of machine-made sand methylene blue value, stone powder content and crushing index, and put forward relevant suggestions.

Objective To verify the accuracy of rapid detection results for sulfur dioxide. Methods Distillation iodine titration method was used to detect 598 batches of food samples in the rapid detection project, and the accuracy of the rapid detection results was analyzed. Results The overall accuracy of the sulfur dioxide rapid detection project was 93%, with a positive accuracy of 94% and a negative accuracy of 96%. The accuracy is less affected by the factors of rapid detection personnel, ranging from 92% to 94%; The fluctuation range of food variety factors is 75% to 100%; The fluctuation range of fast inspection product factors is 83% to 100%. The quick test results have a moderate degree of consistency with the laboratory results, with a Kappa value of 0.465. The higher the sulfur dioxide content in the sample, the more obvious the quick test results are, and the higher the accuracy of the quick test results.Continuously strengthening the management of rapid inspection products, selecting suitable food varieties, and sampling representative samples can further improve the accuracy of results. Conclusion The data from this validation proves that the fast detection method has high accuracy and can meet the requirements of on-site risk screening, effectively preventing food safety risks.

Objective Study why nicotinamide is transformed tonicotinic acid occurred when detect vitamin ${\mathrm{B}}_{3}$ in milk powdercontaining lactic acid bacteria by GB 5009.89-2016 high performanceliquid chromatography method, and its mechanism was discussed. MethodsThe samples were pretreated according to standard procedures, and theeffects of the placement time of the sample extraction solution, theplacement time of the sample solution before acid hydrolysis and the $\mathrm{{pH}}$ value of acidhydrolysis were investigated by single factor test. Results Thetransformation of nicotinamide to nicotinic acid occurred in theplacement step after the sample was dissolved and before acidhydrolysis, but after adjusting the pH value to 1.7 specified in thestandard for acid hydrolysis, the transformation was completelyinhibited. Conclusion If you want to detect the content of nicotinicacid or nicotinamide separately in samples containing lactic acidbacteria, you need to adjust the $\mathrm{{pH}}$ value to 1.7 when thesample is dissolved to inhibit the transformation of nicotinamide tonicotinic acid.

Objective To investigate the laboratory detectioncapability of the determination of hexachlorocyclohexane pesticideresidues in plant extract concentrates of various laboratories under thegroup. Methods Using plant extract concentrate as the substrate, $\beta$ -hexachlorocyclohexane and $\delta$ -hexachlorocyclohexane was used asthe target substance, and a comparison sample was prepared by adding amatrix. After uniformity and stability verification, robust statisticalalgorithm A was used to calculate the robust mean and robust standarddeviation. The laboratory detection ability of hexachlorocyclohexanepesticide residues in plant extract concentrate was evaluated based onthe $Z$ -ratio score. Results Theuniformity and stability test results of the comparison samples meet therequirements, and the satisfaction rate of the detection of pesticideresidues in plant extract concentrate is 100%. The participatinglaboratories have good detection capabilities. Conclusion Compared withproficiency testing, inter laboratory comparisons have the advantages oflow cost and convenient organization, making them an effectivesupplement to proficiency testing activities.

Objective The application of quality control chart in the quantitative detection of Staphylococcus aureus in milk was discussed by collecting the routine detection process of Staphylococcus aureus in milk and testing the results of Staphylococcus aureus in quality control samples simultaneously. Methods Monitoring the detection data by utilizing the center line of the single value control chart and the moving range control chart, an upper warning limit, a lower warning limit, an upper control limit and a lower control limit, standard error and data point inside and outside the boundary of the range control chart are used to monitor and evaluate the laboratory detection process, and the status of the personnel, instruments and reagents in the experimental detection process is judged. Results By observing the range of test data and analyzing the distribution characteristics and changes of data, the results showed that single value control chart and moving range control chart could effectively monitor the detection process of Staphylococcus aureus in milk, and the data results were reliable. Conclusion The construction of the quality control chart provides an effective means of food hygiene quality control for laboratory testing of the project, and helps to promote the smooth development of the quality control work in the laboratory testing process.

Objective To optimize the ultrasonic extraction technologyof flavonoids, polyphenols and saponins from Mirabilis himalaica, and toevaluate their antioxidant activities. Methods Based on the singlefactor tests of ethanol concentration, liquid-solid ratio, extractiontemperature and extraction time, Box-Behnken response surface method wasused to optimize the extraction process of flavonoids, polyphenols andsaponins. The antioxidant activity of DPPH, ABTS, superoxide anion andhydroxyl radical was investigated in vitro. Results The optimizedultrasonic extraction technology was ${60}\%$ ethanol concentration, ${30}\mathrm{\;{mL}}/\mathrm{g}$ liquid-solid ratio, 50℃ extractiontemperature and 55 min extraction time. The extracts had strongscavenging effect on free radicals. Conclusion It is proved that theoptimized ultrasonic extraction technology of flavonoids, polyphenolsand saponins from Mirabilis himalaica is reasonable, and the extractshave antioxidant activity in vitro.