To investigate the relationship between the Systemic Inflammatory Response Index (SIRI) and the risk of albuminuria in hypertensive patients based on data from the National Health and Nutrition Examination Survey (NHANES).

This study utilized NHANES data from 2003 to 2018, including 5 705 hypertensive patients. Weighted logistic regression models were employed to adjust for confounding factors, and restricted cubic spline analysis was conducted to assess the correlation. Finally, subgroup analyses were performed to observe the correlation between SIRI and albuminuria in different hypertensive populations.

Among the 5 705 recruited participants, 54.28% were male. The prevalence of albuminuria was 12.81%. In the multivariate logistic regression model 3 with full adjustment for confounding variables, for every one standard deviation increase in SIRI levels, there was a 20% increase in the risk of albuminuria (OR=1.20,95% CI:1.07-1.34). When SIRI was analyzed as quartiles, with Q1 serving as the reference group, Q2 (OR=1.42,95% CI:1.02-1.97), Q3 (OR=1.55,95% CI:1.13-2.11), and Q4 (OR=1.94,95% CI:1.40-2.69) all demonstrated a significant positive correlation with the risk of albuminuria. Restricted cubic spline fitting revealed a non-linear positive correlation between SIRI and albuminuria. Stratified and interaction analyses confirmed the robustness of the results.

SIRI levels demonstrate a non-linear positive correlation with the risk of albuminuria in hypertensive patients and represent a high-risk factor across different age groups and genders within the hypertensive population.