To analyze the incidence rate, spatial trends and clustering characteristics of the echinococcosis in Tibet Autonomous Region from 2019 to 2023, with the aim of providing a scientific basis for the formulation of targeted prevention and control strategies.

Utilizing the echinococcosis surveillance data from Tibet Autonomous Region between 2019 and 2023, χ² tests were conducted using SPSS 25.0 software to compare differences between groups. ArcGIS 10.8 software was used for spatial trend surface analysis and spatial autocorrelation analysis.

From 2019 to 2023, a total of 508 074 individuals were screened in Tibet Autonomous Region, with 460 new cases of echinococcosis identified, resulting in an annual average incidence rate of 0.091%. Significant differences in incidence rates were observed between different years and regions. Spatial trend analysis revealed a higher incidence in the west and lower in the east, with a higher incidence in the middle and lower incidence at both ends in the north-south direction. Spatial autocorrelation analysis indicated that high-high clustering areas were concentrated in southwestern Tibet, while low-low clustering areas were concentrated in central and southern Tibet.

From 2019 to 2023, the incidence of echinococcosis in Tibet Autonomous Region exhibited significant spatial trends and clustering characteristics. It is recommended to strengthen surveillance in southwestern Tibet, assess the epidemiological situation, and explore prevention and control models suitable for this region to reduce the high incidence of echinococcosis.

To explore the influence of socioeconomic status on cognitive level and the longitudinal mediating role of loneliness and social participation among the elderly.

A total of 2 060 research samples were included in the 2011, 2014 and 2018 longitudinal data of the China Elderly Health Influencing Factors Longitudinal Survey (CLHLS), and the data were analyzed using cross-lagged mediation model.

There was a positive correlation between the pre-test socioeconomic status and the post-test cognitive level of the elderly, and the association was statistically significant （β=1.048, P<0.001）. The results of 95% of the bootstrap mediating effect test showed that the longitudinal mediating effect of loneliness in the elderly between socioeconomic status and cognition was insignificant -0.004 （-0.012-0.004）. The socioeconomic status of the elderly indirectly positively affected the cognitive level by positively affecting social participation 0.022 （0.009-0.036）, and the mediating effect was 33.06%. The longitudinal chain mediating effect between loneliness and social participation between socioeconomic status and cognition was significantly 0.010（0.002-0.019）, and the mediating effect was 21.03%.

The socioeconomic status of the elderly affects the cognitive level, the social participation of the elderly is the mediating variable of the socioeconomic status affecting the cognitive level,and there is a chain mediating effect between economic status and cognitive level in the elderly's loneliness and social participation. In the future prevention of cognitive dysfunction in older adults, special attention should be paid to the impact of socioeconomic status loneliness, and social participation.

To explore the complex relationship between pain, ability to perform daily activities, life satisfaction and sleep in older patients with chronic diseases, and to provide new perspectives and intervention strategies to improve their sleep.

Based on the data of China Health and Retirement Longitudinal Study (CHARLS) 2020, this study selected patients with chronic diseases aged 60 years and above as the study subjects, and screened out the sample size of 8 591 that met the criteria.T-test, analysis of variance (ANOVA), and Pearson's correlation analysis were used for the univariate analyses, and PROCESS 4.2 was used for the mediation effect analyses and tests.

Pain in older adults was negatively correlated with sleep duration (r=-0.197) and life satisfaction (r= -0.132), and positively correlated with ability to perform daily activities (r=0.292). The mediation test reported that pain in older adults had a direct effect on sleep duration (95% CI: -0.082--0.057), with ability to perform daily activities (95% CI: -0.015--0.017) and life satisfaction (95% CI: -0.005-0.002) acting as chained mediators between the two.

When improving the health management of older patients with chronic diseases, there is a need to focus on pain, daily mobility and life satisfaction in order to develop more effective intervention strategies.

To explore the reasonable setting of the experimental teaching project of the core course of undergraduate preventive medicine under the background of "new medicine".

A questionnaire was used to investigate the familiarity and score of the core experimental courses of preventive medicine among professionals in medical institutions and universities, and the results were statistically analyzed. Interviews with experts were conducted for experimental projects with low scores and those recommended by employers to explore reasonable experimental teaching projects for core courses of preventive medicine.

A total of 218 valid questionnaires were collected. The overall score of most experimental items in "Public Health Skills" was more than 8 points, and there was no significant difference in scores among different units (P>0.05). The overall score of the experimental items of the other preventive medicine experimental courses was more than 6 points, and the scores of the classical experimental operation experimental items of the CDC and the primary medical and health institutions were lower than those of other units (P<0.05). After sorting out the open questions in the questionnaire and interviews with experts, each employer intended to recommend adding experimental projects of on-site emergency handling and practical operation.

At present, the experimental teaching project of the core course of the undergraduate specialty of preventive medicine is reasonable. The reasonable setting of classic experimental operation experimental items and comprehensive practical experimental items in the core courses of undergraduate preventive medicine is worth studying.

To investigate the current status and related factors of distribution of HIV delivery test among men who have sex with men (MSM) in Guangxi, aiming to provide references for promoting expanded HIV testing strategies for MSM.

From September 2021 to February 2022, 330 MSM were recruited in Nanning, Guilin, Liuzhou and Beihai, Guangxifor aprospective cohort study.Generalized Estimating Equations were used in analyses of related factors.

Among the 319 MSM participants in the follow-up survey, 63.95% (204/319) underwent HIV delivery test.Multivariate generalized estimating equations showed that MSM with health insurance (aOR=1.959, 95% CI: 1.047-3.664), those with a college and above (aOR=1.736, 95% CI: 1.173-2.569), those who had undergone HIV testing in the past 3 months (aOR=3.565, 95% CI: 2.048-6.205), and those who had used HIV self-testing in the past 3 months (aOR=1.780, 95% CI: 1.227-2.582) were more willing to undergo HIV delivery test.

The proportion of HIV delivery test of MSM in Guangxi was63.95%.MSM with health insurance, a college or above education,had HIV test, and HIV self-testing in the past 3 months were more willing to undergo HIV delivery test.We should strengthen the publicity and promotion of HIV delivery test, encouraging individuals to participate in HIV delivery test in this population.

To investigate the relationship between the Systemic Inflammatory Response Index (SIRI) and the risk of albuminuria in hypertensive patients based on data from the National Health and Nutrition Examination Survey (NHANES).

This study utilized NHANES data from 2003 to 2018, including 5 705 hypertensive patients. Weighted logistic regression models were employed to adjust for confounding factors, and restricted cubic spline analysis was conducted to assess the correlation. Finally, subgroup analyses were performed to observe the correlation between SIRI and albuminuria in different hypertensive populations.

Among the 5 705 recruited participants, 54.28% were male. The prevalence of albuminuria was 12.81%. In the multivariate logistic regression model 3 with full adjustment for confounding variables, for every one standard deviation increase in SIRI levels, there was a 20% increase in the risk of albuminuria (OR=1.20,95% CI:1.07-1.34). When SIRI was analyzed as quartiles, with Q1 serving as the reference group, Q2 (OR=1.42,95% CI:1.02-1.97), Q3 (OR=1.55,95% CI:1.13-2.11), and Q4 (OR=1.94,95% CI:1.40-2.69) all demonstrated a significant positive correlation with the risk of albuminuria. Restricted cubic spline fitting revealed a non-linear positive correlation between SIRI and albuminuria. Stratified and interaction analyses confirmed the robustness of the results.

SIRI levels demonstrate a non-linear positive correlation with the risk of albuminuria in hypertensive patients and represent a high-risk factor across different age groups and genders within the hypertensive population.

To mailto:analyze the serovars, antimicrobial resistance status and distribution of antimicrobial resistance genes of Salmonella in Haidian District, Beijing. To discover the connection between antimicrobial resistance phenotypes and genotypes, and to explore the impact of disinfectant use during the COVID-19 on antimicrobial resistance of Salmonella.

Serotyping and drug susceptibility testing were performed on 107 strains andnext-generation sequencing (NGS) was performed on 27 strains of Salmonella collected from 2021 to 2023.

Salmonella enteritidis had the highest proportion (57.01%). Ceftazidime/avibactam and ertapenem had the highest susceptibility rates (100.0%). Ciprofloxacin had the highest intermediate rate (63.6%), and nalidixic acid had the highest resistance rate (74.8%). Antibiotic susceptibility tests showed increased resistance to multiple drugs. Among 27 strains, the carrying rate of aminoglycoside resistance genes was 100.0%. Most strains carried four or fewer resistance genes (88.9%). Salmonella enteritidis with drug-resistant genotypes of aph(6)-Id, aac(6')-Iaa, aph(3'')-Ib, blaTEM-1B and sul2 accounted for the largest proportion (42.9%). Other serovarsSalmonella with only one type of aminoglycoside resistance gene accounted for the largest proportion (53.8%). The phenotypic and genotypic resistance patterns of Salmonella to streptomycin (sensitivity 100.0%, positive predictive value 77.8%), ampicillin (sensitivity 55.6%, positive predictive value 100.0%), cefotaxime (sensitivity 60.0%, positive predictive value 80.0%), sulfamethoxazole-trimethoprim (sensitivity 60.0%, positive predictive value 85.7%), and chloramphenicol (sensitivity 50.0%, positive predictive value 100.0%) showed good agreement.

The antimicrobial resistance situation of Salmonella in Haidian District is serious. The impact of disinfectants and the correlation between phenotypes and genotypes should be focused on in the future.

To provide a theoretical basis for improving the monitoring and management of hepatitis B case data in Qinghai by analyzing the duplicate reporting (re-reporting) of hepatitis B cases in Qinghai from 2018 to 2022.

The data of cases with reported disease type of hepatitis B in Qinghai Province from 2018 to 2022 were collected through the National Notifiable Disease Reporting System (NNDRS), and five types of double-checking rules were set to check hepatitis B cases by using R4.3.2 software , and the restated caseswere further analysedusing χ² test and Cochran-Armitage trend test.

The cumulative number of repeated reported hepatitis B cases in Qinghai Province from 2018 to 2022 was 6 107 (13.01%), and when the time span of the hepatitis B cases included in the study ranged from 1 to 5 years, the restatement rates were 3.76%, 6.90%, 9.31%, 11.39%, and 13.01%, respectively, and the restatement rate was higher the longer the time span of the included cases (Z=57.931,P<0.001). When the time span of the included cases was 5 years, the restatement rates of the eight cities and states in Qinghai Province ranged from 9.45% to 15.25%, and the restatement rates of acute, chronic, and unclassified hepatitis B cases were 11.79%, 13.06% and 12.58%, respectively.

There is a more serious inter-regional and inter-annual restatement of hepatitis B cases reported in Qinghai Province from 2018-2022, and hepatitis B checking should be strengthened at all levels and in all departments, and targeted measures should be taken to reduce the situation of repeated reporting and improve the monitoring and management of hepatitis B cases.

To investigate the epidemiological characteristics and trends of notifiable infectious diseases among ≥ 60-year-olds in Chaoyang District, Beijing, and to provide a basis for the prevention and control of infectious diseases in the elderly population.

The data of ≥ 60-year-old cases of notifiable infectious diseases in Chaoyang District from 2014 to 2023 were collected through the Infectious Disease Reporting Information System of the Chinese Information System for Disease Control and Prevention, and the incidence trends and epidemiological characteristics of cases were descriptively analyzed.

From 2014 to 2023, the average annual incidence rate of notifiable infectious diseases among ≥ 60-year-old population in Chaoyang District was 864.01/100 000 showing an upward trend over the years (AAPC=31.50%, P<0.05). The incidence was highest in the ≥ 85-year-old population, and the incidence rate of males was 1 020.40/100 000 and higher than that of females (922.03/100 000) (χ²=150.333, P<0.001). 48 979 cases were mainly respiratory infections, accounting for 84.56%, its incidence showed an increasing trend, while that of intestinal infectious diseases showed a decreasing trend (AAPC=40.77%, -9.12%, P<0.05). A total of 317 deaths had been reported, with an average annual mortality rate of 4.63 per 100 000.

From 2014 to 2023, the incidence of notifiable infectious diseases among ≥ 60-year-old population in Chaoyang District showed a significant upward trend, and it is necessary to pay attention to tuberculosis, AIDS and influenza. Males are at high risk of respiratory and bloodborne and sexually transmitted infections; The incidence of respiratory and intestinal infectious diseases from 2020 to 2023 has no obvious seasonal characteristics, and the peak increases.