Latest ArticlesChronic inflammation is considered as a potential pathological state, which is the long-term presence of low concentrations of inflammatory factors in the body and continuous infection of the body, manifested by aggregation and infiltration of monocytes, lymphocytes and other cells, tissue proliferation, lesions, etc. Research shows that chronic inflammation can mediate cancer, diabetes, cardiovascular, nervous system, inflammatory bowel disease, lung disease and other diseases. Curcumin is an active component of polyphenols extracted from turmeric, a traditional Chinese medicine. It has significant anti-inflammatory activity, and its efficacy in controlling or treating a variety of chronic inflammatory diseases has been widely reported. On the other hand, inflammation-related signaling pathways, such as JAKs/STATs, PI3K/AKT/mTOR, Wnt/β-catenin, NF-κB, MAPK/ERK, etc., play key roles in the pathogenesis of various chronic inflammatory diseases. Signaling molecules in the pathway are considered to be important targets of new therapeutic approaches, and curcumin can participate in related inflammation-related signaling pathways to produce anti-inflammatory effects. In this paper, the pharmacological studies of curcumin in chronic inflammatory diseases in the past five years and the regulatory role of curcumin in the inflammatory signaling pathway were reviewed, to provide a reference for the research and development of curcumin in the prevention and treatment of chronic inflammatory diseases.
To investigate the compatibility between Shenlu Tablets and drug packaging materials by screening and determination of 20 elements in Shenlu Tablets.
For accelerated testing, the samples were stored at a temperature of 40 ℃ and a relative humidity of 90% for 0, 1, 2, and 3 months. Compatibility study was carried out by comparing the content of elements. At the same time, elemental determination was carried out on the corresponding raw and auxiliary materials of Shenlu Tablets to determine the source of the elements. Elements that were classified as 1, 2A, 2B (As,Cd,Pb,Hg,Co,V,Ni,Ag) were used as risk assessment elements using ICH Q3D. Risk elements in ginseng deer supplements were assessed according to "Chinese Pharmacopoeia" 2020 Edition Fourth General Chapter 9302 Harmful Traditional Chinese Medicine Guidelines.
The 20 elements showed a good linearty, with the correlation coefficient r of 0.997 3~0.999 9, the recovery rate of spiked sample of 92.7%~98.4%, and the recovery rate of drug packaging material of 82.1%~101.7%. The detection limits of all elements were within 0.000 17~0.17 μg·g-1. 19 elements except Hg were detected in Shenlu Tablets. Except for As, Ag, Sb, Hg, Bi, the other 15 elements were detected in the packaging materials used for the patch. Among the raw and auxiliary materials corresponding to Shenlu Tablets, the elements detected in the traditional Chinese medicinal materials are basically the same without obvious element aggregation. The compatibility results show that, compared with the results of the accelerated test in 3 months and in 0 months, six was no obvious migration of each element in the patch and the corresponding packaging material for the three batches of Shenlu Tablets. The maximum theoretical limit of 8 risk elements in Shenlu Tablets was compared with the average content of the accelerated test samples, and the average content of the samples was far less than the maximum theoretical limit L value.
The microwave digestion-ICP-MS was used to determine 20 elements in Shenlu Tablets with high precision, repeatability and stability. There is no significant difference in the contribution of different Chinese herbal medicines to the elements in Shenlu supplement, and there does not exist single source. Combining the results of compatibility and risk analysis, the compatibility between the drug and the packaging material is good, and the risk of element intake is low. This study helps comprehensively evaluate the safety and compatibility of the drug, providing a reference for the quality control of similar drugs and the establishment of element intake risk assessment.
Alzheimer's disease (AD) is a chronic degenerative disease of the central nervous system, characterized by β-amyloid deposition and abnormal phosphorylation of Tau protein, while its etiology and pathogenesis have not been fully elucidated. The most common presentation of AD is of an elderly individual with progressive problems of memory impairment, cognitive dysfunction, mental symptoms, and loss of living ability. Dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) is a highly evolutionary conserved protein kinase, which is related to retardation, neurodegeneration, severe cognitive impairment, and early onset AD. Compelling data have implicated that DYRK1A phosphorylates a variety of substrates on serine or threonine residues, thereby regulating the different cellular processes involved in brain development and function. Thus, DYRK1A might be a promising target for the prevention and treatment of AD, as it is implicated in the formation of senile plaques, neurofibrillary tangles, oxidative stress injury and inflammatory responses. In this paper, we reviews the structure, distribution, and function of DYRK1A, as well as its role in the pathogenesis of AD, in order to provide a theoretical basis for the treatment of AD.
To investigate the anti-neuroinflammatory effect of Aucubin extracted from Rehmannia glutinosa in lipopolysaccharide (LPS)-induced neuroinflammation model in vitro.
N9 cells were activated by 10 μg·mL-1 LPS to establish an in vitro neuroinflammatory model. After treatment with Aucubin for 24 h, NO content was detected by Griess method, cell viability was detected by MTT method, cell morphology was photographed by microscopy, the level of Iba-1 (a specific marker of microglia) was detected by immunofluorescence, CD11b level and CD86/CD206 ratio were determined by flowsight assay, and the levels of IL-6, IL-1β, IL-4 and IL-10 were detected by kits.
Compared with the model group, the aucubin group effectively improved cell morphology, reduced cell supernatant NO level, decreased cell marker CD11b level and CD86/CD206 value, and regulated the release of inflammatory factors.
Aucubin inhibited the activation of microglia to M1 phenotype and promoted the transformation of M2 phenotype. It also regulated the release of inflammatory factors, thus inhibited the activation of N9 microglia and finally suppressed LPS-induced neuroinflammation.
To establish the HPLC-PDA fingerprint of Folium Photiniae combined with chemometrics to identify and screen the quality markers of Folium Photiniae, in order to provide a scientific basis for the quality of Folium Photiniae.
The fingerprint was obtained by an Agilent Eclipse XDB-C18 (250 mm×4.6 mm,5 μm) chromatographic column with a mobile phase of acetonitrile (A)-0.1% formic acid aqueous solution (B) in a gradient elution. The volume flow rate was set at 1.0 mL·min-1, the wavelength was 350 nm and the column temperature was 35 ℃. The fingerprints of 15 batches of Folium Photiniae were established using the developed method and the similarity was evaluated. The common peaks were analyzed by chemical identification pattern to distinguish Folium Photiniae from different origins, and the quality markers of Folium Photiniae were screened.
The similarity of the 15 batches of Folium Photiniae were all above 0.996, and a total of 10 common peaks were calibrated. Cluster analysis, principal component analysis and partial least squares analysis screened out chromatographic peak No.1 (neochlorogenic acid), No.2 (chlorogenic acid), No.4 (rutin), No.5 (hyricoside), and No.6 (isoquercitrin) as the quality markers of Folium Photiniae. The contents of neochlorogenic acid and chlorogenic acid is positively correlated with the quality of Folium Photiniae. The contents of rutin, hypericin and isoquercitrin may be negatively correlated with the quality of Folium Photiniae, indicating that the contents of these three components in Folium Photiniae should be limited at a low level. Further quantitative analysis of the above five components indicated the linear ranges of 0.135 3~2.706 0, 0.134 0~2.680 0, 0.008 5~0.170 5, 0.015 6~0.312 8, 0.005 9~0.118 9 μg, respectively. The linear relationship of each component is good (R2≥0.999 0), and the average recovery rate is 99.30% to 101.90%.
The established HPLC fingerprint and multi-component determination method are proved to be stable and reliable, which can provide a basis for the quality evaluation of Folium Photiniae.
In recent years, molecular targeted drugs involved in the pathogenesis and progression of cancer are being extensively investigated. Anlotinib, a novel multi-target tyrosine kinase inhibitor, is the first third-line treatment approved for patients with advanced non-small cell lung cancer in China, and has been approved for the treatment of soft tissue sarcoma, small cell lung cancer, medullary thyroid cancer and differentiated thyroid cancer. Numerous studies in China and abroad have found that this drug has three major functions, which are anti-tumor angiogenesis, inhibition of tumor growth and remodelling of the tumor microenvironment, and it can inhibit the development of solid tumours through various mechanisms. In this review, we summarize the role of anlotinib in various malignancies and research progress of related mechanism, to provide reference for its clinical application in oncology treatment.
This article reviews and analyzes the process of pharmaceutical innovation research in China to understand the frontier and hot spots of pharmaceutical innovation research, in order to provide reference for future research and practice. The relevant documents were searched in database CNKI, and CiteSpace visualization software was used to visually analyze and compare the selected documents, such as organization and author, keyword co-occurrence and clustering, keyword timeline and burst detection. A total of 2 255 literatures were included in this study. The results showed that the articles published on pharmaceutical innovation research has increased in volatility in the past 3 decades, and intuitively showed that the main affiliations, authors and major journals in this research field have not formed research clusters, and the institutional cooperation of scholars is limited. There are 10 clusters of high-frequency keywords, which are consistent with the development trend of pharmaceutical innovation. The emergence of 23 high-frequency keywords represents the research frontier in the field of pharmaceutical innovation. The cooperation density between institutions and authors remains a relatively low level, and a stable cooperative network relationship has not been formed between authors and institutions. In terms of research content, the development stage of China's pharmaceutical innovation research is consistent with the development of medicine, and the research content and field need to go further. The management performance and efficiency of pharmaceutical innovation and the cultivation of pharmaceutical innovation talents are more important research contents in recent years. There is still a large development space in pharmaceutical innovation research.
There has been much uncertainty existing in the pharmacological treatment of cardiac arrhythmias. Ivabradine is a novel drug with potential anti-arrhythmic benefits in addition to its ability of reducing heart rate without affecting hemodynamics. However, it is not currently approved for the treatment of arrhythmias other than sinus arrhythmias because of its potential arrhythmogenic risk. This review summarizes the evidence from basic and clinical studies regarding the use of ivabradine in sinus, atrial, junctional, and ventricular arrhythmias. Whether its benefits outweigh the risks for other types of arrhythmias except sinus arrhythmias is inconclusive and needs further proofs from additional studies.
To establish a detection method for exogenous DNA in neomycin sulfate drugs based on the concept of analytical quality by design (AQbD).
The MODDE Pro11 software was used to design the experiment, investigate the key influencing factors and optimize the parameters. Qubit® DNA detection kit based on fluorescence staining method was employed for the determination of exogenous DNA.
The universal detection method of exogenous DNA in neomycin sulfate was established. The key effect factors are solvent type, solvent concentration and sample concentration. When NaCl was used as solvent, the optimal analysis conditions were solvent concentration at 1.4 mol·L-1 and sample concentration at 1.8 mg·mL-1. The linear range of DNA standard was 20~100 ng·mL-1 (r=0.995 7, n=2). The accuracy was above 81.0%. The recoveries in ruggedness tests were 80%~120%.
The established method is accurate, robust and universal. This study provides reference for the development of determination of exogenous DNA in aminoglycoside antibiotics.
The aim of the article is to analyze the current research progress of COVID-19 vaccines in China and abroad based on patent data, and to make statistics on the main types and hot technologies, so as to provide reasonable suggestions for future vaccine research and development. Innojoy patent search engine and Baiten patent network were used to retrieve and analyze the patent data, and technology prediction was made according to the concept model of technology prediction. At present, the research hotspots of COVID-19 vaccines are mainly distributed in the technical fields related to the use of antigens, antibodies, peptides and genetic engineering. The research on COVID-19 vaccines in China mostly focuses on recombinant protein/epitope/polypeptide/subunit vaccines and nucleic acid vaccines, and the technical hotspots focus on antigen improvement techniques. The current research in the field of COVID-19 vaccines in the world and in China has made some progress, making the patent market active. The COVID-19 vaccine-related market and technical structure tend to enter a more developed stage.
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62199257
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
