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Chronic inflammation is considered as a potential pathological state, which is the long-term presence of low concentrations of inflammatory factors in the body and continuous infection of the body, manifested by aggregation and infiltration of monocytes, lymphocytes and other cells, tissue proliferation, lesions, etc. Research shows that chronic inflammation can mediate cancer, diabetes, cardiovascular, nervous system, inflammatory bowel disease, lung disease and other diseases. Curcumin is an active component of polyphenols extracted from turmeric, a traditional Chinese medicine. It has significant anti-inflammatory activity, and its efficacy in controlling or treating a variety of chronic inflammatory diseases has been widely reported. On the other hand, inflammation-related signaling pathways, such as JAKs/STATs, PI3K/AKT/mTOR, Wnt/β-catenin, NF-κB, MAPK/ERK, etc., play key roles in the pathogenesis of various chronic inflammatory diseases. Signaling molecules in the pathway are considered to be important targets of new therapeutic approaches, and curcumin can participate in related inflammation-related signaling pathways to produce anti-inflammatory effects. In this paper, the pharmacological studies of curcumin in chronic inflammatory diseases in the past five years and the regulatory role of curcumin in the inflammatory signaling pathway were reviewed, to provide a reference for the research and development of curcumin in the prevention and treatment of chronic inflammatory diseases.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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